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About Natdecita Injection
Natdecita Injection belongs to the group of medicines called hypomethylation agents used to treat myelodysplastic syndrome. A myelodysplastic syndrome is a group of malignancies known as myelodysplastic syndromes that occur when immature blood cells in the bone marrow do not mature or turn into healthy blood cells.
Natdecita Injection contains ‘Decitabine’, which works by helping the bone marrow produce normal blood cells and kills abnormal cells in the bone marrow.
Decitabine should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer chemotherapeutic agents. Decitabine should usually be given for at least four cycles but may be continued if your doctor decides you will benefit from additional treatment. The most common adverse reactions of Natdecita Injection are injection site reactions, excessive tiredness, headache, dizziness, confusion, fast heartbeat, difficulty falling asleep or staying asleep, weakness, shortness of breath, nausea, constipation, diarrhoea, vomiting, heartburn, chest discomfort and swelling of the hands, feet, ankles, lower legs, or stomach. Talk with your doctor if you experience any of these side effects persistently.
Decitabine may harm your fetus. Avoid taking Natdecita Injection if you are pregnant or breastfeeding. You or your partner should not become pregnant while you are using decitabine. It would be best if you used birth control to prevent pregnancy in yourself or your partner during your treatment with decitabine and for two months afterwards. Call your doctor if you or your partner becomes pregnant while using decitabine. If you are breastfeeding. Do not breastfeed while you take this drug and for two weeks after your last dose. Natdecita Injection may cause dizziness, sleepiness, tiredness, and blurred vision, so drive only if alert. Natdecita Injection is not recommended for children below 18 years as safety and effectiveness have not been established. Inform your doctor about your health condition and medications before taking Natdecita Injection to rule out interactions.
Uses of Natdecita Injection
Natdecita Injection is used to treat blood and bone marrow disorders. The detailed uses of Natdecita Injection are as follows:

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Key Benefits
Natdecita Injection belongs to the group of medicines called hypomethylation agents used to treat myelodysplastic syndrome. Natdecita Injection contains ‘Decitabine’, which works by helping the bone marrow produce normal blood cells and kills abnormal cells in the bone marrow. On the other hand, it can treat blood cancer, known as acute myeloid leukemia (AML).
How Natdecita Injection Works
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Drug Warnings
Before taking the Natdecita Injection, let your doctor know about all your medical conditions, sensitivities, and medications you are using. Before and during your therapy, your doctor will prescribe laboratory testing on a regular basis. You may have a higher risk of infection. Hands must be washed frequently. Avoid contact with those who have illnesses, colds, or the flu. You may bleed more easily. Take precautions to avoid injury. Do not skip any scheduled dose or take other medications unless prescribed by the doctor.
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Alcohol
Safe if prescribed
You are recommended to avoid alcohol consumption while on treatment with Natdecita Injection as it might cause increased dizziness.
Pregnancy
Consult your doctor
Natdecita Injection should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.
Breast Feeding
Consult your doctor
Natdecita Injection should not be used in breastfeeding. Discuss with your doctor if you have any concerns.
Driving
Safe if prescribed
Natdecita Injection may cause dizziness, sleepiness, and blurred vision. Do not drive or operate heavy machinery unless you are alert.
Liver
Consult your doctor
Inform your doctor before receiving the Natdecita Injection if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.
Kidney
Consult your doctor
Inform your doctor before receiving the Natdecita Injection if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.
Children
Safe if prescribed
Natdecita Injection is not recommended for children below 18 years as the safety and effectiveness have not been established.
Heart
Natdecita Injection may be used in patients with heart problems, but only under strict medical supervision. It pose risks like cardiomyopathy and heart failure, so close monitoring is essential.
Geriatrics
Consult your doctor
Geriatric patients can receive Natdecita Injection, but they may be more vulnerable to side effects like low blood counts or heart complications. Close medical supervision and dose adjustments are often necessary.
Natdecita Injection is used to treat Myelodysplastic syndrome.
Natdecita Injection contains Decitabine, which works by helping the bone marrow produce normal blood cells and by killing abnormal cells in the bone marrow.
Decitabine therapy should usually be given as a three- or five-day regimen based on your medical condition and response to the treatment. Do not stop taking Natdecita Injection on your own. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Natdecita Injection.
Natdecita Injection can be used to treat blood cancer known as acute myeloid leukemia (AML).
Natdecita Injection therapy may cause a change in skin colour or pale skin or red spots on the skin. Consult your doctor immediately if you notice these symptoms persistently.
Natdecita Injection might cause neutropenia (low white blood cells) and thrombocytopenia (low platelets). Blood count should be checked regularly during treatment with Natdecita Injection.
Decitabine may raise blood sugar. If you have high blood sugar (diabetes), talk with your doctor.
No, Natdecita Injection is not a vesicant. It is an anti-cancer drug that is not known to cause severe tissue damage when it leaks from the injection site into surrounding tissues. It belongs to the group of medications called hypo methylation agents used to treat myelodysplastic syndrome.
Natdecita Injection effectively treats myelodysplastic syndrome, a group of disorders in which the bone marrow produces misshapen blood cells and insufficient healthy blood cells. It works by promoting the production of normal blood cells in the bone marrow and eliminating abnormal cells. However, the degree of effectiveness varies among individuals based on their medical condition.
Yes, Natdecita Injection may cause hair loss as a common side effect. To cope with hair loss, manage stress, maintain a healthy diet, avoid harsh hair treatments, use gentle hair care products, and consider medical treatments or therapies as advised by a doctor.
Natdecita Injection is administered through an intravenous route (into a vein) slowly over 3 hours by the doctor or nurse. It is usually administered every 8 hours for 3 days depending on the prescribed dose and treatment plan.
The side effects of Natdecita Injection include vomiting, nausea, injection site reactions, excessive tiredness, headache, dizziness, confusion, fast heartbeat, difficulty falling asleep or staying asleep, weakness, shortness of breath, constipation, diarrhoea, heartburn, chest discomfort and swelling of the hands, feet, ankles, lower legs, or stomach. Consult the doctor if any of these side effects persist or worsen.
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