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compositionComposition:PIMOZIDE-4MG
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Prescription Medicine
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Monozide 4mg Tablet is used to treat schizophrenia and Tourette syndrome. It contains Pimozide which works by inhibiting the receptor (dopamine) in the brain that regulates mood, behaviour and emotions. In some cases, this medicine may cause side effects such as drowsiness, excessive sweating, dizziness, dry mouth, constipation, weight gain, and blurred vision. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PIMOZIDE-4MG

Manufacturer/Marketer :

Group Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Monozide 4mg Tablet

Monozide 4mg Tablet is an oral medication prescribed to help control severe motor and vocal tics in people living with Tourette's syndrome. This medicine is typically reserved for individuals whose symptoms have not improved with other standard treatments. It works on the central nervous system to help reduce the frequency and intensity of these involuntary movements and sounds.

To get the best results, you must take this medicine consistently every day, exactly as directed by your healthcare provider. You can take the tablet with or without food, but it is best to choose one method and stick to it at the same time each day. Incorporating stress-reduction techniques and maintaining a regular sleep schedule can also help manage your symptoms, as stress and fatigue are common triggers for tics.

While taking Monozide 4mg Tablet, you may experience some common side effects such as drowsiness, dry mouth, and constipation. However, you must contact your doctor immediately if you experience serious symptoms, such as a fast or irregular heartbeat, severe muscle stiffness, or uncontrollable movements of your face or tongue. Regular monitoring by your doctor is necessary to ensure the medication is working safely.

Before starting this medication, talk to your doctor if you have a history of heart rhythm problems, seizures, or liver issues. Do not take this if you have congenital long QT syndrome, a history of irregular heartbeats, or low levels of potassium or magnesium in your blood. It is also unsuitable for anyone taking certain medicines that can affect heart rhythm.

Monozide 4mg Tablet can interact dangerously with other medications, including certain antibiotics, antidepressants, and heart medications, which can raise the risk of serious heart issues. You should avoid alcohol and smoking while taking this medicine, as they can worsen drowsiness and alter how the drug works in your body. If you are pregnant, breastfeeding, or are an older adult, talk to your doctor to discuss whether this medication is safe for you.

Uses of Monozide 4mg Tablet

Here is the main condition where Monozide 4mg Tablet is used to help control severe involuntary movements and vocal sounds:

  • Tourette's Syndrome Tics: Monozide 4mg Tablet is used to reduce the frequency and severity of both motor (physical) and phonic (vocal) tics in patients who have not responded satisfactorily to other standard therapies.

Key Benefits

Monozide 4mg Tablet provides several important benefits by helping control tics and improving day-to-day functioning:

  • Reduces Motor and Vocal Tics: It helps decrease the frequency and severity of involuntary movements and vocalisations associated with Tourette's syndrome.
  • Relieves Physical Discomfort: By reducing repetitive movements, it helps lessen muscle strain, fatigue, and discomfort caused by frequent tics.
  • Improves Daily Functioning: Better control of tics can make it easier to participate in school, work, and social activities with greater confidence.
  • Supports Emotional Well-Being: Reduced tic severity may help lower the stress, embarrassment, and anxiety often associated with Tourette's syndrome, improving overall quality of life.
Side effects of Monozide 4mg Tablet
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Quit smoking as smoking impairs erectile function by significantly damaging blood vessels.
  • Maintain a healthy weight as overweight can cause erectile dysfunction.
  • Exercise regularly as physical activity enhances blood flow and overall health, benefiting erectile function.
  • Consume a healthy diet loaded with whole grains, fruits and vegetables.
  • Limit alcohol consumption as excessive alcohol intake can impair erectile function.
  • Manage stress by practicing techniques such as yoga, relaxation exercises or meditation.
  • In case erectile dysfunction is due to psychological factors, consider couple counselling or sex therapy to address relationship and anxiety issues.
  • Openly discuss your concerns with your partner.
  • Eat smaller meals and chew food thoroughly.
  • Try foods with softer textures.
  • If you have difficulty swallowing liquids, use thickener.
  • Learn new swallowing techniques from a speech and language therapist.
  • Avoid alcohol and caffeine as these may dry your throat and mouth making it more difficult to swallow.
  • Consider alternative forms of feeding, such as feeding tubes through nose or a hole into your stomach.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Monozide 4mg Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow Monozide 4mg Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Monozide 4mg Tablet Works

