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compositionComposition:GLIMEPIRIDE-2MG+METFORMIN-500MG+PIOGLITAZONE-15MG
prescriptionPrescription Medicine
Nexgem Plus Tablet 10's

Nexgem Plus Tablet is used to treat type 2 diabetes. It works by reducing sugar production in the liver, delaying sugar absorption from the intestines, and removing sugar from the blood. In some cases, this medicine may cause side effects such as stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLIMEPIRIDE-2MG+METFORMIN-500MG+PIOGLITAZONE-15MG

Manufacturer/Marketer :

Nextel Pharma

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nexgem Plus Tablet

Nexgem Plus Tablet belongs to a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a chronic (long-lasting) condition that affects the way our body processes glucose.

Nexgem Plus Tablet contains Glimepiride, Metformin, and Pioglitazone. Glimepiride lowers blood sugar by causing the pancreas to produce insulin. Metformin reduces the production of sugar in the liver and delays sugar absorption from the intestines. Pioglitazone increases the body's sensitivity to insulin. Thereby, Nexgem Plus Tablet helps to control blood sugar levels.

In some cases, you may experience stomach pain, nausea, diarrhoea, vomiting, headache, a metallic taste, or low blood sugar. Most of these side effects of Nexgem Plus Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Nexgem Plus Tablet or any other medicines, please tell your doctor. Nexgem Plus Tablet is not recommended for children. Consult your doctor if you are breastfeeding, pregnant or planning for pregnancy. Avoid alcohol consumption with Nexgem Plus Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Uses of Nexgem Plus Tablet

Nexgem Plus Tablet is used in the treatment of type 2 diabetes mellitus. The detailed uses of Nexgem Plus Tablet are as follows:

  • Manages Type 2 Diabetes Mellitus: Nexgem Plus Tablet to treat type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.
  • Reduces Risk of Diabetes-Related Complications: By effectively controlling blood sugar levels, Nexgem Plus Tablet helps reduce the risk of long-term complications such as neuropathy and cardiovascular disease.

Have a query?

Directions for Use

  • Nexgem Plus Tablet can be taken with food to avoid stomach upset or as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Nexgem Plus Tablet as a whole with a glass of water.
  • Do not chew, crush or break it.

Key Benefits

  • Nexgem Plus Tablet is effective in controlling blood sugar levels in people with Type 2 Diabetes.
  • It combines three complementary antidiabetic agents to provide comprehensive glycemic control when diet, exercise, or monotherapy is insufficient.
  • Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood.
  • Metformin works by reducing the sugar production by cells in the liver and delaying sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin, which enables these cells to remove sugar more effectively from the blood.
  • Pioglitazone works by increasing the sensitivity of liver, muscle and fat cells to insulin and enabling them to remove glucose from the blood more effectively.
  • This medicine ensures long-lasting glycaemic control, reducing the frequency of dosage. It also prevents unnecessary sugar spikes.
  • Nexgem Plus Tablet manages blood glucose levels, thereby lowering the risk of complications such as nerve problems, kidney problems, eye problems, and cardiovascular disease.

How Nexgem Plus Tablet Works

Nexgem Plus Tablet contains Glimepiride, Metformin, and Pioglitazone. Glimepiride lowers blood sugar by causing the pancreas to produce insulin. Metformin reduces the production of sugar in the liver and delays sugar absorption from the intestines. Pioglitazone increases the body's sensitivity to insulin. Thereby, Nexgem Plus Tablet helps to control blood sugar levels.

Storage

Store in a cool and dry place away from sunlight
Side effects of Nexgem Plus Tablet
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Nexgem Plus Tablet

Take Nexgem Plus Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include loss of consciousness, lactic acidosis (buildup of lactic acid in the blood), and pancreatitis (inflammation of the pancreas). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • If you are allergic to Nexgem Plus Tablet or any other medicines, please tell your doctor.
  • Nexgem Plus Tablet is not recommended for children.
  • Avoid breastfeeding while taking Nexgem Plus Tablet as it may be excreted in human milk.
  • If you are pregnant or planning for pregnancy, please inform your doctor before taking Nexgem Plus Tablet as it may harm the unborn baby.
  • Nexgem Plus Tablet should be used with caution in elderly patients.
  • Avoid alcohol consumption with Nexgem Plus Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).
  • Drive only if you are alert after taking Nexgem Plus Tablet .
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

