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compositionComposition:AMIKACIN SULPHATE-1000MG
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Prescription Medicine
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Mikacin 1000 mg/4 ml Injection 4 ml is used to treat bacterial infections. It contains Amikacin sulphate, which works by inhibiting the production of bacterial proteins which are necessary for the survival of the bacteria. Thereby, leads to the death of the bacterial cell. Thus, it helps treat bacterial infections. In some cases, you may experience certain common side effects such as irritation at the site of application, skin rash, nausea, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMIKACIN SULPHATE-1000MG

Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Mikacin 1000 mg/4 ml Injection 4 ml

Mikacin 1000 mg/4 ml Injection 4 ml is a prescription antibiotic injection used to treat severe and life-threatening bacterial infections. It is commonly prescribed to target serious infections in the blood, lungs, bones, joints, and abdomen. This medicine is highly effective in clearing bacteria when other standard treatments may not be strong enough or suitable.

Since this medication is injected directly, it must be taken consistently at the exact times prescribed by your healthcare provider. Because it bypasses the digestive system, you do not need to worry about taking it with or without food. Drinking plenty of water while receiving this treatment is one of the most helpful lifestyle changes you can make to support your recovery and protect your body.

While this medicine is vital for fighting serious infections, it can cause some side effects, such as mild stomach discomfort or irritation where you receive the injection. However, you must contact your doctor immediately if you experience serious symptoms, including changes in your hearing, dizziness, or a sudden decrease in how much you urinate.

Before starting your treatment, tell your healthcare provider if you have a history of kidney disease, hearing loss, or neuromuscular disorders. Do not take this medicine if you have had a severe allergic reaction to similar antibiotic injections in the past.

This injection can interact with certain other medications, including strong water pills and other antibiotics, which may increase the risk of kidney or ear damage. If you are pregnant, breastfeeding, or an elderly patient, discuss the risks and benefits thoroughly with your doctor or pharmacist before starting treatment.

Uses of Mikacin 1000 mg/4 ml Injection 4 ml

Your doctor may prescribe Mikacin 1000 mg/4 ml Injection 4 ml to treat several types of serious bacterial infections, including:

  • Severe blood infections: Mikacin 1000 mg/4 ml Injection 4 ml helps clear dangerous bacteria from the bloodstream, helping to resolve life-threatening conditions like sepsis.
  • Serious lung infections: It targets bacteria causing severe pneumonia and deep chest infections, helping to restore normal breathing.
  • Abdominal infections: It treats complex infections inside the stomach and abdominal cavity, such as peritonitis.
  • Complicated urinary tract infections: It helps eliminate deep-seated bacterial infections in the kidneys and urinary tract.
  • Bone and joint infections: It treats stubborn bacterial infections in deep tissues and bones that are difficult for other medicines to reach.

Key Benefits

Mikacin 1000 mg/4 ml Injection 4 ml offers several important benefits in the treatment of serious bacterial infections by providing rapid antibacterial action, helping control infection effectively, and supporting a faster recovery process. 

  • Rapid Onset of Action: Because it is administered by injection, the medicine begins working quickly to fight infection.
  • Effectively Treats Serious Bacterial Infections: Helps control severe infections before they can spread and cause additional complications.
  • Supports Faster Recovery: By targeting infection promptly, it helps patients begin recovering sooner.
  • Active Against Resistant Bacteria: Remains effective against many bacterial strains that may not respond to standard antibiotics.
  • Provides a Reliable Treatment Option: Can be used when other antibiotics are ineffective or inappropriate.
  • Reduces the Risk of Infection Progression: Helps prevent worsening of infection and associated health complications.
  • Suitable for Hospital-Based Care: Enables healthcare professionals to deliver precise and effective treatment in critical situations.
  • Improves Clinical Outcomes: Effective infection control can support better recovery and overall treatment success.
Side effects of Mikacin 1000 mg/4 ml Injection 4 ml
  • Eat nutrient-rich foods, including carrots, potatoes, fruits, vegetables, and healthy fats.
  • Stay hydrated by drinking plenty of fluids to flush out waste from the body.
  • Exercise regularly for overall wellness.
  • Avoid harmful substances, including excessive alcohol and smoking.
  • Be cautious with medications like ibuprofen, naproxen, and aspirin - consult your doctor before taking them.
  • Seek medical advice to identify and address underlying health issues.
  • Changes in kidney function need immediate medical attention.
  • Always monitor your blood pressure and inform your healthcare team if there are any sudden changes.
  • Take medicines as prescribed and eat a balanced diet suggested by your dietician for healthy kidney function.
  • Physical activity and exercise must be included in your daily routine to have proper kidney functioning and to maintain a healthy weight.
  • Get enough sleep to reduce the stress levels that have a direct impact on your kidney functioning.
  • Drink more fluids as dehydration can decrease blood flow to kidneys and increase BUN levels.
  • Eat less protein and stop protein supplements as high protein diet may increase BUN levels.
  • Severe cases may require kidney transplant or dialysis.

