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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METRONIDAZOLE-600MG

Manufacturer/Marketer :

Lekar Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Metrogyl ER Tablet

Metrogyl ER Tablet is a prescription antibiotic and antiprotozoal medication used to treat a wide variety of bacterial and parasitic infections. It works by stopping the growth of certain bacteria and parasites that cause illness in different parts of the body, such as the digestive tract, reproductive system, and skin. It is only effective against specific types of infections and will not work for viral illnesses like the common cold.

For the best results, you must take this medication consistently at evenly spaced times throughout the day as prescribed by your healthcare provider. You can take this medicine with food or a full glass of milk to help prevent stomach upset. Incorporating simple lifestyle habits, such as staying well-hydrated and resting, can further support your body's natural recovery process.

While taking this medication, you may experience mild temporary symptoms like a metallic taste or nausea. However, if you experience more serious side effects, such as persistent numbness, tingling in your hands or feet, or severe abdominal pain, you should contact your doctor immediately.

Do not take this if you have a known allergy to similar anti-infective medications. It is highly important to talk to your doctor before starting this medicine if you have a history of liver disease, kidney disease, or nervous system disorders.

You must completely avoid alcohol and products containing alcohol during your treatment, as combining them can cause severe sickness, including rapid heart rate, redness, and vomiting. If you are pregnant, breastfeeding, or are an elderly individual, consult your healthcare provider to discuss the specific risks and benefits before beginning therapy.

Uses of Metrogyl ER Tablet

Metrogyl ER Tablet is used to treat various bacterial and parasitic infections. The uses of Metrogyl ER Tablet are as follows: 

  • Bacterial infections: Metrogyl ER Tablet helps clear bacterial infections in the abdomen, bones, joints, and respiratory tract.
  • Vaginal infections: It treats bacterial vaginosis by restoring the natural balance of bacteria in the vaginal area.
  • Parasitic infections: It eliminates parasites causing intestinal infections, like amebiasis, or sexually transmitted infections, like trichomoniasis.

Key Benefits

Metrogyl ER Tablet helps treat bacterial and parasitic infections by eliminating the organisms responsible for the infection. This helps relieve symptoms and supports faster recovery.

  • Relieves Infection Symptoms: Helps reduce symptoms such as diarrhoea, pelvic pain, abdominal discomfort, and unusual vaginal discharge by treating the underlying infection.
  • Treats Bacterial and Parasitic Infections: Effectively targets and eliminates certain bacteria and parasites responsible for a variety of infections.
  • Promotes Faster Recovery: Helps clear the infection and supports a quicker return to normal daily activities.
  • Prevents Infection Spread: By controlling the infection early, it may help prevent the infection from worsening or spreading to other parts of the body.

Directions for Use

To get the maximum benefit from treatment with Metrogyl ER Tablet , follow these instructions carefully: 

  • Swallow the tablet whole with a full glass of water or milk.
  • Do not crush, chew, or break the tablet, as this can affect how the medicine is absorbed and may cause an unpleasant taste.

Always follow your doctor's exact instructions regarding the duration of your treatment. It is vital to complete the entire course of medication, even if your symptoms improve after a few days, to prevent the infection from returning.

How Metrogyl ER Tablet Works

The active drug, metronidazole, enters the cells of the invading bacteria or parasites. Once inside, it interacts with the organism's genetic material (DNA) and disrupts its structure. This prevents the bacteria or parasites from multiplying, repairing themselves, or surviving, which quickly stops the infection from spreading and allows your immune system to clear the remaining pathogens.
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Alcohol

Unsafe

You are recommended not to consume alcohol while on treatment with Metrogyl ER Tablet and for 48 hours after completing the course to avoid unpleasant side effects such as nausea, vomiting, stomach pain, palpitations, headache, and hot flushes.

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Pregnancy

Unsafe

Metrogyl ER Tablet should not be used during pregnancy, especially during the first trimester. Inform your doctor if you are pregnant or planning to become pregnant.

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Breast Feeding

Unsafe

Metrogyl ER Tablet may pass into breast milk. Avoid breastfeeding while taking Metrogyl ER Tablet and for 12-24 hours after completing the course.

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Driving

Caution

Metrogyl ER Tablet may cause dizziness and drowsiness; therefore, avoid driving or operating machinery unless you are alert.

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Liver

Caution

Metrogyl ER Tablet should be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your liver condition.

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Kidney

Caution

Metrogyl ER Tablet should be taken with caution, especially if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending on your kidney condition.

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Children

Safe if prescribed

Metrogyl ER Tablet should be given to children only if prescribed by a doctor. Your doctor may adjust the dose as per the age of your child.

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Heart

Consult your doctor

Please consult your doctor before using Metrogyl ER Tablet if you have pre-existing heart problems.