Monozide 4mg Tablet contains pimozide, an antipsychotic medicine that helps control the symptoms of Tourette's syndrome. Monozide 4mg Tablet works by blocking dopamine receptors in the brain. Dopamine is a natural chemical messenger involved in controlling movement, behaviour, and emotions. In people with Tourette's syndrome, excessive dopamine activity is thought to contribute to involuntary movements and vocal sounds. By reducing the effects of dopamine, Monozide 4mg Tablet helps calm overactive nerve signals and suppress unwanted tics. Together, these actions help reduce the frequency and severity of motor and vocal tics, improving daily functioning and quality of life.
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Alcohol

Unsafe

Avoid consumption of alcohol with Monozide 4mg Tablet as it may increase the risk of drowsiness and other adverse effects.

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Pregnancy

Unsafe

Monozide 4mg Tablet is not recommended for use during pregnancy especially in the third trimester as it may cause unwanted side effects to the baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Monozide 4mg Tablet is usually not recommended for breastfeeding mothers as it may be excreted in human milk in small amounts. Therefore, please consult a doctor if you are breastfeeding.

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Driving

Unsafe

Monozide 4mg Tablet may cause dizziness, blurred vision or drowsiness. Therefore, avoid driving if you feel drowsy, dizzy or experience any vision problems after taking Monozide 4mg Tablet.

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Liver

Caution

Take Monozide 4mg Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Monozide 4mg Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Monozide 4mg Tablet is not recommended for children below 12 years as the safety and effectiveness were not established.

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Heart

Unsafe

Monozide 4mg Tablet is not recommended in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

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Geriatrics

Caution

Monozide 4mg Tablet can be given in elderly patients with extreme caution, due to the increased risk of death.

What if I have taken an overdose of Monozide 4mg Tablet

If you take too much of this medicine, seek emergency medical attention or contact a poison control center immediately. Symptoms of an overdose may include severe muscle stiffness, extreme drowsiness, low blood pressure, or a dangerously irregular heartbeat.

Diet & Lifestyle Advise

  • Avoid grapefruit: Do not eat grapefruit or drink grapefruit juice while taking this medicine. Grapefruit can increase the amount of the drug in your bloodstream, raising the risk of severe side effects.
  • Stay hydrated: Drink plenty of water throughout the day to help manage dry mouth and prevent constipation.
  • Eat a high-fiber diet: Consume fruits, vegetables, and whole grains to help keep your digestion regular, as this medication can cause constipation.
  • Manage stress: Practice relaxation techniques such as mindfulness, deep breathing exercises, or gentle yoga, as stress can increase the frequency of tics.
  • Get regular medical checks: Keep all appointments for blood tests and heart monitoring (ECGs) as recommended by your doctor to ensure the medicine is safe for your heart.
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How Soon It Starts Working

The time required for Monozide 4mg Tablet to start to work: Monozide 4mg Tablet shows its action within 3 to 6 hours of administration. The time for which the effects of Monozide 4mg Tablet last: Monozide 4mg Tablet effect lasts for 24 hours.

What if you forget to take Monozide 4mg Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure what to do, talk to your doctor or pharmacist.

Storage

• Store Monozide 4mg Tablet tablets at room temperature, ideally between 15°C and 30°C (59°F to 86°F). • Keep the medication in its original container, tightly closed, to protect it from moisture and direct light.

