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Nifen Plus 100/325/15 Tablet 10's is used to treat mild to moderate pain. It can relieve pain, swelling, and inflammation associated with various chronic (long-term) conditions, such as rheumatoid arthritis (joint pain, especially in the hands and feet) and osteoarthritis (joint pain, especially in the knees, hip, hands, neck, and lower back). It can also relieve acute (short-term) pain such as toothache, ear pain, throat pain, muscle ache, and backache. It may cause side effects such as nausea, vomiting, indigestion, stomach pain, headache, heartburn, and diarrhoea.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

NIMESULIDE-100MG+PARACETAMOL-325MG+SERRATIOPEPTIDASE-15MG

Manufacturer/Marketer :

Meridian Medicare Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Nifen Plus 100/325/15 Tablet 10's

Nifen Plus 100/325/15 Tablet 10's is an oral tablet prescribed to relieve severe pain, reduce swelling, and lower inflammation associated with bone, joint, and tissue conditions. It is commonly used to treat conditions like arthritis, dental pain, and swelling after surgeries or physical injuries. This medication helps ease discomfort so you can regain your daily mobility and comfort.

For the best results, you should take this medicine consistently at the times recommended by your doctor, usually once or twice daily. Always take Nifen Plus 100/325/15 Tablet 10's after meals or with a glass of milk to protect your stomach from irritation. Supporting your treatment with plenty of rest, gentle stretching, and a balanced diet can help speed up your recovery.

Most people tolerate this medicine well, though some may experience mild side effects like nausea, dizziness, or a mild upset stomach. However, you must consult your doctor immediately if you experience severe abdominal pain, persistent vomiting, or yellowing of your eyes and skin. These could be signs of serious internal complications.

Talk to your doctor before taking Nifen Plus 100/325/15 Tablet 10's if you have a history of heart issues, high blood pressure, or kidney problems. Do not take this if you have active stomach ulcers, severe liver disease, or if you are in the late stages of pregnancy.

This medicine can interact with blood thinners and other pain relievers, which can increase the risk of bleeding or liver damage. You must avoid alcohol while taking this medicine, as it significantly increases your risk of liver damage. Pregnant, breastfeeding, or elderly individuals should always consult their doctor before using this medicine to ensure it is safe for their specific situation. Because nimesulide has been linked to a higher risk of liver injury than many other NSAIDs, it should be used only for the shortest duration prescribed by your doctor. 

Uses of Nifen Plus 100/325/15 Tablet 10's

Nifen Plus 100/325/15 Tablet 10's is used in the treatment of pain and inflammation in various conditions. The detailed uses of Nifen Plus 100/325/15 Tablet 10's are as follows:

  • Osteoarthritis: Reduces severe joint pain, stiffness, and localised inflammation, helping you move more comfortably.
  • Rheumatoid Arthritis: Eases chronic joint swelling and pain, allowing for better daily function and joint mobility.
  • Post-operative Pain: Relieves acute surgical pain and reduces tissue swelling around healing wounds.
  • Dental Pain: Controls sharp toothaches and reduces gum swelling after dental surgeries or extractions.
  • Sports Injuries: Alleviates sudden swelling, muscle strains, and sprains, helping you recover faster from soft tissue trauma.

Key Benefits

Nifen Plus 100/325/15 Tablet 10's helps relieve pain, reduce swelling, and improve comfort in a variety of painful conditions.

The following are the benefits of Nifen Plus 100/325/15 Tablet 10's:

  • Helps relieve pain from muscle, joint, dental, and other inflammatory conditions.
  • Reduces swelling and inflammation in affected tissues.
  • Improves mobility and makes everyday activities more comfortable.
  • Supports the natural healing process after injury or surgery.
  • Promotes better rest by relieving pain and discomfort.
  • Provides comprehensive pain relief with three medicines in a single treatment.
Side effects of Nifen Plus 100/325/15 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Gently massage the affected area using your hands or a massager.
  • Light exercises such as walking or climbing stairs may help the muscles return to normal.
  • Apply heat/ice to the affected area.
  • Drink electrolyte-rich fluids.

