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compositionComposition:NALTREXONE-50MG
prescription
Prescription Medicine
info
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Nalsign 50mg Tablet is used to treat alcohol and opioid dependence. It contains Naltrexone, which works by blocking the effect of opioid receptors and decreasing the craving/urge to use alcohol or opioids. In some cases, this medicine may cause side effects such as nausea, vomiting, muscle cramps, dizziness, drowsiness, and appetite changes. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

NALTREXONE-50MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Nalsign 50mg Tablet

Nalsign 50mg Tablet is a prescription medication used to help people with alcohol use disorder or opioid use disorder remain drug- or alcohol-free. It works by blocking certain receptors in the brain to reduce cravings and prevent the pleasurable effects of these substances. This medicine is typically prescribed as part of a complete treatment program that includes counseling and support.

To get the most benefit, you must take Nalsign 50mg Tablet consistently every day exactly as directed by your doctor. You can take this tablet with or without food, though taking it with a meal or a glass of water can help prevent an upset stomach. Combining this medication with counseling, support groups, and healthy stress-management habits greatly improves your chances of long-term recovery.

While taking Nalsign 50mg Tablet, you may experience mild side effects like nausea, headache, sleepiness, or mild anxiety. However, you must contact your doctor immediately if you experience serious symptoms such as yellowing of your eyes or skin, dark urine, severe abdominal pain, or changes in your mood, including depression or thoughts of self-harm.

Talk to your doctor before starting Nalsign 50mg Tablet if you have liver disease, kidney problems, or any mental health conditions. Do not take this medicine if you are currently using or dependent on opioid drugs, are experiencing active opioid withdrawal, or are in liver failure.

Taking Nalsign 50mg Tablet while using opioid pain relievers or cough medicines will block their effects and can trigger sudden, severe withdrawal symptoms. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor to discuss the risks and benefits before starting this treatment.

Uses of Nalsign 50mg Tablet

Nalsign 50mg Tablet is used as part of a comprehensive treatment programme to support recovery from alcohol or opioid dependence. Its main uses include:

  • Alcohol dependence: Nalsign 50mg Tablet helps individuals with alcohol use disorder reduce their urge to drink and maintain sobriety when used alongside counseling and behavioral therapy.
  • Opioid dependence: Nalsign 50mg Tablet blocks the physical effects of opioid medications and street drugs, helping individuals who have already gone through detox remain free from opioids.

Key Benefits

Nalsign 50mg Tablet supports the treatment of alcohol dependence and opioid dependence by reducing the rewarding effects associated with these substances. It is generally used as part of a broader recovery plan that may include counselling and behavioural support.

  • Reduces Alcohol Cravings: May help decrease the urge to drink alcohol, making it easier to maintain treatment goals and focus on recovery.
  • Blocks Opioid Effects: Prevents opioids from activating certain receptors in the brain, reducing effects such as euphoria if opioids are used during treatment.
  • Helps Reduce Relapse Risk: By reducing alcohol cravings or blocking the rewarding effects of opioids, Nalsign 50mg Tablet may help lower the likelihood of returning to problematic substance use.
  • Supports Long-Term Recovery: Can be used as part of an ongoing treatment plan alongside counselling, behavioural therapy, and other forms of professional support.
  • Does Not Produce a High: Nalsign 50mg Tablet does not cause opioid-like euphoria and is not considered physically dependence-forming.
Side effects of Nalsign 50mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.

Directions for Use

  • Nalsign 50mg Tablet can be taken with or without food, but taking it with food helps reduce stomach upset.
  • Follow the recommended dosage and duration for your specific medical condition to achieve optimal results.
  • Swallow Nalsign 50mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Nalsign 50mg Tablet Works

Nalsign 50mg Tablet contains naltrexone, which belongs to a class of medicines known as opioid antagonists. It works by binding tightly to specific docking sites in the brain called opioid receptors. By occupying these receptors, Nalsign 50mg Tablet blocks the pleasurable sensations and 'high' that opioids normally produce. It also helps reduce the rewarding effects and cravings associated with alcohol. Over time, this can help reduce the desire to use these substances.
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Alcohol

Caution

Consumption of alcohol is not recommended during treatment with this medicine.