Drug Warnings

  • Attend Regular ECG Monitoring: Your doctor will likely perform an electrocardiogram (ECG) before you start taking this medicine and periodically during treatment to monitor your heart's rhythm.
  • Avoid Driving Until You Know Its Effects: Do not drive, operate machinery, or perform dangerous activities until you know how this medication affects you, as it can cause significant drowsiness.
  • Avoid Alcohol: Avoid drinking alcohol, as it can dangerously increase the sedative effects of this medicine.
  • Report Unusual Muscle Movements: Tell your doctor immediately if you notice any unusual, uncontrollable muscle movements, especially in your face, lips, or tongue.
  • Do Not Stop Suddenly: Never stop taking this medicine abruptly, as doing so can cause your tics to worsen suddenly.

Drug-Drug Interactions

verifiedApollotooltip

Here are the medicines that may interact with Monozide 4mg Tablet and increase the risk of serious side effects or reduce treatment safety:

  • QT-prolonging medicines: Do not take this medication with other drugs that affect heart rhythm, such as certain antibiotics (like erythromycin or clarithromycin), antimalarials, or certain heart medications.
  • Antidepressants: Medicines like sertraline, fluoxetine, or paroxetine can increase the levels of Monozide 4mg Tablet in your blood, raising the risk of serious heart side effects.
  • Central Nervous System depressants: Taking this medicine with sleeping pills, anxiety medications, muscle relaxants, or strong pain relievers can cause extreme drowsiness and slowed breathing.

PimozideDanazol
Critical
PimozideAmitriptyline
Critical

Drug-Drug Interactions

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PimozideDanazol
Critical
How does the drug interact with Monozide 4mg Tablet:
Using Monozide 4mg Tablet together with danazol may significantly increase the blood levels of Monozide 4mg Tablet.

How to manage the interaction:
Taking Danazol with Monozide 4mg Tablet is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medication without doctor's advice.
PimozideAmitriptyline
Critical
How does the drug interact with Monozide 4mg Tablet:
Combining Amitriptyline and Monozide 4mg Tablet may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitriptyline with Monozide 4mg Tablet may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
PimozideTamoxifen
Critical
How does the drug interact with Monozide 4mg Tablet:
Taking Tamoxifen with Monozide 4mg Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Monozide 4mg Tablet with Tamoxifen is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PimozideGranisetron
Critical
How does the drug interact with Monozide 4mg Tablet:
Taking Granisetron with Monozide 4mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Granisetron with Monozide 4mg Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
PimozideFlecainide
Critical
How does the drug interact with Monozide 4mg Tablet:
Coadministration of Flecainide with Monozide 4mg Tablet can increase the risk of developing irregular heart rhythms.

How to manage the interaction:
Taking Flecainide with Monozide 4mg Tablet is generally avoided, but it can be taken if advised by a doctor. However, if you experience dizziness, shortness of breath, or palpitations, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PimozideClomipramine
Critical
How does the drug interact with Monozide 4mg Tablet:
When Clomipramine is taken with Monozide 4mg Tablet, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Clomipramine and Monozide 4mg Tablet, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
PimozideHydroxyzine
Critical
How does the drug interact with Monozide 4mg Tablet:
Taking Hydroxyzine with Monozide 4mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Hydroxyzine with Monozide 4mg Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
PimozideFosaprepitant
Critical
How does the drug interact with Monozide 4mg Tablet:
When Monozide 4mg Tablet is taken with Fosaprepitant, it can increase the Monozide 4mg Tablet levels in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Fosaprepitant with Monozide 4mg Tablet is not recommended, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, prolonged diarrhea, or vomiting, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PimozideSorafenib
Critical
How does the drug interact with Monozide 4mg Tablet:
Using Monozide 4mg Tablet together with Sorafenib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Sorafenib with Monozide 4mg Tablet can cause an interaction, consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
PimozideAprepitant
Critical
How does the drug interact with Monozide 4mg Tablet:
Using Monozide 4mg Tablet together with aprepitant may significantly increase the blood levels of Monozide 4mg Tablet. High blood levels of Monozide 4mg Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Aprepitant and Monozide 4mg Tablet together is not recommended; as it can lead to an interaction, you can take them if your doctor advises you to. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, get immediate medical help. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

