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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Biological E Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Mifrex Plus Tablet Kit 10's

Mifrex Plus Tablet Kit 10's is a combination prescription medicine taken orally for the medical termination of an early pregnancy, typically up to 70 days or 10 weeks from the first day of your last menstrual period. This medication is prescribed under strict medical supervision to safely end an early pregnancy without the need for immediate surgical intervention. It is highly effective when taken exactly as directed by your healthcare provider.

This treatment involves a specific, sequential dosing schedule that must be followed precisely as directed by your doctor, rather than a continuous daily routine. The tablets are typically taken orally, with or without food, though taking them with a light, non-greasy meal may help manage potential nausea. Staying hydrated and resting in a comfortable environment during the process will help support your body's recovery.

Common side effects include abdominal cramping, vaginal bleeding, nausea, vomiting, diarrhoea, and dizziness. While bleeding and cramping are expected parts of the process, you must contact your doctor or seek emergency medical care immediately if you experience excessively heavy bleeding (soaking through more than two thick sanitary pads per hour for two consecutive hours), severe pain, or a high fever.

Before starting Mifrex Plus Tablet Kit 10's, tell your doctor if you have an intrauterine device (IUD) in place, an ectopic pregnancy (a pregnancy outside the womb), chronic adrenal failure, severe anaemia, or bleeding disorders. Do not take this medicine if you have a known allergy to any of its ingredients, have an unconfirmed pregnancy, or do not have close access to emergency medical services.

This medication can interact with other drugs such as certain blood thinners, steroids, and liver enzyme-affecting medicines, which can alter how the treatment works or increase bleeding risks. Avoid drinking alcohol or smoking during this treatment, as they can worsen side effects like dizziness, nausea, and dehydration. If you are breastfeeding or have underlying medical conditions, discuss the safety and timing of this treatment with your doctor.

Uses of Mifrex Plus Tablet Kit 10's

Mifrex Plus Tablet Kit 10's may be prescribed for the following conditions: 

  • Medical termination of intrauterine pregnancy: Mifrex Plus Tablet Kit 10's helps end an early pregnancy (up to 10 weeks or 70 days of gestation) by blocking the hormones necessary for the pregnancy to continue and causing the uterus to empty.
  • Management of early pregnancy loss (miscarriage): In certain cases of incomplete miscarriage or missed abortion, Mifrex Plus Tablet Kit 10's helps clear the remaining tissue from the uterus safely and completely.

Key Benefits

Mifrex Plus Tablet Kit 10's offers a non-surgical option for ending an early pregnancy, allowing the process to take place in a private and comfortable setting under medical supervision. Some of the key benefits of this treatment include:

  • Avoids surgical anaesthesia: Since this is an oral medication regimen, it eliminates the risks and anxiety associated with general or local anaesthesia used in surgical procedures.
  • High success rate: When taken within the recommended timeframe and in the correct sequence, this combination is highly effective at completely clearing the uterus.
  • Privacy and control: It allows you to plan the second step of the process at home or in a familiar environment where you can have supportive care nearby.
Side effects of Mifrex Plus Tablet Kit
  • Your doctor may reduce your medication dose gradually if you have too much cortisol, while still managing your condition.
  • Try hot baths, massages, and gentle exercises like water aerobics or tai chi to ease aches and pains.
  • Limit sodium and fatty foods to reduce health risks.
  • Consume foods rich in calcium, like dairy, leafy greens, fortified plant milk, and salmon, to support bone health.
  • Include sources of vitamin D in your meals, such as cod liver oil, egg yolks, fortified milk, and fatty fish like swordfish and salmon.
  • Make time for things you enjoy and set limits to avoid getting too tired.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.

Directions for Use

  • Mifrex Plus Tablet Kit 10's should be taken on an empty stomach or as advised by your doctor.
  • Take Mifrex Plus Tablet Kit 10's exactly as directed by your doctor. Misoprostol should be taken 36 to 48 hours after mifepristone.
  • Swallow Mifrex Plus Tablet Kit 10's as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Mifrex Plus Tablet Kit 10's Works

Mifrex Plus Tablet Kit 10's contains mifepristone and misoprostol, which work together to medically terminate an early pregnancy. Mifepristone works by blocking the action of progesterone, a hormone that is essential for maintaining pregnancy. Without adequate progesterone activity, the lining of the uterus begins to break down, causing the pregnancy to detach from the uterine wall and stop developing. Misoprostol is usually taken 24 to 48 hours after mifepristone. It works by softening and dilating the cervix and stimulating contractions of the uterus. These contractions help expel the pregnancy tissue from the uterus through the vagina. Together, these actions help complete the medical termination process by ending the pregnancy and allowing the uterus to empty its contents
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Alcohol

Unsafe

Alcohol is known to cause excessive drowsiness and increases uterine bleeding if taken along with Mifrex Plus Tablet Kit 10's.

