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  3. Nifen Plus 100/325/15 Tablet 10's

Nifen Plus 100/325/15 Tablet 10's, Pack of 10 TabletS
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Nifen Plus 100/325/15 Tablet 10's is used to treat mild to moderate pain. It can relieve pain, swelling, and inflammation associated with various chronic (long-term) conditions, such as rheumatoid arthritis (joint pain, especially in the hands and feet) and osteoarthritis (joint pain, especially in the knees, hip, hands, neck, and lower back). It can also relieve acute (short-term) pain such as toothache, ear pain, throat pain, muscle ache, and backache. It may cause side effects such as nausea, vomiting, indigestion, stomach pain, headache, heartburn, and diarrhoea.
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Composition :

NIMESULIDE-100MG + PARACETAMOL-325MG + SERRATIOPEPTIDASE-15MG

Manufacturer/Marketer :

Meridian Medicare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Nifen Plus 100/325/15 Tablet 10's

Nifen Plus 100/325/15 Tablet 10's belongs to the class of medications called ‘analgesics’ used to treat mild to moderate pain. It can relieve pain, swelling, and inflammation associated with various chronic (long-term) conditions, such as rheumatoid arthritis (joint pain, especially in the hands and feet) and osteoarthritis (joint pain, especially in the knees, hip, hands, neck, and lower back). It can also relieve acute (short-term) pain such as toothache, ear pain, throat pain, muscle ache, and backache.

Nifen Plus 100/325/15 Tablet 10's is a combination medicine that contains Nimesulide, Paracetamol, and Serratiopeptidase. Nimesulide and Paracetamol are pain killers. They can also reduce fever and inflammation. They act by blocking the action of chemical messengers responsible for pain, fever, and inflammation. On the other hand, Serratiopeptidase is an enzyme which works by breaking down abnormal proteins at the site of inflammation and promotes healing.

Nifen Plus 100/325/15 Tablet 10's is available in the form of a tablet. It would be best if you took this Nifen Plus 100/325/15 Tablet 10's precisely as prescribed by your doctor. Nifen Plus 100/325/15 Tablet 10's may cause side effects such as nausea, vomiting, indigestion, stomach pain, headache, heartburn, and diarrhoea. These side effects are usually mild and temporary. However, if any of these side effects persist or worsen, consult a doctor immediately.

Do not take Nifen Plus 100/325/15 Tablet 10's if you are allergic to any of its contents. Nifen Plus 100/325/15 Tablet 10's should not be used in patients with liver failure, severe kidney failure, heart failure, gastric ulcers, bleeding disorders, and alcohol or drug abuse. Before taking Nifen Plus 100/325/15 Tablet 10's, inform your doctor if you are pregnant or breastfeeding. Nifen Plus 100/325/15 Tablet 10's should not be given to children below 12 years of age. In elderly people, Nifen Plus 100/325/15 Tablet 10's may be given with caution. Alcohol should not be taken while using Nifen Plus 100/325/15 Tablet 10's as it further increases the risk of liver damage. Nifen Plus 100/325/15 Tablet 10's may not affect your ability to drive. However, do not drive or operate heavy machinery if you feel dizzy.

Uses of Nifen Plus 100/325/15 Tablet 10's

Treatment of Mild to moderate pain.

Directions for Use

• Take Nifen Plus 100/325/15 Tablet 10's with food to avoid any stomach upset.• Follow your doctor’s recommendations on the dosage and timing of this medication based on your medical conditions to achieve optimal results.• Swallow it as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

Nifen Plus 100/325/15 Tablet 10's is a combination medicine that contains Nimesulide, Paracetamol, and Serratiopeptidase. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID). Paracetamol is an analgesic and antipyretic. Both medicines can reduce pain and fever. They act by blocking the action of chemical messengers responsible for pain, fever, and inflammation. Serratiopeptidase is an enzyme. It causes thinning of the fluids around the damaged tissue, thereby making fluid drainage easier in the swollen tissue. This effect reduces swelling and promotes faster healing. Together, Nifen Plus 100/325/15 Tablet 10's can effectively reduce pain, swelling, and inflammation.

