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  1. Home
  2. Medicine

  3. Methoget 500 Injection

Prescription drug
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Methoget 500 Injection, Pack of 1 Injection
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Extra 15% Off with Bank Offers

Composition :

METHOTREXATE-500MG

Manufacturer/Marketer :

GLS Pharma Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Methoget 500 Injection

Methoget 500 Injection belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis and severe psoriasis.

Methoget 500 Injection is also used to treat cancer, such as breast cancer, cervical cancer, bladder cancer, ovarian cancer, testicular cancer, lung cancer, head and neck cancer, mycosis fungoides (a type of blood cancer), bone cancer, and advanced-stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system).

Methoget 500 Injection contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time.

Methoget 500 Injection prevents and stops the growth of cancer cells, thereby helping treat cancer. Methoget 500 Injection treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

In some cases, Methoget 500 Injection may cause side effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, and tingling sensation. Talk to your doctor if you experience any of the side effects persistently.

Do not take Methoget 500 Injection if you are pregnant or breastfeeding. Inform your doctor about your medications and health condition to rule out any unpleasant side effects.

Uses of Methoget 500 Injection

Methoget 500 Injection is used to treat autoimmune diseases and certain types of cancer. The detailed uses of Methoget 500 Injection are as follows:

  • Treatment of rheumatoid arthritis: Methoget 500 Injection helps reduce joint pain, swelling, and stiffness by suppressing the overactive immune system that causes joint inflammation.
  • Management of psoriasis: Methoget 500 Injection slows down the rapid growth of skin cells and reduces skin inflammation, helping to control severe psoriasis.
  • Treatment of cancer: Methoget 500 Injection is used as a chemotherapy agent in certain cancers like leukaemia, lymphoma, and breast cancer by interfering with the growth of cancer cells.

Have a query?

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Methoget 500 Injection will be administered by the doctor.
  • Do not self-administer.

Medicinal Benefits

  • Methoget 500 Injection is used to treat rheumatoid arthritis and psoriatic arthritis. It reduces inflammation and pain in joints. It slows or prevents joint damage and disease progression.
  • It helps treat psoriasis by suppressing the overactive immune response that causes skin cell overgrowth. It reduces scaling, redness, and thickness of psoriatic plaques.
  • Methoget 500 Injection is used in the management of breast cancer, lung cancer, head and neck cancer, mycosis fungoides (a type of blood cancer), and advanced-stage non-Hodgkin lymphomas.
  • It works by interfering with DNA synthesis, thereby stopping or slowing the growth of cancer cells.
  • It helps manage inflammation in the digestive tract.
  • Provides disease control by modulating the immune system.
  • Offers long-term relief from autoimmune and inflammatory conditions.
  • Improves treatment outcomes in certain cancers by preventing abnormal cell growth.

How Methoget 500 Injection Works

Methoget 500 Injection contains 'Methotrexate', which works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Methoget 500 Injection prevents and stops the growth of cancer cells, thereby helping treat cancer.

Storage

• Store in a cool and dry place away from sunlight.• Keep Methoget 500 Injection out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Methoget 500 Injection
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

What if I have taken an overdose of Methoget 500 Injection

Methoget 500 Injection is administered by a health care professional in a hospital setting. Hence, the chances of overdose are less. Symptoms of overdose may include vomiting, diarrhoea and gastrointestinal bleeding, as well as severe bone marrow suppression and disturbance of liver function. Your doctor may take necessary measures if an overdose is suspected.

Drug Warnings

  • Do not take Methoget 500 Injection if you are allergic to any of its contents; if you are pregnant or breastfeeding.
  • Inform your doctor if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, liver, lung or kidney problems.
  • Let your doctor know if you have ulceration in the stomach or bowels, poor general condition, received any vaccinations or if you are due to have any, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs.
  • Methoget 500 Injection may cause a serious, life-threatening reaction. If you experience symptoms such as rash, itching, hives, throat tightness, trouble swallowing, swelling of the face, throat, lips, or tongue, runny or stuffy nose, lightheadedness or dizziness, chest pain, difficulty breathing, wheezing, or feeling faint, consult your doctor immediately.
  • Inform your doctor if you are undergoing radiation therapy; if you receive Methoget 500 Injection while you are being treated with radiation therapy for cancer, it may cause damage to the skin, bones, or other parts of the body.
  • Keep your doctor informed if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

verifiedApollotooltip
MethotrexateEtretinate
Critical
MethotrexateOxacillin
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Methoget 500 Injection:
Co-administration of Etretinate with Methoget 500 Injection may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Methoget 500 Injection is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateOxacillin
Severe
How does the drug interact with Methoget 500 Injection:
Coadministration of Methoget 500 Injection with oxacillin can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between oxacillin and Methoget 500 Injection, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin and pain or burning during urination. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
MethotrexateAmpicillin
Severe
How does the drug interact with Methoget 500 Injection:
Co-administration of Methoget 500 Injection with Ampicillin can increase the levels and side effects of Methoget 500 Injection.

