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compositionComposition:LUMATEPERONE-42MG
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Nexluma Capsule 10's is a prescription medicine used to treat schizophrenia and depressive episodes associated with bipolar disorder (bipolar depression) in adults. This medicine helps reduce symptoms such as hallucinations, unusual beliefs, sadness, low energy, and difficulty thinking clearly.

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Written By Dr. Yarragunta Lakshmi Thulasi , Pharm D (PB)
Reviewed By Dr. Aneela S , PhD, M Pharmacy
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More about the Product

Composition :

LUMATEPERONE-42MG

Manufacturer/Marketer :

Shine Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Nexluma Capsule 10's

Nexluma Capsule 10's is an oral prescription medicine primarily used to treat schizophrenia in adults. It is also approved for the treatment of depressive episodes associated with bipolar I or bipolar II disorder (bipolar depression), either alone or in combination with lithium or valproate in some regions, depending on local prescribing guidelines.

Nexluma Capsule 10's works by balancing the activity of certain natural chemicals (neurotransmitters), including dopamine, serotonin, and glutamate, in the brain. This helps improve symptoms such as hallucinations, delusions, disorganized thinking, depressed mood, and emotional instability.

For the best results, take Nexluma Capsule 10's exactly as prescribed by your doctor, preferably at the same time every day. It should be taken with food (at least 350 calories) to ensure proper absorption. Continue taking the medicine even if you begin to feel better, as stopping treatment suddenly may increase the risk of symptom recurrence.

Common side effects include sleepiness, dizziness, fatigue, dry mouth, and nausea. These are generally mild and improve as your body adjusts to the medicine. However, seek immediate medical attention if you develop severe muscle stiffness, high fever, confusion, seizures, uncontrolled body movements, or signs of a severe allergic reaction.

Before starting Nexluma Capsule 10's, tell your doctor if you have liver disease, heart disease, low blood pressure, diabetes, high cholesterol, seizures, dementia, or a history of stroke. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Nexluma Capsule 10's may interact with certain medicines that affect liver enzymes or cause drowsiness. Avoid alcohol during treatment because it may worsen dizziness and sleepiness.

Uses of Nexluma Capsule 10's

Nexluma Capsule 10's is used in the treatment of schizophrenia and depressive episodes associated with bipolar I or II disorder. The detailed uses of Nexluma Capsule 10's are as follows:

  • Schizophrenia: Nexluma Capsule 10's helps reduce symptoms such as hallucinations, delusions, disorganised thoughts, and social withdrawal, allowing people with schizophrenia to function better in daily life.
  • Bipolar depression: Nexluma Capsule 10's helps improve depressive symptoms associated with bipolar I or bipolar II disorder, including sadness, loss of interest, fatigue, sleep disturbances, and impaired concentration.

Key Benefits

Nexluma Capsule 10's helps restore the balance of brain chemicals involved in mood, thinking, and behaviour. It can improve overall functioning while having a relatively lower tendency to cause movement disorders or significant weight gain compared with some older antipsychotic medicines. Benefits may include:

  • Reduces psychotic symptoms: Helps control hallucinations, delusions, and disorganised thinking.
  • Improves mood: Reduces depressive symptoms associated with bipolar disorder.
  • Supports daily functioning: Helps improve concentration, motivation, and social interactions.
  • Lower risk of movement problems: Compared with many traditional antipsychotics, Nexluma Capsule 10's generally has a lower risk of causing extrapyramidal symptoms.
  • May have a favourable metabolic profile: May cause less weight gain and fewer metabolic changes than some other atypical antipsychotics, although monitoring is still important.

Directions for Use

  • Take Nexluma Capsule 10's with food for better absorption or as advised by a doctor
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety
  • Swallow the medicine as a whole with a glass of water
  • Do not crush, break, or chew it.

How Nexluma Capsule 10's Works

Nexluma Capsule 10's contains Lumateperone, which works through multiple mechanisms to regulate brain activity. It modulates dopamine D2 receptors, helping reduce hallucinations and delusions while minimizing movement-related side effects. It also blocks serotonin (5-HT2A) receptors, which contributes to improvements in mood, anxiety, and psychotic symptoms. Together, these actions help restore communication between brain cells and improve mood, perception, and thinking.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Nexluma Capsule 10's as it may cause increased dizziness. Nexluma Capsule 10's may also increase the effects of alcohol.