How Nifen Plus 100/325/15 Tablet 10's Works

Nifen Plus 100/325/15 Tablet 10's is a combination medicine that contains Nimesulide, Paracetamol, and Serratiopeptidase. Nimesulide and Paracetamol are pain killers. They can also reduce fever and inflammation. They act by blocking the action of chemical messengers responsible for pain, fever, and inflammation. On the other hand, Serratiopeptidase is an enzyme which works by breaking down abnormal proteins at the site of inflammation and promotes healing.

Storage

Keep this medicine out of the sight and reach of children.
Side effects of Nifen Plus 100/325/15 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Gently massage the affected area using your hands or a massager.
  • Light exercises such as walking or climbing stairs may help the muscles return to normal.
  • Apply heat/ice to the affected area.
  • Drink electrolyte-rich fluids.

What if I have taken an overdose of Nifen Plus 100/325/15 Tablet 10's

Do not take more than the prescribed dose of Nifen Plus 100/325/15 Tablet 10's as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Nifen Plus 100/325/15 Tablet 10's may cause liver damage on higher doses or when used for prolonged periods. So, if you notice signs of liver damage such as loss of appetite, nausea, vomiting, unexplained weight loss, dark urine, and fatigue, or if you have abnormal liver function tests, discontinue the treatment immediately and consult your doctor. Do not use other analgesics while using Nifen Plus 100/325/15 Tablet 10's. Nifen Plus 100/325/15 Tablet 10's may have affected fertility, so it is not recommended for women trying to conceive. Nifen Plus 100/325/15 Tablet 10's may interfere with blood clotting, so it is recommended to stop using this medicine at least 2 weeks before surgery.

Drug-Drug Interactions

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ParacetamolLomitapide
Severe
ParacetamolValdecoxib
Severe

Drug-Drug Interactions

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ParacetamolLomitapide
Severe
How does the drug interact with Nifen Plus 100/325/15 Tablet:
Co-administration of Lomitapide and Nifen Plus 100/325/15 Tablet may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Nifen Plus 100/325/15 Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolValdecoxib
Severe
How does the drug interact with Nifen Plus 100/325/15 Tablet:
Co-administration of Nifen Plus 100/325/15 Tablet and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Nifen Plus 100/325/15 Tablet and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolKetamine
Severe
How does the drug interact with Nifen Plus 100/325/15 Tablet:
Co-administration of ketamine and Nifen Plus 100/325/15 Tablet may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Nifen Plus 100/325/15 Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolTeriflunomide
Severe
How does the drug interact with Nifen Plus 100/325/15 Tablet:
Co-administration of Teriflunomide with Nifen Plus 100/325/15 Tablet may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Nifen Plus 100/325/15 Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolLeflunomide
Severe
How does the drug interact with Nifen Plus 100/325/15 Tablet:
Co-administration of Nifen Plus 100/325/15 Tablet and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Nifen Plus 100/325/15 Tablet and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolMipomersen
Severe
How does the drug interact with Nifen Plus 100/325/15 Tablet:
Co-administration of Mipomersen with Nifen Plus 100/325/15 Tablet may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Nifen Plus 100/325/15 Tablet and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ParacetamolKetoconazole
Severe
How does the drug interact with Nifen Plus 100/325/15 Tablet:
Co-administration of Nifen Plus 100/325/15 Tablet and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Nifen Plus 100/325/15 Tablet and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolOxazepam
Severe
How does the drug interact with Nifen Plus 100/325/15 Tablet:
Co-administration of Nifen Plus 100/325/15 Tablet may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Nifen Plus 100/325/15 Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include more glucosamine, chondroitin sulphate, Vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.

  • Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching and low-impact aerobic exercises like walking on a treadmill, bike riding, and swimming. You can also strengthen your muscle strength by lifting light weights.

  • In the chronic conditions of arthritis or joint pain, fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids with a minimum level of chemicals called cytokines, which ramp up inflammation.

  • Your sitting posture is important, especially when have pain and inflammation condition. Try to sit as little as possible and only for a short time (10-15 min). Use back support like a rolled-up towel at the back of your curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.

