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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Ngmine 250 Injection is used to prevent the formation of blood clots. It works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation. This helps in reducing the rate of cardiovascular events such as myocardial infarction (heart attack) or stroke, especially in people who have had heart surgery, known as angioplasty.

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Whats That

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Composition :

BIVALIRUDIN-250MG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Ngmine 250 Injection

Ngmine 250 Injection belongs to the group of medicines called blood thinners used to prevent the formation of blood clots. Blood clots are formed to stop bleeding that occurs due to tissue injury. Though blood clots are useful for stopping bleeding, they may be harmful when abnormally formed within blood vessels as they block blood vessels. Ngmine 250 Injection is used in combination with aspirin during Percutaneous transluminal coronary angioplasty (PTCA) and Percutaneous coronary intervention (PCI) (angioplasty procedures) in unstable angina patients to reduce the chance of blood clot formation.

Ngmine 250 Injection contains Bivalirudin, which works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation. This results in lower cardiovascular events like myocardial infarction (heart attack) or other severe chest pain-related problems.

Ngmine 250 Injection will be administered by your doctor. So, do not self-administer. The dose of the medicine will be decided by your doctor based on your health condition. Ngmine 250 Injection may cause certain side effects such as nose bleeds, skin rash, bleeding in the bowels, blood in urine, low haemoglobin, thrombocytopenia (low platelets), hypersensitivity reactions, and elevations of liver enzyme levels. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

Ngmine 250 Injection should not be used if you are allergic to it or if you ever had a brain stroke, bleeding in the brain or transient ischemic attack (stroke). Talk to your doctor before receiving Ngmine 250 Injection if you have/had a recent severe injury or surgery due to the risk of severe bleeding problems, have/had a heart problem, kidney disease or using any blood thinner medicine. Pregnant or breastfeeding mothers should inform the doctor before receiving this medicine. Ngmine 250 Injection is not recommended for children as efficacy and safety have not been established.

Uses of Ngmine 250 Injection

Ngmine 250 Injection is used to prevent blood clots. The detailed uses of Ngmine 250 Injection are as follows:<br/>• Prevents the formation of blood clots: Ngmine 250 Injection inhibits fibrin production, stopping platelets from clumping together to form clots.<br/>• Reduces the risk of heart attack and stroke: Ngmine 250 Injection lowers the chance of serious cardiovascular events, especially in patients undergoing procedures like angioplasty.<br/>• Provides protection after heart surgeries: Ngmine 250 Injection helps maintain healthy blood flow and prevents clot-related complications following cardiac interventions.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Ngmine 250 Injection will be administered by the doctor or healthcare professional in a medical setting.• Do not self-administer.

Medicinal Benefits

Ngmine 250 Injection belongs to the group of medicines called antithrombolytic agents (direct thrombin inhibitors) used to prevent the formation of blood clots. Ngmine 250 Injection works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation. This helps in reducing the rate of cardiovascular events such as myocardial infarction (heart attack) or stroke, especially in people who have had heart surgery, known as angioplasty.

How Ngmine 250 Injection Works

Ngmine 250 Injection contains Bivalirudin, which works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation. This results in lower cardiovascular events like myocardial infarction (heart attack) or other severe chest pain-related problems.

Storage

• Store in a cool and dry place away from sunlight.• Keep Ngmine 250 Injection out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Ngmine 250 Injection

What if I have taken an overdose of Ngmine 250 Injection

Since Ngmine 250 Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Do not receive Ngmine 250 Injection if you are allergic to it or if you have a medical condition that causes bleeding from the stomach or intestine, had a transient ischemic attack (stroke) or if you are suffering from severe liver disease. Let your doctor know if you have bleeding problems, had/have a recent serious injury or surgery, kidney/liver disease, or are taking any blood thinner medicine before receiving this medicine. Consult your doctor immediately if you develop a medical condition called thrombotic thrombocytopenic purpura (blood disorder) while on treatment with Ngmine 250 Injection. Pregnant or breastfeeding mothers should inform their doctor before receiving this medicine. Ngmine 250 Injection is not recommended for children as efficacy and safety have not been established.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Ngmine 250 Injection:
When Etodolac is taken with Ngmine 250 Injection, the risk or severity of bleeding and haemorrhage increases.

How to manage the interaction:
Taking Ngmine 250 Injection with Estradiol can cause an interaction, consult a doctor before taking it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Ngmine 250 Injection:
Co-administration of Mifepristone with Ngmine 250 Injection can increase the risk of negative side effects.

How to manage the interaction:
Taking Ngmine 250 Injection with Mifepristone together is not generally recommended as it may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience persistent, excessive bleeding, consult the doctor. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Ngmine 250 Injection:
Coadministration of Ngmine 250 Injection and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Ngmine 250 Injection and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
How does the drug interact with Ngmine 250 Injection:
Using Dasatinib together with Ngmine 250 Injection may increase the risk of bleeding.