Directions for Use

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can interfere with how the medicine is absorbed.
  • Always take this medicine after a meal or with food to minimise the risk of an upset stomach.
  • Take the medicine at the exact times prescribed by your doctor to maintain steady levels of pain relief in your body.
  • Never take more than the recommended dose, and do not extend your treatment period unless specifically instructed by your doctor.
  • Always follow your doctor's exact instructions regarding how long you should continue taking this medication.

How Nifen Plus 100/325/15 Tablet 10's Works

Nifen Plus 100/325/15 Tablet 10's works through a combination of three active ingredients that target pain, swelling, and fever from different angles in your body. • Nimesulide: It is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the production of specific chemical messengers in the body, known as prostaglandins, which are responsible for causing pain, heat, and inflammation at the site of injury. • Paracetamol: It acts as a pain reliever and fever reducer. Its exact way of working is not fully understood, but it is thought to act partly in the brain and nervous system to reduce pain perception and regulate the body's temperature control centre, helping to quickly bring down fevers and ease general body aches. • Serratiopeptidase: It is a proteolytic enzyme that breaks down abnormal proteins and fluid build-up at the site of inflammation, which thins out inflammatory fluids, improves blood flow, and directly reduces tissue swelling and congestion.
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Alcohol

Caution

Consumption of alcohol may increase the risk of liver damage and serious side effects.

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Pregnancy

Unsafe

Nifen Plus 100/325/15 Tablet 10's is not recommended for use in pregnancy. Please consult your doctor if you are pregnant before taking this medicine.

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Breast Feeding

Unsafe

Nifen Plus 100/325/15 Tablet 10's should not be used in breastfeeding mothers as it may pass into breastmilk and cause unwanted effects to the nursing baby. However, if prescribed, the doctor may advise you to stop breastfeeding.

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Driving

Safe if prescribed

Nifen Plus 100/325/15 Tablet 10's may not affect your ability to drive. However, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Unsafe

Nifen Plus 100/325/15 Tablet 10's should not be used if you have severe liver disease, as this medicine may worsen your condition.

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Kidney

Caution

Nifen Plus 100/325/15 Tablet 10's should be used with caution if you have kidney problems. your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Nifen Plus 100/325/15 Tablet 10's is not recommended for use in children below 12 years of age.

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Heart

Unsafe

This medicine is not recommended in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

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Geriatrics

Caution

Nifen Plus 100/325/15 Tablet 10's can be given in elderly patients with extreme caution and only if prescribed by the doctor.

What if I have taken an overdose of Nifen Plus 100/325/15 Tablet 10's

If you suspect an overdose, seek immediate medical attention or visit the nearest emergency room. An overdose of this medication can cause serious liver damage and other severe internal complications.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of water throughout the day to help your kidneys flush out the medicine safely.
  • Eat anti-inflammatory foods: Include foods rich in omega-3 fatty acids, such as walnuts, flaxseeds, and leafy green vegetables, to help naturally reduce body inflammation.
  • Avoid strenuous activities: Rest the affected joint or muscle to prevent further tissue damage while the medicine helps you heal.
  • Apply gentle heat or cold: Use ice packs for fresh injuries to reduce swelling, or warm compresses for chronic joint stiffness, as advised by your physical therapist.
  • Engage in low-impact movement: Once your pain eases, practice gentle stretches or short walks to prevent joint stiffness and improve blood circulation.
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How Soon It Starts Working

  • The time required for Nifen Plus 100/325/15 Tablet 10's to start to work: The time required for Nifen Plus 100/325/15 Tablet 10's to start to work is 30 to 60 minutes after administration.
  • The time for which the effects of Nifen Plus 100/325/15 Tablet 10's last: The effect of Nifen Plus 100/325/15 Tablet 10's lasts for 6 to 8 hours.