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Pregnancy

Unsafe

Mifrex Plus Tablet Kit 10's is used for medical abortion. If taken in pregnancy, it can lead to abortion.

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Breast Feeding

Unsafe

Mifrex Plus Tablet Kit 10's should not be taken if breastfeeding as it may pass through the milk to the baby.

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Driving

Unsafe

Driving is unsafe when taking Mifrex Plus Tablet Kit 10's as it might increase the risk of excessive bleeding.

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Liver

Caution

Mifrex Plus Tablet Kit 10's to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Mifrex Plus Tablet Kit 10's to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Mifrex Plus Tablet Kit 10's is not recommended for children below the age of 12. The safety and effectiveness of Mifrex Plus Tablet Kit 10's have not been established in children due to limited testing of this drug on children by competent authorities worldwide. If necessary, your doctor will decide whether to give Mifrex Plus Tablet Kit 10's or not.

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Heart

Caution

Mifrex Plus Tablet Kit 10's should be used under caution in cardiac patients as it can lead to QT prolongation.

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Geriatrics

Consult your doctor

Limited information is available for use in erderly patients. Please consult your doctor.

What if I have taken an overdose of Mifrex Plus Tablet Kit 10's

If you take more than the prescribed amount of Mifrex Plus Tablet Kit 10's, seek immediate medical attention or contact a poison control centre right away. An overdose can cause severe side effects, including extreme nausea, vomiting, dizziness, or dangerously heavy bleeding.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water, clear broths, or electrolyte solutions to replace fluids lost through sweating, vomiting, or diarrhoea.
  • Eat light, bland foods: Stick to plain foods like toast, crackers, rice, or applesauce to help manage nausea or an upset stomach during the process.
  • Prioritise physical rest: Avoid strenuous physical activities, heavy lifting, or intense exercise for at least a few days to let your body recover from cramping and bleeding.
  • Avoid tampons and douching: Use only sanitary pads (not tampons or menstrual cups) for your bleeding to reduce the risk of introducing bacteria into the uterus.
  • Apply warm heat: Use a heating pad or a warm water bottle on your lower abdomen to help soothe uterine cramps.

Have a query?

How Soon It Starts Working

The time required for Mifrex Plus Tablet Kit 10's to start to work: The time required for Mifrex Plus Tablet Kit 10's to show its action is unknown. The time for which the effects of Mifrex Plus Tablet Kit 10's last: The duration of action for Mifrex Plus Tablet Kit 10's is unknown.

What if you forget to take Mifrex Plus Tablet Kit 10's

Because this medication involves a strict, time-sensitive sequence, missing a dose or failing to take the second part of the treatment at the correct time can cause the procedure to fail or lead to medical complications. If you miss a dose or deviate from the schedule, call your doctor or clinic immediately for urgent instructions. Do not take a double dose to make up for a missed one.

Storage

• Store Mifrex Plus Tablet Kit 10's at controlled room temperature, between 68°F and 77°F (20°C to 25°C). • Keep the tablets in their original blister packaging until you are ready to use them, to protect them from moisture and direct light.

Drug Warnings

  • Check the packaging: Always inspect the blister pack before use; do not take the medication if the seal is broken, torn, or damaged.
  • Have a support person nearby: Ensure a trusted friend, family member, or partner knows you are undergoing this treatment and is available to assist you if needed.
  • Plan for follow-up care: You must schedule a follow-up visit with your doctor 7 to 14 days after taking the medication to confirm the pregnancy has been completely ended and to check for complications.
  • Avoid driving: Do not drive or operate machinery until you know how this medication affects you, as severe cramping, bleeding, and dizziness are common.
  • Understand future fertility: You can become pregnant again very quickly after this treatment; discuss reliable birth control options with your doctor during your follow-up visit.

Drug-Drug Interactions

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact with Mifrex Plus Tablet Kit 10's: 

  • Blood thinners: Taking medications that prevent blood clots can significantly increase your risk of severe, uncontrolled uterine bleeding.
  • Corticosteroids: This medication can block the effects of long-term steroid therapy, which may require a doctor to adjust your steroid dose.
  • Certain seizure medications and antibiotics: Drugs like rifampin, carbamazepine, or phenytoin can speed up how your body processes this medicine, potentially making it less effective.


Drug-Food Interactions

Certain foods and beverages may affect how Mifrex Plus Tablet Kit 10's works or increase the risk of side effects: 

  • Grapefruit juice: Avoid consuming grapefruit or grapefruit juice while taking this medication, as it can increase the levels of the medicine in your body and heighten the risk of side effects.