verifiedApollotooltip
MetforminIopydol
Critical
MetforminIoversol
Critical

Drug-Drug Interactions

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MetforminIopydol
Critical
How does the drug interact with Nexgem Plus Tablet:
Co-administration of Iopydol with Nexgem Plus Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Nexgem Plus Tablet with Iopydol is not recommended, please consult your doctor before taking it.
MetforminIoversol
Critical
How does the drug interact with Nexgem Plus Tablet:
Co-administration of Ioversol with Nexgem Plus Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Nexgem Plus Tablet with Ioversol is not recommended, please consult your doctor before taking it.
MetforminIoxitalamic acid
Critical
How does the drug interact with Nexgem Plus Tablet:
Co-administration of Nexgem Plus Tablet and Ioxitalamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Nexgem Plus Tablet with Ioxitalamic acid is not recommended, please consult your doctor before taking it.
MetforminIopromide
Critical
How does the drug interact with Nexgem Plus Tablet:
Co-administration of Iopromide with Nexgem Plus Tablet can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with Nexgem Plus Tablet is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
MetforminIocetamic acid
Critical
How does the drug interact with Nexgem Plus Tablet:
Co-administration of Nexgem Plus Tablet and Iocetamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Nexgem Plus Tablet with Iocetamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIodamide
Critical
How does the drug interact with Nexgem Plus Tablet:
Co-administration of Nexgem Plus Tablet and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Nexgem Plus Tablet with Iodamide is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIobitridol
Critical
How does the drug interact with Nexgem Plus Tablet:
Co-administration of Nexgem Plus Tablet and Iobitridol can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Nexgem Plus Tablet with Iobitridol is generally avoided as it can result in an interaction. Please consult your doctor before taking it.
MetforminIopanoic acid
Critical
How does the drug interact with Nexgem Plus Tablet:
Co-administration of Iopanoic acid with Nexgem Plus Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Nexgem Plus Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.
MetforminIopamidol
Critical
How does the drug interact with Nexgem Plus Tablet:
Co-administration of Iopamidol with Nexgem Plus Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Nexgem Plus Tablet with Iopamidol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIopentol
Critical
How does the drug interact with Nexgem Plus Tablet:
Co-administration of Iopentol with Nexgem Plus Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Nexgem Plus Tablet with Iopentol is not recommended, please consult your doctor before taking it.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
  • Maintain a healthy body weight, as obesity is also related to the onset of diabetes.
  • Maintain a low-fat and low-sugar diet. Replace carbohydrate-containing foods with whole grains, fruits and vegetables, as carbohydrates turn to sugars, leading to high blood sugar.
  • Avoid consumption of alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Nexgem Plus Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

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Pregnancy

Unsafe

Nexgem Plus Tablet is not recommended for pregnant women as it may harm an unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Nexgem Plus Tablet as it may be excreted in breastmilk and cause adverse effects in the baby. Therefore, please consult a doctor before using Nexgem Plus Tablet if you are breastfeeding.

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Driving

Caution

Nexgem Plus Tablet may decrease alertness in some people. Therefore, drive only if you are alert after taking Nexgem Plus Tablet .

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Liver

Caution

Take Nexgem Plus Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Nexgem Plus Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Nexgem Plus Tablet is not recommended for children as the safety and effectiveness were not established.

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Heart

Nexgem Plus Tablet should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Nexgem Plus Tablet .

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Geriatrics

Caution

Nexgem Plus Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Nexgem Plus Tablet .

FAQs

Nexgem Plus Tablet is used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.

Nexgem Plus Tablet contains Glimepiride, Metformin, and Pioglitazone. Glimepiride lowers blood sugar by causing the pancreas to produce insulin. Metformin reduces the production of sugar in the liver and delays sugar absorption from the intestines. Pioglitazone increases the body's sensitivity to insulin. Thereby, Nexgem Plus Tablet helps to control blood sugar levels.

Nexgem Plus Tablet may increase the risk of low blood sugar levels, especially with alcohol intake, when you exercise more than usual, delay or miss snacks or meals. However, if you experience any signs of low blood pressure such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.

You are not recommended to take Nexgem Plus Tablet with pregabalin as it may cause weight gain and fluid retention that could lead to heart failure. However, please consult a doctor before using Nexgem Plus Tablet with other medicines.

In type 1 diabetes, the body does not produce insulin as the islet cells (insulin-producing cells) in the pancreas are completely destroyed. In type 2 diabetes, though islet cells are working, the body does not respond to insulin as the body becomes resistant to it.

You are not recommended to stop taking Nexgem Plus Tablet on your own, as discontinuing Nexgem Plus Tablet suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Nexgem Plus Tablet , please consult your doctor so that alternative medicine may be prescribed.

Yes, Nexgem Plus Tablet may cause stomach upset as a side effect. Drink water/fluids in small, frequent amounts and chew the food properly while eating.

You are recommended to avoid consumption of alcohol with Nexgem Plus Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Inform the doctor if you are taking any other medicines, have any other medical conditions, and if you are pregnant or breastfeeding.

Yes, Nexgem Plus Tablet may lead to vitamin B12 deficiency, particularly on long-term use. Consult the doctor if you experience symptoms of vitamin b12 deficiency such as headache, loss of appetite, fatigue, mental impairment, pins and needle sensation, and pale skin.

Store Nexgem Plus Tablet at room temperature, in a dry place. Keep out of sight and reach of children.

Nexgem Plus Tablet may cause side effects like stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. If the side effects persist or worsen, please consult your doctor.

Country of origin

India
Other Info - NEX0297

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Nov 18, 2025 | 7:29 AM IST

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