How to manage the interaction:
Although taking Ngmine 250 Injection and Dasatinib together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs: bruising, feeling dizzy or lightheaded, dark stools, headache, weakness, contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Ngmine 250 Injection:
Using Deferasirox together with Ngmine 250 Injection may increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Co-administration of Ngmine 250 Injection with Deferasirox can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Ngmine 250 Injection:
Co-administration of Prasugrel with Ngmine 250 Injection can increase the risk of bleeding.

How to manage the interaction:
Although taking Prasugrel and Ngmine 250 Injection together can evidently cause an interaction, it can be taken if a doctor has suggested it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Ngmine 250 Injection:
Coadministration of Ngmine 250 Injection with Enoxaparin can increase the risk or severity of bleeding.

How to manage the interaction:
Co-administration of Ngmine 250 Injection with Enoxaparin can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms like bleeding, bruising, dizziness, black or red stools, severe headache, weakness, or vomiting call a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Ngmine 250 Injection:
Co-administration of Ngmine 250 Injection and Rivaroxaban can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Ngmine 250 Injection and Rivaroxaban can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Ngmine 250 Injection:
Taking cefdinir with Ngmine 250 Injection may increase the effects of Ngmine 250 Injection.

How to manage the interaction:
Although taking Cefdinir and Argatroban together can evidently cause an interaction, but it can be taken if prescribed by a doctor. In case you experience any side effects like chest tightness, shortness of breath, swelling of legs, or palpitations, consult a doctor. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Ngmine 250 Injection:
Co-administration of Ibrutinib with Ngmine 250 Injection can increase the risk of bleeding.

How to manage the interaction:
Taking Ibrutinib with Ngmine 250 Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a diet rich in whole grains, vegetables, fruits, skinless poultry, fish, eggs, and low-fat dairy products.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Managing stress with meditation, yoga, and massage.
  • Avoid eating fried food, fast food, boxed food, canned food, and processed frozen meals.

Habit Forming

No

Therapeutic Class

ANTICOAGULANTS / ANTITHROMBOTICS. ANTICONVULSANTS
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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Hence, avoid alcohol consumption while receiving Ngmine 250 Injection to prevent unpleasant side effects.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Ngmine 250 Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited data are available on the effect of Ngmine 250 Injection on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Ngmine 250 Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Not applicable

Ngmine 250 Injection does not affect your ability to drive.

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Liver

Caution

Ngmine 250 Injection should be used with caution in patients with liver impairment. Please inform your doctor if you have liver disease or any concerns regarding this.

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Kidney

Caution

Ngmine 250 Injection should be used with caution in patients with kidney impairment. Please inform your doctor if you have kidney disease or any concerns regarding this.

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Children

Unsafe

Ngmine 250 Injection is not recommended for use in children, as efficacy and safety have not been established.

Have a query?

FAQs

Ngmine 250 Injection is used to prevent blood clots.

Ngmine 250 Injection works by inhibiting the clumping of platelets, thereby reducing the chance of blood clot formation. This helps in reducing the rate of cardiovascular events such as myocardial infarction (heart attack).

No, you are not recommended to take ibuprofen with Ngmine 250 Injection as co-administration of these two medicines may increase the risk of bleeding more easily. However, please consult a doctor before taking other medicines with Ngmine 250 Injection.

Ngmine 250 Injection may cause anaemia (low haemoglobin and low red blood cell count). So it would be best if you include iron-rich food in your diet to prevent anaemia.

Ngmine 250 Injection does not affect the functioning of the liver. However, long-term use of Ngmine 250 Injection may slightly increase the risk of mild liver damage, particularly in those with increased liver enzyme levels. Therefore, if you have any liver problem, please inform your doctor before starting Ngmine 250 Injection.

It is best to avoid drinking alcohol while taking Ngmine 250 Injection. Intake of alcohol might increase the risk of stomach or intestinal bleeding.

Store Ngmine 250 Injection at controlled room temperature (15-25°C) in a cool and dry place. Do not freeze. Keep out of reach of children.

You might not feel any difference after taking Ngmine 250 Injection, but you should continue taking it as prescribed by your doctor. Even though you don't notice any difference, you will still receive all benefits of Ngmine 250 Injection.

Ngmine 250 Injection should not be taken by individuals with allergies, bleeding issues, strokes, liver disease, or taking any blood thinners. It is important to inform your doctor if you develop thrombotic thrombocytopenic purpura while on treatment with Ngmine 250 Injection. Pregnant or breastfeeding mothers should inform your doctor before receiving Ngmine 250 Injection. Ngmine 250 Injection is not recommended for children as efficacy and safety have not been established.

No, Ngmine 250 Injection does not usually cause hair loss. However if you notice hair loss while on treatment with Ngmine 250 Injection, please consult your doctor.

The common side effects of Ngmine 250 Injection are nose bleeds, skin rash, bruising, bleeding in the bowels, blood in urine, low haemoglobin, and thrombocytopenia (low platelets). If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Other Info - NGM0004

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