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  3. Midfix 1 Injection 5 ml

Midfix 1 Injection 5 ml, Pack of 1 Injection
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Midfix 1 Injection 5 ml is used to induce sedation and relieve anxiety and muscle tension. It is used to induce sleepiness during therapeutic procedures (like endoscopy or colonoscopy) or complicated medical tests known as procedural sedation. It contains Midazolam, which relaxes muscles, reduces anxiety and induces drowsiness. It may cause side effects such as redness, pain or swelling at the injection site, headache, drowsiness, dizziness, confusion, dry mouth, tiredness or muscle spasms.
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Composition :

MIDAZOLAM-1MG

Manufacturer/Marketer :

VARENYAM HEALTHCARE PVT LTD

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Midfix 1 Injection 5 ml

Midfix 1 Injection 5 ml belongs to a class of drugs called benzodiazepines (sedatives) used to induce sedation and relieve anxiety and muscle tension. It is used to induce sleepiness during therapeutic procedures (like endoscopy or colonoscopy) or complicated medical tests known as procedural sedation. Conscious sedation is a technique in which drugs help you relax (sedative), reduce anxiety and inhibit pain (anaesthetic) during a medical test or procedure. It is usually referred to as procedural sedation and analgesia.

Midfix 1 Injection 5 ml contains Midazolam which works by increasing GABA activity (a chemical messenger in the brain that acts as a natural nerve-calming agent) involved in inducing drowsiness. Thereby, Midfix 1 Injection 5 ml relaxes muscles, reduces anxiety and causes drowsiness.

Midfix 1 Injection 5 ml will be administered by a healthcare professional; do not self-administer. Sometimes, it may cause side effects such as redness, pain or swelling at the injection site, headache, drowsiness, dizziness, confusion, dry mouth, tiredness or muscle spasms. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Midazolam or any other medicines, please tell your doctor. If you are pregnant or planning pregnancy, inform your doctor before taking Midfix 1 Injection 5 ml. It may be excreted in breast milk. Therefore, avoid breastfeeding for 24 hours after taking Midfix 1 Injection 5 ml. Midfix 1 Injection 5 ml should be used with caution in elderly patients as there is an increased risk of breaking bones and falling. Special care should be taken while treating children with Midfix 1 Injection 5 ml. Avoid consumption of alcohol while on treatment with Midfix 1 Injection 5 ml as it may increase the sedative effect. Midfix 1 Injection 5 ml may cause drowsiness or affect concentration and coordination. It is an offence to drive if Midfix 1 Injection 5 ml affects you. Therefore, avoid driving if you feel drowsy after taking Midfix 1 Injection 5 ml.

Uses of Midfix 1 Injection 5 ml

Management of Conscious sedation

Directions for Use

Midfix 1 Injection 5 ml will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Midfix 1 Injection 5 ml contains Midazolam used to induce conscious sedation (awake but very relaxed state of calm or drowsiness) during therapeutic procedures or medical tests. Midfix 1 Injection 5 ml increases the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent) that is involved in inducing drowsiness. Thereby, Midfix 1 Injection 5 ml relaxes muscles, reduces anxiety and causes drowsiness.

How Midfix 1 Injection 5 ml Works

Midfix 1 Injection 5 ml contains Midazolam which works by increasing GABA activity (a chemical messenger in the brain that acts as a natural nerve-calming agent) involved in inducing drowsiness. Thereby, Midfix 1 Injection 5 ml relaxes muscles, reduces anxiety and causes drowsiness.

Storage

Store in a cool and dry place away from sunlight
Side effects of Midfix 1 Injection 5 ml
  • Get plenty of fresh air.
  • Take regular sips of a cold drink.
  • Take ginger containing foods like ginger tea and ginger biscuits.
  • Do not take heavy meals at a time, take small and frequent meals.
  • Hiccups can be controlled if you can hold your breath for a short time.
  • Drink plenty of warm fluids and gargle with salt water.
  • Swallow some sugar as it can give relief to some extent.
  • You can try to pull your knees up to your chest and lean forward, which helps relieve hiccups.
  • Try to breathe in a paper bag for a while, but don't keep the paper over your head.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

What if I have taken an overdose of Midfix 1 Injection 5 ml

The overdose of Midfix 1 Injection 5 ml is unlikely as it is administered by a doctor. However, in case of overdose, patients may experience drowsiness, loss of co-ordination, speech problems, involuntary eye movements, low blood pressure, apnoea (breathing stops temporarily), cardiorespiratory depression (slow or shallow breathing and heartbeat) and coma.Therefore, if you suspect any adverse reactions or unusual symptoms while on treatment with Midfix 1 Injection 5 ml, please inform your doctor immediately.

