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  1. Home
  2. Medicine

  3. Nalotrexat 50 Tablet 10's

Prescription drug
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Nalotrexat 50 Tablet 10's, Pack of 10
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Composition :

NALTREXONE-50MG

Manufacturer/Marketer :

Steris Healthcare

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Nalotrexat 50 Tablet 10's

Nalotrexat 50 Tablet 10's belongs to the class of medications called 'opioid-antagonist' used to treat alcohol dependence (chronic alcoholism) and opioid dependence. It is used along with counselling and social support to help patients dependent on alcohol abstain from drinking alcoholic drinks.

Nalotrexat 50 Tablet 10's contains naltrexone, which works by blocking the effect of opioid receptors and decreasing cravings and urges to use alcohol or opioids.

Nalotrexat 50 Tablet 10's may cause side effects such as nausea, vomiting, muscle cramps, dizziness, drowsiness, appetite disorders, and toothache. If any side effects persist or worsen, speak with a doctor.

Before taking the Nalotrexat 50 Tablet 10's, let your doctor know about all your medical conditions, allergic reactions, and all medications you are using. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Uses of Nalotrexat 50 Tablet 10's

Nalotrexat 50 Tablet 10's is used in the management of alcohol and opioid dependence. The detailed uses of Nalotrexat 50 Tablet 10's are as follows:

  • Treats Opioid Dependence: Nalotrexat 50 Tablet 10's helps to prevent relapse in individuals who have been detoxified from opioids by blocking the effects of opioid drugs and reducing cravings.
  • Manages Alcohol Dependence: Nalotrexat 50 Tablet 10's is used to support recovery from alcohol addiction by decreasing the urge to drink.

Have a query?

Directions for Use

  • Nalotrexat 50 Tablet 10's can be taken with or without food, but taking it with food helps reduce stomach upset.
  • Follow the recommended dosage and duration for your specific medical condition to achieve optimal results.
  • Swallow Nalotrexat 50 Tablet 10's as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Nalotrexat 50 Tablet 10's is used to treat alcohol dependence (chronic alcoholism) and opioid dependence.
  • It helps reduce cravings and the urge to consume alcohol or use opioids, supporting recovery and long-term abstinence.
  • The active ingredient, Naltrexone, acts as an opioid receptor antagonist, which means it blocks the euphoric and sedative effects of alcohol and opioids.
  • By preventing pleasurable effects, Nalotrexat 50 Tablet 10's reduces the motivation to relapse or continue substance use.
  • It is used along with counselling, behavioural therapy, and social support to improve treatment outcomes.
  • Nalotrexat 50 Tablet 10's helps individuals maintain sobriety, enhance self-control, and support recovery from addiction.
  • Nalotrexat 50 Tablet 10's plays a vital role in managing substance dependence and promoting a healthier, addiction-free lifestyle.

How Nalotrexat 50 Tablet 10's Works

Nalotrexat 50 Tablet 10's contains 'naltrexone'. It works by blocking the effect of opioid receptors and decreasing cravings and urges to use alcohol or opioids. It is used along with counselling and social support to help patients dependent on alcohol abstain from drinking alcoholic drinks.

Storage

• Store in a cool and dry place away from sunlight.• Keep Nalotrexat 50 Tablet 10's out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Nalotrexat 50 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.

What if I have taken an overdose of Nalotrexat 50 Tablet 10's

An overdose of Nalotrexat 50 Tablet 10's may cause unpleasant side effects. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

  • Inform your doctor about all your medical conditions (particularly hepatitis or liver failure), allergic reactions (with food and medications), and medications you are taking (especially opioid analgesics).
  • Let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding.
  • Nalotrexat 50 Tablet 10's usage is contraindicated in patients with current physiologic opioid dependence, patients in acute opioid withdrawal, or any individual who has failed the naloxone challenge test or has a positive urine screen for opioids.
  • Nalotrexat 50 Tablet 10's may cause dizziness and sedation; therefore, avoid driving vehicles or operating machinery until you return to normal.
  • Do not use other medications without the doctor's notice, especially opioid-containing ones.

Drug-Drug Interactions

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NaltrexonePethidine
Critical
NaltrexoneOpium
Critical

Drug-Drug Interactions

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NaltrexonePethidine
Critical
How does the drug interact with Nalotrexat 50 Tablet:
Taking Pethidine with Nalotrexat 50 Tablet can block the effects of Pethidine and make the medication less effective.