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Pregnancy

Caution

There are no adequate and well-controlled studies of naltrexone in pregnant women. Nalsign 50mg Tablet should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

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Breast Feeding

Caution

Caution should be exercised while using Nalsign 50mg Tablet in nursing mothers. Inform your doctor if you are a nursing mother. A decision should be made whether to discontinue nursing or discontinue the drug, considering the importance of the drug to the mother.

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Driving

Caution

Nalsign 50mg Tablet may cause side effects which could affect your ability to drive or operate machinery.

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Liver

Caution

Nalsign 50mg Tablet should be used with caution in patients with liver disease. So, inform your doctor if you have liver impairment. Regular monitoring of liver function tests is advisable while you are taking this medicine.

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Kidney

Caution

Caution is recommended in administering Nalsign 50mg Tablet to patients with moderate to severe renal impairment. So, inform your doctor if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Nalsign 50mg Tablet.

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Children

Caution

Nalsign 50mg Tablet should not be used in children and adolescents under 18 since clinical data in this age group are unavailable.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Nalsign 50mg Tablet. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Safe if prescribed

Nalsign 50mg Tablet is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Nalsign 50mg Tablet

If you suspect an overdose, seek immediate medical attention or call your local poison control centre right away.

Diet & Lifestyle Advise

  • Follow Your Alcohol Recovery Plan: If Nalsign 50mg Tablet is being used for alcohol dependence, follow the alcohol-related guidance provided by your treatment team. Drinking alcohol does not usually cause a disulfiram-like reaction with Nalsign 50mg Tablet, but continued drinking can undermine recovery goals.
  • Stay Hydrated: Drink adequate water throughout the day, particularly if you experience mild symptoms such as headache or dry mouth.
  • Support Overall Recovery: Eat balanced, nutrient-rich meals and engage in regular physical activity as appropriate for your health to support energy, sleep, and general well-being.
  • Participate in Behavioural Support: Attend counselling, behavioural therapy, or a structured support programme as recommended, as Nalsign 50mg Tablet is commonly used as part of a comprehensive recovery plan.
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How Soon It Starts Working

The time required for Nalsign 50mg Tablet to start to work: Nalsign 50mg Tablet ideally shows its action within 1 hour after administration.

The time for which the effects of Nalsign 50mg Tablet last: The effect of Nalsign 50mg Tablet lasts for 24 to 36 hours.

What if you forget to take Nalsign 50mg Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Nalsign 50mg Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original container, tightly closed, to protect it from moisture and direct light.

Drug Warnings

  • Carry emergency identification: Always carry a medical alert card or wear a bracelet stating that you are taking Nalsign 50mg Tablet, so emergency medical personnel know you cannot be treated with standard opioid pain relievers.
  • Complete opioid detox first: You must be completely free of all opioids (including prescription pain medicines and illicit drugs) for at least 7 to 10 days before starting Nalsign 50mg Tablet to avoid triggering severe, sudden withdrawal symptoms.
  • Beware of sensitivity changes: After taking Nalsign 50mg Tablet, your body will become highly sensitive to lower doses of opioids. Attempting to overcome the block by taking large amounts of opioids is extremely dangerous and can lead to a fatal overdose.
  • Monitor your mood: Keep track of any changes in your mental health, and ask a trusted family member or friend to watch for signs of depression or unusual behavior.
  • Liver health checks: Keep all appointments for scheduled blood tests, as your doctor will want to check your liver function periodically while you take this medicine.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Nalsign 50mg Tablet and require caution, avoidance, closer monitoring, or treatment adjustments:

  • Opioid pain medications (such as morphine, codeine, oxycodone, or hydrocodone): Nalsign 50mg Tablet will block the pain-relieving effects of these medicines.
  • Opioid-containing cough syrups or diarrhoea medicines: Taking these while on Nalsign 50mg Tablet will render them ineffective and may cause sudden withdrawal symptoms.
NaltrexoneMethadone
Critical
NaltrexonePentazocine
Critical

Drug-Drug Interactions

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NaltrexoneMethadone
Critical
How does the drug interact with Nalsign 50mg Tablet:
Taking Methadone with Nalsign 50mg Tablet can increase the risk or severity of harmful side effects.

