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compositionComposition:PIPERACILLIN-4000MG+TAZOBACTAM-500MG
prescriptionPrescription Medicine
Neopip T 4.5 gm Injection 1's

Neopip T 4.5 gm Injection 1's is used to treat bacterial infections. It is used to treat various hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (like diabetic foot infections) and uterine infections. It contains Piperacillin and Tazobactam, which kills bacteria. It may cause side effects such as nausea, constipation, diarrhoea, headache, and trouble sleeping. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PIPERACILLIN-4000MG+TAZOBACTAM-500MG

Manufacturer/Marketer :

Amr Healthcare

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Neopip T 4.5 gm Injection 1's

Neopip T 4.5 gm Injection 1's belongs to the 'Antibiotics' class of drugs, primarily used to treat bacterial infections. It is used to treat various hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (like diabetic foot infections) and uterine infections. Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly.

Neopip T 4.5 gm Injection 1's contains two medicines, namely: Piperacillin (Penicillin antibiotic) and Tazobactam (beta-lactamase inhibitor). Piperacillin belongs to the class of 'Penicillin antibiotics.' It has bactericidal (ability to kill bacteria) activity against gram-positive and gram-negative aerobic (requires oxygen to survive) and anaerobic (survives with little or no oxygen) bacteria. Piperacillin acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor. Beta-lactamases are the enzymes produced by bacteria to gain multi-resistance to β-lactam antibiotics, such as penicillins and cephalosporins. Tazobactam prevents the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms. In Neopip T 4.5 gm Injection 1's, Tazobactam works by preventing bacteria from destroying Piperacillin.

Neopip T 4.5 gm Injection 1's will be administered by a healthcare professional. Like all medicines, Neopip T 4.5 gm Injection 1's also causes side effects, although not everybody gets them. Common side effects of Neopip T 4.5 gm Injection 1's include nausea, constipation, diarrhoea, headache, and trouble sleeping. If any of these effects persist or worsen, seek medical advice promptly. 

Brief your medical history to the doctor if you have any allergic reactions to antibiotics. Please inform your doctor if you have any liver, kidney diseases, bleeding disorders, and fits before using Neopip T 4.5 gm Injection 1's. Do not use Neopip T 4.5 gm Injection 1's while having vaccinations with live bacterial vaccines (typhoid vaccine) since Neopip T 4.5 gm Injection 1's may affect vaccines' activity. Neopip T 4.5 gm Injection 1's should be used during pregnancy only if the doctor advises you. It is also excreted into breast milk in small amounts. Hence, it is recommended to consult your doctor if you are pregnant or breastfeeding before taking Neopip T 4.5 gm Injection 1's. 

Uses of Neopip T 4.5 gm Injection 1's

Neopip T 4.5 gm Injection 1's is used to treat bacterial infections. The detailed uses of Neopip T 4.5 gm Injection 1's are as follows:

  • Treatment of Intra-Abdominal Infections: Neopip T 4.5 gm Injection 1's treats serious intra-abdominal infections by targeting the bacteria that cause them.
  • Respiratory Tract Infections: Neopip T 4.5 gm Injection 1's is used to treat severe respiratory infections, including pneumonia.
  • Skin and Soft Tissue Infections: Neopip T 4.5 gm Injection 1's treats complicated skin and soft tissue infections, including those from surgical wounds, bites, or diabetic foot infections.
  • Urinary tract infections: Neopip T 4.5 gm Injection 1's is also effective in treating urinary tract infections, helping to eliminate the bacteria that cause these infections.
  • Gynaecological Infections: Neopip T 4.5 gm Injection 1's is used to treat severe infections in women, including pelvic inflammatory disease and endometritis, by targeting a broad range of bacteria.

Key Benefits

Neopip T 4.5 gm Injection 1's contains two medicines, namely: Piperacillin and Tazobactam. Piperacillin is a Penicillin antibiotic. It acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor that prevents the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms. In Neopip T 4.5 gm Injection 1's, Tazobactam works by preventing bacteria from destroying Piperacillin. Thus, Neopip T 4.5 gm Injection 1's helps treat various bacterial infections of the stomach, lungs, skin and uterus.

Side effects of Neopip T 4.5 gm Injection
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • The first dose of Neopip T 4.5 gm Injection 1's will be administered by the healthcare professional.
  • The doctor may teach you how to properly use the medication by yourself.
  • Check the label for directions and use Neopip T 4.5 gm Injection 1's as advised by the doctor.
  • Do not use Neopip T 4.5 gm Injection 1's if it looks cloudy, has changed colour, or has particles in it.