Drug-Disease Interactions

Inform your doctor if you have any of the following conditions before taking Mifrex Plus Tablet Kit 10's: 

  • Adrenal gland disorders: Do not take this medication if you have chronic adrenal failure, as it blocks the action of essential hormones produced by the adrenal glands.
  • Bleeding disorders or severe anaemia: This medication causes significant bleeding and should be avoided or used with extreme caution if you have a pre-existing bleeding disorder or very low iron levels.
  • Ectopic pregnancy: This treatment is not effective for a pregnancy outside of the womb (ectopic pregnancy) and should not be used if this condition is suspected.

Drug-Drug Interactions

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How does the drug interact with Mifrex Plus Tablet Kit:
Using Mifrex Plus Tablet Kit together with Fondaparinux may increase the risk and/or severity of vaginal bleeding in women

How to manage the interaction:
Taking Fondaparinux with Mifrex Plus Tablet Kit together is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mifrex Plus Tablet Kit:
Co-administration of Mifrex Plus Tablet Kit and Hydrocortisone can reduce the effects of Hydrocortisone.

How to manage the interaction:
Taking Hydrocortisone with Mifrex Plus Tablet Kit is not recommended, consult a doctor before taking it. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Mifrex Plus Tablet Kit:
When Mifrex Plus Tablet Kit is taken with Dabigatran etexilate, it may increase the risk of severe vaginal bleeding.

How to manage the interaction:
Taking Mifrex Plus Tablet Kit with Dabigatran etexilate is not recommended, but it can be taken if prescribed by the doctor. However, if you experience heavy, persistent vaginal bleeding, consult the door. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mifrex Plus Tablet Kit:
Using Mifrex Plus Tablet Kit together with Budesonide may significantly reduce the effects of Budesonide.

How to manage the interaction:
Taking Budesonide with Mifrex Plus Tablet Kit is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mifrex Plus Tablet Kit:
Co-administration of Mifrex Plus Tablet Kit with Bivalirudin can increase the risk of side effects.

How to manage the interaction:
Taking Bivalirudin with Mifrex Plus Tablet Kit together is not generally recommended as it may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience persistent, excessive bleeding, consult the doctor. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Mifrex Plus Tablet Kit:
Co-administration of Sirolimus with Mifepristone can increase the levels of Sirolimus in the blood, which can increase the risk or severity of side effects.

How to manage the interaction:
Taking Sirolimus with Mifepristone is not recommended, they can be taken together if a doctor advises. Do not stop taking any medications without consulting a doctor.
Mifepristone + MisoprostolFluticasone Propionate
Critical
How does the drug interact with Mifrex Plus Tablet Kit:
Co-administration of Fluticasone Propionate with Mifrex Plus Tablet Kit can increase the risk of side effects.

How to manage the interaction:
Taking Mifrex Plus Tablet Kit and Fluticasone Propionate is not recommended, but can be taken if prescribed by a doctor. Do no discontinue any medications without consulting a doctor.
How does the drug interact with Mifrex Plus Tablet Kit:
Co-administration of Mifepristone with Simvastatin can increase the blood levels of simvastatin, which may increase the risk of side effects.

How to manage the interaction:
Taking Simvastatin with Mifepristone is not recommended, but can be taken if prescribed by the doctor. If you experience any symptoms, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
Critical
How does the drug interact with Mifrex Plus Tablet Kit:
When Mifrex Plus Tablet Kit is taken with Ergotamine, it may increase the blood levels of Ergotamine, which may result in side effects.

How to manage the interaction:
Taking Ergotamine with Mifepristone is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mifrex Plus Tablet Kit:
Co-administration of Beclomethasone with Mifrex Plus Tablet Kit may make it less effective as a therapy.

How to manage the interaction:
Taking Beclomethasone with Mifrex Plus Tablet Kit is not recommended, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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MIFEPRISTONE-200MG+MISOPROSTOL-200MCGFruit juices, Fruits
Moderate

Drug-Food Interactions

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MIFEPRISTONE-200MG+MISOPROSTOL-200MCGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grapefruit or grapefruit juice along with Mifrex Plus Tablet Kit may cause the medication's blood levels to rise to unwanted levels and raise the chance of adverse effects. Avoid taking grapefruit or grapefruit juice along with Mifrex Plus Tablet Kit as this can raise the chance of adverse effects. However, consult a doctor if you experience headache, dizziness, fatigue, nausea, vomiting, cramping, diarrhea, hypokalemia (low blood potassium), fluid retention, swelling, and high blood pressure.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ABORTIFACIENT, CERVICAL RIPENING AGENTS]

FAQs

Mifrex Plus Tablet Kit 10's is used for the medical termination of the pregnancy before 63 days after the first day of the last menses period. Mifrex Plus Tablet Kit 10's also works in the second trimester of pregnancy.

