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compositionComposition:PACLITAXEL-250MG
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MITOTAX 250MG INJECTION 41.7ML is used to treat various types of cancers, including ovarian and breast cancer (in advanced/spreading state or after surgery) and advanced-stage non-small cell lung cancer. It contains ‘Paclitaxel’, which stops cell division and prevents certain cancer cell growth. Sometimes, MITOTAX 250MG INJECTION 41.7ML may cause common side effects, such as nausea, vomiting, mild diarrhoea, and joint or muscle pain. It is not recommended for children below 18 years.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PACLITAXEL-250MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About MITOTAX 250MG INJECTION 41.7ML

MITOTAX 250MG INJECTION 41.7ML is a specialised medicine given to treat advanced ovarian, breast, and non-small cell lung cancers, as well as AIDS-related Kaposi's sarcoma. It works by targeting and slowing the growth of abnormal cells that multiply rapidly in the body.

 

This medicine is given as an injection into a vein by a healthcare professional, usually in cycles that repeat every few weeks. Because it is given in a clinical setting, your healthcare team will manage your schedule. Staying well-hydrated and eating small, frequent, and easy-to-digest meals can help your body better handle the treatment process.

 

While receiving MITOTAX 250MG INJECTION 41.7ML, you may experience common side effects such as temporary hair loss, muscle aches, or mild nausea. However, it is vital to contact your healthcare provider immediately if you experience serious side effects, such as a high fever, severe chest pain, or sudden breathing difficulties.

 

Talk to your doctor before starting this medicine if you have pre-existing liver damage, heart conditions, or low white blood cell counts. Do not take this if you have a history of severe allergic reactions to similar medications or if your baseline blood cell counts are exceptionally low.


This medicine can interact with other treatments, including certain vaccines and medications processed by the liver, which can increase your risk of severe complications. Always consult your doctor if you are pregnant, breastfeeding, or planning a family, as this medicine is not recommended for these groups.

Uses of MITOTAX 250MG INJECTION 41.7ML

Your doctor may prescribe MITOTAX 250MG INJECTION 41.7ML to help manage the following conditions:

  • Ovarian cancer: Helps treat advanced cases of ovarian cancer, often when standard therapies have not produced the desired results.
  • Breast cancer: Helps prevent cancer from returning after surgery or manages advanced stages of breast cancer that have spread to other areas.
  • Non-small cell lung cancer: Works alongside other treatments to slow down tumour growth in patients who are not candidates for surgery.
  • AIDS-related Kaposi's sarcoma: Helps shrink and manage blood vessel tumours when other first-line therapies fail to work.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Stops Cancer Spread: MITOTAX 250MG INJECTION 41.7ML brings real-world relief by stopping cancer cells from spreading, which can significantly reduce the physical pain and pressure caused by growing tumours.
  • Improves Symptom Control: By slowing down the progression of advanced cancers, this treatment helps patients manage their symptoms more effectively, improving their daily comfort and giving them more meaningful time with loved ones.
  • Supports Combination Therapy: Because it works well alongside other therapies, it provides a reliable, clinically proven option for combination treatment plans, helping patients achieve better long-term health outcomes.
Side effects of Mitotax 250mg Injection 41.7ml
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • If you experience symptoms such as mouth ulcers, redness, difficulty in swallowing or talking, abdominal pain, and painful bowel movements as a drug side effect, consult your doctor as they may adjust the dose if necessary or prescribe alternative medication.
  • Practice good hygiene, such as washing your hands regularly, to prevent infection.
  • Drink plenty of water to keep your mucous membranes hydrated and promote healing.
  • Avoid spicy or acidic foods, which can irritate the mucous membranes and exacerbate inflammation.
  • Increase your intake of omega-3 fatty acids, found in fatty fish, nuts, and seeds, to reduce inflammation.
  • Follow a soft food diet to reduce discomfort and promote healing.
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Your doctor may recommend regular liver function tests (LFT) to monitor liver enzyme levels.
  • To support your liver, eat a healthy diet with lots of fruits, vegetables, lean proteins, and healthy fats.
  • Avoid eating processed meats, sugary foods, and unhealthy fats.
  • Limit your alcohol consumption, since too much can worsen liver function and contribute to high levels of Alkaline Phosphatase (ALP).
  • Stay active with regular exercise, drink plenty of water, and try to avoid harmful chemicals that can damage your liver.
  • Quit smoking to lower the risk of elevated ALP levels.
  • Try taking pain relievers like paracetamol, ibuprofen or naproxen to releve discomfort and pain.
  • Avoid strenuous activities that worsen muscle and joint pain.
  • Do gentle stretching exercises to enhance muscle flexibility and reduce joint pain.
  • Apply cold or warm compresses to your joints and muscles for pain relief.
  • Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • If your joint/muscle pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • MITOTAX 250MG INJECTION 41.7ML will be administered by the doctor or healthcare professional in a medical setting.
  • Do not self-administer.

