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compositionComposition:LAMIVUDINE-150MG+NEVIRAPINE-200MG+STAVUDINE-40MG
prescription
Prescription Medicine
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Nevilast 40 mg Tablet is used to treat HIV infection. It works by inhibiting the reverse transcriptase enzyme which is required for viral reproduction. In some cases, this medicine may cause side effects such as headache, difficulty sleeping, nausea, diarrhoea, dry mouth, fever, and peripheral neuropathy (tingling and numbness of feet and hands). Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LAMIVUDINE-150MG+NEVIRAPINE-200MG+STAVUDINE-40MG

Manufacturer/Marketer :

Genix Lifescience Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nevilast 40 mg Tablet

Nevilast 40 mg Tablet is a combination prescription medicine used to treat HIV-1 infection. Because it contains stavudine, this regimen is now considered a legacy or alternative treatment in many countries due to its higher risk of long-term side effects. Current HIV treatment guidelines generally recommend newer tenofovir-based combinations as preferred first-line therapy. Your doctor will determine whether this medicine is appropriate for your individual treatment needs.

It belongs to a class of antiviral drugs that work together to lower the amount of HIV in the blood and strengthen the body’s immune system. By keeping the virus from multiplying, this medicine helps prevent the development of severe opportunistic infections and other complications associated with HIV.

To achieve the best results, you must take Nevilast 40 mg Tablet consistently at regular intervals. Your doctor will typically instruct you to take this medicine twice daily, and it can be taken with or without food. Along with taking this medication regularly, maintaining a healthy lifestyle, eating a balanced diet, and avoiding high-risk habits are essential steps to support your immune system and overall health.

While taking Nevilast 40 mg Tablet , some patients may experience mild side effects, but serious issues can also occur. It is vital to monitor your body closely and contact your doctor immediately if you notice signs of liver damage, severe skin reactions, or nerve pain. Regular blood tests and clinical check-ups are necessary to ensure the medicine is working safely and effectively.

Do not take this if you have a history of severe liver problems, pancreas issues, or severe nerve damage. Before you start using Nevilast 40 mg Tablet , tell your doctor about all your medical conditions, especially if you have kidney disease, a history of alcohol abuse, or pre-existing nerve pain in your limbs. This medicine may not be suitable for everyone, and your healthcare provider will evaluate if it is safe for you.

Nevilast 40 mg Tablet can interact with several other medications, including certain antibiotics, antifungals, and other antiviral drugs, which can alter its effectiveness or increase side effects. Drinking alcohol while taking this medicine significantly increases your risk of severe liver damage and pancreas problems, so it should be avoided entirely. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly patient, talk to your doctor or pharmacist to discuss the risks and benefits before starting treatment.

Uses of Nevilast 40 mg Tablet

Your doctor may prescribe this medicine to treat several conditions, including:

  • HIV-1 Infection: Nevilast 40 mg Tablet may be prescribed in selected situations to manage HIV-1 infection when considered appropriate by your healthcare provider. Because it contains stavudine, newer antiretroviral combinations are generally preferred as first-line treatment in current clinical guidelines 

Key Benefits

Nevilast 40 mg Tablet helps control HIV infection by reducing the amount of virus in the body and supporting your immune system. The combination of three antiretroviral medicines in a single tablet simplifies treatment and helps improve long-term treatment success. Key benefits include:

  • Suppresses HIV Replication: This medication reduces the amount of HIV in your body (viral load), helping protect your immune system and lowering the risk of HIV-related illnesses. It controls HIV infection but does not cure it.
  • Supports Long-Term Immune Health: By keeping the virus under control, this medication helps maintain immune function, allowing you to stay healthier, reduce the risk of progressing to AIDS, and improve your overall quality of life.
  • Simplifies Daily Treatment: Combining three antiretroviral medicines into one tablet reduces pill burden, making it easier to take your medication consistently. Good adherence helps maintain viral suppression and reduces the risk of the virus developing resistance.
Side effects of Nevilast 40 mg Tablet
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Maintain good oral hygiene.
  • Rinsing with salt water may also help relieve mouth ulcers.
  • Avoid foods that cause inflammation like spicy, salty or sugary foods.
  • Eat soft foods like yoghurt, apple sauce, and mashed potatoes.
  • Drink enough fluids.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.

