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compositionComposition:GLYCERYL TRINITRATE-50MG
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Prescription Medicine
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Niplast 10 Transdermal Patch 1's belongs to the class of anti-anginal drugs, which is used in the treatment of angina pectoris, heart attack (myocardial infarction) and Perioperative hypertension. It helps relax and widen blood vessels, which improves blood flow and reduces the workload on the heart.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLYCERYL TRINITRATE-50MG

Manufacturer/Marketer :

Hetero Healthcare Ltd

Consume Type :

Topical

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Niplast 10 Transdermal Patch 1's

Niplast 10 Transdermal Patch 1's is a prescription topical ointment used to treat and relieve the painful symptoms of chronic anal fissures, which are small tears in the lining of the back passage. It is designed specifically to help heal these tears by reducing pressure and muscle spasms in the affected area. By targeting the local muscles, this medicine provides focused relief where it is needed most.

To get the best results, you must apply Niplast 10 Transdermal Patch 1's consistently and exactly as prescribed, at regular intervals as directed by your doctor. Since this is a topical ointment applied locally, its use is not affected by food, meaning you can apply it at any time of day regardless of your meals. Making simple dietary changes, such as eating more high-fibre foods and drinking plenty of water, can also significantly improve your healing progress by keeping your stools soft.

While using Niplast 10 Transdermal Patch 1's, the most common side effect you may experience is a mild to moderate headache, which occurs because the medicine relaxes blood vessels. However, if you experience severe dizziness, blurred vision, or a rapid, pounding heartbeat, you should stop using the ointment and consult your doctor immediately.

Before you begin using this medicine, it is important to tell your doctor if you have a history of heart problems, glaucoma, or severe anaemia. Do not use this medicine if you have very low blood pressure, severe dehydration, or if you are currently taking certain medications for erectile dysfunction.

Avoid drinking alcohol while using Niplast 10 Transdermal Patch 1's, as alcohol can interact with the medicine to cause a dangerous drop in your blood pressure, making you feel dizzy or faint. Additionally, if you are pregnant, breastfeeding, or are an older adult, you should consult your doctor before starting this treatment to ensure it is safe for your specific situation.
 

Uses of Niplast 10 Transdermal Patch 1's

Niplast 10 Transdermal Patch 1's is used to treat and relieve the painful symptoms of chronic anal fissures. The detailed uses of Niplast 10 Transdermal Patch 1's are as follows:

  • Anal fissures: Niplast 10 Transdermal Patch 1's is prescribed to treat the pain associated with chronic anal fissures. It works by relaxing the tight muscle ring around the back passage, which reduces pain, relieves spasms, and allows the delicate torn skin to heal.
     

Key Benefits

Niplast 10 Transdermal Patch 1's offers targeted relief directly at the site of discomfort, providing several clinically proven benefits:

  • Targeted pain relief: By relaxing the spasm of the anal sphincter muscle, it rapidly reduces the sharp, tearing pain experienced during and after bowel movements.
  • Improved healing environment: Relaxing the tight muscle improves local blood circulation, delivering the oxygen and nutrients needed to repair the torn tissue.
  • Non-surgical management: Using this ointment consistently can help heal chronic fissures, often helping patients avoid the need for surgical procedures.
     

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Wash your hands. Clean and dry the area of skin. Apply the patch to the side of the chest or the upper arm.
  • The area should be hairless to ensure that the patch has good contact with the skin.
  • Do not use moisturiser or powder.

How Niplast 10 Transdermal Patch 1's Works

Niplast 10 Transdermal Patch 1's contains glyceryl trinitrate, which belongs to a group of medicines called vasodilators. When you apply the ointment, it is absorbed locally into the tissues of the back passage, where it releases a substance called nitric oxide. Nitric oxide is a natural chemical that signals the surrounding smooth muscles to relax. In the anal canal, this relaxation affects the internal anal sphincter muscle, which is often tight and spasming due to the fissure. Once this muscle relaxes, the blood vessels in the area widen, significantly increasing blood flow to the damaged tissue. This combination of reduced muscle tension and increased blood flow relieves pain and allows the tear to heal naturally.
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Alcohol

Unsafe

Concomitant use of nitrates and alcohol may cause hypotension. So intake of alcohol should be avoided with Niplast 10 Transdermal Patch 1's.

