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compositionComposition:NICORANDIL-48MG
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Prescription Medicine
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Nicoduce 48mg Injection prevents or treats angina pectoris (heart-related chest pain). It contains Nicorandil, a potassium-channel activator that opens potassium channels present on the muscle cells within the walls of blood vessels, relaxes these muscle cells, and widens blood vessels. Thus, it reduces the heart's workload by making it easier for the heart to pump blood around the body and does not require much oxygen. Also, it helps to prevent angina by increasing oxygen and blood supply to the heart muscle by widening coronary arteries within the heart.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

NICORANDIL-48MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nicoduce 48mg Injection

Nicoduce 48mg Injection is an injectable medication used to treat unstable angina, which is a severe and unpredictable form of chest pain. It helps improve blood flow to the heart muscle, relieving discomfort during acute cardiac events. This medicine is primarily prescribed when other standard chest pain treatments are not suitable or have not provided enough relief.

Since this medication is given as an injection or infusion by healthcare professionals, it is typically used in a hospital setting for immediate care rather than on a regular daily schedule at home. It is injected directly into a vein to ensure it works quickly when your heart needs urgent support. Adopting a heart-healthy diet, such as reducing your salt intake and avoiding processed foods, can support your recovery during and after your treatment.

We understand that being treated for a heart condition can feel overwhelming. Your healthcare team will monitor you closely and support you throughout your treatment to help keep you safe and comfortable.

Common side effects of this medication include headaches, dizziness, and a temporary drop in blood pressure. If you experience serious side effects, such as a severe skin rash, painful mouth sores, or extreme dizziness, contact your doctor or healthcare provider immediately. If you develop severe difficulty breathing, swelling of the face, lips, tongue, or throat, lose consciousness, or have symptoms of severe low blood pressure such as fainting, seek emergency medical care or call 112 immediately if you are outside a healthcare setting.

Before starting this medication, tell your doctor if you have a history of kidney disease, liver damage, or low blood pressure. You should not receive this medicine if you are in cardiogenic shock, have extremely low blood pressure, or suffer from severe heart failure where your heart cannot pump blood properly.

This medicine must never be used with certain erectile dysfunction medications like sildenafil, as this combination can cause a dangerous and sudden drop in blood pressure. You should also consult your doctor if you are pregnant, breastfeeding, or an elderly individual, as special care or dose adjustments may be needed.

Uses of Nicoduce 48mg Injection

Your doctor may prescribe Nicoduce 48mg Injection to help manage the following conditions:

  • Unstable Angina: Nicoduce 48mg Injection helps by widening the blood vessels supplying the heart, which improves blood flow and oxygen delivery to relieve severe, unpredictable chest pain.
  • Acute Heart Failure: In some specialised hospital or critical care situations, your doctor may use Nicoduce 48mg Injection to help reduce the workload on the heart. However, its primary approved use is for treating unstable angina, and its use in acute heart failure depends on your doctor's clinical judgement.
  • Prevention of coronary complications during medical procedures: During heart procedures like angioplasty, Nicoduce 48mg Injection helps keep the coronary arteries open and maintains steady blood flow to protect the heart muscle.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Rapid Chest Pain Relief: Nicoduce 48mg Injection provides rapid relief from severe chest pain. Because it is injected directly into the bloodstream, it goes to work almost immediately to relax constricted blood vessels, providing quick relief from intense heart pain and pressure.
  • Reduces Heart Workload: This medication also helps reduce the overall workload on your heart. By widening both the arteries and veins, Nicoduce 48mg Injection decreases the effort your heart needs to pump blood, which helps prevent further strain on a weakened heart muscle and supports faster recovery.
  • Support Heart Procedure: Additionally, it provides crucial protection during complex heart procedures. By maintaining consistent blood flow to the heart muscle, it lowers the risk of sudden complications and blood flow blockages during coronary interventions.

Directions for Use

  • Nicoduce 48mg Injection is given only in clinical settings by healthcare professionals, usually through slow intravenous injection.
  • The dose and duration are decided by the doctor, based on the patient's condition and response to treatment.
  • Do not self-administer this injection, as incorrect use can lead to serious side effects.
  • Patients are carefully monitored during and after administration to ensure safety and manage any side effects promptly.

