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compositionComposition:NILOTINIB-200MG
prescription
Prescription Medicine
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Myelotib 200 mg Capsule 28's is used to treat Philadelphia chromosome-positive chronic myeloid leukaemia (a type of blood cancer). It contains Nilotinib, which works by blocking the action of an abnormal protein produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thus, it stops the multiplication, inhibits the growth of cancerous cells, and then causes their death.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

NILOTINIB-200MG

Manufacturer/Marketer :

Del Trade International Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Myelotib 200 mg Capsule 28's

Myelotib 200 mg Capsule 28's is a prescription medicine used to treat a specific type of blood cancer called Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). It is prescribed for adults and children who have been newly diagnosed or those who can no longer tolerate or respond to previous leukemia treatments.

For this medicine to work effectively, it must be taken consistently at the same times each day as directed by your doctor. It is vital to take Myelotib 200 mg Capsule 28's on an empty stomach, meaning you should not eat any food for at least one hour before and two hours after your dose. Avoiding grapefruit products and limiting heavy, high-fat meals around your dosing times will also help keep the medicine at safe levels in your body.

Common side effects when taking this medicine include skin rash, itching, mild headaches, nausea, and muscle aches. However, you must contact your doctor immediately if you experience serious symptoms such as shortness of breath, a fluttering or rapid heartbeat, sudden swelling, or yellowing of your eyes.

Before starting treatment, tell your doctor if you have a history of heart rhythm problems, liver disease, pancreatitis, or low blood levels of potassium or magnesium. Do not take this if you have long QT syndrome, an inherited heart rhythm disorder, or if you have uncorrected low levels of potassium or magnesium in your blood.

Certain medicines, including strong antibiotics, anti-seizure drugs, and even over-the-counter stomach acid reducers, can alter the amount of Myelotib 200 mg Capsule 28's in your bloodstream, potentially causing dangerous heart issues or reducing the treatment's effectiveness. You should also avoid smoking and alcohol because they can increase stress on your liver and aggravate side effects. Pregnant or breastfeeding women must not take this medicine, and elderly patients should be closely monitored by their healthcare team.

Uses of Myelotib 200 mg Capsule 28's

Myelotib 200 mg Capsule 28's is used to treat the following conditions:

  • Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase: Myelotib 200 mg Capsule 28's helps stop the growth and spread of leukemia cells in patients who are in the early, stable stage of this blood cancer.
  • Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in accelerated phase: It helps control the overproduction of abnormal white blood cells in patients whose disease has started to progress more rapidly.

Key Benefits

Using Myelotib 200 mg Capsule 28's as prescribed helps control chronic myeloid leukaemia (CML) and supports long-term disease management. Here are the key benefits you can expect:

  • Targets the cause of CML: Myelotib 200 mg Capsule 28's targets the specific abnormal proteins that drive leukaemia growth, helping to restore normal blood cell production.
  • Relieves CML symptoms: It may help reduce symptoms such as fatigue, night sweats, and a swollen spleen, allowing you to feel more energetic and comfortable.
  • Helps prevent disease progression: By keeping the cancer under control, it helps prevent CML from advancing to more aggressive phases.
  • Supports long-term outcomes: This targeted approach aims to help patients achieve very low or even undetectable levels of leukaemia cells in the blood, which can significantly improve long-term survival and overall quality of life.
Side effects of Myelotib 200 mg Capsule
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

  • Myelotib 200 mg Capsule 28's should be taken on an empty stomach, at least 2 hours before or 1 hour after eating food, or as advised by the doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Myelotib 200 mg Capsule 28's as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Myelotib 200 mg Capsule 28's Works