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Geriatrics

Caution

Metrogyl ER Tablet should be taken with caution in elderly patients as it can cause age-related problems. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Metrogyl ER Tablet

Do not take more than the prescribed dose of Metrogyl ER Tablet , as it may cause an overdose. The symptoms of an overdose include nausea, vomiting, seizures (fits), loss of muscle coordination, and numbness, burning, pain, or tingling in the hands or feet. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Avoid Alcohol Completely: Do not consume alcohol, including beer, wine, spirits, or alcohol-containing products such as certain cough syrups, while taking this medicine.
  • Stay Well-Hydrated: Drink plenty of fluids, such as water and clear broths, especially if you are recovering from a digestive tract infection.
  • Choose Simple Foods: Eat bland, easy-to-digest foods if you experience nausea or stomach discomfort after taking your medication.
  • Support Gut Health: Consider taking a probiotic supplement a few hours after your dose to help maintain healthy gut bacteria and support digestive health.

Have a query?

How Soon It Starts Working

The time required for Metrogyl ER Tablet to start to work: Metrogyl ER Tablet ideally shows its action within 4 hours after administration. The time for which the effects of Metrogyl ER Tablet last: The effect of Metrogyl ER Tablet lasts for 12 hours.

What if you forget to take Metrogyl ER Tablet

If you miss a dose of Metrogyl ER Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular schedule. Never take a double dose to make up for the missed one.

Storage

• Store the oral tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). • Keep the medication in its original packaging to protect it from direct light, moisture, and extreme heat. Do not store it in the bathroom cabinet.

Drug Warnings

  • Avoid Alcohol After Treatment: Wait at least 72 hours after your final dose before consuming alcohol to help prevent severe nausea, vomiting, flushing, headaches, and other reactions.
  • Use Caution When Driving: Do not drive or operate machinery if you feel dizzy, lightheaded, or confused after taking this medicine.
  • Inform Your Doctor About Blood Thinners: Tell your doctor if you are taking blood-thinning medicines, as Metrogyl ER Tablet may increase the risk of bleeding.
  • Watch for Nerve Symptoms: Stop taking the medicine and contact your healthcare provider immediately if you develop tingling, numbness, weakness, or other unusual nerve-related symptoms.

Drug-Drug Interactions

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact with Metrogyl ER Tablet :

  • Blood Thinners: Taking Metrogyl ER Tablet with blood thinners such as warfarin may increase the risk of bleeding.
  • Lithium: Metrogyl ER Tablet may increase lithium levels in the body and raise the risk of lithium toxicity, including kidney-related complications.
  • Disulfiram: Do not take Metrogyl ER Tablet if you have used disulfiram within the previous two weeks, as this combination may cause severe confusion and mental health symptoms.


Drug-Food Interactions

The following food and beverage interactions may occur while taking Metrogyl ER Tablet : 

  • Alcohol and Propylene Glycol: Consuming alcohol or products containing propylene glycol while taking Metrogyl ER Tablet may cause a severe reaction characterised by vomiting, flushing, rapid heartbeat, headaches, and nausea.


Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking Metrogyl ER Tablet , as it may worsen your condition or require closer monitoring.

  • Severe Liver Disease: If you have severe liver damage, your body may process Metrogyl ER Tablet more slowly, increasing the risk of side effects.
  • Nervous System Disorders: Use this medicine with caution if you have a pre-existing neurological condition, as it may worsen nerve-related symptoms.
MetronidazoleAmprenavir
Critical
Critical

Drug-Drug Interactions

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MetronidazoleAmprenavir
Critical
How does the drug interact with Metrogyl ER Tablet:
Co-administration of Amprenavir with Metrogyl ER Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Taking Metrogyl ER Tablet with Amprenavir is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience throbbing in the head and neck, throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain, rapid heartbeat, palpitation, low blood pressure, dizziness, lightheadedness, blurred vision, and confusion, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Critical
How does the drug interact with Metrogyl ER Tablet:
Drinking alcohol while taking Metrogyl ER Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Taking Metrogyl ER Tablet with Ethanol is avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience flushing, throbbing in head and neck, throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain, rapid heartbeat, palpitation, low blood pressure, dizziness, lightheadedness, blurred vision, and confusion, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Metrogyl ER Tablet:
Coadministration of Disulfiram with Metrogyl ER Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metrogyl ER Tablet and Disulfiram together is generally avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, confusion, weakness, shortness of breath, or palpitations, contact your doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Metrogyl ER Tablet:
Coadministration of Metrogyl ER Tablet with warfarin can increase the risk of bleeding.

How to manage the interaction:
There is a possible interaction between Metrogyl ER Tablet and warfarin, but they can be taken together if a doctor has prescribed them. Consult a doctor if experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not stop using any medications without talking to a doctor.
How does the drug interact with Metrogyl ER Tablet:
Coadministration of Metrogyl ER Tablet with mebendazole may increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Metrogyl ER Tablet and mebendazole, they can be taken together if your doctor has prescribed them. However, if you experience any unusual symptoms like fever, body ache, painful red rash, cough, peeling of the skin, or Drooling, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Metrogyl ER Tablet:
Coadministration of Busulfan and Metrogyl ER Tablet may increase the risk of side effects.

