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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy

Met XL R 25/2.5 Tablet belongs to the class of antihypertensive medicines used in the treatment of high blood pressure. This medicine also helps reduce the chances of heart problems such as heart attack and stroke. It is a combination medicine which suppress the contraction of blood vessels and promote smooth blood flow. It also alters the response to nerve impulses in the heart thereby making the heart pump blood easier. Common side effects include headache, nausea, dizziness, stomach upset, and weakness.

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rxMedicinePrescription drug

Whats That

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Synonym :

METOPROLOL SUCCINATE+RAMIPRIL

Manufacturer/Marketer :

Ajanta Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Met XL R 25/2.5 Tablet

Met XL R 25/2.5 Tablet is primarily used to treat hypertension (high blood pressure). Hypertension is a medical condition in which the blood exerts high pressure (the force exerted by circulating blood) against the walls of blood vessels.

Met XL R 25/2.5 Tablet is composed of metoprolol and ramipril. Metoprolol helps in slowing down the heart rate, making it easier for the heart to pump blood throughout the body. Ramipril relaxes and widens the blood vessels, making it easier for the heart to pump blood to all parts of the body.

In some cases, you may experience certain common side effects like tiredness, dizziness, shortness of breath, bradycardia, hypotension, diarrhoea, headache, and rash. Most of these side effects do not require medical attention and will resolve gradually over time. Talk to your doctor if you experience these side effects persistently.

You can take Met XL R 25/2.5 Tablet with food or without food. Swallow it as a whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you on how often you should take Met XL R 25/2.5 Tablet , based on your medical condition. 

Avoid taking Met XL R 25/2.5 Tablet if you are allergic to it or any other. Try not to stop taking this medicine on your own, even if your blood pressure is normal, as it may worsen your condition. Let your doctor know if you have any liver, kidney or heart problems, are pregnant or breastfeeding.

Uses of Met XL R 25/2.5 Tablet

Met XL R 25/2.5 Tablet is used in the treatment of Hypertension (high blood pressure). The detailed uses of Met XL R 25/2.5 Tablet are as follows:

  • Treatment of Hypertension: Met XL R 25/2.5 Tablet controls hypertension by relaxing blood vessels and lowering blood pressure, making it easier for the heart to pump blood.&
  • Prevention of Cardiovascular Risk: Met XL R 25/2.5 Tablet protects against heart attacks, strokes, heart failure, and other cardiovascular complications by lowering blood pressure and reducing heart strain.
  • Kidney Protection: Met XL R 25/2.5 Tablet reduces the risk or delays the worsening of kidney problems by lowering blood pressure and slowing kidney disease progression.

Directions for Use

  • Take Met XL R 25/2.5 Tablet with or without food as advised by the doctor.
  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Swallow Met XL R 25/2.5 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Met XL R 25/2.5 Tablet is a combination of two blood pressure-lowering medications, metoprolol and ramipril.
  • Metoprolol is a beta-blocker that works by decreasing the heart rate and increasing the heart's efficiency in pumping blood throughout the body.
  • Ramipril is an ACE inhibitor that relaxes blood vessels and decreases stress on the heart, allowing blood to flow more easily.
  • Met XL R 25/2.5 Tablet helps treat hypertension and thus reduces the chance of having a heart attack, stroke, heart-related chest pain (angina) or other cardiovascular diseases.

How Met XL R 25/2.5 Tablet Works

Met XL R 25/2.5 Tablet is composed of Metoprolol and Ramipril. Metoprolol is a beta-blocker, which helps in slowing down the heart rate, making it easier for the heart to pump blood throughout the body. Ramipril is an angiotensin-converting enzyme inhibitor, which relaxes and widens the blood vessels making it easier for the heart to pump blood to all body parts. Hence, it reduces the chance of having a heart attack, stroke, heart-related chest pain (angina) or other cardiovascular diseases.