Mifrex Plus Tablet Kit 10's contains Mifepristone and Misoprostol. Mifepristone works by blocking the effect of progesterone (female hormone), which is needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. Misoprostol is a prostaglandin analogue that helps increase uterine contractions and relaxes the cervix. Misoprostol should be taken 24-36 hours after taking mifepristone, either orally or vaginally.

No, Mifrex Plus Tablet Kit 10's should be taken in the dose and duration as advised by the doctor. Taking it in more than the recommended dose might cause unpleasant side effects like excessive uterine or vaginal bleeding.

No, Mifrex Plus Tablet Kit 10's is not known to affect any future chances of pregnancy. Mifrex Plus Tablet Kit 10's is used for medical abortion of early or unwanted pregnancy.

After taking Mifrex Plus Tablet Kit 10's, you may or may not experience vaginal bleeding, which does not indicate complete abortion. Your doctor will examine with the performing ultrasonography to confirm if the abortion is complete.

Do not take Mifrex Plus Tablet Kit 10's, if you have a heart fitted with an artificial valve, heart diseases like high blood pressure or high blood cholesterol levels (increased fat in your blood), have asthma, have blood clot problems, have a bleeding disorder, have liver or kidney disease, have anaemia (low haemoglobin) or otherwise malnourished. Taking Mifrex Plus Tablet Kit 10's in these conditions can cause life-threatening conditions in an individual.

Store Mifrex Plus Tablet Kit 10's in a cool, dry place away from sunlight. Keep it out of reach of children.

Mifrex Plus Tablet Kit 10's may cause interaction with certain medications, including corticosteroids, antifungals, antibiotics, anti-epileptics, immunosuppressants, and migraine medications. Taking Mifrex Plus Tablet Kit 10's with these medications may cause negative complications. It's essential to inform your doctor about all medications and health histories you are taking, and they will assess your condition and help manage it to avoid complications.

You should take Mifrex Plus Tablet Kit 10's exactly as directed by your doctor. Your doctor will determine the dose and duration based on your pregnancy status, menstrual cycle, medical history, and especially sexual intimation time history. Follow your doctor's instructions carefully and complete the full course as prescribed for a safe and healthy abortion process.

The common side effects of Mifrex Plus Tablet Kit 10's may include nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Most of these side effects of Mifrex Plus Tablet Kit 10's subside with time. If these symptoms become worse, please consult a doctor for relief.

Bleeding and cramping typically begin within 1 to 4 hours after taking the second part of the medication, though it can sometimes take up to 24 hours. The heaviest bleeding and most intense cramping usually occur while the pregnancy tissue is being passed. Talk to your doctor if you do not experience any bleeding within 24 hours of taking the second medicine.

Yes, the bleeding is usually much heavier than a normal menstrual period and is often accompanied by large blood clots and cramping. This is a normal part of how the medication clears the pregnancy from your body. Talk to your doctor if the bleeding is light or if it is excessively heavy, such as soaking through two pads an hour for two hours in a row.

Yes, your doctor will often recommend or prescribe specific pain medications, such as ibuprofen, to help manage the cramping. Avoid taking aspirin, as it can potentially increase bleeding. Always talk to your doctor or pharmacist before taking any over-the-counter pain medicines during this treatment.

If you vomit shortly after taking either of the medications (especially within 30 to 45 minutes), some of the medicine may not have been fully absorbed. Call your doctor or clinic immediately to find out if you need to take another dose. Talk to your doctor about anti-nausea medications that can help prevent this.

The only way to confirm that the treatment was completely successful and that no pregnancy tissue remains in your uterus is to have a follow-up assessment. This is usually done 7 to 14 days after the treatment through an ultrasound, blood test, or a specific clinic evaluation. Talk to your doctor to schedule this critical visit.

The active ingredients can pass into breast milk in small amounts, which might cause mild diarrhoea in a breastfed infant. Many doctors advise discarding breast milk or pausing breastfeeding for a short period (such as 24 to 48 hours) after taking the second medication. Talk to your doctor to get personalised advice based on your situation.

Most women see their normal menstrual cycle return within 4 to 8 weeks after the treatment is completed. Keep in mind that you can become pregnant again almost immediately after the pregnancy is ended, even before your period returns. Talk to your doctor about starting a reliable method of birth control.

You should seek emergency medical care immediately if you experience extremely heavy bleeding (soaking more than two pads per hour for two hours), severe abdominal pain that doesn't respond to pain medication, a fever over 100.4°F (38°C) lasting more than four hours, or a foul-smelling discharge. Talk to your doctor if you have any sudden changes in how you feel.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Road No. 35,Jubilee Hills, Hyderabad, Telangana -500033
Other Info - MIF0050
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