How to manage the interaction:
Taking Metrogyl ER Tablet and Busulfan together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience unusual bruising or bleeding, fever, diarrhea, sore throat, muscle aches, shortness of breath, or burning during urination, contact a doctor immediately. Do not discontinue the medication without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIMICROBIALS]

FAQs

Metrogyl ER Tablet is used to treat and prevent bacterial and parasitic infections, including blood, brain, bone, lung, stomach lining, pelvic area and genital infections, amoebiasis, gum and teeth infections, infected leg ulcers or pressure sores, stomach ulcers caused by Helicobacter pylori, urinary or genital infections caused by the Trichomonas parasite. Furthermore, it can also be used to treat infections that occur after childbirth or wound infections following surgery.

Metrogyl ER Tablet works by preventing the production of proteins required by harmful microorganisms for their survival. Thereby, Metrogyl ER Tablet helps treat and prevent bacterial and parasitic infections.

No. Metrogyl ER Tablet is an antimicrobial medicine that acts only against bacterial infections, not against viral infections such as the common cold and flu.

If you miss a dose of Metrogyl ER Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular schedule. Never take a double dose to make up for the missed one.

Metrogyl ER Tablet may cause jaundice in a rare case. Please consult your doctor immediately if you notice yellowing of the skin and eyes.

Metrogyl ER Tablet may also be used with other medications to treat certain stomach/intestinal ulcers caused by a bacteria (H. pylori). Even so, it can only be used if advised by a doctor.

Do not take more than the prescribed dose of Metrogyl ER Tablet , as it may cause an overdose. The symptoms of an overdose include nausea, vomiting, seizures (fits), loss of muscle coordination, and numbness, burning, pain, or tingling in the hands or feet. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

If the symptoms do not improve within a few days after starting this medicine or if they worsen, consult your doctor. They will reassess the condition and provide guidance on appropriate treatment.

Metrogyl ER Tablet may interact with certain medications. So, do not use any other medications with Metrogyl ER Tablet unless recommended by the doctor. Your doctor will check for potential interactions and prescribe you if necessary.

Antibiotics like Metrogyl ER Tablet may reduce the vaccine's activity. To ensure an adequate vaccine response, vaccination should be administered at least 14 days after completing treatment with Metrogyl ER Tablet or 10 days before starting therapy with Metrogyl ER Tablet . Talk to your doctor if you have any questions or concerns.

Let your doctor know about your child’s medical history and ongoing medications before prescribing Metrogyl ER Tablet .

Yes, it is normal. Metrogyl ER Tablet can cause urine discolouration. This is harmless and should resolve on its own once your child stops taking the medication.

Metrogyl ER Tablet may interfere with some drugs. Always check with a doctor before giving any medication, especially if your child is feverish. The doctor will advise the best course of treatment for your child.

To ensure the medication's effectiveness and progress of the medical condition, the doctor may perform certain lab tests, such as a complete blood count (CBC), liver function test (LFT), and kidney function test (KFT) if necessary.

Common side effects of Metrogyl ER Tablet may include nausea, vomiting, upset stomach, loss of appetite, dry mouth, and a metallic taste. Most of these side effects do not require medical attention and will gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

No, you must avoid all alcohol during treatment and for at least 3 days after your last dose. Combining the two can cause a severe, unpleasant reaction, including vomiting, rapid heartbeat, and intense headaches. Talk to your doctor if you have concerns about avoiding alcohol.

A metallic taste is a very common and temporary side effect of metronidazole. You can manage this by chewing sugar-free gum, sucking on hard candies, or maintaining good oral hygiene. Talk to your doctor if this symptom becomes too uncomfortable to manage.

You should only take this medicine during pregnancy if it is clearly needed and prescribed by your doctor. Your healthcare provider will weigh the benefits against the risks, especially during the first trimester. Talk to your doctor to discuss your options.

You can take this medication with or without food. However, taking it with a meal or a glass of milk is highly recommended as it helps prevent stomach irritation, nausea, and indigestion. Talk to your doctor or pharmacist if you have persistent stomach discomfort.

The medication begins working against the infection within a few hours of your first dose. However, it may take a few days before you notice a significant improvement in your physical symptoms. Talk to your doctor if your symptoms do not improve or get worse after a few days.

Stopping the medication early can allow the remaining bacteria or parasites to multiply and cause the infection to return, potentially making it resistant to future treatments. Always complete the entire course prescribed by your doctor. Talk to your doctor if you feel you need to stop early due to side effects.

Yes, like many antibiotics, Metrogyl ER Tablet can disrupt the natural balance of microorganisms in your body, which may lead to an overgrowth of yeast. This can result in a vaginal yeast infection or oral thrush. Talk to your doctor if you notice unusual discharge, itching, or white patches in your mouth.

Metrogyl ER Tablet can sometimes cause urine to appear dark brown or reddish-brown. This is usually harmless and occurs due to breakdown products of the medicine. However, if dark urine occurs together with yellowing of the skin or eyes, severe fatigue, or abdominal pain, seek medical advice promptly. Talk to your doctor if you are concerned.

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Country of origin

India

Manufacturer/Marketer address

SHETH GOVINDRAO SMRITI 83 B&CDR A B ROAD WORLI MUMBAI MH 400018 INDIA
Other Info - MET1616
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