Storage

• Store in a cool and dry place away from sunlight.• Keep Met XL R 25/2.5 Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Met XL R 25/2.5 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • If you are having unusual stomach issues after taking the medicine, consult your doctor to determine the underlying cause and further management.
  • In mild to moderate cases, your doctor may start by recommending anti-inflammatory medications (corticosteroids) to help reduce stomach inflammation and suggest lifestyle changes.
  • Eating smaller meals (5-6 times daily) instead of big meals can help improve your digestion.
  • Make sure to drink plenty of water, but stay away from caffeine, alcohol, and carbonated drinks, as they can make your symptoms worse.
  • Smoking and stress can worsen your stomach inflammation, so try to quit smoking and manage stress with exercise and relaxation techniques.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

What if I have taken an overdose of Met XL R 25/2.5 Tablet

Do not take more than the prescribed dose of Met XL R 25/2.5 Tablet , as it may cause serious side effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • Try not to stop taking this medicine on your own even if your blood pressure is normal as it may worsen your condition. 
  • Do not take Met XL R 25/2.5 Tablet if you are hypersensitive to metoprolol, ramipril, any beta-blocker, any other ACE inhibitor, or any of the excipients of Met XL R 25/2.5 Tablet .
  • Inform your doctor if you have angioedema (swelling under the skin),  diabetes, moderate to severe renal impairment, diabetic nephropathy, severe bradycardia, second- or third-degree heart block, cardiogenic shock, cardiac failure, sick sinus syndrome, or liver problems.
  • Met XL R 25/2.5 Tablet is not advised to be used during pregnancy or breastfeeding.
  • Met XL R 25/2.5 Tablet is not recommended for children because its safety and efficacy have not been proven.
  • Met XL R 25/2.5 Tablet may cause dizziness, so drive carefully.
  • Inform your doctor if you take any other prescription or non-prescription medications or herbal supplements to rule out any potential side effects or drug interactions.
  • You should monitor your blood pressure regularly to be sure that Met XL R 25/2.5 Tablet is working efficiently.
  • Additionally, maintaining a healthy diet and engaging in regular exercise are essential for controlling blood pressure.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Met XL R 25/2.5 Tablet:
Taking aliskiren together with Met XL R 25/2.5 Tablet may increase the risk of serious side effects such as kidney problems, low blood pressure, and high potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney problems, muscle paralysis and irregular heart rhythm.

How to manage the interaction:
Taking Met XL R 25/2.5 Tablet with Aliskiren is not recommended, but can be taken if prescribed by a doctor. However, consult your doctor if you feel nausea, vomiting, weakness, confusion, tingling in the hands and feet, a sensation of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. You must drink enough fluids while taking these medications. It is advised to reduce the intake of foods high in potassium, including tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Met XL R 25/2.5 Tablet:
Taking Met XL R 25/2.5 Tablet with telmisartan may increase the risk of side effects such as low blood pressure, kidney function impairment, and high blood potassium.

How to manage the interaction:
Although there is a possible interaction, telmisartan can be taken with Met XL R 25/2.5 Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms of high potassium such as nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Maintain adequate fluid intake during treatment with these medications. Do not discontinue the medications without consulting a doctor.
RamiprilEprosartan
Severe
How does the drug interact with Met XL R 25/2.5 Tablet:
Coadministration of Met XL R 25/2.5 Tablet together with eprosartan may increase the risk of side effects such as low blood pressure, kidney function impairment, and a condition called hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Met XL R 25/2.5 Tablet together with Eprosartan can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor if you feel nausea, vomiting, weakness, confusion, tingling in the hands and feet, a sensation of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. You must drink enough fluids while taking these medications. Do not stop taking any medication without consulting your doctor.
RamiprilPotassium acetate
Severe
How does the drug interact with Met XL R 25/2.5 Tablet:
Taking Met XL R 25/2.5 Tablet with potassium acetate may significantly increase potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney problems, muscle paralysis and irregular heart rhythm

How to manage the interaction:
Although there is a interaction between Met XL R 25/2.5 Tablet and Potassium acetate, but it can be taken if prescribed by a doctor. However, if you notice any nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, or irregular heartbeat, you should contact a doctor immediately. Avoid taking a potassium-rich diet (tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes) while taking these medications. Do not stop using any medications without talking to a doctor.
RamiprilPotassium citrate
Severe
How does the drug interact with Met XL R 25/2.5 Tablet:
Taking Potassium citrate with Met XL R 25/2.5 Tablet may increase potassium levels in the blood. High potassium levels can lead to kidney problems, muscle paralysis, and abnormal heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium citrate and Met XL R 25/2.5 Tablet, you can take these medicines together if prescribed by your doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. It is advised to reduce the intake of potassium-rich foods. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Met XL R 25/2.5 Tablet:
Taking leflunomide with Met XL R 25/2.5 Tablet can increase the risk of liver problems.

How to manage the interaction:
Although taking Met XL R 25/2.5 Tablet with Leflunomide can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Met XL R 25/2.5 Tablet:
Co-administration of Allopurinol with Met XL R 25/2.5 Tablet may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Allopurinol and Met XL R 25/2.5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Met XL R 25/2.5 Tablet:
Taking Met XL R 25/2.5 Tablet and amiloride together may increase the levels of potassium in your blood.