Habit Forming

No

Therapeutic Class

ANALGESICS

Nifen Plus 100/325/15 Tablet 10's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Consumption of alcohol may increase the risk of liver damage and serious side effects.

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Pregnancy

Unsafe

Nifen Plus 100/325/15 Tablet 10's is not recommended for use in pregnancy. Please consult your doctor if you are pregnant before taking this medicine.

bannner image

Breast Feeding

Unsafe

Nifen Plus 100/325/15 Tablet 10's should not be used in breastfeeding mothers as it may pass into breastmilk and cause unwanted effects to the nursing baby. However, if prescribed, the doctor may advise you to stop breastfeeding.

bannner image

Driving

Safe if prescribed

Nifen Plus 100/325/15 Tablet 10's may not affect your ability to drive. However, do not drive or operate heavy machinery if you feel dizzy.

bannner image

Liver

Unsafe

Nifen Plus 100/325/15 Tablet 10's should not be used if you have severe liver disease, as this medicine may worsen your condition.

bannner image

Kidney

Caution

Nifen Plus 100/325/15 Tablet 10's should be used with caution if you have kidney problems. your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

bannner image

Children

Unsafe

Nifen Plus 100/325/15 Tablet 10's is not recommended for use in children below 12 years of age.

Have a query?

FAQs

Nifen Plus 100/325/15 Tablet 10's is used to treat mild to moderate pain. It can relieve pain, swelling, and inflammation associated with various chronic (long-term) conditions, such as rheumatoid arthritis (joint pain, especially in the hands and feet) and osteoarthritis (joint pain, especially in the knees, hip, hands, neck, and lower back). It can also relieve acute (short-term) pain such as toothache, ear pain, throat pain, muscle ache, and backache.

Nifen Plus 100/325/15 Tablet 10's contains Nimesulide, Paracetamol, and Serratiopeptidase. Nimesulide and Paracetamol are painkillers and can also reduce fever and inflammation. They act by blocking the action of chemical messengers responsible for pain, fever, and inflammation. Serratiopeptidase is an enzyme that can reduce swelling and promote the healing of damaged tissue. Together, Nifen Plus 100/325/15 Tablet 10's can effectively treat pain, swelling, and inflammation associated with various conditions.

Nifen Plus 100/325/15 Tablet 10's contains Nimesulide and Paracetamol, which may cause liver damage when used in higher doses or longer durations. So, take this medicine for a dose and duration as intended by your doctor. Also, avoid alcohol intake while using this medicine, as alcohol may increase the risk of liver damage.

In general, Nifen Plus 100/325/15 Tablet 10's is given for short-term pain relief. So, you can stop taking this medicine if your pain subsides. However, it is advised to consult your doctor before stopping this medication.

Nifen Plus 100/325/15 Tablet 10's may cause side effects such as nausea, vomiting, indigestion, stomach pain, headache, heartburn, and diarrhoea. These side effects are usually mild and temporary. However, if any of these side effects persist or worsen, consult a doctor immediately.

You can use other painkillers if prescribed by your doctor. However, ensure other painkillers don't contain nimesulide, paracetamol, and serratiopeptidase to avoid an overdose.

Do not exceed the recommended dose or duration of Nifen Plus 100/325/15 Tablet 10's, as this can lead to serious side effects such as liver damage or stomach problems. Taking more than the prescribed dose or using it for a prolonged period can be harmful. If you experience unexplained weight loss, dark urine, or fatigue, which may be signs of liver damage, seek medical attention immediately. Additionally, if your pain persists or is severe, do not adjust the dose on your own. Always consult your doctor first for proper guidance and care.

Nifen Plus 100/325/15 Tablet 10's should be stored in a cool and dry place, away from direct sunlight. Keep it out of reach of children.

Country of origin

India

Manufacturer/Marketer address

Shamti Solan-173212 (Himachal Pradesh) Pin Code :-173212, India
Other Info - NIF0058

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 18, 2025 | 6:45 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.5164.pdf
  2. https://www.ema.europa.eu/en/documents/referral/nimesulide-article-107-procedures-annex-iii_en.pdf
  3. https://www.webmd.com/vitamins/ai/ingredientmono-1115/serrapeptase

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