How to manage the interaction:
Taking Pethidine with Nalotrexat 50 Tablet is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
NaltrexoneOpium
Critical
How does the drug interact with Nalotrexat 50 Tablet:
Combining Nalotrexat 50 Tablet with Opium can block the effects of opium, which reduces its ability to effectively treat your illness.

How to manage the interaction:
Taking Nalotrexat 50 Tablet with Opium is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, diarrhoea, aches, fever, runny nose, sneezing, nervousness, irritability, shivering, and abdominal cramps, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NaltrexoneMethadone
Critical
How does the drug interact with Nalotrexat 50 Tablet:
Taking Methadone with Nalotrexat 50 Tablet can increase the risk or severity of harmful side effects.

How to manage the interaction:
Taking Methadone with Nalotrexat 50 Tablet is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
NaltrexoneMorphine
Critical
How does the drug interact with Nalotrexat 50 Tablet:
Using Morphine with Nalotrexat 50 Tablet can block morphine's effects, which reduces its ability to effectively treat illness.

How to manage the interaction:
Taking Morphine with Nalotrexat 50 Tablet together is generally avoided as it can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
NaltrexonePentazocine
Critical
How does the drug interact with Nalotrexat 50 Tablet:
Taking Nalotrexat 50 Tablet with Pentazocine can reduce the effects of pentazocine and make the medication less effective.

How to manage the interaction:
Taking Pentazocine with Nalotrexat 50 Tablet is generally avoided, but can be taken together if prescribed by a doctor. However, if you experience any symptoms like nausea, vomiting, diarrhoea, aches, fever, runny nose, sneezing, nervousness, irritability, shivering, and abdominal cramps, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
NaltrexoneDezocine
Critical
How does the drug interact with Nalotrexat 50 Tablet:
Coadministration of Nalotrexat 50 Tablet with Dezocine can block the effects of Dezocine and make the medication less effective.

How to manage the interaction:
Taking Nalotrexat 50 Tablet with Dezocine is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
NaltrexoneTapentadol
Critical
How does the drug interact with Nalotrexat 50 Tablet:
Using Tapentadol together with Nalotrexat 50 Tablet can block the effects of tapentadol, which reduces its ability to effectively treat your illness.

How to manage the interaction:
Taking Tapentadol with Nalotrexat 50 Tablet is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, blurred vision, muscle spasm or stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhoea call a doctor right away. Do not stop using any medications without a doctor’s advice.
NaltrexoneLeflunomide
Severe
How does the drug interact with Nalotrexat 50 Tablet:
Taking Leflunomide and Nalotrexat 50 Tablet can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between Leflunomide and Nalotrexat 50 Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NaltrexoneNaloxegol
Severe
How does the drug interact with Nalotrexat 50 Tablet:
Coadministration of Nalotrexat 50 Tablet and Naloxegol can increase the effects of Naloxegol. This can increase the risk or severity of side effects.

How to manage the interaction:
Although taking Nalotrexat 50 Tablet and Naloxegol together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A patient is advised to have a diet that increases serotonin levels, which makes a person feel good & involves eating foods high in carbohydrates, especially the complex carbohydrates present in starchy food items like legumes (e.g., beans, lentils and peas), root vegetables (e.g., potatoes and carrots), pasta and bread. Eating such foods in combination with protein in meals will benefit.
  • Deficiencies in B-complex vitamins such as thiamine, folate or folic acid, and B12 are common with alcoholism, and inadequate stores of other B vitamins and vitamin C frequently occur. A patient should consume supplements and vitamins as per their doctor's recommendation.
  • Malnutrition is common during alcohol consumption and is revealed slowly and gradually. The patient becomes very tired and develops a weaker immune system, which means the patient is more susceptible to infections. These problems need to be identified and treated during the recovery process—ideally by a team of healthcare professionals.
  • The patient should change his drinking priorities and prefer drinks like apple cider, vanilla shake, mixing juice or lemonade with sparkling water, etc.
  • Get physical activity and enough rest.
  • Reduce caffeine and stop smoking, if possible.