How Neopip T 4.5 gm Injection 1's Works

Neopip T 4.5 gm Injection 1's contains two medicines, namely: Piperacillin (Penicillin antibiotic) and Tazobactam (beta-lactamase inhibitor). Piperacillin belongs to the class of 'Penicillin antibiotics.' It has bactericidal (ability to kill bacteria) activity against gram-positive and gram-negative aerobic (requires oxygen to survive) and anaerobic (survives with little or no oxygen) bacteria. Piperacillin acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor. Beta-lactamases are the enzymes produced by bacteria to gain multi-resistance to β-lactam antibiotics, such as penicillins and cephalosporins. Tazobactam prevents the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms. In Neopip T 4.5 gm Injection 1's, Tazobactam works by preventing bacteria from destroying Piperacillin.
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Alcohol

Caution

Avoid alcohol consumption while taking Neopip T 4.5 gm Injection 1's to prevent unpleasant side-effects, such as nausea and vomiting.

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Pregnancy

Caution

Neopip T 4.5 gm Injection 1's should be used with caution during pregnancy since it crosses the placenta in humans. Please consult your doctor before taking Neopip T 4.5 gm Injection 1's if you are pregnant or planning to conceive.

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Breast Feeding

Caution

There is limited data on how Neopip T 4.5 gm Injection 1's affects breastfed infants. Neopip T 4.5 gm Injection 1's is excreted into breast milk. Please consult your doctor before taking Neopip T 4.5 gm Injection 1's if you are breastfeeding.

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Driving

Caution

It is unknown whether Neopip T 4.5 gm Injection 1's affects your ability to drive and operating machinery. Drive only if you are physically stable and mentally focussed. If you experience dizziness or fatigue after taking Neopip T 4.5 gm Injection 1's, do not drive or operate any machinery.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Neopip T 4.5 gm Injection 1's. Your doctor will prescribe Neopip T 4.5 gm Injection 1's only if the benefits outweigh the risk.

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Kidney

Caution

Penicillin antibiotics are easily removed by dialysis. Beta-lactam antibiotics like Tazobactam should be cautiously administered in patients with renal impairment. Prolonged use of Neopip T 4.5 gm Injection 1's may cause nephrotoxicity and alterations in renal function, hence please let your doctor know if you have any history of kidney diseases before taking Neopip T 4.5 gm Injection 1's. Your doctor will prescribe Neopip T 4.5 gm Injection 1's only if the benefits outweigh the risk.

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Children

Caution

Safety and efficacy of Neopip T 4.5 gm Injection 1's in children less than two months of age have not been established.

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Heart

Caution

Exercise caution while taking Neopip T 4.5 gm Injection 1's in heart patients.

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Geriatrics

Safe if prescribed

Neopip T 4.5 gm Injection 1's can be safely given in elderly patients if recommended by the physician.

What if I have taken an overdose of Neopip T 4.5 gm Injection 1's

The overdose of Neopip T 4.5 gm Injection 1's is unlikely as it is administered by a doctor. However, in case of overdose, it may cause vomiting, nausea and diarrhoea. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Include more fibre-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, and brown rice should be included in your diet. 
  • Eating grapefruit during antibiotics treatment can prevent the body from utilizing Neopip T 4.5 gm Injection 1's properly. So, avoid intake of grapefruit or grapefruit juice with the antibiotic. 
  • Avoid intake of alcoholic beverages with Neopip T 4.5 gm Injection 1's as it can make you dehydrated and affect your sleep. This can make it more challenging for your body to aid the Neopip T 4.5 gm Injection 1's in fighting off infections.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Do not walk barefoot at places like gym showers to prevent bacterial infections. 

Have a query?

How Soon It Starts Working

The time required for Neopip T 4.5 gm Injection 1's to start to work: The time required for Neopip T 4.5 gm Injection 1's to show its action is unknown. The time for which the effects of Neopip T 4.5 gm Injection 1's last: The effect of Neopip T 4.5 gm Injection 1's lasts for 4 to 7 hours.

What if you forget to take Neopip T 4.5 gm Injection 1's

If you miss a dose of Neopip T 4.5 gm Injection 1's call your doctor for instructions.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

If you have a history of any cystic fibrosis (damaged lungs and digestive system), kidney disease, fits, colitis (inflammation of the colon), bleeding disorders, or heart or liver diseases, please inform your doctor before starting Neopip T 4.5 gm Injection 1's. Please seek medical advice if you are pregnant or breastfeeding before taking Neopip T 4.5 gm Injection 1's. Patients aged above 65 years are not at an increased risk of having side effects. However, the dosage should be adjusted if the patient has a history of renal impairment. Safety and efficacy of Neopip T 4.5 gm Injection 1's in children less than two months of age have not been established.

