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  3. Multaq 400Mg Tablet

Multaq 400Mg Tablet, Pack of 10 TabletS
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Multaq 400Mg Tablet is used to treat arrhythmia (irregular heartbeat). It contains Dronedarone, which works by blocking abnormal electrical signals in the heart and restoring normal heart rhythm. In some cases, this medicine may cause side effects such as slow heartbeat, diarrhoea, nausea and vomiting. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

DRONEDARONE-400MG

Manufacturer/Marketer :

Aventis Pharma

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Multaq 400Mg Tablet

Multaq 400Mg Tablet belongs to a group of medications known as 'anti-arrhythmic', primarily used to treat arrhythmia (irregular heartbeat) in patients with paroxysmal (sudden attack) or persistent atrial fibrillation (irregular heartbeat due to poor blood flow). Besides this, Multaq 400Mg Tablet is also used to treat 'cardioversion', which is a medical procedure that changes the abnormal heartbeat to a normal rhythm. Arrhythmia is a problem associated with the rate at which the heart beats.

Multaq 400Mg Tablet contains 'Dronedarone', a Class III anti-arrhythmic drug that restores normal heart rhythm and reduces heart rate in atrial fibrillation. Multaq 400Mg Tablet blocks abnormal electrical signals in the heart. Also, it prevents ventricular fibrillation (a rapid contraction of the heart muscle) and ventricular tachycardia (lower chambers of the heart ventricles that beat quickly than normal).

Take Multaq 400Mg Tablet as prescribed by your doctor. Your dose and duration of Multaq 400Mg Tablet will be advised by your doctor, depending on your medical condition. In some cases, you may experience a slow heartbeat, diarrhoea, nausea and vomiting. Most of these side effects of Multaq 400Mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Please inform your doctor if you are using any prescription, non-prescription drugs, including vitamins and herbal products. Let your doctor know if you have any allergic reactions to Multaq 400Mg Tablet or any other medicines before starting Multaq 400Mg Tablet. Inform your doctor if you have heart, kidney or liver problems and electrolyte imbalance. It is advised to consult a doctor if you are a pregnant or breastfeeding mother. Multaq 400Mg Tablet is not recommended for use during pregnancy. Do not stop taking Multaq 400Mg Tablet without consulting your doctor, since it may worsen your condition and increase the risk of future heart problems.

Uses of Multaq 400Mg Tablet

Multaq 400Mg Tablet is used in the treatment of arrhythmia (irregular heartbeat). The detailed uses of Multaq 400Mg Tablet are as follows:<br/> • Maintains normal heart rhythm: Multaq 400Mg Tablet helps maintain a normal heartbeat in patients with atrial fibrillation or atrial flutter.<br/> • Reduces hospitalisation risk: Multaq 400Mg Tablet reduces the risk of hospital admissions caused by heart rhythm disturbances.<br/> • Supports long-term rhythm control: Multaq 400Mg Tablet is often part of a long-term strategy to prevent recurrence of abnormal heart rhythms.<br/>

Directions for Use

  • Multaq 400Mg Tablet can be taken with meals for better absorption or as advised by the doctor.
  • Follow your doctor's instructions regarding the dosage and duration for safe and effective treatment.
  • Swallow Multaq 400Mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

Multaq 400Mg Tablet contains Dronedarone, a class III anti-arrhythmic drug. It treats arrhythmia (irregular heartbeat) in patients with paroxysmal (sudden attack) or persistent atrial fibrillation (irregular heartbeat due to poor blood flow). It blocks abnormal electrical signals in the heart and works by restoring normal heart rhythm. It also prevents ventricular fibrillation (a rapid contraction of heart muscle) and ventricular tachycardia (the lower chambers of the heart (ventricles) beat faster than normal). Multaq 400Mg Tablet is used in cardioversion, a medical procedure that changes the abnormal heartbeat to a normal rhythm.

How Multaq 400Mg Tablet Works

Multaq 400Mg Tablet contains 'Dronedarone', a Class III anti-arrhythmic drug that restores normal heart rhythm and reduces heart rate in atrial fibrillation. Multaq 400Mg Tablet blocks abnormal electrical signals in the heart. Also, it prevents ventricular fibrillation (a rapid contraction of heart muscle) and ventricular tachycardia (lower chambers of the heart ventricles that beat quickly than normal).

