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  3. Neurokem D 50/20 Capsule 10's

Neurokem D 50/20 Capsule 10's, Pack of 10
Neurokem D 50/20 Capsule 10's, Pack of 10
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Neurokem D 50/20 Capsule is used in the treatment of diabetic neuropathic pain and fibromyalgia. It contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain. Neurokem D 50/20 Capsule may cause certain side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation.

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Synonym :

DULOXETINE HYDROCHLORIDE+PREGABALIN

Composition :

DULOXETINE-20MG + PREGABALIN-50MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Neurokem D 50/20 Capsule

Neurokem D 50/20 Capsule belongs to an anticonvulsant class of medicines. It is used in the treatment of diabetic neuropathic pain and fibromyalgia. Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged. Diabetic neuropathic pain/diabetic neuropathy is a condition causing moderate to severe pain due to damage of nerves in the thigh, hip, buttock and leg regions. Symptoms may include tingling, shooting pain, burning, or even an electric shock sensation. Fibromyalgia is a chronic condition with moderate pain and tenderness all over the body resulting in fatigue and trouble sleeping.

Neurokem D 50/20 Capsule is a combination of Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.

Neurokem D 50/20 Capsule can be taken with or without food or as prescribed by your doctor. Neurokem D 50/20 Capsule may cause certain side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation. These side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist, inform your doctor.

Neurokem D 50/20 Capsule should be avoided if you are allergic to it. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, glaucoma (an eye condition), bleeding disorders, or are at risk of hyponatremia (low sodium levels, especially in patients taking diuretics or water pills). If you are pregnant or breastfeeding, inform your doctor before taking this medicine. It is not recommended for use in children and young adults as it increases the risk of suicidal tendencies. 

Uses of Neurokem D 50/20 Capsule

Neurokem D 50/20 Capsule is used to treat nerve pain. The detailed uses of Neurokem D 50/20 Capsule are as follows:<br/>• Manages diabetic nerve pain: Neurokem D 50/20 Capsule helps reduce pain caused by nerve damage due to diabetes (diabetic neuropathy).<br/>• Relieves fibromyalgia symptoms: Neurokem D 50/20 Capsule is effective in easing widespread muscle pain and tenderness seen in fibromyalgia.<br/>

Directions for Use

• Neurokem D 50/20 Capsule can be taken with or without food as advised by the doctor.• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Swallow Neurokem D 50/20 Capsule as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

Neurokem D 50/20 Capsule contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain. Neurokem D 50/20 Capsule effectively treats neuropathic pain, and improves nerve conduction for proper nerve signal functioning in the body. 

How Neurokem D 50/20 Capsule Works

Neurokem D 50/20 Capsule contains Ozenoxacin, a quinolone antibiotic medicine. It works by inhibiting the protein synthesis responsible for bacterial cell growth, thereby killing the bacteria and treating bacterial infections.

Storage

• Store in a cool and dry place away from sunlight.• Keep Neurokem D 50/20 Capsule out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Neurokem D 50/20 Capsule
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of Neurokem D 50/20 Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Neurokem D 50/20 Capsule may include autonomic instability, blurred vision, coma, confusion, diarrhoea, excessive sleepiness, muscle twitching, numbness, seizures, somnolence, speech disturbances, syncope, tachycardia, and vomiting. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Neurokem D 50/20 Capsule should be avoided if you are allergic to any of the components in it. Do not stop taking Neurokem D 50/20 Capsule suddenly without your doctor’s advice, as it may cause withdrawal symptoms like dizziness, tingling sensation, sleep disturbances, restlessness, nausea or vomiting, headache, or excessive sweating. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, or glaucoma (an eye condition). Neurokem D 50/20 Capsule may increase suicidal thoughts, so it is advised to use caution in patients with mania, bipolar disorder or depression. It is not recommended for use in children below 18 years of age as the safety and efficacy of this medicine are not established. Pregnant or breastfeeding mothers should inform the doctor before using Neurokem D 50/20 Capsule .

Drug-Drug Interactions

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DuloxetineLinezolid
Critical
DuloxetineMetoclopramide
Critical