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Pregnancy

Unsafe

Nexluma Capsule 10's is not usually recommended during pregnancy, especially in the third trimester. Therefore, please inform your doctor if you are pregnant or planning a pregnancy before taking Nexluma Capsule 10's.

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Breast Feeding

Consult your doctor

Nexluma Capsule 10's may pass into the breastmilk. Therefore, please inform your doctor if you are a breastfeeding mother before taking Nexluma Capsule 10's.

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Driving

Unsafe

Do not drive or operate machinery as Nexluma Capsule 10's may cause tiredness, dizziness and drowsiness.

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Liver

Caution

Nexluma Capsule 10's to be used with caution if you have liver disease. Inform your doctor before taking Nexluma Capsule 10's if you have a history of liver disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Nexluma Capsule 10's to be used with caution if you have a history of kidney disease. Inform your doctor before receiving Nexluma Capsule 10's if you have a history of kidney diseases. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

The safety and effectiveness of Nexluma Capsule 10's in children below 18 years have not been established.

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Heart

Consult your doctor

Please consult your doctor before taking Nexluma Capsule 10's if you have pre-existing heart problems.

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Geriatrics

Caution

Nexluma Capsule 10's can be used in geriatric patients, but with caution due to increased risk of stroke, sedation, and heart rhythm changes. Close monitoring is essential, especially in elderly individuals with dementia or cardiovascular conditions.

What if I have taken an overdose of Nexluma Capsule 10's

If you think you or someone else has taken more Nexluma Capsule 10's than prescribed, seek immediate medical attention or contact your local poison control center right away. Do not wait for symptoms to appear. Symptoms of an overdose may include extreme drowsiness or unusual sleepiness, severe dizziness or fainting, confusion or difficulty responding, fast or irregular heartbeat, low blood pressure, difficulty breathing, and seizures (rare)

Diet & Lifestyle Advise

  • Eat a balanced diet: Include plenty of fruits, vegetables, whole grains, lean proteins, and healthy fats in your meals. A nutritious diet supports your overall health and may help reduce the risk of weight gain and metabolic changes associated with antipsychotic medicines.
  • Stay physically active: Engage in regular physical activity, such as walking, cycling, swimming, or yoga, for at least 150 minutes each week, if appropriate for your health. Exercise can improve mood, support cardiovascular health, and help maintain a healthy weight.
  • Avoid alcohol and recreational drugs: Do not drink alcohol or use recreational drugs while taking Nexluma Capsule 10's. These substances can increase drowsiness, dizziness, and impaired judgment, and may worsen your mental health symptoms or interfere with treatment.
  • Maintain a regular sleep routine: Go to bed and wake up at the same time each day to promote healthy sleep. A consistent sleep schedule supports your mental well-being and may help improve your response to treatment.
  • Attend regular health check-ups: Keep all scheduled appointments with your healthcare provider to monitor your weight, blood sugar, cholesterol, blood pressure, and overall treatment response. Regular monitoring helps detect and manage potential side effects early.
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How Soon It Starts Working

  • The time required for Nexluma Capsule 10's to start to work: The time required for Nexluma Capsule 10's to show its action is unknown.
  • The time for which the effects of Nexluma Capsule 10's last: The duration of action for Nexluma Capsule 10's is unknown.

What if you forget to take Nexluma Capsule 10's

If you miss a dose, take it as soon as you remember on the same day with food.If it is nearly time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses together.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not stop treatment suddenly: Continue taking Nexluma Capsule 10's exactly as prescribed, even if you feel better. Stopping the medicine without your doctor's advice may cause your symptoms to return or worsen.
  • Avoid alcohol: Do not drink alcohol while taking Nexluma Capsule 10's, as it can increase drowsiness, dizziness, and impaired judgment, making accidents more likely.
  • Be careful when driving: Avoid driving, operating heavy machinery, or performing activities requiring mental alertness until you know how Nexluma Capsule 10'saffects you, as it may cause sleepiness or dizziness.
  • Inform your healthcare provider about all medicines: Tell your doctor or pharmacist about all prescription medicines, over-the-counter medicines, herbal products, and supplements you take. Medicines that strongly affect the CYP3A4 enzyme (such as ketoconazole, clarithromycin, rifampicin, carbamazepine, or phenytoin) may alter how Nexluma Capsule 10's works.
  • Attend regular health monitoring: Keep all follow-up appointments so your healthcare provider can monitor your weight, blood sugar, cholesterol, blood pressure, and overall response to treatment, as antipsychotic medicines may cause metabolic changes.
  • Seek immediate medical attention for serious symptoms: Contact your doctor immediately if you develop high fever, severe muscle stiffness, confusion, uncontrolled body movements, seizures, difficulty swallowing, or signs of an allergic reaction such as swelling of the face, lips, tongue, or throat, or difficulty breathing.
  • Stay hydrated and avoid overheating: Nexluma Capsule 10'smay affect your body's ability to regulate temperature. Drink plenty of fluids and avoid excessive heat or strenuous exercise, especially during hot weather.
  • Boxed Warning – Increased mortality in older adults with dementia-related psychosis: Nexluma Capsule 10'sis not approved for the treatment of patients with dementia-related psychosis. Older adults with dementia-related psychosis treated with antipsychotic medicines have an increased risk of death, mainly due to cardiovascular events (such as heart failure or sudden death) or infections (such as pneumonia).