Directions for Use

Mikacin 1000 mg/4 ml Injection 4 ml should be administered exactly as prescribed by your healthcare provider. Following the correct administration technique and treatment schedule is important to ensure the medicine works effectively and safely.

  • This medicine is administered as an injection into a large muscle or as a slow intravenous (IV) infusion directly into a vein.
  • It is usually prepared and given by a trained healthcare professional in a hospital, clinic, or specialised home-care setting.
  • If you are authorised to administer the medicine at home, carefully follow the training and instructions provided by your healthcare team.
  • Wash your hands thoroughly before handling the medication or injection equipment.
  • Always use sterile needles, syringes, and other equipment for each dose.
  • Do not use the medicine if the solution appears cloudy, discoloured, or contains visible particles.
  • Follow your doctor's prescribed dosing schedule and treatment duration exactly.
  • Do not skip doses or stop treatment early, even if your symptoms improve, unless advised by your doctor.
  • Contact your healthcare provider if you have any questions or concerns about administering the medication.

How Mikacin 1000 mg/4 ml Injection 4 ml Works

Mikacin 1000 mg/4 ml Injection 4 ml contains amikacin sulphate, an aminoglycoside antibiotic that is used to treat serious bacterial infections. Amikacin sulphate works by entering bacterial cells and binding to structures that are responsible for producing proteins. By interfering with this process, it prevents the bacteria from making the essential proteins they need to grow, repair themselves, and multiply. Without these vital proteins, the bacteria are unable to survive and spread. As the number of bacteria decreases, your body's immune system can more effectively eliminate the remaining infection. Together, these actions help clear bacterial infections, reduce symptoms, and support recovery.
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Alcohol

Caution

You are advised not to consume alcohol while taking Mikacin 1000 mg/4 ml Injection 4 ml as it may lead to unwanted side-effects.

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Pregnancy

Caution

Mikacin 1000 mg/4 ml Injection 4 ml belongs to pregnancy category-D. If you are pregnant, the doctor will prescribe Mikacin 1000 mg/4 ml Injection 4 ml only if the benefits outweigh the potential risks.

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Breast Feeding

Caution

If you are breastfeeding, talk to your doctor before taking Mikacin 1000 mg/4 ml Injection 4 ml. The doctor will prescribe Mikacin 1000 mg/4 ml Injection 4 ml only if the benefits outweigh the potential risks.

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Driving

Caution

Mikacin 1000 mg/4 ml Injection 4 ml may cause dizziness, therefore you are advised to drive and operate machinery only if you are alert.

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Liver

Safe if prescribed

Mikacin 1000 mg/4 ml Injection 4 ml is safe to be used in people with liver problems if prescribed by a doctor.

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Kidney

Caution

Mikacin 1000 mg/4 ml Injection 4 ml should be used with caution in patients with kidney disease. Dose adjustment may be needed in such patients.

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Children

Safe if prescribed

Mikacin 1000 mg/4 ml Injection 4 ml can be given to children if prescribed by the doctor. Dose adjustment may be required as per the age and weight of the child.

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Heart

Caution

Exercise caution before using Mikacin 1000 mg/4 ml Injection 4 ml in case of heart problems. Please consult your doctor if you have any concerns.