Habit Forming

Not enough scientific literature available around this hence it is best to consult your physician

Therapeutic Class

OPIOID ANTAGONISTS

Nalotrexat 50 Tablet 10's Substitute

Substitutes safety advice
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Alcohol

Caution

Consumption of alcohol is not recommended during treatment with this medicine.

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Pregnancy

Caution

There are no adequate and well-controlled studies of naltrexone in pregnant women. Nalotrexat 50 Tablet 10's should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

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Breast Feeding

Caution

Caution should be exercised while using Nalotrexat 50 Tablet 10's in nursing mothers. Inform your doctor if you are a nursing mother. A decision should be made whether to discontinue nursing or discontinue the drug, considering the importance of the drug to the mother.

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Driving

Caution

Nalotrexat 50 Tablet 10's may cause side effects which could affect your ability to drive or operate machinery.

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Liver

Caution

Nalotrexat 50 Tablet 10's should be used with caution in patients with liver disease. So, inform your doctor if you have liver impairment. Regular monitoring of liver function tests is advisable while you are taking this medicine.

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Kidney

Caution

Caution is recommended in administering Nalotrexat 50 Tablet 10's to patients with moderate to severe renal impairment. So, inform your doctor if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Nalotrexat 50 Tablet 10's.

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Children

Caution

Nalotrexat 50 Tablet 10's should not be used in children and adolescents under 18 since clinical data in this age group are unavailable.

FAQs

Nalotrexat 50 Tablet 10's is used to treat alcohol dependence (chronic alcoholism) and opioid dependence.

Nalotrexat 50 Tablet 10's works by blocking the effect of opioid receptors and decreasing cravings and urges to use alcohol or opioids, but it is used along with counselling and social support to help patients who are dependent on alcohol abstain from drinking alcoholic drinks.

No, Nalotrexat 50 Tablet 10's should not be used with an opioid analgesic, as it may cause serious adverse effects of the drug. If you have any concerns, please discuss them with your doctor.

Before taking Nalotrexat 50 Tablet 10's, inform your doctor about your medical conditions (particularly hepatitis or liver failure), allergic reactions, and medications you are already taking (especially opioid analgesics). Also, let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding.

Take the missed dose as soon as you remember. Take the rest of the day's doses at evenly spaced intervals unless otherwise directed by your doctor.

Using Nalotrexat 50 Tablet 10's in any individual who has failed the naloxone challenge test or has a positive urine screen for opioids is contradicted.

Nalotrexat 50 Tablet 10's may cause side effects such as nausea, vomiting, drowsiness or sedation, anorexia (eating disorder), decreased appetite, insomnia, and toothache. If the side effects persist or worsen, speak with a doctor.

Nalotrexat 50 Tablet 10's should be used with caution in patients with liver disease. So, inform your doctor if you have liver impairment. Regular monitoring of liver function is advisable while you are taking this medicine.

Nalotrexat 50 Tablet 10's can be taken with pain relievers other than opioid medications if prescribed by the doctor. Please consult the doctor before taking painkillers/any other medications with Nalotrexat 50 Tablet 10's.

Nalotrexat 50 Tablet 10's cough and cold medicines, thereby, you may not benefit from these medicines. Consult a doctor before taking Nalotrexat 50 Tablet 10's with cold, cough or allergy medicines.

You are advised to take Nalotrexat 50 Tablet 10's only for the duration prescribed by the doctor. Please consult the doctor if you have any concerns regarding the duration of treatment.

Nalotrexat 50 Tablet 10's may not make you high. It might cause sedation, drowsiness, and dizziness. Therefore, avoid driving, operating machinery or doing things that require alertness.

Yes, Nalotrexat 50 Tablet 10's decreases cravings and urge to use opioids by blocking the action of opioid receptors.

Country of origin

India

Manufacturer/Marketer address

A.O. : 328-A, Tanaji Chowk, New Mill Road, Kurla (West), Mumbai 400070.
Other Info - NAL0056

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Nov 5, 2025 | 11:01 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/product/6073/smpc#PRODUCTINFO
  2. https://www.mims.com/india/drug/info/naltrexone?type=full&mtype=generic
  3. https://www.webmd.com/drugs/2/drug-7399/naltrexone-oral/details
  4. https://www.drugs.com/naltrexone.html#what-to-avoid
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