Directions for Use

  • Nevilast 40 mg Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow Nevilast 40 mg Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Nevilast 40 mg Tablet Works

Nevilast 40 mg Tablet combines three antiretroviral medicines that inhibit HIV replication through complementary mechanisms. Stavudine and lamivudine are both nucleoside reverse transcriptase inhibitors (NRTIs) that interfere with viral DNA synthesis by causing premature DNA chain termination, while nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds to a different site on the same reverse transcriptase enzyme, preventing it from functioning. Together, these medicines effectively suppress HIV replication. The first component, stavudine, belongs to a group called nucleoside reverse transcriptase inhibitors (NRTIs). Once inside infected cells, it mimics the natural genetic building blocks of the virus. When the virus tries to use this fake building block to copy its genetic code, the process is blocked, stopping the virus from multiplying. The second component, lamivudine, is also an NRTI. It works similarly by inserting itself into the growing viral DNA chain, which causes the chain to break prematurely. This halts the replication of viral genetic material, preventing the virus from spreading to new cells. The third component, nevirapine, is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Instead of mimicking building blocks, nevirapine directly binds to the reverse transcriptase enzyme, the tool the virus uses to copy itself. By locking this enzyme, nevirapine stops it from functioning, shutting down the replication process. Together, these three components work synergistically to keep the virus under tight control.
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Alcohol

Caution

Avoid drinking alcohol while on Nevilast 40 mg Tablet as it may increase the risk of liver damage.

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Pregnancy

Caution

Nevilast 40 mg Tablet should be used with caution in pregnant women. It is given only if clinically needed and when benefits outweigh the risk.

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Breast Feeding

Caution

If Nevilast 40 mg Tablet is prescribed during breastfeeding, the doctor may advise you to stop breastfeeding as this medicine can pass into breast milk.

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Driving

Caution

Nevilast 40 mg Tablet may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Nevilast 40 mg Tablet should be used with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Nevilast 40 mg Tablet should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Caution

Dose adjustment may be necessary for use in children when prescribed by a child specialist.

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Heart

Caution

Nevilast 40 mg Tablet should be taken with extreme caution in patients with heart disease. Please consult your physician.

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Geriatrics

Caution

Nevilast 40 mg Tablet should be used with extreme caution in elderly patients due to an increased risk of adverse effects. Dose adjustments maybe needed in some patients.

What if I have taken an overdose of Nevilast 40 mg Tablet

In case of an accidental overdose, seek emergency medical attention or contact a poison control centre immediately. Watch closely for severe side effects like extreme fatigue, breathing difficulties, or severe nausea, and provide the medical team with details of the exact amount taken.

Diet & Lifestyle Advise

  • Avoid alcohol completely: Alcohol significantly increases your risk of developing severe liver damage and pancreas inflammation while taking this medicine.
  • Eat a nutrient-rich diet: Focus on balanced meals with lean proteins, whole grains, and healthy fats to support your immune system and prevent muscle loss.
  • Practice strict food hygiene: Wash all fresh produce thoroughly and ensure meats, poultry, and eggs are fully cooked to lower your risk of foodborne infections while your immune system is recovering.
  • Stay well-hydrated: Drink plenty of water throughout the day to help your kidneys safely process and eliminate the medication.
health query

Have a query?

How Soon It Starts Working

The time required for Nevilast 40 mg Tablet to start to work: Nevilast 40 mg Tablet ideally starts to show its action within 1 to 2 hours of administration. The time for which the effects of Nevilast 40 mg Tablet last: The effect of Nevilast 40 mg Tablet lasts for 12 to 24 hours.

What if you forget to take Nevilast 40 mg Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one. Keeping a consistent schedule is crucial to prevent the virus from becoming resistant to Nevilast 40 mg Tablet .

Storage

• Store Nevilast 40 mg Tablet tablets at room temperature, ideally between 15°C and 30°C (59°F to 86°F). • Keep the container tightly closed and store it in a dry place.