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Geriatrics

Caution

Exercise caution before using Mikacin 1000 mg/4 ml Injection 4 ml in case of geriatric problems. Please consult your doctor if you have any concerns.

What if I have taken an overdose of Mikacin 1000 mg/4 ml Injection 4 ml

The overdose of Mikacin 1000 mg/4 ml Injection 4 ml is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with Mikacin 1000 mg/4 ml Injection 4 ml, please inform your doctor immediately.

Diet & Lifestyle Advise

Adopting certain lifestyle habits can support your recovery and help protect your body while you are receiving Mikacin 1000 mg/4 ml Injection 4 ml treatment:

  • Stay highly hydrated: Drink plenty of water throughout the day unless your doctor tells you otherwise. This helps your kidneys process and safely clear the medication from your body.
  • Avoid alcohol: Refrain from drinking alcohol during your treatment, as it can dehydrate your body and increase strain on your kidneys.
  • Eat a nourishing diet: Focus on balanced, nutrient-rich meals to help your immune system fight off the infection and regain its strength.
  • Get plenty of rest: Allow your body to rest and heal, especially during the first few days of treatment when your body is working hard to clear the infection.
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Have a query?

How Soon It Starts Working

The time required for Mikacin 1000 mg/4 ml Injection 4 ml to start to work: The time required for Mikacin 1000 mg/4 ml Injection 4 ml to start to work is immediately after administration. The time for which the effects of Mikacin 1000 mg/4 ml Injection 4 ml last: The effect of Mikacin 1000 mg/4 ml Injection 4 ml lasts for 8 to 12 hours.

What if you forget to take Mikacin 1000 mg/4 ml Injection 4 ml

As Mikacin 1000 mg/4 ml Injection 4 ml is administered under medical supervision, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

•Store unopened vials at room temperature, ideally between 20°C to 25°C (68°F to 77°F). • Keep the medicine protected from direct sunlight, moisture, and high heat. Do not freeze the injection solution.

Drug Warnings

  • Inspect the Injection Before Use: Always check the injection vial before use. The liquid should be clear to pale yellow. Do not use it if you notice any cloudiness, discolouration, or floating particles.
  • Use Sterile Equipment Every Time: Always use a fresh, sterile needle and syringe for every injection to prevent dangerous skin and blood infections.
  • Rotate Injection Sites: If you are receiving injections into a muscle, rotate the injection site each time to minimise pain, bruising, and muscle tissue damage.
  • Attend All Monitoring Appointments: Make sure to attend all scheduled medical appointments for blood tests, as your doctor needs to monitor your kidney function and hearing closely during treatment.
  • Complete the Full Course of Treatment: Finish the complete course of treatment exactly as prescribed, even if your symptoms clear up early, to prevent the infection from returning or becoming drug-resistant.

Drug-Drug Interactions

verifiedApollotooltip

Using Mikacin 1000 mg/4 ml Injection 4 ml alongside other substances or when you have certain medical conditions can alter how the medicine works or increase the risk of side effects. Below is a summary of key interactions:

Drug-Drug Interactions

Certain medicines can interact with Mikacin 1000 mg/4 ml Injection 4 ml and increase the risk of serious side effects or alter how the medication works. Inform your doctor about all prescription medicines, over-the-counter products, vitamins, and herbal supplements you are taking before starting treatment: 

  • Strong water pills (loop diuretics): Taking this medicine with medications like furosemide can significantly increase the risk of hearing loss or ear damage.
  • Other kidney-affecting medicines: Combining this injection with certain other antibiotics or medications (such as cisplatin or amphotericin B) can increase the risk of kidney damage.
  • Muscle relaxants: This medicine may enhance the effects of muscle relaxants used during surgeries, which can occasionally lead to breathing difficulties.


