Methotrexate-5 Tablet 10's
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Composition :
METHOTREXATE-5MG
Manufacturer/Marketer :
Care Formulations Lab
Consume Type :
ORAL
Return Policy :
Not Returnable
Expires on or after :
About Methotrexate-5 Tablet
Methotrexate-5 Tablet is used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis, severe psoriasis, and severe psoriatic arthritis.
It is also used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (a type of blood cancer), and advanced-stage non-Hodgkin lymphomas (cancer that starts in the lymphatic system).
Methotrexate-5 Tablet contains 'Methotrexate', which works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time.
Methotrexate-5 Tablet prevents and stops the growth of cancer cells, thereby helping treat cancer. It treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.
In some cases, Methotrexate-5 Tablet may cause side effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, and lowered resistance to infections. You are advised to talk to your doctor if you experience these side effects persistently.
Do not take Methotrexate-5 Tablet if you are pregnant or breastfeeding. Methotrexate-5 Tablet may cause dizziness and fatigue, so drive only if you are alert. Inform your doctor about your medications and health condition to rule out any unpleasant side effects/interactions.
Uses of Methotrexate-5 Tablet
Methotrexate-5 Tablet is used in the treatment of rheumatoid arthritis, psoriatic arthritis, psoriasis, and cancer. The detailed uses of Methotrexate-5 Tablet are as follows:
- Treatment of Rheumatoid Arthritis: Methotrexate-5 Tablet is commonly prescribed to manage the symptoms of rheumatoid arthritis, reducing inflammation and pain in the joints.
- Management of Psoriasis: Methotrexate-5 Tablet can be used to treat severe psoriasis, helping to clear the skin and reduce scaling.
- Chemotherapy for Certain Cancers: Methotrexate-5 Tablet may be utilised in lower doses as part of a chemotherapy treatment regimen for specific types of cancers, such as osteosarcoma or certain leukaemias.
- Autoimmune Disease Management: Methotrexate-5 Tablet is sometimes used to manage other autoimmune conditions, where it helps to suppress the immune system and reduce abnormal immune responses.
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Directions for Use
- Take Methotrexate-5 Tablet with food or as advised by your doctor.
- It is advised to take Methotrexate-5 Tablet once a week; however, follow your doctor’s recommendation regarding the dosage and duration.
- Swallow Methotrexate-5 Tablet as a whole with a glass of water.
- Do not crush, break, or chew it.
Medicinal Benefits
- Methotrexate-5 Tablet is used to treat rheumatoid arthritis and psoriatic arthritis. It reduces inflammation and pain in joints. It slows or prevents joint damage and disease progression.
- It helps treat psoriasis by suppressing the overactive immune response that causes skin cell overgrowth. It reduces scaling, redness, and thickness of psoriatic plaques.
- Methotrexate-5 Tablet is used in the management of breast cancer, lung cancer, head and neck cancer, mycosis fungoides (a type of blood cancer), and advanced-stage non-Hodgkin lymphomas.
- It works by interfering with DNA synthesis, thereby stopping or slowing the growth of cancer cells.
- It helps manage inflammation in the digestive tract.
- Provides disease control by modulating the immune system.
- Offers long-term relief from autoimmune and inflammatory conditions.
- Improves treatment outcomes in certain cancers by preventing abnormal cell growth.
How Methotrexate-5 Tablet Works
Methotrexate-5 Tablet contains 'Methotrexate', which works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Methotrexate-5 Tablet prevents and stops the growth of cancer cells, thereby helping treat cancer. Methotrexate-5 Tablet treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.
Storage
• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Methotrexate-5 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
- Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
- Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
- Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
- Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
- Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
- Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
- Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
- Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
- Get sufficient sleep and manage stress which helps in improving white blood cell count.
- Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
- Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
- Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
- Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
- Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
- Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
- Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
- Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the few steps for dealing with itching caused by drug use:
- Report the itching to your doctor immediately; they may need to change your medication or dosage.
- Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
- Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
- Try not to scratch, as this can worsen the itching and irritate your skin.
- If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
- Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
What if I have taken an overdose of Methotrexate-5 Tablet
Do not take more than the prescribed dose of Methotrexate-5 Tablet as it may cause overdose leading to severe toxic reactions. The symptoms of overdose include unusual weakness, nausea, vomiting, easy bruising or bleeding, mouth sores, decreased urination, coughing up blood or vomit that looks like coffee grounds and black or bloody stools. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.
Drug Warnings
- Do not take Methotrexate-5 Tablet if you are allergic to any of its contents; if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, chronic liver disease; if you are pregnant or breastfeeding.
- Talk to your doctor before taking Methotrexate-5 Tablet if you have/had liver or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if you are due to have any vaccinations, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs.
- Methotrexate-5 Tablet may cause dizziness and fatigue, so drive only if you are alert.
- Take Methotrexate-5 Tablet exactly as directed by the doctor, as it may cause serious problems if not taken in the dose and duration prescribed by the doctor.
- Stop taking Methotrexate-5 Tablet and consult your doctor immediately if you have mouth sores, diarrhoea, a fever, dehydration, cough, bleeding, shortness of breath, any signs of infection, or a skin rash.