Myelotib 200 mg Capsule 28's contains nilotinib, a tyrosine kinase inhibitor (a targeted medicine that blocks specific proteins helping cancer cells grow and survive) that targets the abnormal protein responsible for the growth of chronic myeloid leukaemia (CML) cells. Myelotib 200 mg Capsule 28's works by specifically binding to and blocking the Bcr-Abl protein (an abnormal protein that causes leukaemia cells to grow and multiply uncontrollably), which is produced by an abnormal gene in patients with Philadelphia chromosome-positive (Ph+) CML. This protein acts like an 'on' switch, telling white blood cells to multiply uncontrollably. By turning off this abnormal signal, Myelotib 200 mg Capsule 28's halts the rapid multiplication of leukaemia cells and encourages them to die off, allowing healthy blood cells to rebuild and take their place.
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Alcohol

Consult your doctor

The interaction of Myelotib 200 mg Capsule 28's with alcohol is unknown. Please discuss with your doctor if you have any concerns regarding this.

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Pregnancy

Unsafe

Myelotib 200 mg Capsule 28's is not recommended for use during pregnancy as it may harm the unborn baby. Therefore, inform your doctor if you are pregnant or planning for pregnancy before taking Myelotib 200 mg Capsule 28's. Also, you are advised to use effective birth control measures during treatment with Myelotib 200 mg Capsule 28's and for up to 2 weeks after the last dose of Myelotib 200 mg Capsule 28's.

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Breast Feeding

Unsafe

You are recommended to avoid breastfeeding during treatment with Myelotib 200 mg Capsule 28's and for two weeks after the final dose. Inform your doctor if you are breastfeeding.

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Driving

Caution

If you experience side effects such as dizziness or visual disorders, avoid driving or operating machinery until you are alert.

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Liver

Caution

Inform your doctor if you have liver problems before taking Myelotib 200 mg Capsule 28's. Your doctor may adjust the dose if necessary based on your condition.

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Kidney

Consult your doctor

Limited information is available on the use of Myelotib 200 mg Capsule 28's in patients with impaired kidney function. Therefore, if you have kidney problems, inform your doctor before taking Myelotib 200 mg Capsule 28's.

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Children

Caution

Myelotib 200 mg Capsule 28's is not recommended for children below 1 year of age as the safety and effectiveness were not established.

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Heart

Consult your doctor

Please consult your doctor if you have heart problems before using Myelotib 200 mg Capsule 28's.

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Geriatrics

Consult your doctor

Please consult a doctor if you have any concerns regarding the use of Myelotib 200 mg Capsule 28's in elderly patients.

What if I have taken an overdose of Myelotib 200 mg Capsule 28's

If you take more than the prescribed dose of Myelotib 200 mg Capsule 28's, seek emergency medical attention immediately. An overdose may cause serious heart rhythm problems.

Diet & Lifestyle Advise

  • Stick to the fasting window: Always schedule your meals strictly around your medication. Eating food close to your dose can dangerously increase the absorption of Myelotib 200 mg Capsule 28's and lead to severe heart complications.
  • Avoid grapefruit entirely: Do not consume grapefruit, grapefruit juice, or Seville oranges, as they interfere with how your body breaks down the medicine.
  • Protect your skin: This medicine can make your skin highly sensitive to sunlight. Wear broad-spectrum sunscreen, protective clothing, and a hat when outdoors.
  • Stay well-hydrated: Drink plenty of water throughout the day to support your kidneys and liver as your body processes the medication and clears away cellular waste.
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How Soon It Starts Working

The time required for Myelotib 200 mg Capsule 28's to start to work: Myelotib 200 mg Capsule 28's ideally shows its action within few hours after administration. The time for which the effects of Myelotib 200 mg Capsule 28's last: The effect of Myelotib 200 mg Capsule 28's lasts for 24 hours.

What if you forget to take Myelotib 200 mg Capsule 28's

If you miss a dose, skip the missed dose entirely and take your next dose at your regularly scheduled time. Do not take two doses at once to make up for a missed one.

Storage

• Store Myelotib 200 mg Capsule 28's capsules at room temperature, ideally between 20°C and 25°C.