How to manage the interaction:
Although taking amiloride along with Met XL R 25/2.5 Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, consult the doctor if you feel weakness, confusion, numbness or tingling, and uneven heartbeats. Do not stop taking any medication without consulting a doctor.
How does the drug interact with Met XL R 25/2.5 Tablet:
Taking Azilsartan medoxomil with Met XL R 25/2.5 Tablet may cause low blood pressure, kidney function impairment, and increased potassium levels in the blood.

How to manage the interaction:
Although taking Met XL R 25/2.5 Tablet together with Azilsartan medoxomil can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience vomiting, weakness, confusion, tingling in the hands and feet, or palpitations. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Met XL R 25/2.5 Tablet:
Taking Met XL R 25/2.5 Tablet with Trimethoprim can increase the potassium levels in the blood, increasing the risk of kidney problems.

How to manage the interaction:
Although there is an interaction between Met XL R 25/2.5 Tablet and trimethoprim, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience weakness, confusion, numbness or tingling, and uneven heartbeats. Do not stop taking any medication without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eating a healthy and balanced diet can be beneficial if you have high blood pressure or a heart condition.
  • Do regular physical activity or exercise.
  • Opt for a diet rich in whole grains, fruits, vegetables, and low-fat dairy products.
  • Limit the intake of sodium chloride (table salt) in your daily diet.
  • Quitting smoking is the best strategy to lower the risk of heart disease.
  • Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Try to include heart-healthy omega-3 fatty acid-containing foods/drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Met XL R 25/2.5 Tablet to avoid unpleasant side effects.

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Pregnancy

Unsafe

Met XL R 25/2.5 Tablet is not recommended during pregnancy.

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Breast Feeding

Unsafe

Met XL R 25/2.5 Tablet is not recommended while breastfeeding.

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Driving

Unsafe

Met XL R 25/2.5 Tablet may cause dizziness or tiredness. If you feel dizzy or tired, do not drive or use any tools or machines.

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Liver

Caution

Met XL R 25/2.5 Tablet to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Met XL R 25/2.5 Tablet to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Met XL R 25/2.5 Tablet is not recommended in children. The safety and efficacy of Met XL R 25/2.5 Tablet in children have not been established.

Have a query?

FAQs

Met XL R 25/2.5 Tablet is indicated in the treatment of hypertension (high blood pressure).

Met XL R 25/2.5 Tablet contains metoprolol and ramipril. Metoprolol is a beta-blocker that slows the heart rate and increases the heart's efficiency in pumping blood throughout the body. Ramipril is an ACE inhibitor that relaxes blood vessels and reduces stress on the heart, allowing blood to flow more freely. Thus, Met XL R 25/2.5 Tablet effectively treats or manages hypertension.

Met XL R 25/2.5 Tablet may cause dizziness or light-headedness. It typically does not require medical attention and resolves gradually over time in most cases. Talk to your doctor if you experience this condition persistently. If you experience dizziness, do not drive until you are alert.

If you forget to take Met XL R 25/2.5 Tablet , take it as soon as you remember. However, if it is almost time for the scheduled dose, skip the missed dose and revert to the original dosing schedule. Do not take a double dose to make up for a forgotten dose.

Inform your doctor that you are taking Met XL R 25/2.5 Tablet if you are due to undergo any surgery. Metoprolol in Met XL R 25/2.5 Tablet can lower your blood pressure too much when it is combined with some anaesthetics.

It is advised to continue your medicine even after your blood pressure is under control or becomes normal, as blood pressure can shoot up at any time. If you have any discomfort, please consult your doctor immediately.

It is recommended that serum potassium and sodium levels be checked regularly. In patients with impaired renal function, serum potassium levels must be checked more frequently.

Met XL R 25/2.5 Tablet is not recommended in children. The safety and efficacy of Met XL R 25/2.5 Tablet in children have not been established.

Met XL R 25/2.5 Tablet is composed of Metoprolol (a beta-blocker) and Ramipril (angiotensin-converting enzyme inhibitor).

To effectively control your high blood pressure while on metoprolol and ramipril, adhere to your doctor's guidance, adopt a healthy lifestyle, regularly check your blood pressure, and be mindful of potential side effects.

Country of origin

India

Manufacturer/Marketer address

Ajanta House, Charkop, Kandivli West, Mumbai 400 067, India
Other Info - MET0520

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