PIPERACILLIN+TAZOBACTAM belongs to the 'Antibiotics' class of drugs, primarily used to treat bacterial infections. It is used to treat various hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (like diabetic foot infections) and uterine infections. Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly.
PIPERACILLIN+TAZOBACTAM contains two medicines, namely: Piperacillin (Penicillin antibiotic) and Tazobactam (beta-lactamase inhibitor). Piperacillin belongs to the class of 'Penicillin antibiotics.' It has bactericidal (ability to kill bacteria) activity against gram-positive and gram-negative aerobic (requires oxygen to survive) and anaerobic (survives with little or no oxygen) bacteria. Piperacillin acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor. Beta-lactamases are the enzymes produced by bacteria to gain multi-resistance to β-lactam antibiotics, such as penicillins and cephalosporins. Tazobactam prevents the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms. In PIPERACILLIN+TAZOBACTAM, Tazobactam works by preventing bacteria from destroying Piperacillin.
PIPERACILLIN+TAZOBACTAM will be administered by a healthcare professional. Like all medicines, PIPERACILLIN+TAZOBACTAM also causes side effects, although not everybody gets them. Common side effects of PIPERACILLIN+TAZOBACTAM include nausea, constipation, diarrhoea, headache, and trouble sleeping. If any of these effects persist or worsen, seek medical advice promptly.
Brief your medical history to the doctor if you have any allergic reactions to antibiotics. Please inform your doctor if you have any liver, kidney diseases, bleeding disorders, and fits before using PIPERACILLIN+TAZOBACTAM. Do not use PIPERACILLIN+TAZOBACTAM while having vaccinations with live bacterial vaccines (typhoid vaccine) since PIPERACILLIN+TAZOBACTAM may affect vaccines' activity. PIPERACILLIN+TAZOBACTAM should be used during pregnancy only if the doctor advises you. It is also excreted into breast milk in small amounts. Hence, it is recommended to consult your doctor if you are pregnant or breastfeeding before taking PIPERACILLIN+TAZOBACTAM.
Bacterial infections, hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, and uterine infections.
PIPERACILLIN+TAZOBACTAM contains two medicines, namely: Piperacillin and Tazobactam. Piperacillin is a Penicillin antibiotic. It acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor that prevents the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms. In PIPERACILLIN+TAZOBACTAM, Tazobactam works by preventing bacteria from destroying Piperacillin. Thus, PIPERACILLIN+TAZOBACTAM helps treat various bacterial infections of the stomach, lungs, skin and uterus.
If you have a history of any cystic fibrosis (damaged lungs and digestive system), kidney disease, fits, colitis (inflammation of the colon), bleeding disorders, or heart or liver diseases, please inform your doctor before starting PIPERACILLIN+TAZOBACTAM. Please seek medical advice if you are pregnant or breastfeeding before taking PIPERACILLIN+TAZOBACTAM. Patients aged above 65 years are not at an increased risk of having side effects. However, the dosage should be adjusted if the patient has a history of renal impairment. Safety and efficacy of PIPERACILLIN+TAZOBACTAM in children less than two months of age have not been established.
Drug-Drug Interaction: PIPERACILLIN+TAZOBACTAM may interact with anticoagulants (heparin), anti-cancer drugs (methotrexate), antibiotics (tobramycin, vancomycin), gout medicines (probenecid), and anaesthetic drugs (vecuronium).
Drug-Food Interaction: Avoid alcohol consumption while taking PIPERACILLIN+TAZOBACTAM to prevent unpleasant side-effects, such as nausea and vomiting.
Drug-Disease Interaction: Before taking PIPERACILLIN+TAZOBACTAM, let your doctor know if you have cystic fibrosis, kidney disease, fits, colitis, bleeding disorders, heart or liver diseases, and are undergoing dialysis treatment.
Avoid alcohol consumption while taking PIPERACILLIN+TAZOBACTAM to prevent unpleasant side-effects, such as nausea and vomiting.
PIPERACILLIN+TAZOBACTAM should be used with caution during pregnancy since it crosses the placenta in humans. Please consult your doctor before taking PIPERACILLIN+TAZOBACTAM if you are pregnant or planning to conceive.
There is limited data on how PIPERACILLIN+TAZOBACTAM affects breastfed infants. PIPERACILLIN+TAZOBACTAM is excreted into breast milk. Please consult your doctor before taking PIPERACILLIN+TAZOBACTAM if you are breastfeeding.
It is unknown whether PIPERACILLIN+TAZOBACTAM affects your ability to drive and operating machinery. Drive only if you are physically stable and mentally focussed. If you experience dizziness or fatigue after taking PIPERACILLIN+TAZOBACTAM, do not drive or operate any machinery.
Let your doctor know if you have any history of liver diseases before taking PIPERACILLIN+TAZOBACTAM. Your doctor will prescribe PIPERACILLIN+TAZOBACTAM only if the benefits outweigh the risk.
Penicillin antibiotics are easily removed by dialysis. Beta-lactam antibiotics like Tazobactam should be cautiously administered in patients with renal impairment. Prolonged use of PIPERACILLIN+TAZOBACTAM may cause nephrotoxicity and alterations in renal function, hence please let your doctor know if you have any history of kidney diseases before taking PIPERACILLIN+TAZOBACTAM. Your doctor will prescribe PIPERACILLIN+TAZOBACTAM only if the benefits outweigh the risk.
Safety and efficacy of PIPERACILLIN+TAZOBACTAM in children less than two months of age have not been established.
Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly. Bacteria occur in three basic shapes: spherical, rod and spiral-shaped. Bacteria may be gram-positive (have thick cell wall) or gram-negative (do not have a cell wall). Some common symptoms of a bacterial infection include cough, fever and tiredness.
Hospital-acquired pneumonia/ nosocomial pneumonia: It is a lower respiratory infection of the lungs that occurs during a hospital stay.
Ventilator-associated pneumonia: A lung infection occurs in people who are on mechanical ventilation breathing machines in hospitals.