What if you forget to take Nifen Plus 100/325/15 Tablet 10's

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a forgotten one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Avoid taking other pain medicines: Do not take other medicines containing paracetamol or additional pain relievers unless your doctor tells you to. Taking them together can increase the risk of serious liver damage and other side effects.
  • Avoid alcohol: Do not drink alcohol while taking this medicine. Alcohol can increase the risk of stomach bleeding and serious liver damage.
  • Watch for signs of bleeding: Contact your doctor immediately if you notice black, tarry stools or vomit that looks like coffee grounds. These may be signs of internal bleeding.
  • Inform your healthcare provider: Tell your doctor, surgeon, or dentist that you are taking this medicine before any medical or dental procedure. It may affect how your blood clots.
  • Be careful when driving: Avoid driving or operating heavy machinery if you feel dizzy or sleepy after taking this medicine.
  • Use only for the prescribed duration: Do not take this medicine for longer than your doctor recommends. Prolonged or unnecessary use may increase the risk of serious liver damage and kidney or heart problems.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (e.g., warfarin): Taking blood-thinning medicines alongside Nifen Plus 100/325/15 Tablet 10's may increase the risk of severe internal bleeding.
  • Other NSAIDs (e.g., ibuprofen or diclofenac): May increase the risk of stomach ulcers and bleeding.
  • Immunosuppressants (e.g., methotrexate): Nifen Plus 100/325/15 Tablet 10's may increase methotrexate levels in your blood, potentially causing toxic side effects.
  • Mood stabilisers (e.g., lithium): Nifen Plus 100/325/15 Tablet 10's may increase lithium levels in your blood, increasing the risk of lithium toxicity.
  • Blood pressure medicines (e.g., lisinopril, furosemide): Nifen Plus 100/325/15 Tablet 10's may reduce the effectiveness of these drugs and increase the risk of kidney damage.
serratiopeptidase + Nimesulide + ParacetamolKetoconazole
Severe
serratiopeptidase + Nimesulide + ParacetamolMipomersen
Severe

Drug-Drug Interactions

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serratiopeptidase + Nimesulide + ParacetamolKetoconazole
Severe
How does the drug interact with Nifen Plus 100/325/15 Tablet:
Co-administration of serratiopeptidase, Nimesulide and Paracetamol with Ketoconazole may increase the risk of liver problems.

How to manage the interaction:
Co-administration of serratiopeptidase, Nimesulide and Paracetamol with Ketoconazole can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, a skin rash or itching, loss of hunger, nausea, vomiting, or yellowing of the skin or the whites of your eyes, consult a doctor. Do not stop using any medications without talking to a doctor.
serratiopeptidase + Nimesulide + ParacetamolMipomersen
Severe
How does the drug interact with Nifen Plus 100/325/15 Tablet:
Taking Mipomersen with of serratiopeptidase, Nimesulide and Paracetamol can increase the risk of liver problems.

How to manage the interaction:
Co-administration of serratiopeptidase, Nimesulide and Paracetamol with Mipomersen can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, a skin rash or itching, loss of hunger, nausea, vomiting, or yellowing of the skin or the whites of your eyes, consult a doctor. Do not stop using any medications without talking to a doctor.
serratiopeptidase + Nimesulide + ParacetamolTeriflunomide
Severe
How does the drug interact with Nifen Plus 100/325/15 Tablet:
Taking Teriflunomide with of serratiopeptidase, Nimesulide and Paracetamol can increase the risk of liver problems.

How to manage the interaction:
Co-administration of serratiopeptidase, Nimesulide and Paracetamol with Teriflunomide can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, a skin rash or itching, loss of hunger, nausea, vomiting, or yellowing of the skin or the whites of your eyes, consult a doctor. Do not stop using any medications without talking to a doctor.
serratiopeptidase + Nimesulide + ParacetamolLeflunomide
Severe
How does the drug interact with Nifen Plus 100/325/15 Tablet:
Taking Leflunomide with of serratiopeptidase, Nimesulide and Paracetamol can increase the risk of liver problems.

How to manage the interaction:
Co-administration of serratiopeptidase, Nimesulide and Paracetamol with Leflunomide can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, a skin rash or itching, loss of hunger, nausea, vomiting, or yellowing of the skin or the whites of your eyes, consult a doctor. Do not stop using any medications without talking to a doctor.
serratiopeptidase + Nimesulide + ParacetamolLomitapide
Severe
How does the drug interact with Nifen Plus 100/325/15 Tablet:
Taking Lomitapide with of serratiopeptidase, Nimesulide and Paracetamol can increase the risk of liver problems.

How to manage the interaction:
Co-administration of serratiopeptidase, Nimesulide and Paracetamol with Lomitapide can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, a skin rash or itching, loss of hunger, nausea, vomiting, or yellowing of the skin or the whites of your eyes, consult a doctor. Do not stop using any medications without talking to a doctor.
serratiopeptidase + Nimesulide + ParacetamolEthanol
Severe
How does the drug interact with Nifen Plus 100/325/15 Tablet:
Taking Ethanol with of serratiopeptidase, Nimesulide and Paracetamol can increase the risk of liver problems.

