Nitnib 25 Capsule belongs to the class of medications called ‘antineoplastic agents’ used in treating gastrointestinal stromal tumors (cancer of the stomach, bowel, or esophagus) in which patients don’t respond to imatinib (another anticancer agent). It is also used to treat renal carcinoma (kidney cancer) that has spread to other parts of the body and advanced pancreatic neuroendocrine tumors (cancer that has affected hormone-producing cells in the pancreas).

Nitnib 25 Capsule contains sunitinib. It acts by slowing down the growth of cancer cells by two processes. It interferes with the action of a protein that promotes cell division and thereby decreases cancer cell production. It can inhibit a process called angiogenesis, the development of blood supply to the cancer cells. This effect inhibits the nutrient supply to the cancer cells, thereby causing cancer cell death eventually.

You should take this medicine exactly as prescribed by the doctor. The common side-effects of Nitnib 25 Capsule are difficulty breathing, increase in blood pressure, extreme tiredness, swelling caused by fluid under the skin and around the eye, pain or irritation in the mouth, mouth sores, dry mouth, taste disturbances, upset stomach, nausea, vomiting, diarrhea, constipation, abdominal pain, loss of appetite, decreased activity of thyroid gland (hypothyroidism), dizziness, headache, nose bleeding, back pain, joint pain, pain in arms and legs, yellowish discoloration of the skin, rash on the palms of the hands and soles of the feet, dryness of the skin, cough, fever, and difficulty to sleep. Inform your doctor immediately if any of these side-effects persist or get worse.

It is not recommended to take Nitnib 25 Capsule if you are allergic to any contents of it. Nitnib 25 Capsule should be used with caution in patients with high blood pressure, heart problems, diabetes, liver or kidney problems, skin disorders, pancreas or gallbladder problems, history of blood clots, aneurysm (weakening of blood vessel wall), problems with the thyroid gland, pancreas, and gallbladder, liver or kidney problems, and thrombotic microangiopathy (damage to the smallest blood vessels). It is not recommended for use in children and adolescents under 18 years of age. It should be used with caution in pregnant and breastfeeding women. Do not consume alcohol as it may increase the risk of side-effects. Nitnib 25 Capsule may cause dizziness, so do not drive or operate heavy machinery if you are not fully alert.

Nitnib 25 Capsule is used to treat certain types of cancers. The detailed uses of Nitnib 25 Capsule are as follows:

• Gastrointestinal stromal tumour (GIST): Nitnib 25 Capsule treats stomach and bowel cancer when other medicines are not effective or cannot be used.
• Metastatic renal cell carcinoma (MRCC): Nitnib 25 Capsule manages kidney cancer that has spread to other parts of the body.
• Pancreatic neuroendocrine tumours (pNET): Nitnib 25 Capsule treats hormone-producing pancreatic tumours that have become worse or cannot be removed surgically.
• Control of tumour progression: Nitnib 25 Capsule slows the growth and spread of cancer cells.

• Take Nitnib 25 Capsule with or without food as advised by your doctor.
• Typically, Nitnib 25 Capsule is taken once daily for 28 days, followed by a 2-week break. This cycle is repeated every 6 weeks, as recommended by your doctor. However, always follow your doctor's instructions regarding dosage and duration.
• Swallow the capsule as a whole with a glass of water.
• Do not open, crush or dissolve Nitnib 25 Capsule.

Nitnib 25 Capsule is a targeted therapy used to treat advanced kidney cancer. It is also used in patients with kidney cancer to prevent recurrence after having kidney surgery. It is used to treat gastrointestinal stromal cancer that cannot be treated with imatinib, another anti-cancer medicine. It is used to manage pancreatic neuroendocrine tumors (cancer of hormone-producing cells of the pancreas) that cannot be treated with surgery. Nitnib 25 Capsule can help to manage the above conditions if taken regularly as prescribed by the doctor.

Nitnib 25 Capsule may cause an increase in blood pressure. So, your doctor may monitor your blood pressure regularly and prescribe blood-pressure-lowering medicines if necessary. Nitnib 25 Capsule may increase the risk of bleeding, and the risk is high if you are taking any blood thinners such as warfarin and acenocoumarol. Nitnib 25 Capsule may cause heart problems, so notify your doctor if you experience extreme tiredness, shortness of breath, and swelling of the feet and ankles. Nitnib 25 Capsule may cause heart rhythm abnormalities, so inform your doctor if you experience dizziness or abnormal heartbeats. Nitnib 25 Capsule should be used with caution in patients with a recent history of blood clots, heart attack, or stroke as this medicine may cause chest pain, shortness of breath, difficulty speaking, weakness of one side of the body, or dizziness. Nitnib 25 Capsule should be used with caution in patients with aneurysm (weakening of blood vessel wall), thrombotic microangiopathy (damage to the small blood vessels), and liver or kidney problems. Nitnib 25 Capsule may cause inflammation of the pancreas or gallbladder and lead to symptoms such as abdominal pain (upper abdominal region), fever, and vomiting, in patients with a history of pancreatic or gallbladder disorders. Nitnib 25 Capsule may cause thyroid gland problems, so inform your doctor if you experience frequent fatigue and extreme cold than others. Nitnib 25 Capsule may cause skin ulceration (pyoderma gangrenosum) or infection (necrotizing fasciitis). So, inform your doctor if you notice symptoms of infection around a skin injury such as fever, pain, swelling, redness, and drainage of pus or blood from the wound. However, these effects are usually reversible after the discontinuation of therapy. If you develop severe skin rashes, especially with blistering or peeling of the skin, notify your doctor immediately as it can be a sign of a serious skin condition. Nitnib 25 Capsule may cause headaches, high blood pressure, and vision problems in patients with a history of fits or seizures. While using Nitnib 25 Capsule, blood sugar levels should be monitored regularly in patients with diabetes. In addition, notify your doctor immediately if you notice signs of low blood sugar such as fatigue, hunger, sweating, pounding heartbeat, and loss of consciousness.