Drug Warnings

  • Watch for skin reactions: Check your skin regularly during the first 6–8 weeks of treatment. Contact your doctor immediately if you develop a rash, especially if it is accompanied by fever, blisters, or mouth sores.
  • Attend regular monitoring: Keep all scheduled appointments for blood tests so your doctor can monitor your liver function and overall response to treatment.
  • Do not stop treatment on your own: Continue taking Nevilast 40 mg Tablet exactly as prescribed. Stopping treatment suddenly can increase the amount of virus in your body and promote drug resistance.
  • Never miss doses: Always keep an adequate supply of your medication, especially when travelling, and take it at the same time every day to maintain effective viral suppression.
  • Inform your healthcare provider: Tell your doctor, dentist, or pharmacist that you are taking Nevilast 40 mg Tablet before starting any new medicines or undergoing any medical or dental procedures.
  • Discuss your treatment options regularly: Because stavudine-containing regimens are no longer preferred in current HIV treatment guidelines due to their higher risk of long-term side effects, ask your doctor whether switching to a newer first-line antiretroviral regimen is appropriate for you. This should only be done under medical supervision.

Drug-Drug Interactions

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Inform your doctor about all the medicines you are using before using this, as they may interact with Nevilast 40 mg Tablet and affect your treatment.

  • Rifampicin: May significantly lower the levels of nevirapine in your blood, making Nevilast 40 mg Tablet much less effective against the virus.
  • Other antiretroviral drugs: Avoid taking other medicines that contain the same active ingredients (stavudine, lamivudine, or nevirapine) to prevent serious toxic build-up.
  • Medicines that cause nerve damage: Combining Nevilast 40 mg Tablet with drugs known to cause nerve pain can increase the severity of tingling, numbness, and burning in your hands and feet.
Lamivudine + Nevirapine + StavudineRanolazine
Critical
Lamivudine + Nevirapine + StavudineEmtricitabine
Critical

Drug-Drug Interactions

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Lamivudine + Nevirapine + StavudineRanolazine
Critical
How does the drug interact with Nevilast 40 mg Tablet:
Co-administration of ranolazine with nevirapine may lower ranolazine blood levels, reducing its effectiveness.

How to manage the interaction:
Although there is an interaction between nevirapine and ranolazine, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Lamivudine + Nevirapine + StavudineEmtricitabine
Critical
How does the drug interact with Nevilast 40 mg Tablet:
Coadministration of lamivudine with emtricitabine may reduce the overall effectiveness of both medications.

How to manage the interaction:
Although there is an interaction between emtricitabine and lamivudine, it can be taken if a doctor prescribes it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Lamivudine + Nevirapine + StavudineAtazanavir
Critical
How does the drug interact with Nevilast 40 mg Tablet:
Taking atazanavir with nevirapine can decrease the blood levels and effects of atazanavir and increase the nevirapine levels and effects in the blood.

How to manage the interaction:
Although there is an interaction between nevirapine and atazanavir, it can be taken if your doctor has advised it. However, if you experience a rash on any parts of your body, less desire to eat, nausea, vomiting, jaundice (yellowing of the skin and/or eyes), dark-coloured urine, pale-coloured stools, or pain or ache in the right abdominal area below your ribs, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Lamivudine + Nevirapine + StavudineVoclosporin
Severe
How does the drug interact with Nevilast 40 mg Tablet:
Coadministration of nevirapine with voclosporin may decrease the effectiveness of voclosporin in treating your condition due to lowered blood levels.

How to manage the interaction:
Although there is an interaction between nevirapine and voclosporin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Lamivudine + Nevirapine + StavudineDaclatasvir
Severe
How does the drug interact with Nevilast 40 mg Tablet:
Taking nevirapine with daclatasvir may lower daclatasvir blood levels, reducing effectiveness in treating your condition.

How to manage the interaction:
Although there is an interaction between daclatasvir and nevirapine, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Lamivudine + Nevirapine + StavudineDolutegravir
Severe
How does the drug interact with Nevilast 40 mg Tablet:
Taking nevirapine with dolutegravir can lower blood levels and effectiveness of dolutegravir.

How to manage the interaction:
Although there is an interaction between dolutegravir and nevirapine, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Lamivudine + Nevirapine + StavudineCariprazine
Severe
How does the drug interact with Nevilast 40 mg Tablet:
Taking cariprazine with nevirapine can lower blood levels of cariprazine, reducing its effectiveness.

How to manage the interaction:
Although there is an interaction between cariprazine and nevirapine, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Lamivudine + Nevirapine + StavudineTeriflunomide
Severe
How does the drug interact with Nevilast 40 mg Tablet:
Coadministration of nevirapine and teriflunomide can increase the risk and severity of liver problems.