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Pregnancy

Consult your doctor

Inform your doctor if you are pregnant or planning pregnancy before using this Niplast 10 Transdermal Patch 1's. Your doctor will weigh the benefits and potential risks before prescribing Niplast 10 Transdermal Patch 1's.

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Breast Feeding

Consult your doctor

Inform your doctor if you are a nursing mother before using this Niplast 10 Transdermal Patch 1's. Your doctor will weigh the benefits and potential risks before prescribing Niplast 10 Transdermal Patch 1's.

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Driving

Caution

Niplast 10 Transdermal Patch 1's may cause dizziness. So, driving vehicles and operating machinery which requires concentration should be avoided.

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Liver

Consult your doctor

Inform your doctor before using Niplast 10 Transdermal Patch 1's if you have liver problems or a history of liver conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Inform your doctor before using Niplast 10 Transdermal Patch 1's if you have kidney problems or a history of kidney conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

The safety and effectiveness of Niplast 10 Transdermal Patch 1's in children have not been established.

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Heart

Safe if prescribed

Niplast 10 Transdermal Patch 1's is commonly used for heart conditions like angina to improve blood flow. It should be used cautiously in patients with low blood pressure or recent heart events.

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Geriatrics

Caution

Geriatric patients can use Niplast 10 Transdermal Patch 1's, but it may be more sensitive to side effects like dizziness or low blood pressure. Careful monitoring and gradual dose adjustments help ensure safe and effective use.

What if I have taken an overdose of Niplast 10 Transdermal Patch 1's

If you apply too much ointment or accidentally swallow it, you may experience a severe drop in blood pressure, leading to extreme dizziness, fainting, a rapid heart rate, or a severe headache. Wash off any excess ointment immediately and seek emergency medical attention.

Diet & Lifestyle Advise

  • Eat more fibre: Include fibre-rich foods like whole grains, vegetables, fruits, and legumes in your daily meals to help soften your stool.
  • Drink plenty of fluids: Stay well-hydrated by drinking water throughout the day, which helps keep stool soft and easy to pass.
  • Avoid straining: Do not strain or push during bowel movements, as this increases pressure on the back passage and can reopen healing tears.
  • Use sitz baths: Sit in a tub of warm water for 15 to 20 minutes several times a day to help relax the muscle sphincter and soothe local pain.
  • Do not delay: Go to the bathroom as soon as you feel the urge. Delaying can cause the stool to become hard and difficult to pass.
     
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How Soon It Starts Working

  • The time required for Niplast 10 Transdermal Patch 1's to start to work: Niplast 10 Transdermal Patch 1's ideally shows its action within 15 to 30 minutes after administration.
  • The time for which the effects of Niplast 10 Transdermal Patch 1's last: The effect of Niplast 10 Transdermal Patch 1's lasts for 3 to 6 hours.

What if you forget to take Niplast 10 Transdermal Patch 1's

If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose and continue with your regular schedule. Do not apply a double amount of ointment to make up for a missed application.

Storage

• Store Niplast 10 Transdermal Patch 1's at room temperature, custody between 15°C and 25°C.

Drug Warnings

  • Sit or lie down if dizzy: If you feel lightheaded or dizzy after applying the ointment, sit or lie down immediately until the sensation passes.
  • Stand up slowly: Avoid sudden changes in posture, such as standing up quickly from a sitting or lying position, to prevent a sudden drop in blood pressure.
  • Protect your fingers: Always use a disposable glove or plastic wrap during application to prevent the medicine from absorbing through your hands, which helps avoid headaches.
  • Do not share: This medicine has been prescribed specifically for you. Do not share it with others, even if they have identical symptoms.
    Inspect the tube: Before your first use, check that the safety seal on the tube is intact. Do not use the product if the packaging is damaged.
     

verifiedApollotooltip
  • Erectile dysfunction medicines: Do not use Niplast 10 Transdermal Patch 1's if you are taking medications like sildenafil, tadalafil, or vardenafil. Combining these can cause an extremely dangerous drop in blood pressure.
  • Blood pressure medications: Taking this ointment alongside blood pressure-lowering drugs, such as beta-blockers or ACE inhibitors, can increase your risk of severe dizziness and fainting.
  • Other nitrates: Avoid using other nitrate medications (such as those prescribed for heart conditions) at the same time, as this can increase the risk of severe side effects.

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verifiedApollotooltip
  • Alcohol: Avoid drinking alcohol while using this medicine. Alcohol can worsen the blood pressure-lowering effects of the ointment, leading to severe dizziness or fainting.
     