Drug Warnings

If you are allergic to Midazolam or any other medicines, please inform your doctor. If you are pregnant or planning pregnancy, inform your doctor before taking Midfix 1 Injection 5 ml. Midfix 1 Injection 5 ml may be excreted in breast milk. Therefore, avoid breastfeeding for 24 hours after taking Midfix 1 Injection 5 ml. Midfix 1 Injection 5 ml should be used with caution in elderly patients as there is an increased risk of breaking bones and falling. Special care should be taken while giving Midfix 1 Injection 5 ml to children, and the dose should be adjusted appropriately. Avoid consumption of alcohol with Midfix 1 Injection 5 ml as it may increase the sedative effect of Midfix 1 Injection 5 ml. Midfix 1 Injection 5 ml may cause drowsiness or affect concentration and coordination. It is an offence to drive if Midfix 1 Injection 5 ml affects you. Therefore, avoid driving if you feel drowsy after taking Midfix 1 Injection 5 ml. Do not take Midfix 1 Injection 5 ml with opioids as it may increase the risk of difficulties in breathing, drowsiness or coma. However, if the concomitant use is advised by a doctor, the dose and duration should be limited by a doctor.

Drug-Drug Interactions

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MidazolamDelavirdine
Critical
MidazolamCobicistat
Critical

Drug-Drug Interactions

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MidazolamDelavirdine
Critical
How does the drug interact with Midfix 1 Injection 5 ml:
The negative effects of Midfix 1 Injection 5 ml and Delavirdine might be increased when used together.

How to manage the interaction:
Taking Midfix 1 Injection 5 ml together Delavirdine may cause an interaction. They can, however, be taken if a doctor has prescribed them. Consult a doctor if you have any of the following symptoms: excessive sleepiness, dizziness, confusion, or weak or rapid breathing. Do not discontinue any medication without consulting a doctor.
MidazolamCobicistat
Critical
How does the drug interact with Midfix 1 Injection 5 ml:
Cobicistat and Midfix 1 Injection 5 ml co-administration may considerably enhance Midfix 1 Injection 5 ml blood levels and effects.

How to manage the interaction:
Although taking Cobicistat and Midfix 1 Injection 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamAtazanavir
Critical
How does the drug interact with Midfix 1 Injection 5 ml:
Atazanavir and Midfix 1 Injection 5 ml co-administration may considerably enhance Midfix 1 Injection 5 ml blood levels and effects.

How to manage the interaction:
Although taking Atazanavir and Midfix 1 Injection 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamIdelalisib
Critical
How does the drug interact with Midfix 1 Injection 5 ml:
Idelalisib and Midfix 1 Injection 5 ml co-administration may considerably enhance Midfix 1 Injection 5 ml blood levels and effects.

How to manage the interaction:
Although taking Idelalisib and Midfix 1 Injection 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamIndinavir
Critical
How does the drug interact with Midfix 1 Injection 5 ml:
Indinavir and Midfix 1 Injection 5 ml co-administration may considerably enhance Midfix 1 Injection 5 ml blood levels and effects.

How to manage the interaction:
Although taking Indinavir and Midfix 1 Injection 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamKetoconazole
Critical
How does the drug interact with Midfix 1 Injection 5 ml:
Co-administration of Ketoconazole and Midfix 1 Injection 5 ml may increase the risk of side effects.

How to manage the interaction:
Although taking Ketoconazole and Midfix 1 Injection 5 ml together is not recommended as it may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamAmprenavir
Critical
How does the drug interact with Midfix 1 Injection 5 ml:
Co-administration of Amprenavir and Midfix 1 Injection 5 ml may significantly increase the blood levels and effects of Midfix 1 Injection 5 ml.

How to manage the interaction:
Although taking Amprenavir along with Midfix 1 Injection 5 ml can possibly lead to an interaction, they can be taken if a doctor advices them. In case of increased or prolonged drowsiness and breathing difficulties, consult a doctor. Do not stop using any medications without talking to a doctor.
MidazolamTelaprevir
Critical
How does the drug interact with Midfix 1 Injection 5 ml:
Telaprevir and Midfix 1 Injection 5 ml co-administration may considerably enhance Midfix 1 Injection 5 ml blood levels and effects.

How to manage the interaction:
Although taking Telaprevir and Midfix 1 Injection 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamSodium oxybate
Critical
How does the drug interact with Midfix 1 Injection 5 ml:
Sodium oxybate and Midfix 1 Injection 5 ml co-administration may considerably enhance Midfix 1 Injection 5 ml blood levels and effects.

How to manage the interaction:
Although taking Sodium oxybate and Midfix 1 Injection 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamBoceprevir
Critical
How does the drug interact with Midfix 1 Injection 5 ml:
Boceprevir and Midfix 1 Injection 5 ml co-administration may considerably enhance Midfix 1 Injection 5 ml blood levels and effects.