How to manage the interaction:
Taking Methadone with Nalsign 50mg Tablet is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
NaltrexonePentazocine
Critical
How does the drug interact with Nalsign 50mg Tablet:
Taking Nalsign 50mg Tablet with Pentazocine can reduce the effects of pentazocine and make the medication less effective.

How to manage the interaction:
Taking Pentazocine with Nalsign 50mg Tablet is generally avoided, but can be taken together if prescribed by a doctor. However, if you experience any symptoms like nausea, vomiting, diarrhoea, aches, fever, runny nose, sneezing, nervousness, irritability, shivering, and abdominal cramps, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
NaltrexoneOpium
Critical
How does the drug interact with Nalsign 50mg Tablet:
Combining Nalsign 50mg Tablet with Opium can block the effects of opium, which reduces its ability to effectively treat your illness.

How to manage the interaction:
Taking Nalsign 50mg Tablet with Opium is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, diarrhoea, aches, fever, runny nose, sneezing, nervousness, irritability, shivering, and abdominal cramps, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NaltrexoneMorphine
Critical
How does the drug interact with Nalsign 50mg Tablet:
Using Morphine with Nalsign 50mg Tablet can block morphine's effects, which reduces its ability to effectively treat illness.

How to manage the interaction:
Taking Morphine with Nalsign 50mg Tablet together is generally avoided as it can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
NaltrexoneTapentadol
Critical
How does the drug interact with Nalsign 50mg Tablet:
Using Tapentadol together with Nalsign 50mg Tablet can block the effects of tapentadol, which reduces its ability to effectively treat your illness.

How to manage the interaction:
Taking Tapentadol with Nalsign 50mg Tablet is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, blurred vision, muscle spasm or stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhoea call a doctor right away. Do not stop using any medications without a doctor’s advice.
NaltrexoneDezocine
Critical
How does the drug interact with Nalsign 50mg Tablet:
Coadministration of Nalsign 50mg Tablet with Dezocine can block the effects of Dezocine and make the medication less effective.

How to manage the interaction:
Taking Nalsign 50mg Tablet with Dezocine is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
NaltrexonePethidine
Critical
How does the drug interact with Nalsign 50mg Tablet:
Taking Pethidine with Nalsign 50mg Tablet can block the effects of Pethidine and make the medication less effective.

How to manage the interaction:
Taking Pethidine with Nalsign 50mg Tablet is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
NaltrexoneNaloxegol
Severe
How does the drug interact with Nalsign 50mg Tablet:
Coadministration of Nalsign 50mg Tablet and Naloxegol can increase the effects of Naloxegol. This can increase the risk or severity of side effects.

How to manage the interaction:
Although taking Nalsign 50mg Tablet and Naloxegol together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without first talking to your doctor.
NaltrexoneLeflunomide
Severe
How does the drug interact with Nalsign 50mg Tablet:
Taking Leflunomide and Nalsign 50mg Tablet can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between Leflunomide and Nalsign 50mg Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Food: No major clinically significant interactions with specific foods are generally known. Follow the administration instructions provided for your particular Nalsign 50mg Tablet formulation.
  • Alcohol: Nalsign 50mg Tablet does not typically cause an immediate disulfiram-like reaction if alcohol is consumed. However, if it is prescribed for alcohol dependence, drinking may interfere with recovery goals and should be discussed with your treatment team.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Not enough scientific literature available around this hence it is best to consult your physician

Therapeutic Class

[OPIOID ANTAGONISTS]