How to manage the interaction:
Although there is an interaction between nevirapine and teriflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-coloured urine, or bleeding, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Lamivudine + Nevirapine + StavudineBexarotene
Severe
How does the drug interact with Nevilast 40 mg Tablet:
Taking bexarotene with Nevilast 40 mg Tablet increases the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Although there is an interaction between Nevilast 40 mg Tablet and bexarotene, they can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, or abdominal pain, contact a doctor right away. Do not discontinue any medications without consulting your doctor.
Lamivudine + Nevirapine + StavudineSimeprevir
Severe
How does the drug interact with Nevilast 40 mg Tablet:
Taking simeprevir and nevirapine together can reduce simeprevir effectiveness by lowering its blood levels.

How to manage the interaction:
Although there is an interaction between nevirapine and simeprevir, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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  • Alcohol: Avoid alcohol entirely, as it severely increases the risk of life-threatening pancreas inflammation and liver damage.
LAMIVUDINE-150MG+NEVIRAPINE-200MG+STAVUDINE-40MGHigh fat foods
Mild

Drug-Food Interactions

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LAMIVUDINE-150MG+NEVIRAPINE-200MG+STAVUDINE-40MGHigh fat foods
Mild
Common Foods to Avoid:
Frozen Meals, Cheese, Red Meat, Potato Chips, Hamburgers, Hot Dogs, Ice Cream

How to manage the interaction:
Taking Nevilast 40 mg Tablet with high fatty foods can reduce the effectiveness of Nevilast 40 mg Tablet Avoid taking high-fat food while taking Nevilast 40 mg Tablet, as this can lead to interaction.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIRETROVIRAL AGENTS]

FAQs

Nevilast 40 mg Tablet is used to treat HIV infection.
Nevilast 40 mg Tablet is a combination of three medicines: Stavudine, lamivudine and nevirapine. These three drugs work by inhibiting the reverse transcriptase enzyme from working, which is required by the HIV-infected cells to make new viruses. Thereby preventing viral replication and controlling the infection.
Nevilast 40 mg Tablet may cause side-effects such as muscle pain and discomfort, difficulty in sleeping, stomach pains, allergic reactions, feeling sick, vomiting, inflammation of the liver, changes in the shape or location of body fat. Inform your doctor if any of these side-effects persist or get worse.
Nevilast 40 mg Tablet may cause lactic acidosis (excess of lactic acid in the blood), a rare but a severe side effect, especially in women who are very obese. However, if you experience stomach pain, vomiting or nausea while taking Nevilast 40 mg Tablet , please consult a doctor immediately.
Nevilast 40 mg Tablet doesn’t cure HIV infection. However, it helps to control the disease and prevent opportunistic infections.
No, Nevilast 40 mg Tablet should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.
If you miss a dose of Nevilast 40 mg Tablet , take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.
Do not stop taking Nevilast 40 mg Tablet without talking to your doctor. If you suddenly stop taking Nevilast 40 mg Tablet , you may experience confusion, fever, mental state changes or severe muscle stiffness. Your doctor will probably decrease your dose gradually depending upon your disease condition.
No, you must avoid alcohol while taking this medicine. Alcohol significantly increases your risk of developing severe, potentially life-threatening liver damage and pancreas inflammation. Talk to your doctor if you find it difficult to avoid alcohol.
If you notice any rash, especially during the first few weeks of treatment, contact your doctor immediately. Some rashes can be severe or life-threatening. Do not take any new medicines for the rash without professional medical advice.
You should only take this medicine during pregnancy if your doctor determines the benefits outweigh the risks. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor immediately to discuss safe treatment options.
No, you can take Nevilast 40 mg Tablet with or without food. However, it is important to take it at the same times every day to keep a consistent level of the medicine in your body. Talk to your doctor or pharmacist if you experience stomach upset.
Watch for yellowing of your skin or eyes, dark-colored urine, light-colored stools, severe nausea, vomiting, or pain in the upper right side of your stomach. If you experience any of these symptoms, contact your doctor right away.
No, you must never share your medication with anyone else. Prescriptions are highly individualised based on weight, medical history, and specific lab results. Sharing this medicine can cause severe harm or treatment failure in others.

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Country of origin

INDIA

Manufacturer/Marketer address

2Nd Floor, 8-3-166/7/1 Erragadda, Hyderabad-500018
Other Info - NEV0001
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