Drug Warnings

  • Inspect Before Use: Check the capsules before taking them. Do not use any capsule that is cracked, broken, or leaking powder.
  • Attend ECG Monitoring: Keep all scheduled electrocardiogram (ECG) appointments so your doctor can monitor your heart's electrical rhythm.
  • Have Regular Blood Tests: Attend all recommended blood tests to monitor your potassium, magnesium, and blood cell counts during treatment.
  • Avoid Taking Acid-Reducing Medicines Together: Do not take antacids, H2 blockers, or proton pump inhibitors at the same time as Myelotib 200 mg Capsule 28's, as they can reduce the absorption of the medicine.
  • Space Out Antacid Use: If you need to take an antacid, take it at least 2 hours before or 2 hours after your dose of Myelotib 200 mg Capsule 28's.

Drug-Drug Interactions

verifiedApollotooltip
  • Strong CYP3A4 inhibitors (like ketoconazole, clarithromycin): May dangerously increase the levels of Myelotib 200 mg Capsule 28's in your blood, raising the risk of severe side effects.
  • Strong CYP3A4 inducers (like rifampin, phenytoin): May lower the levels of Myelotib 200 mg Capsule 28's in your blood, making the treatment less effective.
  • Stomach acid reducers (like omeprazole or ranitidine): Can reduce the absorption of Myelotib 200 mg Capsule 28's, lowering its effectiveness.
  • Medicines that prolong the QT interval (like certain heart rhythm drugs or antipsychotics): May increase the risk of life-threatening irregular heartbeats.
NilotinibBCG vaccine
Critical
NilotinibCisapride
Critical

Drug-Drug Interactions

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NilotinibBCG vaccine
Critical
How does the drug interact with Myelotib 200 mg Capsule:
Combining BCG vaccine with Myelotib 200 mg Capsule can increase the risk of infection.

How to manage the interaction:
Taking Myelotib 200 mg Capsule with BCG vaccine is not recommended, please consult your doctor before taking it. if you experience any symptoms , contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibCisapride
Critical
How does the drug interact with Myelotib 200 mg Capsule:
Combining Cisapride and Myelotib 200 mg Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Cisapride and Myelotib 200 mg Capsule together is generally avoided as it can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
NilotinibLeuprorelin
Critical
How does the drug interact with Myelotib 200 mg Capsule:
Using Myelotib 200 mg Capsule together with leuprolide can increase the risk of an irregular heart rhythm that may be serious

How to manage the interaction:
Taking Leuprorelin with Myelotib 200 mg Capsule is not recommended, as it can result in an interaction. It can be taken if your doctor has suggested it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
NilotinibZiprasidone
Critical
How does the drug interact with Myelotib 200 mg Capsule:
Taking Myelotib 200 mg Capsule with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Myelotib 200 mg Capsule with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
NilotinibYellow fever vaccine
Critical
How does the drug interact with Myelotib 200 mg Capsule:
Combining Yellow fever vaccine with Myelotib 200 mg Capsule can increase the risk of infection.

How to manage the interaction:
Taking Myelotib 200 mg Capsule with Yellow fever vaccine is not recommended, please consult your doctor before taking it. if you experience any symptoms , contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibSaquinavir
Critical
How does the drug interact with Myelotib 200 mg Capsule:
Combining Saquinavir and Myelotib 200 mg Capsule can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Saquinavir and Myelotib 200 mg Capsule together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibSparfloxacin
Critical
How does the drug interact with Myelotib 200 mg Capsule:
Coadministration of Sparfloxacin with Myelotib 200 mg Capsule can prolong the QT interval.

