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compositionComposition:ACETYLCYSTEINE-200MG
prescription
Prescription Medicine
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Nebtules 200 Injection 2 ml contains acetylcysteine, which is used to treat paracetamol overdose. It works by protecting the liver from damage caused by high levels of paracetamol. You may experience common side effects like injection site reactions, nausea, and vomiting.

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

ACETYLCYSTEINE-200MG

Manufacturer/Marketer :

K V Pharmaceuticals

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Nebtules 200 Injection 2 ml

Nebtules 200 Injection 2 ml is a prescription medicine used as an antidote (a medicine that counteracts the harmful effects of a poison or overdose) to treat paracetamol overdose. It helps protect the liver from serious damage when treatment is started as soon as possible after an overdose. This medicine is given directly into a vein (intravenously) by a healthcare professional, usually in a hospital.

The dose and duration of treatment depend on the amount of paracetamol taken, the time since the overdose, and your clinical condition. Your healthcare team will monitor you closely during treatment and may perform blood tests to assess your liver function and determine whether additional treatment is needed.

Most people tolerate this medicine well. Like all medicines, it can cause side effects, although not everybody gets them. Common side effects include nausea, vomiting, flushing (temporary warmth and redness of the skin), or irritation at the injection site. Consult your doctor right away if you develop difficulty breathing, wheezing, severe itching, swelling of your face, lips, tongue, or throat, or feel faint during treatment, as these may be signs of a serious allergic reaction.

Before receiving this medicine, tell your doctor if you have asthma or have previously had an allergic reaction to acetylcysteine. Also tell your doctor about all medicines you are taking, including over-the-counter medicines and herbal products.

If you are pregnant, breastfeeding, an older adult, or if this medicine is prescribed for your child, your doctor will decide whether this treatment is appropriate based on your individual clinical condition.

Uses of Nebtules 200 Injection 2 ml

Your doctor will prescribe or give Nebtules 200 Injection 2 ml for the following critical medical situations:

  • Paracetamol overdose: Nebtules 200 Injection 2 ml is used to protect the liver from severe damage or failure when an individual has taken too much paracetamol.
  • Prevention of liver injury: Nebtules 200 Injection 2 ml helps the liver neutralise harmful toxins, preventing permanent organ damage during a toxic exposure.

Key Benefits

When used as directed as part of your treatment plan, Nebtules 200 Injection 2 ml may provide the following benefits:

  • Helps protect the liver after a paracetamol overdose: Helps reduce the risk of serious liver damage when treatment is started promptly.
  • Supports the body's natural defence against toxins: Helps restore the liver's ability to remove harmful substances produced after a paracetamol overdose.
  • May reduce the risk of serious complications: Early treatment may lower the risk of liver failure and other complications caused by paracetamol poisoning.
  • Supports recovery after an overdose: Helps protect liver cells while your body clears the harmful by-products of paracetamol.
  • Provides emergency treatment when needed: Plays an important role in the medical management of paracetamol overdose in hospital.
Side effects of Nebtules 200 Injection 2 ml
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Wear loose-fitting clothes and breathable fabrics.
  • Keep your room cool by using a fan or AC.
  • Avoid or limit spicy food, alcohol and caffeine as they can trigger hot flashes.
  • Manage stress by practising relaxation techniques with yoga and meditation.
  • Quit smoking.
  • Maintain a healthy weight by including fruits and vegetables in your diet.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Nebtules 200 Injection 2 ml will be administered by the doctor.
  • Do not self-administer.

How Nebtules 200 Injection 2 ml Works

Nebtules 200 Injection 2 ml contains acetylcysteine, an antidote (a medicine that counteracts the harmful effects of a poison or overdose). After a paracetamol overdose, the liver produces a harmful substance called NAPQI (a toxic by-product formed when the liver breaks down paracetamol). Normally, the body removes NAPQI using glutathione (a natural antioxidant that helps protect cells from damage). During an overdose, glutathione levels become too low, allowing NAPQI to damage liver cells. Acetylcysteine helps the body restore its supply of glutathione, allowing the harmful NAPQI to be safely removed. This helps protect the liver from further damage and supports recovery.
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Alcohol

Consult your doctor

The interaction of alcohol with Nebtules 200 Injection 2 ml is unknown. Please consult a doctor before consuming alcohol with Nebtules 200 Injection 2 ml.

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Pregnancy

Caution

Nebtules 200 Injection 2 ml is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Caution

Nebtules 200 Injection 2 ml is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

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Driving

Safe if prescribed

Nebtules 200 Injection 2 ml usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Nebtules 200 Injection 2 ml should be used with caution if you have a history of liver diseases/conditions. Your doctor will decide to administer Nebtules 200 Injection 2 ml if the benefits are greater than the risks.

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Kidney

Caution

Nebtules 200 Injection 2 ml should be used with caution if you have a history of kidney diseases/conditions. Your doctor will decide to administer Nebtules 200 Injection 2 ml if the benefits are greater than the risks.

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Children

Caution

Your doctor will determine the dose of Nebtules 200 Injection 2 ml based on your child's age and weight.

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Heart

Caution

Nebtules 200 Injection 2 ml is generally considered safe for heart patients and may even provide protective effects against oxidative stress and reperfusion injury during cardiac procedures. However, its effectiveness and safety can vary depending on dosage and timing, so it should only be used under medical supervision.