- Inform your doctor if you are taking any other medicines, including supplements and herbal products.
Drug-Drug Interactions
MethotrexateEtretinate
Critical
MethotrexateNitrous oxide
Severe
Drug-Drug Interactions
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MethotrexateEtretinate
Critical
How does the drug interact with Methotrexate-5 Tablet-5 Tablet:
Co-administration of Etretinate with Methotrexate-5 Tablet may increase the risk or severity of liver problems.
How to manage the interaction:
Taking Etretinate with Methotrexate-5 Tablet is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
Co-administration of Etretinate with Methotrexate-5 Tablet may increase the risk or severity of liver problems.
How to manage the interaction:
Taking Etretinate with Methotrexate-5 Tablet is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateNitrous oxide
Severe
How does the drug interact with Methotrexate-5 Tablet-5 Tablet:
Combine use of nitrous oxide with Methotrexate-5 Tablet may increase the levels and side effects of nitrous oxide.
How to manage the interaction:
Although there is a possible interaction between nitrous oxide and Methotrexate-5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, pale skin, easy bruising or bleeding, unusual weakness, mouth sores, black or bloody stools, and decreased urine output, consult the doctor. Do not discontinue any medications without doctors advice.
Combine use of nitrous oxide with Methotrexate-5 Tablet may increase the levels and side effects of nitrous oxide.
How to manage the interaction:
Although there is a possible interaction between nitrous oxide and Methotrexate-5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, pale skin, easy bruising or bleeding, unusual weakness, mouth sores, black or bloody stools, and decreased urine output, consult the doctor. Do not discontinue any medications without doctors advice.
How does the drug interact with Methotrexate-5 Tablet-5 Tablet:
Combine use of tenofovir alafenamide with Methotrexate-5 Tablet may increase the levels or side effects of tenofovir alafenamide.
How to manage the interaction:
Although there is a possible interaction between tenofovir alafenamide and Methotrexate-5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting your doctor.
Combine use of tenofovir alafenamide with Methotrexate-5 Tablet may increase the levels or side effects of tenofovir alafenamide.
How to manage the interaction:
Although there is a possible interaction between tenofovir alafenamide and Methotrexate-5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting your doctor.
Severe
How does the drug interact with Methotrexate-5 Tablet-5 Tablet:
The combined use of entecavir with Methotrexate-5 Tablet may increase levels of Entecavir, and increase the risk or severity of kidney damage.
How to manage the interaction:
Although there is a possible interaction between entecavir and Methotrexate-5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult a doctor. Do not stop using any medications without consulting a doctor.
The combined use of entecavir with Methotrexate-5 Tablet may increase levels of Entecavir, and increase the risk or severity of kidney damage.
How to manage the interaction:
Although there is a possible interaction between entecavir and Methotrexate-5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Methotrexate-5 Tablet-5 Tablet:
Taking Human immunoglobulin with Methotrexate-5 Tablet may increase the risk or severity of kidney problems.
How to manage the interaction:
Taking Human immunoglobulin with Methotrexate-5 Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Taking Human immunoglobulin with Methotrexate-5 Tablet may increase the risk or severity of kidney problems.
How to manage the interaction:
Taking Human immunoglobulin with Methotrexate-5 Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Methotrexate-5 Tablet-5 Tablet:
Coadministration of Methotrexate-5 Tablet with tolmetin can increase the levels and side effects of Methotrexate-5 Tablet.
How to manage the interaction:
Although there is a possible interaction between tolmetin and Methotrexate-5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
Coadministration of Methotrexate-5 Tablet with tolmetin can increase the levels and side effects of Methotrexate-5 Tablet.
How to manage the interaction:
Although there is a possible interaction between tolmetin and Methotrexate-5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
Severe
How does the drug interact with Methotrexate-5 Tablet-5 Tablet:
Co-administration of Methotrexate-5 Tablet with Lansoprazole can increase the blood levels and side effects of Methotrexate-5 Tablet.
How to manage the interaction:
Although there is a possible interaction between Methotrexate-5 Tablet and Lansoprazole, you can take these medicines together if prescribed by a doctor. However, if you notice any symptoms of headaches, irritation, confusion, decreased hunger, fatigue, heart palpitations, or diarrhea, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Co-administration of Methotrexate-5 Tablet with Lansoprazole can increase the blood levels and side effects of Methotrexate-5 Tablet.
How to manage the interaction:
Although there is a possible interaction between Methotrexate-5 Tablet and Lansoprazole, you can take these medicines together if prescribed by a doctor. However, if you notice any symptoms of headaches, irritation, confusion, decreased hunger, fatigue, heart palpitations, or diarrhea, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
MethotrexateNafcillin
Severe
How does the drug interact with Methotrexate-5 Tablet-5 Tablet:
Coadministration of Methotrexate-5 Tablet with nafcillin can increase the risk of developing serious infections.
How to manage the interaction:
Although there is a possible interaction between nafcillin and Methotrexate-5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, nausea, vomiting, mouth ulcers, sore throat, body aches, or other flu-like symptoms, consult the doctor.