How Nicoduce 48mg Injection Works

Nicoduce 48mg Injection contains nicorandil, which works through a unique dual action to improve blood flow to your heart. First, it opens up tiny potassium channels in the muscle cells of your blood vessels, causing them to relax and widen. This allows oxygen-rich blood to flow more freely to the heart muscle, relieving chest pain. Second, it acts similarly to a nitrate medication by releasing nitric oxide within the vessels. This further dilates the veins, which reduces the amount of blood returning to the heart, lowering its workload. Together, these two actions effectively relieve chest pain and protect the heart from strain.
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Nicoduce 48mg Injection as it may cause severely low blood pressure.

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Pregnancy

Unsafe

There is limited information on the use of Nicoduce 48mg Injection in pregnant women. Usually, it is not recommended for pregnant women. Therefore, if you are pregnant or planning pregnancy, please inform your doctor.

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Breast Feeding

Consult your doctor

There is limited information on the use of Nicoduce 48mg Injection in breastfeeding mothers. Therefore, please inform your doctor if you are a breastfeeding mother.

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Driving

Unsafe

Nicoduce 48mg Injection may cause dizziness or weakness in some people. Therefore, avoid driving if you feel dizzy or weak after receiving Nicoduce 48mg Injection.

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Liver

Caution

Take Nicoduce 48mg Injection with caution, especially if you have a history of liver disease.

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Kidney

Caution

Take Nicoduce 48mg Injection with caution, especially if you have a history of kidney disease.

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Children

Unsafe

Nicoduce 48mg Injection is not recommended for children as safety and effectiveness were not established.

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Heart

Caution

Take Nicoduce 48mg Injection with caution, especially if you have a history of heart disease.

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Geriatrics

Caution

Nicoduce 48mg Injection should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Nicoduce 48mg Injection

Because this medication is carefully measured and given by trained medical staff, an overdose is rare. If an overdose does occur, it can cause severe low blood pressure, dizziness, and a rapid heart rate. The medical team monitoring you is trained to recognise these signs and will treat them immediately.

Diet & Lifestyle Advise

  • Dietary Advice: Follow a low-sodium diet to help manage your blood pressure and reduce the overall workload on your cardiovascular system.
  • Lifestyle Advice: Avoid sudden physical exertion unless cleared by your cardiologist, as your heart needs time to stabilise.
  • Hydration Advice: Stay adequately hydrated to help your body manage blood pressure fluctuations, but consult your doctor regarding exact fluid intake limits if you have heart failure.
  • Alcohol Warning: Avoid alcohol during your hospital treatment and for as long as your doctor recommends after discharge, as it can increase the blood-pressure-lowering effects of Nicoduce 48mg Injection and raise the risk of dizziness, fainting, or falls. 
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How Soon It Starts Working

The time required for Nicoduce 48mg Injection to start to work: The exact onset time of Nicoduce 48mg Injection has not been clinically established. The time for which the effects of Nicoduce 48mg Injection last: The duration of Nicoduce 48mg Injection’s effect is clinically not established.

What if you forget to take Nicoduce 48mg Injection

Since this medication is administered by healthcare professionals in a hospital or clinical setting, it is highly unlikely that you will miss a dose. However, if your scheduled treatment is delayed or if you have concerns, speak to your healthcare provider immediately.

Storage

•Do not freeze the medication, and keep the vials inside their original outer carton to protect them from direct light.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Product Inspection: Before administration, visually inspect the solution. Do not use if there are visible particles, cloudiness, or discolouration.
  • Aseptic Technique: Always ensure that a sterile needle and syringe are used for preparing and injecting the medication to prevent infection.
  • Infusion Site Alert: Notify your nurse immediately if you feel pain, burning, or swelling at the injection site during the infusion.
  • Fall Prevention: Avoid standing up too quickly from a lying or sitting position after receiving this medication, as it can cause sudden lightheadedness or dizziness.
  • Medical History Alert: Inform your healthcare provider if you have a history of diverticular disease, as this medication has been associated with a risk of gastrointestinal complications in susceptible individuals.