How MITOTAX 250MG INJECTION 41.7ML Works

MITOTAX 250MG INJECTION 41.7ML contains paclitaxel, which acts as a structural block inside rapidly dividing cancer cells. Inside every cell, there are tiny scaffolding structures called microtubules, which must stretch and move to let the cell divide into two. This medicine binds tightly to these structures, freezing them in place. Because the scaffolding cannot move or change shape, the cancer cell is completely unable to divide and multiply. This halts the growth of the tumor, and the locked cells eventually break down and die, helping to stop the spread of the disease.
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Alcohol

Consult your doctor

It is not known if alcohol interacts with this medicine. Please consult your doctor.

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Pregnancy

Unsafe

MITOTAX 250MG INJECTION 41.7ML must not be given during pregnancy unless clearly necessary, as it may cause birth defects. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving MITOTAX 250MG INJECTION 41.7ML.

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Breast Feeding

Unsafe

Avoid breastfeeding whilst on treatment with MITOTAX 250MG INJECTION 41.7ML. Do not restart breastfeeding until your doctor tells you it is safe to do so.

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Driving

Caution

MITOTAX 250MG INJECTION 41.7ML may cause dizziness, tiredness, or nausea. Drive or operate heavy machinery only if you are alert.

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Liver

Caution

Do not use MITOTAX 250MG INJECTION 41.7ML if you have severe liver problems. If you have a history of liver disease, inform your doctor before receiving MITOTAX 250MG INJECTION 41.7ML.

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Kidney

Consult your doctor

If you have a history of kidney diseases, inform your doctor before receiving MITOTAX 250MG INJECTION 41.7ML. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

MITOTAX 250MG INJECTION 41.7ML is not recommended for children below 18 years due to a lack of data on the safety and effectiveness.

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Heart

Caution

MITOTAX 250MG INJECTION 41.7ML should be avoided in heart patients unless strictly advised by a specialist. It may cause serious cardiac side effects like low blood pressure or heart rhythm issues.

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Geriatrics

Caution

Geriatric patients may receive MITOTAX 250MG INJECTION 41.7ML, but only with strict medical supervision. Age-related risks like heart issues, neuropathy, and reduced liver function require careful monitoring during therapy.

What if I have taken an overdose of MITOTAX 250MG INJECTION 41.7ML

Because this medicine is prepared and given by trained medical professionals in a clinic, an overdose is highly unlikely. However, if you suspect an error or experience severe chest pain or breathing problems shortly after an injection, notify your medical team right away.

Diet & Lifestyle Advise

  • Eat Little and Often: Eat small, frequent meals throughout the day to help manage nausea and keep your energy levels steady.
  • Stay Well Hydrated: Drink plenty of fluids, such as water or clear broths, to stay hydrated, especially on your scheduled treatment days.
  • Protect Your Gums: Use a soft-bristled toothbrush to protect your gums, as this medicine can make them sensitive and prone to bleeding.
  • Prevent Infections: Wash your hands frequently and avoid close contact with people who are sick, as your body's ability to fight off infections will be temporarily lowered.
  • Protect Your Feet: Wear loose, supportive, and comfortable shoes to protect your feet if you experience numbness or nerve pain.
health query

Have a query?

How Soon It Starts Working

The time required for MITOTAX 250MG INJECTION 41.7ML to start to work: The time required for MITOTAX 250MG INJECTION 41.7ML to show its action is unknown. The time for which the effects of MITOTAX 250MG INJECTION 41.7ML last: The effect of MITOTAX 250MG INJECTION 41.7ML lasts for 27 hours.

