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Meprate Tablet is used to treat the absence of menstrual periods (amenorrhea) and abnormal uterine bleeding. Besides this, it also prevents endometrial hyperplasia (thickening of the uterine lining with the risk of cancer) and overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Serum Institute Of India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Meprate Tablet

Meprate Tablet is a prescription medication used to treat absent or irregular menstrual periods, as well as abnormal bleeding from the uterus. It helps restore hormonal balance in women who produce lower levels of natural progesterone, ensuring a healthier menstrual cycle.

For the best results, you must take Meprate Tablet consistently and exactly as prescribed by your doctor. It is typically taken once a day for a set number of days during your menstrual cycle, and you can take it with or without food. To support your body during treatment, try to maintain a balanced diet and regular, moderate physical activity, which can help optimize your hormonal health.

While taking Meprate Tablet , you may experience mild, temporary side effects such as breast tenderness, headaches, or minor bloating. However, you should contact your doctor immediately if you notice more serious signs, such as sudden chest pain, severe swelling in your legs, or shortness of breath.

Do not take this if you have a history of blood clots, liver damage, breast cancer, or unusual vaginal bleeding that has not been evaluated by a doctor. It is essential to discuss your complete medical history with your healthcare provider to ensure this medication is safe for you. If you develop any new medical condition or discover that you may have one of these contraindications while taking Meprate Tablet , contact your doctor promptly for advice before making any changes to your treatment. 

Certain medications, such as rifampin or some seizure treatments, can make Meprate Tablet less effective, and smoking while taking this medicine can increase your risk of blood clots. Additionally, if you are pregnant, breastfeeding, or planning a pregnancy, consult your doctor, as this medication is generally not recommended during these times.

Uses of Meprate Tablet

Your doctor may prescribe Meprate Tablet for several conditions relating to hormonal balance and the menstrual cycle. The main uses include:

  • Amenorrhoea (absence of menstrual periods): Meprate Tablet helps restore normal monthly menstrual cycles in women who have stopped menstruating for several months.
  • Abnormal uterine bleeding: Meprate Tablet controls and stops heavy or irregular bleeding from the uterus caused by a hormonal imbalance rather than a structural issue.
  • Prevention of endometrial hyperplasia: Meprate Tablet protects the lining of the uterus from overgrowing in women who are taking estrogen therapy after menopause.
  • Hormone replacement therapy (HRT): Meprate Tablet may be prescribed alongside estrogen therapy in postmenopausal women with an intact uterus to help protect the uterine lining and reduce the risk of endometrial hyperplasia.

Key Benefits

When taken as prescribed, Meprate Tablet helps regulate menstrual health and manage abnormal uterine bleeding, improving overall comfort and quality of life. Key benefits include:

  • Helps restore regular and predictable menstrual cycles.
  • Reduces the discomfort and uncertainty associated with irregular or missed periods.
  • Helps control heavy or prolonged uterine bleeding.
  • Supports healthy regulation of the uterine lining.
  • Reduces the risk of fatigue and weakness caused by excessive blood loss.
  • Improves physical comfort and confidence in daily activities.
Side effects of Meprate Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Use hot or cold packs on your breasts to help alleviate discomfort.
  • Choose a supportive, well-fitting bra, preferably one that has been professionally fitted.
  • Practice relaxation techniques to manage stress and anxiety that may accompany severe breast pain.
  • Limit or avoid caffeine consumption.
  • Eat a low-fat diet and focus on foods rich in complex carbohydrates.
  • Rubbing evening primrose oil on your breasts may help balance fatty acids in the cells and reduce pain.
  • Keep track of when your breast pain occurs and any other symptoms to determine if the pain is regular or not.
  • Vitamin E supplements may help reduce pain for women who experience pain linked to their menstrual cycle.
  • Over-the-counter pain relievers like acetaminophen or ibuprofen can provide relief, but be sure to consult your doctor for the correct dosage, as prolonged use may cause side effects.
Managing Medication-Triggered Thrombophlebitis (Inflammation of a vein): A Step-by-Step Guide:
  • If you have symptoms such as pain, swelling, redness, or warmth in your veins after taking medication, contact your doctor right once. Share information about your symptoms, medication regimen, and medical history.
  • Your doctor will then assess your medication regimen to determine if it's contributing to the thrombophlebitis. This assessment will help identify the best course of action to manage your condition and prevent further complications.
  • Your doctor may suggest certain diet and lifestyle changes to help manage your condition. This may include increasing your intake of foods rich in omega-3 fatty acids, staying hydrated, exercising regularly, and maintaining a healthy weight. Your doctor may also advise medications to reduce inflammation, prevent blood clots, or manage pain if necessary.
  • If your condition does not improve or persists, consult your doctor and report your condition. Your doctor will assess your progress, adjust your treatment plan if necessary, and provide appropriate advice to ensure the best possible outcome.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Keep your skin clean by gently washing your face two times daily and after sweating. Choose a mild and non-abrasive cleanser.
  • Use gentle alcohol-free skin care products. Avoid products that might irritate your skin such as exfoliants, astringents and toners.
  • Acne may also occur due to oil in the hair. Thus, if you have oily hair, shampoo more frequently than you do now and keep your hair away from face.
  • Keep your hands off your face as touching face throughout the day might worsen acne. Also, do not pick, squeeze or pop acne as it will prolong the healing process and increase the risk of dark spots and scarring.
  • Avoid tanning by applying a broad spectrum sunscreen and wearing sun-protective clothing when outdoors.