Drug-Drug Interactions

verifiedApollotooltip
  • PDE5 Inhibitors (such as sildenafil, tadalafil, or vardenafil): May cause a dangerous and sudden drop in blood pressure when used together. Do not take these medications while receiving Nicoduce 48mg Injection.
  • Soluble Guanylate Cyclase Stimulators (such as riociguat): Taking these together can significantly increase the risk of severe low blood pressure.
  • Other Blood Pressure-Lowering Medications: Medicines that lower blood pressure, including antihypertensives, vasodilators, and certain antidepressants (such as MAO inhibitors or tricyclic antidepressants), may increase the blood-pressure-lowering effect of Nicoduce 48mg Injection. Your doctor will monitor you and adjust treatment if needed.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • Alcohol: Consuming alcohol while on this medication can cause a severe drop in blood pressure, leading to extreme dizziness, headache, or fainting.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[VASODILATORS]

FAQs

Nicoduce 48mg Injection is used to treat Angina pectoris (heart-related chest pain).
Nicoduce 48mg Injection contains Nicorandil which works by relaxing and widening blood vessels. Thereby, Nicoduce 48mg Injection reduces the workload of the heart by making it easier for the heart to pump blood around the body and does not require much oxygen. Also, Nicoduce 48mg Injection helps to prevent angina by increasing oxygen and blood supply to the heart muscle by widening coronary arteries within the heart.
Nicoduce 48mg Injection may cause headache as a common side effect, especially in the first few days of treatment. However, if the condition persists or worsens, please consult a doctor so that the dose may be reduced initially.
Nicoduce 48mg Injection is not recommended for patients with severe hypotension (low blood pressure) as it may increase the risk of worsening the condition. Therefore, inform your doctor if you have low blood pressure before taking Nicoduce 48mg Injection.
You are not recommended to take aspirin (pain reliever) with Nicoduce 48mg Injection as co-administration of these two medicines may increase the risk of ulcers or other adverse effects. However, please consult a doctor before taking other medicines with Nicoduce 48mg Injection.
You are recommended to avoid receiving Nicoduce 48mg Injection if you have hypotension (severe low blood pressure), low blood volume, pulmonary oedema (accumulation of fluid in the lungs) or any heart problems such as left ventricular failure with low filling pressure, cardiac decompensation or cardiogenic shock.
You are not recommended to take more than the prescribed dose of Nicoduce 48mg Injection as it may cause Nicoduce 48mg Injection overdose resulting in symptoms such as weakness, dizziness (signs of low blood pressure), and fast or irregular heartbeat. However, if you experience any of these symptoms while receiving Nicoduce 48mg Injection, please consult a doctor immediately.
Nicoduce 48mg Injection is given as an injection or a continuous infusion directly into a vein (intravenously) by a healthcare professional in a hospital or clinic. Talk to your doctor if you have questions about this procedure.
There is limited clinical evidence regarding the safety of Nicoduce 48mg Injection during pregnancy. It should only be used if the potential benefit outweighs the risk to the baby. Talk to your doctor if you are pregnant or planning to become pregnant.
No, you must not take sildenafil or any other PDE5 inhibitor while using Nicoduce 48mg Injection. Combining them can lead to a severe, life-threatening drop in blood pressure. Talk to your doctor about safe alternatives.
No, Nicoduce 48mg Injection does not cure heart disease. It works to manage symptoms such as severe chest pain (angina) and improve blood flow during acute situations or medical procedures. Talk to your doctor about long-term management plans.
In some cases, Nicoduce 48mg Injection can cause or worsen ulcers in the mouth, stomach, or digestive tract. If you have a history of stomach ulcers or experience unusual abdominal pain, talk to your doctor immediately.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.652 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Nicorandil - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Ikorel 10mg tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. [Accessed on 13 Mar 2025]Check here
  4. Ikorel 10mg tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. [Accessed on 13 Mar 2025]Check here
  5. Nicorandil [Internet]. Lhch.nhs.uk. [Accessed on 13 Mar 2025]Check here
  6. Nicorandil - an overview - ScienceDirect Topics [Internet]. Sciencedirect.com. [Accessed on 13 Mar 2025]Check here
  7. National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 47528, Nicorandil.[Accessed on 13 Mar 2025]Check here

Country of origin

India

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Other Info - NIC0209
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