How to manage the interaction:
Co-administration of serratiopeptidase, Nimesulide and Paracetamol with Ethanol can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, a skin rash or itching, loss of hunger, nausea, vomiting, or yellowing of the skin or the whites of your eyes, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Consuming alcohol while taking Nifen Plus 100/325/15 Tablet 10's may increase the risk of severe liver damage and stomach bleeding.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANALGESICS]

FAQs

Nifen Plus 100/325/15 Tablet 10's is used to treat mild to moderate pain. It can relieve pain, swelling, and inflammation associated with various chronic (long-term) conditions, such as rheumatoid arthritis (joint pain, especially in the hands and feet) and osteoarthritis (joint pain, especially in the knees, hip, hands, neck, and lower back). It can also relieve acute (short-term) pain such as toothache, ear pain, throat pain, muscle ache, and backache.
Nifen Plus 100/325/15 Tablet 10's contains Nimesulide, Paracetamol, and Serratiopeptidase. Nimesulide and Paracetamol are painkillers and can also reduce fever and inflammation. They act by blocking the action of chemical messengers responsible for pain, fever, and inflammation. Serratiopeptidase is an enzyme that can reduce swelling and promote the healing of damaged tissue. Together, Nifen Plus 100/325/15 Tablet 10's can effectively treat pain, swelling, and inflammation associated with various conditions.
Nifen Plus 100/325/15 Tablet 10's contains Nimesulide and Paracetamol, which may cause liver damage when used in higher doses or longer durations. So, take this medicine for a dose and duration as intended by your doctor. Also, avoid alcohol intake while using this medicine, as alcohol may increase the risk of liver damage.
In general, Nifen Plus 100/325/15 Tablet 10's is given for short-term pain relief. So, you can stop taking this medicine if your pain subsides. However, it is advised to consult your doctor before stopping this medication.
Nifen Plus 100/325/15 Tablet 10's may cause side effects such as nausea, vomiting, indigestion, stomach pain, headache, heartburn, and diarrhoea. These side effects are usually mild and temporary. However, if any of these side effects persist or worsen, consult a doctor immediately.
You can use other painkillers if prescribed by your doctor. However, ensure other painkillers don't contain nimesulide, paracetamol, and serratiopeptidase to avoid an overdose.
Do not exceed the recommended dose or duration of Nifen Plus 100/325/15 Tablet 10's, as this can lead to serious side effects such as liver damage or stomach problems. Taking more than the prescribed dose or using it for a prolonged period can be harmful. If you experience unexplained weight loss, dark urine, or fatigue, which may be signs of liver damage, seek medical attention immediately. Additionally, if your pain persists or is severe, do not adjust the dose on your own. Always consult your doctor first for proper guidance and care.
Nifen Plus 100/325/15 Tablet 10's should be stored in a cool and dry place, away from direct sunlight. Keep it out of reach of children.
No, you should not take Nifen Plus 100/325/15 Tablet 10's on an empty stomach. Taking it with food or milk helps protect your stomach lining and prevents common side effects like nausea or indigestion. Talk to your doctor if you experience ongoing stomach discomfort.
No, you must avoid alcohol completely while taking Nifen Plus 100/325/15 Tablet 10's. Alcohol combined with this medication significantly increases the risk of severe liver damage and stomach bleeding. Talk to your doctor if you find it difficult to avoid alcohol.
Nifen Plus 100/325/15 Tablet 10's is generally not recommended for pregnant or breastfeeding women, especially during the third trimester, as it can harm the baby and affect labour. Talk to your doctor to discuss safer pain relief options.
If you have mild stomach discomfort, try taking the tablet with food. However, if you experience severe, persistent stomach pain or notice dark stools, stop taking the medicine immediately and talk to your doctor right away.
Elderly patients are more sensitive to the side effects of Nifen Plus 100/325/15 Tablet 10's, particularly stomach bleeding and kidney or liver issues. Doctors usually prescribe the lowest effective dose for the shortest duration possible. Talk to your doctor about safe monitoring.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Shamti Solan-173212 (Himachal Pradesh) Pin Code :-173212, India
Other Info - NIF0058

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