Directions for Use

To get the most benefit from Meprate Tablet , it is crucial to follow your doctor's exact instructions regarding your schedule. This medication is often prescribed for only a specific number of days each month.

  • Swallow the tablet whole with a full glass of water.
  • Do not chew, crush, or break the tablet.
  • You can take this medication with or without food, but taking it at the same time every day helps keep your hormone levels steady.

Always complete the full course of therapy prescribed by your doctor, even if your symptoms improve before you finish the medication.

How Meprate Tablet Works

Meprate Tablet is a synthetic version of progesterone, which is a female hormone vital for regulating ovulation and menstruation. Under normal circumstances, progesterone balances the effects of estrogen and helps prepare the lining of the uterus for a healthy menstrual cycle. When the body does not produce enough natural progesterone, the uterine lining can grow too thick and shed irregularly, leading to heavy bleeding or missed periods. Meprate Tablet works by replacing the missing progesterone, signaling the body to stop growing the lining and instead prepare to shed it in a controlled, natural manner. This hormonal balance restores a regular menstrual rhythm and prevents abnormal tissue buildup.
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Alcohol

Consult your doctor

There is not enough scientific data available for Meprate Tablet interaction with alcohol; hence, it is best to consult a doctor.

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Pregnancy

Unsafe

Avoid taking Meprate Tablet if you are pregnant or think you may be pregnant, as Meprate Tablet might affect the developing baby.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Meprate Tablet . Consult your doctor if you have any concerns.

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Driving

Caution

It is advised to drive with caution after taking Meprate Tablet as it may interfere with driving capabilities. It can make you feel drowsy.

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Liver

Caution

Meprate Tablet should be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Consult your doctor

There is not enough scientific data available for Meprate Tablet interaction with the kidney; hence, it is best to consult a doctor.

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Children

Unsafe

Meprate Tablet is not recommended for children below 12 years of age.

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Heart

Unsafe

Meprate Tablet is not recommended for use in heart patients. Please consult your physician.

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Geriatrics

Caution

Meprate Tablet should be avoided or taken with caution in geriatric patients as it can lead to serious adverse effects. Please consult your doctor before using Meprate Tablet .

What if I have taken an overdose of Meprate Tablet

Do not take more than the prescribed dose of Meprate Tablet as it may cause an overdose. The symptoms of overdose include seizures (fits), vomiting, nausea, trouble breathing and altered mental status. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

Making specific daily changes can support your body while you are taking Meprate Tablet and help manage your symptoms:

  • Support your bone health: Because some hormonal treatments can affect bone density over time, ensure your diet is rich in calcium and vitamin D. Leafy greens, dairy products, and fortified foods are excellent choices.
  • Avoid smoking: Smoking while taking hormonal medications significantly increases your risk of serious cardiovascular complications, such as blood clots, stroke, or heart attack.
  • Stay hydrated: Drink plenty of water throughout the day to help minimize mild fluid retention, bloating, and headaches.
  • Incorporate weight-bearing exercise: Activities like brisk walking, jogging, or resistance training support bone strength and keep your circulatory system healthy.

Have a query?

How Soon It Starts Working

  • The time required for Meprate Tablet to start to work: The time required for Meprate Tablet to start to work is 2 to 3 hours after administration.
  • The time for which the effects of Meprate Tablet last: The effect of Meprate Tablet lasts for 24 hours.

What if you forget to take Meprate Tablet

Take the missed dose as soon as you remember. However, if it is time for the next dose, skip the missed dose and follow your regular dosing schedule. Do not take a double dose to make up for your missed dose.

Storage

• Store Meprate Tablet at room temperature, between 20°C and 25°C (68°F to 77°F). • Keep the tablets in their original packaging, away from direct sunlight, high heat, and moisture. Avoid storing them in the bathroom cabinet.