What if you forget to take MITOTAX 250MG INJECTION 41.7ML

If you miss an appointment for your injection, contact your cancer clinic or doctor immediately to reschedule. Keeping your treatment cycles on a strict schedule is important to ensure the medicine works as effectively as possible.

Storage

•This medication is stored and handled only by trained healthcare professionals in hospitals or clinics.•Keep all medical equipment and medicines out of the reach of children and pets.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Report Injection Site Pain: Watch the injection site closely during your treatment; tell your nurse immediately if you feel any burning, stinging, or pain, as leaking fluid can damage surrounding tissues.
  • Attend Scheduled Blood Tests: Ensure you complete all scheduled blood tests before each infusion cycle to verify that your blood cell counts are high enough for safe treatment.
  • Avoid Live Vaccinations: Do not receive any 'live' vaccines while receiving this medicine without consulting your doctor first, as your immune system will be weakened.
  • Prevent Pregnancy During Treatment: Use highly reliable birth control during treatment and for several months afterwards, as this medicine can cause severe harm to an unborn baby.
  • Avoid Driving After Infusion: Avoid tasks that require sharp focus, such as driving, if you feel dizzy or unusually tired immediately after your infusion.

Drug-Drug Interactions

verifiedApollotooltip
  • Check Before Taking Other Medicines: May interact with certain medicines used to treat fungal infections (such as ketoconazole) or bacterial infections (such as rifampin), which can affect how your liver processes this medicine.
  • Monitor for Infections: May increase the risk of serious infections when combined with other medicines that lower your immune system's strength.
PaclitaxelClozapine
Severe
PaclitaxelBaricitinib
Severe

Drug-Drug Interactions

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PaclitaxelClozapine
Severe
How does the drug interact with Mitotax 250mg Injection 41.7ml:
Combining Mitotax 250mg Injection 41.7ml with Clozapine can increase the risk of infection.

How to manage the interaction:
Taking Mitotax 250mg Injection 41.7ml with Clozapine together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without first talking to your doctor.
PaclitaxelBaricitinib
Severe
How does the drug interact with Mitotax 250mg Injection 41.7ml:
Coadministration of baricitinib and Mitotax 250mg Injection 41.7ml can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Mitotax 250mg Injection 41.7ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
PaclitaxelRitonavir
Severe
How does the drug interact with Mitotax 250mg Injection 41.7ml:
Taking Ritonavir and Mitotax 250mg Injection 41.7ml may significantly increase the blood levels of Mitotax 250mg Injection 41.7ml.

How to manage the interaction:
Taking Ritonavir with Mitotax 250mg Injection 41.7ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. In case of any unusual symptoms, consult a doctor. Do not stop using any medications without talking to a doctor.
PaclitaxelCladribine
Severe
How does the drug interact with Mitotax 250mg Injection 41.7ml:
Combining Cladribine with Mitotax 250mg Injection 41.7ml can increase the risk of developing serious infections.

How to manage the interaction:
Taking Mitotax 250mg Injection 41.7ml with Cladribine together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
PaclitaxelThalidomide
Severe
How does the drug interact with Mitotax 250mg Injection 41.7ml:
Taking thalidomide together with Mitotax 250mg Injection 41.7ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Mitotax 250mg Injection 41.7ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
PaclitaxelTofacitinib
Severe
How does the drug interact with Mitotax 250mg Injection 41.7ml:
Taking Tofacitinib with Mitotax 250mg Injection 41.7ml may increase the risk of infection.

How to manage the interaction:
Although taking Mitotax 250mg Injection 41.7ml and Tofacitinib together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
PaclitaxelEtanercept
Severe
How does the drug interact with Mitotax 250mg Injection 41.7ml:
When Etanercept is used with Mitotax 250mg Injection 41.7ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Etanercept and Mitotax 250mg Injection 41.7ml, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
PaclitaxelInfliximab
Severe
How does the drug interact with Mitotax 250mg Injection 41.7ml:
Combining Infliximab with Mitotax 250mg Injection 41.7ml can enhance the breakdown of Mitotax 250mg Injection 41.7ml in the body. This can reduce the treatment outcomes and can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Mitotax 250mg Injection 41.7ml with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit Precaution: Grapefruit and grapefruit juice are not known to have a well-established interaction with intravenous MITOTAX 250MG INJECTION 41.7ML. However, because they can affect how some medicines are processed by the body, check with your doctor before consuming grapefruit products during your treatment.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