Storage

• Store in a cool and dry place away from sunlight.• Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Multaq 400Mg Tablet
  • Heart failure needs immediate medical attention. To manage this effect, the doctor's instructions must be followed strictly.
  • Take care of change in your weight as there can be sudden changes.
  • Rest and refrain from physical activity, and restart after a few days.
  • Reduce your salt intake and control your diet with the help of a dietician.
  • Track your symptoms and keep your follow-up appointments to manage severe side effects.
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Multaq 400Mg Tablet

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

Brief your medical history to the doctor if you have any heart problems, liver, kidney diseases and electrolyte imbalance (low potassium and magnesium) before starting Multaq 400Mg Tablet. Multaq 400Mg Tablet may affect QT prolongation (heart muscle takes longer than usual to recharge between beats), which can cause serious fast/irregular heartbeat. Hence, it is advised to inform your doctor if you have heart-related problems like heart failure, slow heartbeat and a family history of heart diseases. Multaq 400Mg Tablet is contraindicated during pregnancy since it has harmful effects on the foetus. Consult your doctor before using Multaq 400Mg Tablet if you are a breastfeeding mother. Do not drive or operate machinery if you experience any side effects that affect your ability to concentrate and drive. Avoid consumption of alcohol with Multaq 400Mg Tablet as it may decrease the efficacy of Multaq 400Mg Tablet. Multaq 400Mg Tablet is not recommended in patients younger than 18 years of age.

Drug-Drug Interactions

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DronedaroneOxytocin
Critical
DronedaronePazopanib
Critical

Drug-Drug Interactions

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DronedaroneOxytocin
Critical
How does the drug interact with Multaq 400Mg Tablet:
Taking oxytocin with Multaq 400Mg Tablet can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Oxytocin with Multaq 400Mg Tablet is not recommended, but should be taken if advised by a doctor. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
DronedaronePazopanib
Critical
How does the drug interact with Multaq 400Mg Tablet:
Taking Multaq 400Mg Tablet together with pazopanib can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Pazopanib with Multaq 400Mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
DronedaroneEnzalutamide
Critical
How does the drug interact with Multaq 400Mg Tablet:
Co-administration of Enzalutamide and Multaq 400Mg Tablet together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Enzalutamide and Multaq 400Mg Tablet together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
DronedaroneKetoconazole
Critical
How does the drug interact with Multaq 400Mg Tablet:
When Multaq 400Mg Tablet is taken with Ketoconazole, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Ketoconazole with Multaq 400Mg Tablet is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
DronedaroneCiprofloxacin
Critical
How does the drug interact with Multaq 400Mg Tablet:
When Multaq 400Mg Tablet is taken with Ciprofloxacin, it can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Ciprofloxacin with Multaq 400Mg Tablet is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
DronedaroneDoxepin
Critical
How does the drug interact with Multaq 400Mg Tablet:
Combining Doxepin with Multaq 400Mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Doxepin with Multaq 400Mg Tablet is not recommended, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, diarrhea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DronedaroneFlecainide
Critical
How does the drug interact with Multaq 400Mg Tablet:
Taking flecainide with Multaq 400Mg Tablet can increase the risk of irregular heart rhythms.

How to manage the interaction:
Although there is an interaction between Flecainide with Multaq 400Mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
DronedaroneDasatinib
Critical
How does the drug interact with Multaq 400Mg Tablet:
Using Multaq 400Mg Tablet together with dasatinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dasatinib with Multaq 400Mg Tablet is not recommended, please consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medication without doctor's advice.
DronedaroneCeritinib
Critical
How does the drug interact with Multaq 400Mg Tablet:
Taking Multaq 400Mg Tablet with ceritinib can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ceritinib with Multaq 400Mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
DronedaroneAtomoxetine
Critical
How does the drug interact with Multaq 400Mg Tablet:
Using Multaq 400Mg Tablet together with atomoxetine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Atomoxetine with Multaq 400Mg Tablet is not recommended, please consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Keep your weight under control with a BMI of 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
  • If you are taking alcohol, then only one serving for women and two servings for men is advisable.
  • Quitting smoking is the best strategy to lower the risk of heart disease.
  • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Try to include heart-healthy omega-3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTIARRHYTHMICS

Multaq 400Mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

It is advised to limit alcohol intake when you are being treated with Multaq 400Mg Tablet.