Drug-Disease Interactions

Certain medical conditions may affect the safety and effectiveness of Mikacin 1000 mg/4 ml Injection 4 ml and may require close monitoring or dose adjustments. Tell your doctor about your complete medical history before receiving this medicine, especially if you have any of the following conditions: 

  • Kidney disease: If your kidneys are not working properly, the medicine can build up in your body, increasing the risk of serious side effects. Your doctor will carefully adjust your dose.
  • Hearing problems: Pre-existing hearing issues or inner ear disorders can be worsened by this medicine.
  • Neuromuscular disorders: Conditions like myasthenia gravis or Parkinson's disease can be aggravated, leading to severe muscle weakness.
AmikacinBCG vaccine
Critical
AmikacinCidofovir
Critical

Drug-Drug Interactions

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AmikacinBCG vaccine
Critical
How does the drug interact with Mikacin 1000 mg/4 ml Injection 4 ml:
Coadministration of BCG vaccine with Mikacin 1000 mg/4 ml Injection 4 ml can reduce its effectiveness.

How to manage the interaction:
Taking Mikacin 1000 mg/4 ml Injection 4 ml with the BCG vaccine can result in an interaction. Furthermore, if you have active TB, you should not undergo BCG therapy. However, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
AmikacinCidofovir
Critical
How does the drug interact with Mikacin 1000 mg/4 ml Injection 4 ml:
Co-administration of cidofovir with Mikacin 1000 mg/4 ml Injection 4 ml can increase the risk of developing kidney problems.

How to manage the interaction:
Taking Cidofovir with Mikacin 1000 mg/4 ml Injection 4 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, dizziness, or palpitations, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
AmikacinTubocurarine
Severe
How does the drug interact with Mikacin 1000 mg/4 ml Injection 4 ml:
Co-administration of Mikacin 1000 mg/4 ml Injection 4 ml with tubocurarine raises the possibility of severe breathing difficulties.

How to manage the interaction:
Co-administration of Mikacin 1000 mg/4 ml Injection 4 ml with Tubocurarine can result in an interaction, but it can be taken if your doctor has advised it. Consult a doctor if you experience shortness of breath, chest discomfort, or palpitation. Do not stop using any medications without consulting a doctor.
AmikacinTorasemide
Severe
How does the drug interact with Mikacin 1000 mg/4 ml Injection 4 ml:
Co-administration of Mikacin 1000 mg/4 ml Injection 4 ml with Torasemide may increase this risk of side effects.

How to manage the interaction:
Although taking Mikacin 1000 mg/4 ml Injection 4 ml and torasemide together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as ringing in the ears, irregular urination, vomiting, weakness, or muscle cramps. Do not discontinue any medications without consulting a doctor.
AmikacinBacitracin
Severe
How does the drug interact with Mikacin 1000 mg/4 ml Injection 4 ml:
Coadministration of Mikacin 1000 mg/4 ml Injection 4 ml with Bacitracin can increase the risk of developing side effects like hearing loss, difficulty breathing, or kidney problems.

How to manage the interaction:
Although taking Mikacin 1000 mg/4 ml Injection 4 ml and bacitracin together can result in an interaction, it can be taken if a doctor has prescribed it. Consult a doctor if you experience ringing in the ears, difficulty breathing, vomiting, increased or decreased urination, swelling, muscle cramps, dizziness, or palpitations. Do not stop using any medications without talking to a doctor.
AmikacinCisatracurium
Severe
How does the drug interact with Mikacin 1000 mg/4 ml Injection 4 ml:
Co-administration of Mikacin 1000 mg/4 ml Injection 4 ml with cisatracurium can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Cisatracurium and Mikacin 1000 mg/4 ml Injection 4 ml, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
AmikacinAtracurium
Severe
How does the drug interact with Mikacin 1000 mg/4 ml Injection 4 ml:
Co-administration of Mikacin 1000 mg/4 ml Injection 4 ml with Atracurium can increase the risk of developing breathing difficulties.

How to manage the interaction:
Taking Atracurium with Mikacin 1000 mg/4 ml Injection 4 ml together can result in an interaction, but it can be taken if your doctor has advised it. Consult your doctor if you experience shortness of breath, palpitations, chest discomfort, or dizziness. Do not discontinue any medications without consulting a doctor.
AmikacinFoscarnet
Severe
How does the drug interact with Mikacin 1000 mg/4 ml Injection 4 ml:
Combining Mikacin 1000 mg/4 ml Injection 4 ml with Foscarnet can raise your chance of seizures or irregular heart rhythms.