FAQs

Nalsign 50mg Tablet is used to treat alcohol dependence (chronic alcoholism) and opioid dependence.
Nalsign 50mg Tablet works by blocking the effect of opioid receptors and decreasing cravings and urges to use alcohol or opioids, but it is used along with counselling and social support to help patients who are dependent on alcohol abstain from drinking alcoholic drinks.
No, Nalsign 50mg Tablet should not be used with an opioid analgesic, as it may cause serious adverse effects of the drug. If you have any concerns, please discuss them with your doctor.
Before taking Nalsign 50mg Tablet, inform your doctor about your medical conditions (particularly hepatitis or liver failure), allergic reactions, and medications you are already taking (especially opioid analgesics). Also, let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding.
Take the missed dose as soon as you remember. Take the rest of the day's doses at evenly spaced intervals unless otherwise directed by your doctor.
Using Nalsign 50mg Tablet in any individual who has failed the naloxone challenge test or has a positive urine screen for opioids is contradicted.
Nalsign 50mg Tablet may cause side effects such as nausea, vomiting, drowsiness or sedation, anorexia (eating disorder), decreased appetite, insomnia, and toothache. If the side effects persist or worsen, speak with a doctor.
Nalsign 50mg Tablet should be used with caution in patients with liver disease. So, inform your doctor if you have liver impairment. Regular monitoring of liver function is advisable while you are taking this medicine.
Nalsign 50mg Tablet can be taken with pain relievers other than opioid medications if prescribed by the doctor. Please consult the doctor before taking painkillers/any other medications with Nalsign 50mg Tablet.
You are advised to take Nalsign 50mg Tablet only for the duration prescribed by the doctor. Please consult the doctor if you have any concerns regarding the duration of treatment.
Nalsign 50mg Tablet may not make you high. It might cause sedation, drowsiness, and dizziness. Therefore, avoid driving, operating machinery or doing things that require alertness.
Yes, Nalsign 50mg Tablet decreases cravings and urge to use opioids by blocking the action of opioid receptors.
You should not drink alcohol while taking Nalsign 50mg Tablet. While it does not cause a severe physical reaction if you drink (unlike some other medications), drinking defeats the purpose of the treatment and can increase the risk of side effects. Talk to your doctor if you are struggling to avoid alcohol.
If you have opioids in your system when you take Nalsign 50mg Tablet, it will trigger a sudden and severe withdrawal reaction, which includes intense nausea, vomiting, sweating, and pain. You must be completely opioid-free for at least 7 to 10 days before starting this medicine. Talk to your doctor to ensure it is safe to start.
No, Nalsign 50mg Tablet is not addictive, does not cause physical dependence, and does not produce a "high" or any mind-altering effects. You can stop taking it without experiencing drug-craving withdrawal symptoms. Talk to your doctor about how long you should continue treatment.
If you need surgery or any medical procedure that requires opioid pain relievers, you must inform your healthcare team in advance. You will need to stop taking Nalsign 50mg Tablet temporarily under medical supervision so that pain medications can work. Talk to your doctor or pharmacist about managing your pain safely.
While weight loss is not a primary purpose of Nalsign 50mg Tablet, some patients experience a mild decrease in appetite or mild nausea when starting the medication, which might lead to minor weight changes. If you experience significant or rapid weight loss, talk to your doctor.
Many over-the-counter and prescription cough medicines contain opioids (such as codeine). Nalsign 50mg Tablet will block these ingredients, making them ineffective, and can trigger withdrawal symptoms. Always check the labels carefully and talk to your pharmacist to find opioid-free cough remedies.
If you take a normal dose of an opioid, Nalsign 50mg Tablet will block its effects, meaning you will not feel high or experience pain relief. However, taking large amounts of opioids to overcome this block is extremely dangerous and can lead to life-threatening respiratory failure or death. If you have taken opioids, contact your doctor immediately or seek emergency medical care.

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Country of origin

India
Other Info - NA32806
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