Drug-Drug Interactions

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  • Strong CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin, ritonavir): These drugs can increase the amount of Nexluma Capsule 10's in your body, raising the risk of side effects such as excessive drowsiness, dizziness, and low blood pressure. Your doctor may recommend avoiding these combinations.
  • Strong or moderate CYP3A4 inducers (rifampicin (rifampin), carbamazepine, phenytoin, phenobarbital): Reduce the effectiveness of Nexluma Capsule 10's by lowering its levels in the body. These combinations are generally not recommended.
  • Medicines that cause drowsiness: Sleeping pills, opioid pain medicines, anti-anxiety medicines (such as benzodiazepines), muscle relaxants, sedating antihistamines, and other antipsychotic medicines may increase the risk of excessive sleepiness, dizziness, falls, and impaired thinking when taken with Nexluma Capsule 10's.
  • Blood pressure-lowering medicines: Medicines used to treat high blood pressure may increase the risk of dizziness, fainting, or low blood pressure when combined with Nexluma Capsule 10's, especially when standing up quickly.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • Food: Take Nexluma Capsule 10's with a meal containing at least 350 calories, as food significantly improves its absorption and helps the medicine work effectively.
  • Alcohol: Avoid drinking alcohol while taking Nexluma Capsule 10's because it can increase drowsiness, dizziness, impaired judgment, and the risk of accidents.
  • Grapefruit and grapefruit juice: Avoid grapefruit products unless advised otherwise by your doctor, as they may increase Nexluma Capsule 10's levels by inhibiting the CYP3A4 enzyme, increasing the risk of side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPSYCHOTICS]

FAQs

Nexluma Capsule 10's is used in the treatment of schizophrenia in adults. It is also used for the treatment of depressive episodes associated with bipolar I or bipolar II disorder (bipolar depression)
Some people notice improvement within 1 to 2 weeks, but full benefits for schizophrenia or bipolar depression may take 4 to 8 weeks or longer. Continue taking the medicine as prescribed and attend follow-up appointments.
Yes. Nexluma Capsule 10's should be taken with food because food significantly improves its absorption and helps ensure the medicine works effectively.
No. Alcohol can increase drowsiness, dizziness, impaired coordination, and difficulty concentrating. Avoid alcoholic beverages during treatment.
Tell your doctor if you are pregnant or planning a pregnancy. Antipsychotic medicines used during the third trimester may cause temporary withdrawal or movement symptoms in newborns. Your doctor will carefully weigh the benefits and risks before recommending treatment.
Weight gain can occur, but it is generally less common and less pronounced than with some other atypical antipsychotics. Your doctor may monitor your weight, blood sugar, and cholesterol during treatment.
Nexluma Capsule 10's may cause sleepiness or dizziness, especially when starting treatment. Avoid driving or operating machinery until you know how the medicine affects you.
In some patients with bipolar depression, Nexluma Capsule 10's may be prescribed alone or together with mood stabilisers such as lithium or valproate. Always tell your doctor about all medicines you take so potential interactions can be assessed before starting treatment.
Mild sleepiness is a common side effect. Taking the medicine in the evening, if recommended by your doctor, may help. If excessive drowsiness persists or interferes with daily activities, consult your doctor. Do not change your dose without medical advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

308-310 Dwarkesh Complex, Sun Pharma Road, Po:Atladra, Vadodara-390 012., Gujarat, India.
Other Info - NEX0508
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