Coadministration of Methotrexate-5 Tablet with nafcillin can increase the risk of developing serious infections.
How to manage the interaction:
Although there is a possible interaction between nafcillin and Methotrexate-5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, nausea, vomiting, mouth ulcers, sore throat, body aches, or other flu-like symptoms, consult the doctor.
MethotrexateProcaine benzylpenicillin
Severe
How does the drug interact with Methotrexate-5 Tablet-5 Tablet:
Coadministration of Methotrexate-5 Tablet with procaine benzyl penicillin can increase the levels and side effects of Methotrexate-5 Tablet.
How to manage the interaction:
Although there is a possible interaction between procaine benzyl penicillin and Methotrexate-5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, or other flu-like symptoms, consult your doctor. Do not stop using any medications without consulting to a doctor.
Coadministration of Methotrexate-5 Tablet with procaine benzyl penicillin can increase the levels and side effects of Methotrexate-5 Tablet.
How to manage the interaction:
Although there is a possible interaction between procaine benzyl penicillin and Methotrexate-5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, or other flu-like symptoms, consult your doctor. Do not stop using any medications without consulting to a doctor.
Severe
How does the drug interact with Methotrexate-5 Tablet-5 Tablet:
Co-administration of Methotrexate-5 Tablet with Rabeprazole can increase the blood levels and side effects of Methotrexate-5 Tablet.
How to manage the interaction:
Although there is a possible interaction between Rabeprazole and Methotrexate-5 Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
Co-administration of Methotrexate-5 Tablet with Rabeprazole can increase the blood levels and side effects of Methotrexate-5 Tablet.
How to manage the interaction:
Although there is a possible interaction between Rabeprazole and Methotrexate-5 Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
Drug-Food Interactions
METHOTREXATE-5MGCaffeine containing foods/drinks
Moderate
Drug-Food Interactions
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METHOTREXATE-5MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu
How to manage the interaction:
Caffeine may reduce the effectiveness of Methotrexate-5 Tablet. Avoid taking caffeine while taking Methotrexate-5 Tablet. This can increase the risk or severity of side effects.
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu
How to manage the interaction:
Caffeine may reduce the effectiveness of Methotrexate-5 Tablet. Avoid taking caffeine while taking Methotrexate-5 Tablet. This can increase the risk or severity of side effects.
Diet & Lifestyle Advise
Arthritis:
- Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
- Performing yoga may also help in improving joint flexibility and pain management.
- Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
- Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.
- De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
- Acupuncture, massage and physical therapy may also be helpful.
- Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
- Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
- Avoid smoking and alcohol consumption.
Psoriasis:
- Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
- Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
- Avoid processed foods, refined sugars, and fatty foods.
- Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
- Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
- Reducing stress and maintaining a good sleep cycle would be helpful.
- Avoiding getting in contact with harsh soaps, detergents and rough fabrics.
Cancer:
- Consume a healthy diet and exercise regularly to maintain a proper weight.
- Avoid smoking and alcohol consumption.
- Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
- Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
- Get optimal sleep; rest well.
Habit Forming
No
Therapeutic Class
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Alcohol
Unsafe
You are recommended to avoid alcohol consumption while taking Methotrexate-5 Tablet .
Pregnancy
Unsafe
Methotrexate-5 Tablet may cause serious birth defects. It is not recommended to take Methotrexate-5 Tablet while you are pregnant.
Breast Feeding
Unsafe
Methotrexate-5 Tablet passes into breast milk. Avoid breastfeeding whilst on treatment with Methotrexate-5 Tablet .
Driving
Caution
Methotrexate-5 Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you experience these symptoms.
Liver
Caution
Do not take Methotrexate-5 Tablet if you have chronic liver disease. Please consult your doctor if you have liver impairment before taking Methotrexate-5 Tablet .
Kidney
Caution
Please consult your doctor if you have kidney impairment before taking Methotrexate-5 Tablet .
Children
Caution
Methotrexate-5 Tablet should be used with caution in children and only if prescribed by the doctor.
Heart
Methotrexate-5 Tablet can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.
Geriatrics
Safe if prescribed
Methotrexate-5 Tablet can be safely used in elderly patients with proper monitoring and individualised care.
FAQs
Country of origin
India
Manufacturer/Marketer address
886 South Civil Line, Jat Colony, Muzaffarnagar. Up
Other Info - MET2014
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Author Details
Reference
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/011719s117lbl.pdfhttp://www.hpra.ie/img/uploaded/swedocuments/pil-2167015-11052016181932-635985875740562500.pdf
- https://www.cipla.com/sites/default/files/Methotrexate%202.5%20mg%20%E2%80%93%20Patient%20Card%20-%20Risk%20Minimisation%20Information%20for%20Patients.pdf
- https://www.stmarkshospital.nhs.uk/wp-content/uploads/2014/07/IBD_methotrexate_leaflet.pdf
- https://www.drugs.com/methotrexate.html
- https://medlineplus.gov/druginfo/meds/a682019.html
