Methergin Injection 1's

Methergin Injection 1's belongs to the class of medication called 'ergot alkaloids' or 'uterotonic' primarily used to prevent and stop heavy bleeding (postpartum-third stage of labour bleeding) after childbirth or after a miscarriage in cesarean section. Besides this, it is also used to improve uterine contraction (antepartum) and produce uterine contraction during the third stage of labor (postpartum). Postpartum haemorrhage is heavy bleeding (more than normal) after the birth of the baby.

Methergin Injection 1's contains a semi-synthetic ergot alkaloid 'Methylergometrine', that stimulates uterine muscles and increases the uterus' contractions, thus reducing blood loss. It also increases the effects of a natural substance called prostaglandins (PGs), increasing contractions and producing labour. As a result, these increased uterine contractions help in the child's delivery and substantially reduce excessive uterine bleeding. 

Methergin Injection 1's will be administered by a healthcare professional. Do not self-administer. The most common side effects of Methergin Injection 1's are nausea, vomiting, stomach pain, and mild headache in some cases. Most of these side effects of Methergin Injection 1's do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

If you ever had surgery on the uterus, cesarean, or premature labour, please inform your doctor to avoid any complications. If you have been given prostaglandins, then do not take Methergin Injection 1's; if both medicines are taken together, it can increase the contractions. Methergin Injection 1's should not be used for a prolonged time if the contractions do not increase or have severe pre-eclamptic toxemia (high blood pressure, protein in the urine, and swelling), blood or heart circulation problem. 

Methergin Injection 1's contains a semi-synthetic ergot alkaloid 'Methylergometrine' primarily used to stop heavy bleeding postpartum, i.e. third stage of labour bleeding after childbirth or after a miscarriage in cesarean section. Additionally, it plays a significant role in birth by increasing uterus contractions and inducing labour in pregnant women. Methergin Injection 1's works by stimulating uterine muscles and expanding the uterus' contractions, thus reducing blood loss. It also increases the effects of a natural substance called prostaglandins (PGs), increases the contraction,s and hence induces labour. As a result, these increased uterine contractions help deliver the child and substantially reduce excessive uterine bleeding.

• Nausea
• Vomiting
• Headache
• Stomach pain

Do not take Methergin Injection 1's if you are allergic to Methergin Injection 1's or any of its ingredients. Increasing the dose of Methergin Injection 1's can be harmful if your womb already has too strong contractions, any obstructions in the pathway that might prevent the delivery or if the baby is not receiving a sufficient oxygen supply. Also, the use of Methergin Injection 1's is not advisable if the baby is wrongly positioned in the birth canal, the baby’s head is too large to fit through the pelvis, the placenta lies near the neck of the womb, the placenta separates from the womb before birth, the womb is over-extended and likely to tear (in case you are carrying more than one baby). If you have been given prostaglandins, do not use Methergin Injection 1's within 6 hours as both medications, if taken together, can increase the contractions. Methergin Injection 1's should not be used for a prolonged time if the contractions do not increase or if you have severe pre-eclamptic toxaemia (high blood pressure, protein in the urine, and swelling) or blood or heart circulation problems.

Drug-Drug Interaction: Methergin Injection 1's may interact with anaesthetics (sevoflurane, halothane, cyclopropane, desflurane), other medicines used to start labour (prostaglandins), anti-diuretic hormone (vasopressin), a neurotransmitter (dopamine), anti-sickness medicine (ondansetron), sympathomimetic agents (epinephrine).

Drug-Food Interaction: Grapefruit juice intake should be avoided with Methergin Injection 1's as it may interact with Methergin Injection 1's to produce unpleasant side effects.

Drug-Disease Interaction: Methergin Injection 1's should not be given to patients with previous cesarean section, hypertension (high blood pressure), heart problem, cervical cancer, herpes infection, kidney problem, if you are more than 40 weeks pregnant or are more than 35 years age, the pelvis is too small for normal delivery.

• PROSTAGLANDINS
• DESFLURANE
• CYCLOPROPANE
• DOPAMINE
• EPINEPHRINE
• HALOTHANE
• ONDANSETRON
• VASOPRESSIN
• SEVOFLURANE

• Long walks can help to relieve stress, keep your body strong, and help in easy delivery.
• Please take a little bit of Castrol oil as it is known to stimulate prostaglandin, which ripens the cervix and get labor started.
• Some food like dates, raspberry tea leaves are known to ripen the cervix and get labor started.
• Acupressure also stimulates labor and helps in delivery.

• Methergin Injection 1's when given for induction of labor, stimulation of labor and prevention of vaginal bleeding after delivery of the baby especially after caesarean surgery. It must be administered only by the intravenous (IV) or intramuscular (IM) route under medical supervision in a hospital setting only. 

Postpartum haemorrhage: It is a serious but rare condition which causes excessive vaginal bleeding within one day after giving birth to the child. It happens mostly in cases of cesarean birth. When a baby is delivered, the uterus of the body contracts and forces out the placenta. After the placenta's delivery, these contractions put pressure on the bleeding vessels at the place where the placenta was attached, resulting in vaginal bleeding. It is normal to lose some amount of blood after delivery, but if a woman is losing more blood than normal, it can be dangerous.