Drug-Drug Interactions

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DuloxetineLinezolid
Critical
How does the drug interact with Neurokem D 50/20 Capsule:
Taking Neurokem D 50/20 Capsule with Linezolid can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking Neurokem D 50/20 Capsule with Linezolid is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting a doctor.
DuloxetineMetoclopramide
Critical
How does the drug interact with Neurokem D 50/20 Capsule:
Coadministration of metoclopramide with Neurokem D 50/20 Capsule increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Metoclopramide with Neurokem D 50/20 Capsule is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
DuloxetineRasagiline
Critical
How does the drug interact with Neurokem D 50/20 Capsule:
Taking Rasagiline with Neurokem D 50/20 Capsule can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Rasagiline and Neurokem D 50/20 Capsule is not recommended as they can possibly result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DuloxetineTranylcypromine
Critical
How does the drug interact with Neurokem D 50/20 Capsule:
Taking Tranylcypromine with Neurokem D 50/20 Capsule can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Neurokem D 50/20 Capsule is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineEliglustat
Critical
How does the drug interact with Neurokem D 50/20 Capsule:
Coadministration of eliglustat and Neurokem D 50/20 Capsule can significantly increase the blood levels of eliglustat. This may increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Neurokem D 50/20 Capsule with Eliglustat is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, or weak pulse. Do not discontinue any medications without consulting your doctor.
DuloxetinePhenelzine
Critical
How does the drug interact with Neurokem D 50/20 Capsule:
Taking phenelzine with Neurokem D 50/20 Capsule can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Neurokem D 50/20 Capsule with Phenelzine is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineSelegiline
Critical
How does the drug interact with Neurokem D 50/20 Capsule:
Taking Neurokem D 50/20 Capsule with selegiline may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Although there is an interaction between Neurokem D 50/20 Capsule and Selegiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineProcarbazine
Critical
How does the drug interact with Neurokem D 50/20 Capsule:
Taking Neurokem D 50/20 Capsule with procarbazine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Neurokem D 50/20 Capsule with Procarbazine is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineSafinamide
Critical
How does the drug interact with Neurokem D 50/20 Capsule:
Coadministration of safinamide with Neurokem D 50/20 Capsule can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Safinamide with Neurokem D 50/20 Capsule is not recommended as it can result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
PregabalinBuprenorphine
Severe
How does the drug interact with Neurokem D 50/20 Capsule:
Using Neurokem D 50/20 Capsule together with Buprenorphine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Buprenorphine and Neurokem D 50/20 Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in- judgment, reaction speed and motor coordination, consult the doctor immediately. Avoid driving or operating dangerous machinery. Do not exceed the doses, frequency, or duration of usage advised by the doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercise regularly, which helps in reducing pain.
  • Rest well, and get enough sleep.
  • Always take a warm bath, as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity, and improve coping skills.

Habit Forming

Yes

Therapeutic Class

ANTICONVULSANT

Neurokem D 50/20 Capsule Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid alcohol consumption during treatment with $nmae as it may increase the risk of serious side effects and worsen your health.

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Pregnancy

Caution

If you are pregnant, especially in the last trimester or planning pregnancy, inform your doctor before taking Neurokem D 50/20 Capsule . It may cause foetal abnormalities if taken in the last trimester of pregnancy. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before taking Neurokem D 50/20 Capsule . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Neurokem D 50/20 Capsule may cause drowsiness. Hence, avoid driving vehicles or operating machines after taking Neurokem D 50/20 Capsule .

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Liver

Caution

If you have liver conditions, inform your doctor before taking Neurokem D 50/20 Capsule . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Kidney

Caution

If you have kidney conditions, inform your doctor before taking Neurokem D 50/20 Capsule . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Children

Unsafe

Neurokem D 50/20 Capsule is not recommended for children below 18 years as the safety and efficacy of use for this medicine are not established. Please seek medical advice for more information.

Have a query?

FAQs

Neurokem D 50/20 Capsule is used in the treatment of diabetic neuropathic pain and fibromyalgia. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.

Do not stop using Neurokem D 50/20 Capsule suddenly as it can cause withdrawal symptoms. Your doctor will gradually reduce the dose based on your clinical condition.

Seek medical attention immediately if you notice any depressive thoughts while using Neurokem D 50/20 Capsule . Your doctor may change the dose or medicine to treat your condition.

Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged.

Neurokem D 50/20 Capsule contains Pregabalin and Duloxetine. Pregabalin is an anticonvulsant drug, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. Both medicines mainly work by increasing the chemical messengers in the brain responsible for regulating pain.

To manage weight gain associated with the use of Neurokem D 50/20 Capsule , maintain a balanced diet and engage in regular exercise. Use the lowest effective dose to help reduce the chances of gaining weight. Keep track of your weight and consult your doctor if you notice significant changes. They can help adjust your treatment or suggest ways to manage your weight more effectively.

Neurokem D 50/20 Capsule may cause sleepiness or drowsiness in some individuals as a mild side effect. If you experience these symptoms, it is important to avoid activities that require full alertness, such as driving or operating machinery. If drowsiness persists for a longer period, please consult your doctor.

Neurokem D 50/20 Capsule may take several weeks or longer to show its full effects. While some patients may notice improvements within the first week, it is important to continue taking the medication as prescribed to achieve the full benefits. Your doctor will likely reduce your dose gradually to avoid withdrawal symptoms.

If you forget to take Neurokem D 50/20 Capsule , take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.

No, taking a higher dose of Neurokem D 50/20 Capsule than recommended will not necessarily make it more effective and may increase the risk of side effects. Additionally, it can become habit-forming if misused or taken in larger amounts than prescribed for a prolonged period, leading to dependence. If you feel your current dose is not effective, please consult your doctor for proper adjustments, rather than increasing the dose on your own.

It is not recommended to drink alcohol while taking Neurokem D 50/20 Capsule , as it may increase the risk of side effects such as drowsiness and dizziness. These effects impair your ability to perform tasks that require focus, so avoid driving or operating machinery while taking Neurokem D 50/20 Capsule . Always consult your doctor for personalized advice.

Neurokem D 50/20 Capsule should typically be stored in a cool and dry place, away from direct sunlight and moisture. Keep it out of reach of children.

Neurokem D 50/20 Capsule may cause common side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation. These side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist or worsen, please inform your doctor.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - NEU1080

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:03 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.larenon.com/wp-content/uploads/2022/11/PBREN-D-LBL.pdf
  2. https://www.sciencedirect.com/science/article/pii/S0304395913002856
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127557/
  4. https://medlineplus.gov/druginfo/meds/a604030.html
  5. https://medlineplus.gov/druginfo/meds/a605045.html

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