How to manage the interaction:
Taking Myelotib 200 mg Capsule with Sparfloxacin is not recommended, please consult your doctor before taking it. If you experience any symptoms, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibMesoridazine
Critical
How does the drug interact with Myelotib 200 mg Capsule:
Combining Mesoridazine and Myelotib 200 mg Capsule can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine and Myelotib 200 mg Capsule together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibGrepafloxacin
Critical
How does the drug interact with Myelotib 200 mg Capsule:
Coadministration of Grepafloxacin with Myelotib 200 mg Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Myelotib 200 mg Capsule with Grepafloxacin is not recommended, please consult your doctor before taking it. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
NilotinibDoxorubicin
Severe
How does the drug interact with Myelotib 200 mg Capsule:
Coadministration of Doxorubicin and Myelotib 200 mg Capsule can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Doxorubicin and Myelotib 200 mg Capsule together can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: Can raise blood levels of Myelotib 200 mg Capsule 28's to toxic heights.
  • High-fat meals: Significantly increase the absorption of the drug, which can cause severe heart rhythm problems.
NILOTINIB-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NILOTINIB-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Grapefruit juice can increase the blood levels of Myelotib 200 mg Capsule, and increase the risk of an irregular heart rhythm. Consumption of grape juice and grape fruit should be avoided as is causes symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with Myelotib 200 mg Capsule. Food may also increase the blood levels of Myelotib 200 mg Capsule. Therefore, you should take Myelotib 200 mg Capsule on an empty stomach, meaning no food should be eaten for at least two hours before or one hour after taking Myelotib 200 mg Capsule.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[KINASE INHIBITORS]

FAQs

Myelotib 200 mg Capsule 28's is used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML).
Myelotib 200 mg Capsule 28's contains Nilotinib, an anticancer drug. In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells.
You are not recommended to take antacids and Myelotib 200 mg Capsule 28's at the same time. You are advised to take antacids containing magnesium hydroxide, aluminium hydroxide, and simethicone about two hours before or two hours after taking Myelotib 200 mg Capsule 28's. However, please consult a doctor before taking other medicines with Myelotib 200 mg Capsule 28's.
You are recommended to avoid grapefruit juice, grapefruit and any supplement containing grapefruit extract while taking Myelotib 200 mg Capsule 28's as it may increase the amount of Nilotinib in the body and cause serious side effects.
No, you must take Myelotib 200 mg Capsule 28's on an empty stomach. Do not eat for at least 1 hour before and 2 hours after your dose, as food can cause your body to absorb too much medicine, leading to severe side effects. Talk to your doctor if you have trouble timing your meals.
If you throw up after taking your capsules, do not take an extra dose to make up for it. Simply wait and take your next dose at the regular scheduled time. Talk to your doctor if vomiting becomes a frequent issue.
This medicine can affect the electrical rhythm of your heart, a condition called QT prolongation (a change in the heart's electrical activity that can lead to serious irregular heart rhythms). Regular ECGs allow your doctor to monitor your heart safety and adjust your treatment if needed. Talk to your doctor if you feel dizzy or faint.
Many acid reducers, especially proton pump inhibitors, can prevent Myelotib 200 mg Capsule 28's from being absorbed properly. If you need an antacid, take it at least 2 hours before or 2 hours after your dose. Talk to your doctor or pharmacist before taking any new medicine for reflux.
You should avoid or strictly limit alcohol while taking this medicine. Both alcohol and Myelotib 200 mg Capsule 28's are processed by your liver, and combining them can increase your risk of liver damage and worsen side effects like dizziness. Talk to your doctor for advice.
No, Myelotib 200 mg Capsule 28's can cause serious harm to an unborn baby. Women who can become pregnant must use highly effective birth control during treatment and for at least several weeks after stopping the medication. Talk to your doctor immediately if you suspect you are pregnant.
No, you should not breastfeed while taking Myelotib 200 mg Capsule 28's and for at least 2 weeks after your final dose, as the medicine may pass into breast milk and harm your baby. Talk to your doctor about safe ways to feed your infant.

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Country of origin

India

Manufacturer/Marketer address

BEETAL HOUSE, 99, MADANGIR BEHIND LOCAL SHOPPING CENTRE DELHI DL 110062 IN.
Other Info - MYE0031
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