How to manage the interaction:
Taking Mikacin 1000 mg/4 ml Injection 4 ml with Foscarnet together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience swelling, sudden weight gain or loss, severe pain, dizziness, or palpitation consult a doctor. Do not stop using any medications without consulting a doctor.
AmikacinDeferasirox
Severe
How does the drug interact with Mikacin 1000 mg/4 ml Injection 4 ml:
Coadministration of Mikacin 1000 mg/4 ml Injection 4 ml with Deferasirox can increase the risk of developing kidney problems.

How to manage the interaction:
Although taking Mikacin 1000 mg/4 ml Injection 4 ml and Deferasirox together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience vomiting, irregular urination, swelling, shortness of breath, muscle cramps, dizziness, or palpitations, seek immediate medical attention. Make sure to hydrate while taking these medications. Do not discontinue any medications without a doctor's advice.
AmikacinHuman immunoglobulin
Severe
How does the drug interact with Mikacin 1000 mg/4 ml Injection 4 ml:
Taking Human immunoglobulin with Mikacin 1000 mg/4 ml Injection 4 ml, may raise the risk of kidney problems.

How to manage the interaction:
Co-administration of Human immunoglobulin with Mikacin 1000 mg/4 ml Injection 4 ml can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, weakness, or palpitation, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Mikacin 1000 mg/4 ml Injection 4 ml is used to treat bacterial infections.
Mikacin 1000 mg/4 ml Injection 4 ml belongs to the group of antibiotic medicines called as aminoglycosides. Mikacin 1000 mg/4 ml Injection 4 ml is used to treat serious bacterial infections. Mikacin 1000 mg/4 ml Injection 4 ml works by inhibiting the production of bacterial proteins which are necessary for the existence of the bacteria. Thereby, leads to the death of bacteria.
Yes, Mikacin 1000 mg/4 ml Injection 4 ml may cause dizziness. You are advised not to drive or operate heavy machinery after taking Mikacin 1000 mg/4 ml Injection 4 ml as it may cause dizziness and can affect vision. Drive or operate machinery only if you are alert.
Yes, antibiotics may cause diarrhoea. Include foods containing probiotics such as yoghurt, cheese, and buttermilk in your diet as it would help in proper digestion. Also, eat fibre-rich food like whole grain, beans, peas, and bananas. Consult your doctor if you have severe diarrhoea. Do not take any anti-diarrheal medicine without consulting your doctor.
It is generally not recommended during pregnancy because it can cause harm to the developing baby, including potential hearing damage. Talk to your doctor to understand the risks and discuss alternative treatments.
Yes, this medicine can affect your kidneys, particularly if used at high doses or for extended periods. Your doctor will monitor your kidney health with regular blood tests during your treatment. Talk to your doctor immediately if you notice changes in your urination.
It is given as an injection directly into a muscle or as a slow infusion (drip) into a vein. This is typically done by a nurse or doctor in a medical setting, though it can sometimes be done at home after proper training. Talk to your doctor or pharmacist if you have questions about how it is given.
Ringing in your ears, dizziness, or hearing loss can be signs of ear damage. Stop using the medicine (if administering at home) and contact your doctor right away to prevent these issues from becoming permanent.
It is highly recommended to avoid alcohol during your treatment. Alcohol can dehydrate your body, which can put extra strain on your kidneys while they are clearing this medicine. Talk to your doctor for specific advice.
Yes, your doctor will likely schedule regular blood tests. These tests help measure the level of the medicine in your blood to make sure you are getting the correct, safe dose and to monitor your kidney health. Talk to your doctor about your monitoring schedule.
Since it is injected directly into your muscle or vein, it begins fighting the bacteria almost immediately. However, it may take a few days before you notice a significant improvement in your symptoms. Talk to your doctor if your condition does not improve.
No, you should never stop your treatment early, even if your symptoms improve. Stopping the medicine too soon can allow the remaining bacteria to multiply and become resistant to antibiotics. Talk to your doctor before making any changes to your therapy.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Mercantile Chamber, 3Rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai €“ 400 001, India.
Other Info - MIK0048
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