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compositionComposition:ACENOCOUMAROL-1MG
prescription
Prescription Medicine
info
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Nicofax-1Mg Tablet is used to prevent and treat various types of thromboembolic diseases (blood clots inside blood vessels), including deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). It is prescribed to prevent formation of unwanted clots if you have a condition that increases this risk, such as atrial fibrillation, or if you have had a heart valve replacement. It is also given to prevent any clots that may have already formed in the blood vessels of your legs, lungs or heart from becoming larger and causing problems. It works by increasing the time it takes for your blood to clot, reducing the risk of a stroke or heart attack. This medication helps to keep blood flowing smoothly in your body by decreasing the amount/number of clotting proteins in the blood. Some people may experience unusual bleeding or skin rash.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ACENOCOUMAROL-1MG

Manufacturer/Marketer :

Chemo Healthcare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nicofax-1Mg Tablet

Nicofax-1Mg Tablet is a prescription medicine used to prevent and treat harmful blood clots from forming in your body. It is commonly prescribed to manage conditions like deep vein thrombosis, which are blood clots in the legs, and pulmonary embolism, which occurs when a clot travels to the lungs. This medication is crucial for reducing the risk of stroke in patients with certain heart conditions.

For this medicine to work effectively, you must take it consistently at the exact same time every day, either with or without food. Keeping a steady schedule helps maintain a stable amount of the drug in your system. Additionally, making structured, consistent choices in your daily diet is essential to prevent fluctuations in how your medicine performs.

While taking Nicofax-1Mg Tablet , it is common to experience some mild side effects, such as minor bruising or slight nosebleeds. However, you must always stay alert for serious complications and contact your doctor immediately if you notice signs of severe, uncontrolled bleeding. Regular monitoring is key to keeping your therapy safe.

You should always talk to your doctor before starting this medication if you have a history of bleeding disorders, high blood pressure, or liver damage. Do not take this medicine if you are pregnant, as it can cause severe harm to an unborn baby.

Certain common medications, herbal supplements, and alcohol can interact with Nicofax-1Mg Tablet and alter how your blood clots. If you belong to specific groups, such as elderly individuals or those who are breastfeeding, you must consult your healthcare provider to ensure this therapy is managed safely.

Uses of Nicofax-1Mg Tablet

Your doctor may prescribe Nicofax-1Mg Tablet to treat several conditions, including:

  • Deep vein thrombosis (DVT): Nicofax-1Mg Tablet helps treat blood clots that have formed in the deep veins of your legs, preventing them from growing larger or traveling to other parts of your body.
  • Pulmonary embolism (PE): Nicofax-1Mg Tablet helps treat blood clots that have blocked the blood vessels in your lungs, helping to restore safe and normal blood flow.
  • Atrial fibrillation: Nicofax-1Mg Tablet prevents harmful blood clots from forming in the chambers of the heart due to an irregular heartbeat, significantly lowering your risk of having a stroke.
  • Heart valve replacement: Nicofax-1Mg Tablet prevents blood clots from forming on artificial heart valves after surgical replacement.

Key Benefits

Nicofax-1Mg Tablet provides important cardiovascular protection by helping control the body’s blood-clotting process. By reducing the formation of harmful clots, this medicine offers several key health benefits:

  • Prevention of Dangerous Blood Clots: Nicofax-1Mg Tablet helps reduce the liver’s production of vitamin K-dependent clotting factors, including factors II, VII, IX, and X, slowing the clotting process and lowering the risk of harmful clot formation.
  • Protection Against Cardiovascular Complications: By helping maintain smoother blood flow, Nicofax-1Mg Tablet reduces the risk of serious clot-related events and supports long-term cardiovascular health.
  • Support for Safer Blood Flow Management: Consistent use of Nicofax-1Mg Tablet as prescribed helps maintain balanced clot control, reducing the likelihood of complications associated with excessive blood clotting.
     

Directions for Use

Follow these steps to take this medicine safely:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet unless your doctor specifically advises you to do so.
  • Try to take your dose at the exact same time every day to maintain a stable level of the medicine in your body.
  • You can take this medicine with or without food, but be consistent with your choice every day.

Always follow your doctor's exact instructions regarding your dose, and never stop taking this medicine suddenly without consulting them first.

How Nicofax-1Mg Tablet Works

To understand how Nicofax-1Mg Tablet works, it helps to understand how your body naturally forms clots. Your liver uses Vitamin K to produce specific proteins that help your blood stick together and clot when you have an injury. Nicofax-1Mg Tablet contains acenocoumarol. It works by inhibiting an enzyme called vitamin K epoxide reductase (VKORC1), which reduces the recycling of active vitamin K in the liver. This lowers the production of vitamin K-dependent clotting factors (such as factors II, VII, IX, and X), slowing the formation of harmful blood clots.
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Alcohol

Caution

You are recommended to avoid the consumption of alcohol with Nicofax-1Mg Tablet as it may increase the risk of bleeding.