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Habit Forming

No

Therapeutic Class

[ANTIANGINALS]

FAQs

Niplast 10 Transdermal Patch 1's belongs to the class of anti-anginal medication primarily used to prevent angina pectoris due to coronary artery disease. It can be used as monotherapy or in combination with other anti-anginal agents.
Niplast 10 Transdermal Patch 1's relaxes the muscles surrounding blood vessels, making the heart's job easier. When used on a regular and long-term basis, this helps to prevent angina episodes.
Patients may benefit from Niplast 10 Transdermal Patch 1's over oral formulations in terms of the convenience of administration, ease of treatment regimens, and avoidance of first-pass and peak-dose effects.
No, you should not combine Niplast 10 Transdermal Patch 1's with an erectile dysfunction medicine such as sildenafil, vardenafil, or tadalafil since it may interfere with the blood pressure-lowering action of Niplast 10 Transdermal Patch 1's.
Yes, headache is the most common side effect encountered while using Niplast 10 Transdermal Patch 1's. Please drink more fluids if you have headache. If the problem persists, consult your doctor.
It is recommended not to use Niplast 10 Transdermal Patch 1's in patients with hypotension (low blood pressure); inform your doctor before using Niplast 10 Transdermal Patch 1's if you have ever had hypotension.
You may be prescribed antianginal drugs when patches are not adequate to prevent angina attacks. However, take antianginal drugs in addition to patches only if prescribed by your doctor.
It is recommended not to use Niplast 10 Transdermal Patch 1's in patients with severe anaemia (doesn't have enough healthy red blood cells); inform your doctor before using Niplast 10 Transdermal Patch 1's if you have ever had anaemia.
It is highly recommended to use a protective finger covering, like plastic wrap or a disposable finger cot, to apply Niplast 10 Transdermal Patch 1's. Applying it with a bare finger allows the medicine to be absorbed through your skin, which can cause severe headaches. Talk to your doctor or pharmacist for further guidance.
The medicine works by relaxing blood vessels to improve blood flow, but this effect can also widen blood vessels in your head, resulting in a headache. These headaches are usually mild and tend to decrease over time as your body adjusts. Talk to your doctor or pharmacist if the headaches are severe or do not go away.
This medicine can cause dizziness or lightheadedness, especially shortly after application. You should avoid driving, operating machinery, or performing tasks that require alertness until you know how the medicine affects you. Talk to your doctor if you experience persistent dizziness.
The safety of this medicine during pregnancy is not fully established. If you are pregnant, think you might be pregnant, or are planning to have a baby, you should consult your healthcare provider to discuss the risks and benefits before using this ointment. Talk to your doctor for personalised advice.
If the ointment accidentally contacts your eyes, rinse them immediately with plenty of clean, cool water for several minutes. If you experience irritation, redness, or vision changes after rinsing, talk to your doctor right away.
Niplast 10 Transdermal Patch 1's is specifically prescribed to treat chronic anal fissures and may not be appropriate or effective for haemorrhoids. You should only use this medicine for the exact condition it was prescribed for. Talk to your doctor for an accurate diagnosis and treatment plan.
Stopping the treatment too soon, even if your pain has stopped, can prevent the fissure from healing completely and may cause it to return. Always complete the full course of treatment as prescribed. Talk to your doctor if you feel you need to stop using the medicine due to side effects.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.1042 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 020145S027Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. DailyMed Database. Fdadrugxsl.Cfm Clinical Monograph. Bethesda, MD: National Library of Medicine; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Nitroglycerin,Nitro Td Patch A Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Glyceryl Trinitrate 5 mg/ml Sterile Concentrate — Summary of Product Characteristics (SmPC) – (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 26 Sep 2025]Check here
  6. Kim KH, Kerndt CC, Adnan G, et al. Nitroglycerin. [Updated 2023 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; [Accessed on 11 Mar 2025]Check here
  7. Elkayam U, Aronow WS. Glyceryl trinitrate (nitroglycerin) ointment and isosorbide dinitrate: a review of their pharmacological properties and therapeutic use. Drugs. 1982 Mar;23(3):165-94 [Accessed on 11 Mar 2025]Check here

Country of origin

India

Manufacturer/Marketer address

HALL NO 3, BASEMENT, A37, MANGOLPURI, INDUSTRIALAREA, PHASE 11, NEW DELHI, DELHI, 110034.
Other Info - NIP0144
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