Here are the important food and drink considerations while taking Monozide 4mg Tablet:

  • Grapefruit and Grapefruit Juice: Avoid these completely, as they slow down the breakdown of this medication in the liver, leading to potentially dangerous levels of the drug in your body.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[NEUROLEPTIC]

FAQs

Monozide 4mg Tablet is used to treat schizophrenia and tourette' s syndrome.
Monozide 4mg Tablet contains Pimozide that works by inhibiting the dopamine (chemical messenger) receptors in the brain. Dopamine is involved in regulating mood, behaviour and emotions. Thereby, Monozide 4mg Tablet prevents dopamine overactivity and helps in controlling psychotic illness. Also, Monozide 4mg Tablet decreases uncontrolled movements or outbursts of sounds or words (tics). Thus, helps in lowering the number of tics in Tourette’s syndrome patients.
You are not recommended to take Monozide 4mg Tablet with levodopa (antiparkinson drug) as it may decrease the effectiveness of levodopa and increase the risk of adverse effects such as low blood pressure, drowsiness, light-headedness and dizziness. However, please consult your doctor before using Monozide 4mg Tablet with any other medicines.
Monozide 4mg Tablet is not recommended for elderly people with dementia (decline in memory, behaviour, thinking and ability to do daily activities) as it may increase the risk of life-threatening adverse effects. Therefore, inform your doctor if you have dementia before taking Monozide 4mg Tablet.
Monozide 4mg Tablet may cause dizziness as a temporary adverse effect. However, if the condition persists or worsens, please consult a doctor.
Monozide 4mg Tablet should be used with caution in patients suffering from fits as it may worsen the condition. Therefore, inform your doctor if you have a history of fits before taking Monozide 4mg Tablet.
Monozide 4mg Tablet may cause side effects like drowsiness, excessive sweating, dizziness, urinating at night, dry mouth, constipation, weight gain, blurred vision or impotence (erectile dysfunction) in men. Most of these side effects of Monozide 4mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
No, you should avoid alcohol. Mixing alcohol with this medication can cause extreme drowsiness, dizziness, and slow your reaction times. Talk to your doctor if you have concerns about avoiding alcohol.
Dry mouth is a common side effect. You can manage this by sipping water frequently, chewing sugarless gum, or sucking on sugar-free hard candies. Talk to your doctor if the dryness becomes severe or persistent.
Some patients may experience weight changes or an increased appetite while taking this medicine. Eating a balanced diet and staying active can help manage this effect. Talk to your doctor for personalized dietary advice.
No, you must not stop taking this medicine suddenly, even if you feel completely better. Stopping abruptly can cause your tics to return or trigger withdrawal symptoms. Talk to your doctor about how to slowly reduce your dose when it is time to stop.
Yes, this medication can alter the electrical activity of your heart, which can lead to serious irregular heartbeats. Your doctor will perform regular ECG tests to monitor your heart safety. Talk to your doctor immediately if you feel dizzy or notice a pounding heartbeat.
This medication should only be used during pregnancy if the potential benefit justifies the risk to the developing baby. If you are pregnant or planning a pregnancy, talk to your doctor to discuss your treatment options.
Your doctor may order regular blood tests to check your electrolyte levels, particularly potassium and magnesium, as low levels can increase the risk of serious heart side effects. Talk to your doctor or pharmacist to learn more about these safety checks.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.6911 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Pimozide Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Pimozide Pimozide. 2011. [Accessed on 22 Mar 2019]Check here
  4. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 20 Feb. 2020]Check here
  5. Pimozide Pimozide. 2002. [Accessed on 22 Mar. 2019]Check here
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 22 Mar. 2019]Check here
  7. R. M. Finder, R. N. Brogden, Phyllis R. Sawyer, T. M. Speight, Rosalind Spencer, & G. S. Avery. Pimozide: A Review of Its Pharmacological Properties and Therapeutic Uses in Psychiatry. Springer Link. November 2012. [Accessed on 24th August 2024]Check here

Country of origin

India
Other Info - MO85606
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