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Pregnancy

Unsafe

Nicofax-1Mg Tablet is recommended not to use in pregnancy. Your doctor will discuss with you the potential risk of taking Nicofax-1Mg Tablet during pregnancy. Please consult your doctor.

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Breast Feeding

Caution

Nicofax-1Mg Tablet should not be taken until prescribed. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor. You and your child may require blood tests if you are breastfeeding while taking Nicofax-1Mg Tablet . However, as a precaution, your doctor may prescribe vitamin K to your child to prevent their blood from thinning.

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Driving

Safe if prescribed

Nicofax-1Mg Tablet has no or negligible influence on the ability to drive or use machines.

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Liver

Caution

Take the Nicofax-1Mg Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take the Nicofax-1Mg Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Nicofax-1Mg Tablet should not be taken until prescribed. Your doctor will weigh the benefits and potential risks before prescribing them. If Nicofax-1Mg Tablet is used in children or adolescents, blood should be tested more often to see how well the medicine works.

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Heart

Safe if prescribed

Nicofax-1Mg Tablet can be used in heart patients if prescribed by the physician to reduce the risk of heart attack and stroke. Please consult your physician if you have any concerns.

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Geriatrics

Consult your doctor

Nicofax-1Mg Tablet should be used in elderly patients only if recommended by the physician.

What if I have taken an overdose of Nicofax-1Mg Tablet

Do not take more than the prescribed dose of Nicofax-1Mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Keep your intake of Vitamin K consistent. Avoid sudden changes in how many green leafy vegetables (like spinach, kale, or broccoli) you eat, as they can alter how the medicine works.
  • Limit or avoid alcohol completely, as it can dangerously change how your liver processes Nicofax-1Mg Tablet , raising your risk of bleeding.
  • Use a soft-bristled toothbrush and a gentle electric razor to minimise the risk of cuts and bleeding gums.
  • Avoid contact sports or any physical activities that carry a high risk of falls, bruising, or head injuries.
  • Always wear shoes or protective footwear to avoid cutting your feet.
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How Soon It Starts Working

The time required for Nicofax-1Mg Tablet to start to work: Nicofax-1Mg Tablet ideally shows its action within 24 to 30 hours after administration. The time for which the effects of Nicofax-1Mg Tablet last: The effect of Nicofax-1Mg Tablet lasts for 2 days.

What if you forget to take Nicofax-1Mg Tablet

If you miss a dose of Nicofax-1Mg Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Always carry a medical alert card or wear a medical ID bracelet stating that you are taking an oral blood thinner.
  • Make sure to get your blood tested regularly as scheduled by your doctor to ensure your dose remains safe and effective.
  • Inform every healthcare provider you visit, including dentists, surgeons, and physical therapists, that you are taking Nicofax-1Mg Tablet before any procedure is scheduled.
  • Check your skin daily for any unexplained bruises or red spots, which could be an early sign of bleeding under the skin.
  • Do not start or stop any other medicines, vitamins, or herbal supplements without talking to your doctor or pharmacist first.

Drug-Drug Interactions

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Drug-Drug Interactions:

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Taking pain relievers like aspirin, ibuprofen, or naproxen alongside Nicofax-1Mg Tablet can severely increase your risk of stomach bleeding.
  • Certain antibiotics, antifungals, and seizure medications can change the levels of Nicofax-1Mg Tablet in your blood, making it either less effective or dangerously increasing your bleeding risk.

Drug-Food Interactions:

  • Foods high in vitamin K, especially green leafy vegetables such as spinach, kale, cabbage, and broccoli, can affect how Nicofax-1Mg Tablet works if your intake changes suddenly. Green tea contains small amounts of vitamin K, but usual amounts are unlikely to have a major effect. Discuss major dietary changes with your doctor.
  • Cranberry juice and grapefruit juice may interact with Nicofax-1Mg Tablet and increase your risk of bleeding.

Drug-Disease Interactions:

Inform your doctor if you have a history of the following conditions before taking Nicofax-1Mg Tablet , as it may worsen your condition or cause complications.