MITOTAX 250MG INJECTION 41.7ML is used to treat Ovarian cancer, breast cancer, non-small cell lung cancer.
MITOTAX 250MG INJECTION 41.7ML works by stopping cell division and preventing the growth of certain cancer cells.
MITOTAX 250MG INJECTION 41.7ML might cause sterility which could be permanent. Please talk to your doctor if you have any concerns.
The most common side effect of MITOTAX 250MG INJECTION 41.7ML is hair loss. The hair may grow back after the treatment with MITOTAX 250MG INJECTION 41.7ML is finished. However, consult your doctor if you have any concerns.
Yes, MITOTAX 250MG INJECTION 41.7ML is cytotoxic. It works by interfering with the growth of cancer cells, preventing them from dividing and causing them to die. However, its cytotoxic nature also means it can affect normal, healthy cells, potentially leading to side effects.
Yes, MITOTAX 250MG INJECTION 41.7ML is considered a vesicant. A vesicant is a chemical substance that, if it leaks out of the vein (extravasation), can cause blistering of the skin and surrounding tissues. If MITOTAX 250MG INJECTION 41.7ML accidentally leaks during intravenous (IV) infusion, it may lead to inflammation, blistering, or even tissue necrosis. Your healthcare provider will take precautions to ensure the drug is infused properly and monitor the infusion site for any signs of leakage. If extravasation occurs, the infusion should be stopped immediately, and steps should be taken to minimize the damage.
MITOTAX 250MG INJECTION 41.7ML is an effective cancer treatment with a low risk of cardiac side effects. Your healthcare team will closely monitor your heart function to ensure your safety. They'll watch for any changes in heart rhythms or blood pressure, and work with you to manage any potential issues. With careful monitoring, you can receive this life-saving treatment with confidence.
MITOTAX 250MG INJECTION 41.7ML is a natural product derived from the bark of the Pacific yew tree (Taxus baccata). It is a chemotherapy medication used to treat various cancers, including breast, ovarian, and lung cancer.
The common side effects of MITOTAX 250MG INJECTION 41.7ML include nausea, vomiting, mild diarrhoea, and joint or muscle pain. Not everyone will experience all of these side effects, and they typically resolve once the treatment is stopped. However, if the side effects persist or worsen, please consult your doctor.
It is given as a slow injection into a vein (intravenous infusion) by a healthcare professional in a clinic or hospital. Talk to your doctor for more details about your specific treatment schedule.
Some patients may feel dizzy, tired, or receive pre-medications that cause drowsiness. It is best to arrange for someone else to drive you home after your appointment. Talk to your doctor or pharmacist.
Numbness or tingling can be a sign of nerve changes. Tell your healthcare team right away so they can monitor this and adjust your treatment if necessary. Talk to your doctor.
No. MITOTAX 250MG INJECTION 41.7ML can harm an unborn baby. Women should avoid becoming pregnant during treatment and follow their doctor's advice about how long to continue contraception after treatment ends. Men should also use effective contraception during treatment and for at least 3–6 months after the last dose, as this medicine may affect sperm. Talk to your doctor about the most appropriate family planning options for you.
Alcohol can increase dizziness and interact with pre-medications given before your infusion. It is best to avoid alcohol during your treatment cycle. Talk to your doctor or pharmacist.
The number of cycles depends on the type of cancer being treated and how well your body responds to the medicine. Your doctor will determine the exact plan. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.3891 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Paclitaxel Paclitaxel. 2005. [Accessed on 24 Jan. 2019]Check here
  3. Paclitaxel Paclitaxel. 2005. [Accessed on 26 Mar. 2019]Check here
  4. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 18 Feb. 2020]Check here
  5. Abraxane 5 mg/ml powder for dispersion for infusion - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2024 [Accessed on 31 December 2024]Check here
  6. Abraxane 5 mg/ml powder for dispersion for infusion - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2024 [Accessed on 31 December 2024]Check here
  7. Maela C. Farrar; Tibb F. Jacobs. Paclitaxel. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. [Revised in May 2022] [Accessed on 7th October 2021]Check here

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy's Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, INDIA
Other Info - MIT0004
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