Drug Warnings

  • Perform regular breast self-exams: Since hormonal therapies can influence breast tissue, monitor your breasts for any unusual changes or lumps, and report them to your doctor.
  • Watch for vision changes: Stop taking the medication and seek medical care immediately if you experience sudden partial or complete loss of vision, double vision, or bulging eyes.
  • Monitor your blood pressure: Hormonal treatments can sometimes cause your blood pressure to rise. It is wise to have it checked regularly while taking this medicine.
  • Avoid prolonged immobility: If you are planning a long flight, a road trip, or have an upcoming surgery that will keep you bedridden, discuss this with your doctor, as immobility increases the risk of blood clots. Be sure to inform your surgeon, anaesthetist, and healthcare team that you are taking Meprate Tablet before any planned procedure. 

Drug-Drug Interactions

verifiedApollotooltip

It is important to keep your doctor and pharmacist updated on all the medicines you take, including prescription drugs, over-the-counter products, and herbal supplements.

Drug-Drug Interactions

Certain medicines may affect how Meprate Tablet works or increase the risk of side effects. Inform your doctor about all prescription medicines, over-the-counter products, and herbal supplements you are taking, especially:

  • Medicines that increase the breakdown of hormones in the liver
  • Certain medicines used to treat seizures
  • Rifampin and certain other medicines used to treat infections may increase the breakdown of Meprate Tablet in the body, making it less effective.
  • Other medicines that may reduce the effectiveness of hormone therapy


Drug-Disease Interactions

Certain medical conditions may affect the safety and effectiveness of Meprate Tablet . Tell your doctor if you have or have ever had any of the following conditions:

  • Active or previous blood clots
  • Liver disease or liver damage
  • Breast cancer or other hormone-sensitive cancers
  • Unexplained vaginal bleeding
  • High blood pressure
  • Diabetes
  • Kidney disease
  • Asthma
  • Migraine
  • Depression
Critical

Drug-Drug Interactions

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How does the drug interact with Meprate Tablet:
Coadministration of Acitretin with Meprate Tablet can increase the risk and severity of birth defects when taken by a pregnant woman.

How to manage the interaction:
Taking Acitretin with Meprate Tablet together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Do not discontinue any medications without consulting a doctor.
Critical
How does the drug interact with Meprate Tablet:
Taking Meprate Tablet and Etretinate may cause severe birth defects if the mother takes the medication during pregnancy.

How to manage the interaction:
Using etretinate and Meprate Tablet together is not recommended, but can be taken if prescribed by a doctor. However, if you experience unusual symptoms contact your doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Meprate Tablet:
Taking Meprate Tablet acetate with Tranexamic acid may increase the risk of blood clots.

How to manage the interaction:
Taking Meprate Tablet with Tranexamic acid is not recommended but can be taken if prescribed by a doctor. Consult your doctor immediately if you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg. Do not stop using any medications without talking to your doctor.
MedroxyprogesteroneFosamprenavir
Severe
How does the drug interact with Meprate Tablet:
Taking Meprate Tablet together with fosamprenavir may decrease the effects of fosamprenavir.

How to manage the interaction:
Although there is a possible interaction between Meprate Tablet and Fosamprenavir, you can take these medicines together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor right away. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Meprate Tablet:
Taking boceprevir and Meprate Tablet may, decrease the blood levels and effects of Meprate Tablet.

How to manage the interaction:
Although taking Meprate Tablet and Boceprevir together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult your doctor immediately. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Meprate Tablet:
Taking Meprate Tablet with amprenavir may make amprenavir less effective.

How to manage the interaction:
There may be a possibility of interaction between Meprate Tablet and Amprenavir, but it can be taken if prescribed by a doctor. If you're having any unusual symptoms, it's important to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Meprate Tablet:
When Meprate Tablet acetate is taken with Topiramate, it reduces the blood levels and effects of Meprate Tablet.

How to manage the interaction:
Co-administration of Meprate Tablet with Topiramate can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're taking birth control and experiencing symptoms like hot flashes, vaginal dryness, or abnormal bleeding, contact your doctor. Do not stop using any medications without talking to your doctor.
Severe
How does the drug interact with Meprate Tablet:
When Meprate Tablet is taken with sugammadex, the effect of Meprate Tablet in the blood may decrease.

How to manage the interaction:
Taking Sugammadex with Meprate Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Meprate Tablet:
Coadministration of Meprate Tablet with mycophenolic acid may decrease the levels and effects of Meprate Tablet.

How to manage the interaction:
There could be a possible interaction between Mycophenolic acid and Meprate Tablet, but they can be taken together if your doctor has prescribed them. However, if you experience hot flashes, vaginal dryness, or abnormal bleeding consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Meprate Tablet:
Taking Bosentan and Meprate Tablet may, reduce the blood levels and effects of Meprate Tablet.