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Pregnancy

Unsafe

Multaq 400Mg Tablet is a pregnancy category X drug, so it is not recommended and unsafe in pregnancy. It can affect and harm the developing baby. Please seek medical advice for more information.

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Breast Feeding

Caution

It is not known if Multaq 400Mg Tablet is excreted into the breast milk. Due to possible effects on the breastfed infant, Multaq 400Mg Tablet is not recommended for use if you are a nursing mother. Please consult your doctor for more information before taking Multaq 400Mg Tablet.

bannner image

Driving

Caution

Multaq 400Mg Tablet is possibly safe and does not affect your ability to drive. However, if you experience any symptoms that may affect your mental focus and ability to drive, do not drive or operate machinery until you feel better.

bannner image

Liver

Caution

Let your doctor know if you have any history of liver disease before taking Multaq 400Mg Tablet. Your doctor will weigh the benefits and any potential risks before prescribing Multaq 400Mg Tablet.

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Kidney

Caution

Let your doctor know if you have any history of kidney disease before taking Multaq 400Mg Tablet. Your doctor will weigh the benefits and any potential risks before prescribing Multaq 400Mg Tablet.

bannner image

Children

Unsafe

Safety and effectiveness of Multaq 400Mg Tablet have not been established in patients below 18 years of age.

Have a query?

FAQs

Multaq 400Mg Tablet is used to treat arrhythmia (irregular heartbeat) in patients with paroxysmal (sudden attack) or persistent atrial fibrillation (irregular heartbeat due to poor blood flow).

Multaq 400Mg Tablet contains Dronedarone, which works as an antiarrhythmic by blocking abnormal electrical signals in the heart. Thus, Multaq 400Mg Tablet helps to treat the uneven heartbeats and helps in normalising the heart rhythm.

Do not stop using Multaq 400Mg Tablet even if you feel better. It should be strictly used as advised by your doctor to avoid the recurrence of symptoms like irregular heartbeat and worsening of the disease.

Multaq 400Mg Tablet should be used with caution in cases of any allergic reactions, heart problems like heart failure, slow heartbeat, QT prolongation (heart muscle takes longer than usual to recharge between beats) in the ECG (electrocardiogram), liver, kidney diseases and electrolyte imbalance (low levels of potassium and magnesium).

Store Multaq 400Mg Tablet away from direct sunlight and at a temperature not exceeding 30°C. Keep this medicine out of sight and reach of children.

If you missed a dose, take Multaq 400Mg Tablet as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.

Multaq 400Mg Tablet is used to treat arrhythmia (irregular heartbeat) in patients with paroxysmal (sudden onset) or persistent atrial fibrillation (irregular heartbeat caused by poor blood flow). Additionally, it is used in ‘cardioversion,' a medical procedure that restores an abnormal heartbeat to a normal rhythm.

Yes, Multaq 400Mg Tablet is safe if taken in dose and duration exactly as prescribed by the doctor.

Warning signals of liver toxicity caused by Multaq 400Mg Tablet may include dark urine, yellowing of the skin or eyes (jaundice), light-coloured stools, loss of appetite, nausea, vomiting, unusual tiredness, and pain in the upper right side of the abdomen. If you notice any of these symptoms, consult the doctor immediately.

Multaq 400Mg Tablet may cause optic neuropathy, the symptoms of optic neuropathy may include blurred vision, sudden vision loss, loss of peripheral vision, difficulty seeing in low light, and pain when moving the eye. If you experience any of these symptoms, consult the doctor immediately.

Multaq 400Mg Tablet should be taken orally with or without food at regular intervals. Swallow it as a whole with a glass of water. Do not chew, crush or break it.

The side effects of Multaq 400Mg Tablet include diarrhoea, slow heartbeat, nausea and vomiting. Consult the doctor if any of these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Behind HDFC Bank, Sai Nagar, Devendra Nagar Road, Raipur, Chhattisgarh (492001) - India
Other Info - MUL0153

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 22, 2025 | 9:24 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022425s013lbl.pdf
  2. https://www.webmd.com/drugs/2/drug-152652/dronedarone-oral/details
  3. https://www.medicines.org.uk/emc/files/pil.10924.pdf
  4. https://www.drugs.com/pregnancy/dronedarone.html

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