Drug-Drug Interactions

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Drug-Drug Interaction: Neopip T 4.5 gm Injection 1's may interact with anticoagulants (heparin), anti-cancer drugs (methotrexate), antibiotics (tobramycin, vancomycin), gout medicines (probenecid), and anaesthetic drugs (vecuronium).

Drug-Food Interaction: Avoid alcohol consumption while taking Neopip T 4.5 gm Injection 1's to prevent unpleasant side-effects, such as nausea and vomiting.

Drug-Disease Interaction: Before taking Neopip T 4.5 gm Injection 1's, let your doctor know if you have cystic fibrosis, kidney disease, fits, colitis, bleeding disorders, heart or liver diseases, and are undergoing dialysis treatment.

Piperacillin + TazobactamArgatroban
Severe
Piperacillin + TazobactamHeparin
Severe

Drug-Drug Interactions

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Piperacillin + TazobactamArgatroban
Severe
How does the drug interact with Neopip T 4.5 gm Injection:
Co-administration of Piperacillin with Argatroban will increase the level or effect of Argatroban.

How to manage the interaction:
Taking Piperacillin and Argatroban together can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Piperacillin + TazobactamHeparin
Severe
How does the drug interact with Neopip T 4.5 gm Injection:
When used together Piperacillin will raise the amount of anticoagulant (blood thinners, are chemical substances that prevent or reduce clotting of blood) effect of Heparin.

How to manage the interaction:
Although there is a possible interaction between Piperacillin and Heparin, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
Piperacillin + TazobactamBivalirudin
Severe
How does the drug interact with Neopip T 4.5 gm Injection:
Co-administration of Piperacillin with Bivalirudin will increase the level or effect of Bivalirudin by anticoagulation.

How to manage the interaction:
Taking Piperacillin and Bivalirudin together can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Piperacillin + TazobactamBCG vaccine
Severe
How does the drug interact with Neopip T 4.5 gm Injection:
Co-administration of BCG vaccine with Piperacillin may reduce the BCG vaccine activity.

How to manage the interaction:
Taking Piperacillin and BCG vaccine together can result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
Piperacillin + TazobactamCholera vaccines
Severe
How does the drug interact with Neopip T 4.5 gm Injection:
Co-administration of the Cholera vaccine with Piperacillin may reduce the Cholera vaccine activity.

How to manage the interaction:
Taking the Cholera vaccine Piperacillin and together can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Piperacillin + TazobactamVancomycin
Severe
How does the drug interact with Neopip T 4.5 gm Injection:
Co-administration of Vancomycin with Piperacillin can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Vancomycin with Piperacillin may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

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Therapeutic Class

[ANTIBIOTIC COMBINATION]

FAQs

Neopip T 4.5 gm Injection 1's is used to treat bacterial infections. It is used to treat various hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (like diabetic foot infections) and uterine infections.

Neopip T 4.5 gm Injection 1's contains Piperacillin and Tazobactam. Piperacillin inhibits bacterial cell wall synthesis, and Tazobactam prevents the bacteria from gaining resistance against Piperacillin. Thus Neopip T 4.5 gm Injection 1's helps in treating various bacterial infections.

Neopip T 4.5 gm Injection 1's should be used with proper caution and doctor consultation if you have any cystic fibrosis (damaged lungs and digestive system), kidney disease, fits, colitis (inflammation of the colon), bleeding disorders, heart or liver diseases and undergoing dialysis.

Neopip T 4.5 gm Injection 1's can affect live vaccines like typhoid vaccine and decrease their effectiveness. Please consult a doctor before you start Neopip T 4.5 gm Injection 1's if you are undergoing any vaccinations.

It is recommended to complete the course of Neopip T 4.5 gm Injection 1's even if you feel better as it is an antibiotic, and stopping it midway may lead to recurring infections. Continue taking Neopip T 4.5 gm Injection 1's for as long as your doctor has prescribed to treat your condition effectually.

Neopip T 4.5 gm Injection 1's is used to treat bacterial infections, including hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, and uterine infections.

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

  • Dr Aneela Siddabathuni

    MPharma., PhD

Last Updated

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We provide you with authentic, trustworthy and relevant information.
See our editorial policy

Country of origin

India

Manufacturer/Marketer address

No. 39, Ellan Nagar Kalapatti Main Road,Nehru Nagar West, Coimbatore- 641014
Other Info - NEO0797

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