How to manage the interaction:
Although there is a interaction between bosentan and Meprate Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience hot flashes(feeling of heat in the body), dryness, or unusual bleeding, don't hesitate to reach out to your doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[HORMONES]

FAQs

Meprate Tablet is used to treat the absence of menstrual periods (amenorrhea) and abnormal uterine bleeding. Besides this, it also prevents endometrial hyperplasia (thickening of the uterine lining with the risk of cancer) and overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy.

Meprate Tablet helps in preparing the endometrium for pregnancy after ovulation. It thickens the lining of the endometrium to accept a fertilised egg. It also prevents muscle contractions of the uterus that would reject an egg in the uterus. So, if the body has a high progesterone level, ovulation will not occur then.

Abnormal uterine bleeding, irregular or missed periods (amenorrhea), abdominal pain during pregnancy, and frequent miscarriages are the signs of low progesterone. Additionally, low progesterone levels lead to high levels of estrogen, and women can have decreased sex drive, weight gain, or gallbladder problems.

Meprate Tablet should be taken in the dose and duration as prescribed by the doctor.

Yes, Meprate Tablet is a synthetic pregnant steroid and a derivative of progesterone.

Less serious but common side effects of Meprate Tablet include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, hair loss, fluid retention, and vaginal yeast infection.

Meprate Tablet is safe and effective if used as per prescribed dose and duration. The patient should follow doctor’s recommendations. Do not exceed the recommended daily dose.

No, Meprate Tablet does not cause withdrawal bleeding. However, if you notice symptoms such as bleeding or spotting even after completing the treatment, inform your doctor.

Take Meprate Tablet as advised by your doctor. The dose and duration depend on your medical condition. It can be taken with or without food, but try to take it at the same time every day to maintain consistent levels of Meprate Tablet in your body. Swallow it as a whole with a glass of water. Do not break, crush or chew it.

Ideally, you should try not to miss a dose of Meprate Tablet as missing a dose increases the chance of breakthrough vaginal bleeding or spotting (blood stain). However, if you miss a dose of Meprate Tablet , take it as soon as you remember. But, if it is time for your next dose, skip the missed dose and take your regular dose. Do not take a double dose to make up for the missed dose.

No, you should not take Meprate Tablet if you are pregnant or planning to become pregnant. If you suspect you have become pregnant while taking this medication, stop taking it immediately and talk to your doctor.

It is normal for withdrawal bleeding to begin approximately 2 to 7 days after you finish your prescribed cycle of Meprate Tablet . If bleeding does not occur within 10 days after your last tablet, contact your doctor for further evaluation.

No, oral Meprate Tablet tablets prescribed for menstrual cycle regulation or abnormal uterine bleeding are not intended to prevent pregnancy. These tablets should not be confused with the injectable depot Meprate Tablet acetate (DMPA) formulation, which is specifically used as a contraceptive. If you need birth control while taking oral Meprate Tablet , talk to your doctor about suitable contraceptive options.

Some women experience mild weight changes or bloating due to fluid retention while taking Meprate Tablet . If you notice sudden or significant weight gain, or swelling in your hands, ankles, or feet, talk to your doctor.

If you are taking it for abnormal bleeding, you may notice improvement within a few days of starting. If you are taking it for missed periods, your bleeding will typically occur a few days after you complete the full prescribed cycle. Talk to your doctor if your symptoms do not improve as expected.

There is no direct chemical interaction between alcohol and Meprate Tablet . However, because both alcohol and hormonal medications can affect your liver, it is best to limit your alcohol consumption during treatment. Talk to your doctor or pharmacist if you have concerns.

If you have high blood pressure, you must use Meprate Tablet with caution. Your doctor will likely want to monitor your blood pressure closely during your treatment, as hormones can sometimes cause it to rise. Talk to your doctor before starting this medication.

Mild mood swings can occur as your body adjusts to the hormone. However, if you experience severe mood changes, persistent sadness, worsening depression, or significant changes in your emotional well-being, contact your doctor promptly. Do not stop taking Meprate Tablet on your own. Speak with your healthcare provider before making any changes to your medication, as they can determine the most appropriate course of action.

For most women taking short courses of oral Meprate Tablet for menstrual disorders, normal menstrual cycles and fertility return after treatment is completed. The exact timing varies depending on the underlying condition being treated and individual hormone levels. If your periods do not return as expected after treatment, or if you are trying to become pregnant, talk to your doctor for further evaluation and guidance.

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Country of origin

INDIA

Manufacturer/Marketer address

212/2, Hadapsar, Off Soli Poonawalla Road, Pune 411028 India.
Other Info - MEP0007
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