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Geriatrics

Caution

Nebtules 200 Injection 2 ml is generally safe for geriatric patients, but older adults may require dose adjustments due to age-related changes in liver or kidney function. It's best used under medical supervision to ensure proper monitoring and minimize side effects.

What if I have taken an overdose of Nebtules 200 Injection 2 ml

An overdose of this medicine is unlikely because it is administered by trained healthcare professionals. If you experience any unusual symptoms during or after the infusion, tell your doctor or nurse immediately so that you can be assessed and treated if needed.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water (unless your doctor advises otherwise) to help your kidneys flush out metabolic waste and toxins from your body.
  • Avoid alcohol completely: Do not drink alcohol while recovering, as it places additional stress on your liver and can worsen existing liver damage.
  • Eat gentle foods: If you experience nausea after treatment, stick to simple, bland foods like toast, rice, or crackers, and eat small, frequent meals.
  • Consult before taking new medicines: Do not take any over-the-counter pain relievers, especially those containing paracetamol, until your doctor confirms it is safe to do so.
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How Soon It Starts Working

The time required for Nebtules 200 Injection 2 ml to start to work: Nebtules 200 Injection 2 ml ideally shows its action within 30 minutes to 1 hour after administration.

The time for which the effects of Nebtules 200 Injection 2 ml last: The effect of Nebtules 200 Injection 2 ml lasts for 8 hours.

What if you forget to take Nebtules 200 Injection 2 ml

This medicine is given by a healthcare professional, so you are unlikely to miss a dose. Your healthcare team will ensure you receive your treatment as prescribed.

Storage

•Store unopened vials or ampoules of this medicine at controlled room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Seek emergency care immediately: If you suspect a paracetamol overdose, go to the nearest emergency department or seek emergency medical help straight away, even if you feel well. Serious liver damage can occur before symptoms develop.
  • Provide accurate information: Tell your healthcare team the amount of paracetamol taken and, if possible, the time it was taken. This helps them decide the most appropriate treatment.
  • Report infusion reactions promptly: Consult your doctor right away if you develop itching, flushing, rash, wheezing, difficulty breathing, dizziness, or swelling during the infusion.
  • Tell your doctor if you have asthma: People with asthma may have a higher risk of breathing problems during treatment. Inform your healthcare team immediately if you develop wheezing or shortness of breath.
  • Do not be concerned about the smell: Acetylcysteine naturally has a strong sulphur-like smell, often compared with rotten eggs. This is normal and does not mean the medicine is spoiled or unsafe.

Drug-Drug Interactions

verifiedApollotooltip
  • Cough suppressants: Combining this medicine with drugs that stop you from coughing can cause a dangerous buildup of fluid or mucus in your lungs.
  • Nitroglycerin: When used together, this medicine may increase the widening of blood vessels, potentially leading to severe headaches or a sudden drop in blood pressure.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • No clinically significant food interactions are known with Nebtules 200 Injection 2 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIDOTES]

FAQs

Nebtules 200 Injection 2 ml is used to treat Paracetamol (acetaminophen) overdose and prevent liver injury.
Nebtules 200 Injection 2 ml works by restoring the body's glutathione, a chemical that eliminates toxic substances. Thus, it helps in the treatment of Paracetamol overdose.
You are recommended to inform your doctor or dentist that you have been treated with Nebtules 200 Injection 2 ml if you are due to undergo any surgery or dental procedure, because it may alter the effects of certain medicines that are used during anaesthesia.
Nebtules 200 Injection 2 ml may interfere with reagent dipstick tests for urinary ketones, giving false positive results. Therefore, if you are about to undergo any laboratory tests, inform your doctor or lab technician that you are taking Nebtules 200 Injection 2 ml.
Nebtules 200 Injection 2 ml may cause allergic reactions in some people. It is not necessary for everyone taking Nebtules 200 Injection 2 ml to have allergic reactions. However, if you notice a skin rash, itching, flushing, difficulty breathing or swelling of the face, inform your doctor immediately.
This medicine is given by intravenous (IV) infusion (slowly into a vein) by a doctor or nurse in a hospital or another healthcare setting. The dose and duration of treatment depend on your clinical condition.
No. This medicine is usually given in a hospital or emergency care setting because you need monitoring during the infusion for possible side effects and to assess your response to treatment.
Yes. If a paracetamol overdose occurs during pregnancy, prompt treatment with acetylcysteine is generally recommended because protecting the mother from liver damage also helps protect the unborn baby.
Tell your doctor or nurse immediately. Some people develop itching, flushing, or a rash during treatment. Your healthcare team may slow or temporarily stop the infusion or provide treatment if needed.
It is best to avoid alcohol until your doctor tells you it is safe, particularly if your liver has been affected by a paracetamol overdose.
Acetylcysteine naturally has a strong sulphur-like smell, often described as similar to rotten eggs. This is normal and does not mean the medicine is spoiled or unsafe.
Most side effects occur during or shortly after the infusion and usually resolve once treatment is completed. Long-term side effects from acetylcysteine are uncommon.
Seek emergency medical care immediately, even if the person feels well. Early treatment with acetylcysteine gives the best chance of preventing serious liver damage.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

G.S. Road, Christian Basti, Dispur, Kamrup Metropolitan, Assam, 781005
Other Info - NEB0384
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