  • Do not take this if you have active bleeding, severe high blood pressure, or severe liver damage.
  • Use with extreme caution if you have a history of stomach ulcers or kidney disease.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICOAGULANT/ANTITHROMBOTIC]

FAQs

Nicofax-1Mg Tablet is used to prevent and treat harmful blood clots, Reducing the risk of a stroke or heart attack.
Nicofax-1Mg Tablet works by reducing the blood's ability to form harmful clots, thereby lowering the risk of stroke, heart attack, and other clot-related complications. It increases the time it takes for blood to clot by affecting clotting factors or preventing blood cells involved in clot formation from sticking together, helping blood flow smoothly through the body.
Please consult your doctor if Nicofax-1Mg Tablet needs to be stopped before undergoing surgery. The doctor might ask you to stop taking Nicofax-1Mg Tablet a few days before surgery to avoid the increased risk of bleeding during the procedure.
Do not take aspirin for pain relief or ibuprofen while you are taking Nicofax-1Mg Tablet unless your doctor says it's OK. They raise the risk of unusual bleeding.
When a blood clot is treated, guidelines recommend that patients take blood thinners for the rest of its life. If they do not, the chance of developing a second clot is 30 to 40 per cent in the next 10 years.
There might be a problem if you are taking herbal therapies with Nicofax-1Mg Tablet , especially that affects blood like Ginkgo Biloba and St John's wort plant extract used as an antidepressant. Together with taking can increase your risk of bleeding. Tell your doctor if you are using any type of herbal supplements before taking Nicofax-1Mg Tablet .
No, you are usually not advised to have a tattoo or body piercing while taking Nicofax-1Mg Tablet as it may increase the risk of bleeding and infection. If you still wish to proceed further, contact your doctor so that the dose may be adjusted or any antibiotics may be prescribed and let the piercer or tattooist know in advance that you are on treatment with a blood thinner.
No, you are not recommended to stop taking Nicofax-1Mg Tablet without consulting your doctor as it may worsen the condition. Therefore, take Nicofax-1Mg Tablet for as long as your doctor has prescribed it.
You can have platelet count, factor V assay, fibrinogen level test, prothrombin time test (PT or PT-INR) and the INR, or international normalised ratio to analyze your blood clotting time.
Yes, taking Nicofax-1Mg Tablet can increase the risk of bleeding as it contains aspirin which is a blood thinner. So, please be very cautious while shaving, cutting fingernails or toenails, or using sharp objects to avoid any bleeding.
Nicofax-1Mg Tablet may cause side effects like unusual bleeding or skin rash. Most of these side effects of Nicofax-1Mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Nicofax-1Mg Tablet can be taken with or without food or as advised by the doctor.
It is best to avoid or strictly limit alcohol while taking Nicofax-1Mg Tablet . Alcohol can interfere with how your liver breaks down the medicine, which can dramatically increase your risk of serious bleeding. Talk to your doctor or pharmacist for personalised advice.
In the beginning, you will need blood tests very frequently—sometimes multiple times a week. Once your dose is stable, these tests are usually spaced out to once every few weeks. Talk to your doctor or pharmacist to set up your testing schedule.
No, you do not need to stop eating green vegetables entirely. The key is consistency. Eat roughly the same amount of Vitamin K-rich foods, like spinach or broccoli, from week to week so your medicine works predictably. Talk to your doctor or pharmacist before making major changes to your diet.
For minor cuts, apply firm, continuous pressure with a clean cloth for at least 10 minutes. If the bleeding does not stop after 10 to 15 minutes of constant pressure, or if the cut is deep, seek emergency medical attention immediately. Talk to your doctor or pharmacist if you experience frequent bleeding.
No, you should not take Nicofax-1Mg Tablet if you are pregnant or planning to become pregnant. This medicine can cross the placenta and cause severe birth defects or bleeding risks for the baby. Talk to your doctor immediately if you suspect you are pregnant.
It can take several days for the effects of Nicofax-1Mg Tablet to completely wear off after you stop taking it. Because of this, you must never stop taking this medicine on your own without direct supervision. Talk to your doctor or pharmacist about how to safely stop or pause your treatment.

Disclaimer

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.2058 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Acenocoumarol [EMC SmPC]. 2025. [Accessed on 03 May 2025]Check here
  3. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 19 Feb. 2020]Check here
  4. Sinthrome 1 mg Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [Accessed on 25 May 2022]Check here
  5. Acenocoumarol [Internet]. Pubchem.ncbi.nlm.nih.gov. 2022 [Accessed on 25 May 2022]Check here
  6. Acenocoumarol: Uses, Interactions, Mechanism of Action - DrugBank Online [Internet]. Go.drugbank.com. 2022 [Accessed on 25 May 2022]Check here
  7. Castellano JM, Narayan RL, Vaishnava P, et al. Anticoagulation during pregnancy in patients with a prosthetic heart valve. Nat Rev Cardiol. 2012;9(7):415-24Check here

Country of origin

India

Manufacturer/Marketer address

plot no : 1, new ahmedabad indl. estate, vill. morraiya, tal, sanand rd, changodar, gujarat 382213.
Other Info - NIC0230
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