How to manage the interaction:
Although taking Boceprevir and Midfix 1 Injection 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Habit Forming

Yes

Therapeutic Class

SEDATIVE-HYPNOTIC DRUGS

Midfix 1 Injection 5 ml Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol with Midfix 1 Injection 5 ml as it may increase the sedative effect of Midfix 1 Injection 5 ml and may also cause breathing problems.

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Pregnancy

Caution

If you are pregnant or planning for pregnancy, inform your doctor before taking Midfix 1 Injection 5 ml. However, if Midfix 1 Injection 5 ml is used for prolonged treatment during the last trimester, it may cause physical dependence and risk of withdrawal symptoms after birth in the baby.

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Breast Feeding

Caution

Midfix 1 Injection 5 ml may be excreted in breast milk. Therefore, avoid breastfeeding for 24 hours after taking Midfix 1 Injection 5 ml.

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Driving

Unsafe

Midfix 1 Injection 5 ml may cause drowsiness or affect concentration and coordination. It is an offence to drive after taking Midfix 1 Injection 5 ml and if it affects your ability to drive. Therefore, avoid driving if you feel drowsy after taking Midfix 1 Injection 5 ml.

bannner image

Liver

Caution

If you have liver conditions, inform your doctor before taking Midfix 1 Injection 5 ml.

bannner image

Kidney

Caution

If you have kidney problems, inform your doctor before taking Midfix 1 Injection 5 ml.

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Children

Caution

If your child has a heart condition, notify your doctor before giving Midfix 1 Injection 5 ml. The dose will be adjusted specifically, and your child will be closely watched. Midfix 1 Injection 5 ml is only advised for sedation in intensive care units for newborns and babies under six months of age, and their breathing and oxygen levels must be closely monitored.

Have a query?

FAQs

Midfix 1 Injection 5 ml is used to induce sedation and relieve anxiety and muscle tension. It is used to induce sleepiness during therapeutic procedures (like endoscopy or colonoscopy) or complicated medical tests known as procedural sedation.

Midfix 1 Injection 5 ml contains Midazolam which works by increasing the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent) that is involved in inducing drowsiness. Thus, it relaxes muscles, reduces anxiety and causes drowsiness.

You are not recommended to take Midfix 1 Injection 5 ml with opioids as co-administration of these medicines as it may increase the risk of adverse effects such as difficulties in breathing, drowsiness or coma. Therefore, before using Midfix 1 Injection 5 ml with any other medicines, please consult your doctor so that the dosage may be adjusted accordingly to use safely.

Yes, Midfix 1 Injection 5 ml may cause dizziness, drowsiness or affect concentration and coordination. Therefore, it is recommended to avoid driving or any other activities that require mental alertness after taking Midfix 1 Injection 5 ml. Also, it is an offence to drive if Midfix 1 Injection 5 ml affects your ability to drive.

Yes, Midfix 1 Injection 5 ml may cause physical dependence and withdrawal symptoms if used for prolonged periods. Therefore, do not stop treatment with Midfix 1 Injection 5 ml suddenly. Your doctor will reduce the dose gradually to avoid withdrawal symptoms.

Midfix 1 Injection 5 ml is not recommended for patients suffering from myasthenia gravis (severe muscle weakness) as it may worsen the condition. Therefore, inform your doctor if you have myasthenia gravis before taking Midfix 1 Injection 5 ml.

Midfix 1 Injection 5 ml is safe if used under the supervision of a doctor. Follow your doctor’s instructions carefully and inform your doctor if you experience any side effects.

Yes, Midfix 1 Injection 5 ml is classified as a controlled substance due to its potential for abuse and dependence. Therefore, it should be used only under the supervision of a doctor and according to the prescribed dosage.

Yes, Midfix 1 Injection 5 ml is a sedative. It is used to induce drowsiness, and relieve anxiety before minor surgical, dental, or other medical procedures.

Yes, Midfix 1 Injection 5 ml contains midazolam, which is a type of benzodiazepine. Benzodiazepines are a class of sedative medications.

Yes, Midfix 1 Injection 5 ml have analgesic properties. It inhibits pain (anaesthetic) during a medical test or procedure.

Yes, Midfix 1 Injection 5 ml can cause retrograde amnesia (temporary memory loss). Therefore, use it only under the guidance of a doctor.

The common side effects of Midfix 1 Injection 5 ml are redness, pain or swelling at the injection site, headache, drowsiness, dizziness, confusion, dry mouth, tiredness or muscle spasms. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Ground & 1st Floor, Tower-H, Sunwelkin, Near IOC Petrol Pump, Harni, Vadodara-390022, Gujarat, India
Other Info - MID0061

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:48 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.5668.pdf
  2. https://www.medicines.org.uk/emc/files/pil.3693.pdf
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