How to manage the interaction:
Although there is a possible interaction between Methoget 500 Injection and ampicillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as tiredness, dizziness, fainting, unusual bleeding or bruising, chills, fever, sore throat, body pains. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateEverolimus
Severe
How does the drug interact with Methoget 500 Injection:
Coadministration of Everolimus with Methoget 500 Injection can increase the risk or severity of kidney disorders.

How to manage the interaction:
Taking Everolimus with Methoget 500 Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.
MethotrexateKetorolac
Severe
How does the drug interact with Methoget 500 Injection:
Coadministration of Methoget 500 Injection with ketorolac can increase the blood levels and side effects of Methoget 500 Injection.

How to manage the interaction:
Although there is a interaction between Methoget 500 Injection and ketorolac, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateTacrolimus
Severe
How does the drug interact with Methoget 500 Injection:
Taking tacrolimus with Methoget 500 Injection may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between tacrolimus and Methoget 500 Injection, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting to a doctor.
MethotrexateTenofovir alafenamide
Severe
How does the drug interact with Methoget 500 Injection:
Combine use of tenofovir alafenamide with Methoget 500 Injection may increase the levels or side effects of tenofovir alafenamide.

How to manage the interaction:
Although there is a possible interaction between tenofovir alafenamide and Methoget 500 Injection, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting your doctor.
MethotrexateAmoxicillin
Severe
How does the drug interact with Methoget 500 Injection:
Co-administration of Methoget 500 Injection with amoxicillin can increase the levels and side effects of Methoget 500 Injection.

How to manage the interaction:
Although there is a possible interaction between Methoget 500 Injection and amoxicillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as tiredness, dizziness, fainting, unusual bleeding or bruising, chills, fever, sore throat, body pains. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexatePhenylbutazone
Severe
How does the drug interact with Methoget 500 Injection:
Coadministration of phenylbutazone with Methoget 500 Injection may increase the levels and side effects of phenylbutazone.

How to manage the interaction:
Although there is a possible interaction between phenylbutazone and Methoget 500 Injection, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateTolmetin
Severe
How does the drug interact with Methoget 500 Injection:
Coadministration of Methoget 500 Injection with tolmetin can increase the levels and side effects of Methoget 500 Injection.

How to manage the interaction:
Although there is a possible interaction between tolmetin and Methoget 500 Injection, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Arthritis:

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Psoriasis:

  • Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
  • Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
  • Avoid processed foods, refined sugars, and fatty foods.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
  • Reducing stress and maintaining a good sleep cycle would be helpful.
  • Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

  • Consume a healthy diet and exercise regularly to maintain a proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

ANTIMETABOLITES

Methoget 500 Injection Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Methoget 500 Injection.

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Pregnancy

Unsafe

Methoget 500 Injection may cause serious birth defects. It is not recommended to take Methoget 500 Injection while you are pregnant.

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Breast Feeding

Unsafe

Methoget 500 Injection passes into breast milk. Avoid breastfeeding whilst on treatment with Methoget 500 Injection and for at least 1 week after the last dose.

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Driving

Caution

Methoget 500 Injection may cause dizziness and tiredness; do not drive or operate heavy machinery until you know how Methoget 500 Injection affects you.

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Liver

Caution

Please consult your doctor if you have liver impairment before receiving Methoget 500 Injection.

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Kidney

Caution

Please consult your doctor if you have kidney impairment before receiving Methoget 500 Injection.

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Children

Caution

The efficacy and safety of Methoget 500 Injection in children have been established in polyarticular-course juvenile rheumatoid arthritis and cancer chemotherapy. Please consult your doctor if you have any concerns regarding the usage of Methoget 500 Injection in children.

FAQs

Methoget 500 Injection acts as an immunosuppressant, which helps in reducing inflammation and preventing joint stiffness, thereby providing relief from rheumatoid arthritis.

Methoget 500 Injection works by suppressing the overactive immune system that is responsible for causing psoriasis. Methoget 500 Injection interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis.

Methoget 500 Injection may affect fertility in men and women. Consult your doctor if you have any concerns regarding this.

Methoget 500 Injection causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infection, such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Methoget 500 Injection may make your skin sensitive to sunlight. Therefore, avoid prolonged or unnecessary exposure to sunlight or ultraviolet light, such as tanning beds and sunlamps. Wear protective clothing, sunglasses, and sunscreen while going out.

Methoget 500 Injection works by suppressing the overactive immune system that is responsible for causing psoriasis. Methoget 500 Injection interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis and psoriatic arthritis.

Country of origin

India
Other Info - ME89289

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Sep 23, 2025 | 9:29 AM IST

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Reference

  1. https://medlineplus.gov/druginfo/meds/a682018.html
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/011719s117lbl.pdf
  3. https://labeling.pfizer.com/ShowLabeling.aspx?id=15282
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