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compositionComposition:NITROFURANTOIN-100MG
prescription
Prescription Medicine
info
Nitrobest Tablet 10's
Nitrobest Tablet 10's
Nitrobest Tablet 10's

Nitrobest Tablet is used to prevent and treat bacterial infections like urinary tract infections (UTIs), including Bladder Infection (cystitis). It is also used to treat kidney infections. It contains Nitrofurantoin, which kills bacteria by entering their cells and destroying their genetic material. As a result, it is effective against bacterial infections. It may cause common side effects like nausea, vomiting, diarrhoea, loss of appetite and headaches. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

NITROFURANTOIN-100MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Nitrobest Tablet

Nitrobest Tablet is an oral prescription medication used to treat and prevent urinary tract infections (UTIs). It specifically targets bacteria in the bladder and urinary tract to clear up the infection. You should take this medicine exactly as prescribed to ensure the infection is completely cleared.

To get the best results, take Nitrobest Tablet at evenly spaced times throughout the day and complete the full course, even if you start feeling better. Taking this medication with food or milk helps your body absorb it better and reduces the chance of an upset stomach. Drinking plenty of water during your treatment is also highly recommended to help flush bacteria out of your urinary tract.

While taking Nitrobest Tablet , some people may experience mild side effects like nausea, loss of appetite, or mild stomach upset. However, if you experience more serious issues such as breathing difficulties, a persistent cough, or signs of liver damage like yellowing of your eyes or skin, stop taking the medicine and consult your doctor immediately.

Do not take this if you have severe kidney disease, as your kidneys will not be able to clear the medicine from your body properly, making it ineffective and potentially harmful. You should also talk to your doctor before starting Nitrobest Tablet if you have liver problems, anemia, diabetes, or a history of lung issues.

Some medicines, like certain antacids containing magnesium, can prevent your body from absorbing Nitrobest Tablet properly. Avoid drinking alcohol during your treatment, as it can worsen side effects like dizziness and stomach upset. If you are pregnant (especially in the final weeks of pregnancy), breastfeeding, or are an older adult, consult your doctor or pharmacist to ensure this medicine is safe for you.

Uses of Nitrobest Tablet

Nitrobest Tablet is used to treat and prevent urinary tract infections (UTIs). The detailed uses of Nitrobest Tablet are as follows:

  • Urinary tract infections (UTIs): Nitrobest Tablet kills the specific bacteria causing acute infections in the bladder and urinary tract.
  • Prevention of urinary tract infections: For individuals who get frequent UTIs, Nitrobest Tablet can be prescribed in a lower dose to stop bacteria from multiplying and causing new infections.
     

Key Benefits

Nitrobest Tablet provides effective treatment for urinary tract infections by targeting the bacteria responsible for the infection. By concentrating in the urine and helping eliminate harmful bacteria, this medicine offers several key benefits:

  • Helps Relieve Urinary Discomfort: Nitrobest Tablet works directly at the site of infection within the urinary tract, helping reduce symptoms such as burning during urination, pain, and the frequent or urgent need to urinate. This can improve comfort and make daily activities easier.
  • Supports Faster Recovery from Infection: By clearing the bacteria causing the infection, this medicine helps your body recover more efficiently. As the infection improves, symptoms gradually subside, helping you return to your normal routine sooner.
  • Helps Prevent Infection Progression: Effective treatment of urinary tract infections can reduce the risk of the infection spreading to the kidneys or causing more serious complications. This supports a safer recovery and helps protect long-term urinary tract health.
Side effects of Nitrobest Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Directions for Use

Swallow the tablet or capsule whole with a full glass of water or milk; do not crush, chew, or break it. If you are using the liquid form, shake the bottle well before each use and measure the dose carefully using a medical measuring spoon or cup, not a regular household spoon.

Always take this medication with food or milk to improve absorption and protect your stomach from irritation. Remember to follow your doctor's exact instructions and complete the entire prescribed course, even if your symptoms disappear after a few days.
 

How Nitrobest Tablet Works

Unlike other antibiotics that work throughout the entire body, Nitrobest Tablet filters rapidly through your kidneys and concentrates in your urine. Once inside your bladder, the medicine enters the bacterial cells and damages their DNA, proteins, and cell walls. This multi-targeted attack stops the bacteria from growing and reproducing, allowing your body's natural defences to easily clear the remaining infection.
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Alcohol

Consult your doctor

No reported interaction with Nitrobest Tablet . But, It is best to consult the physician before taking medication.

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Pregnancy

Caution

Nitrobest Tablet can be safely taken by pregnant women if prescribed by the doctor. But do not take nitrofurantoin during labour and childbirth, as there's a chance that it can affect the baby's blood.

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Breast Feeding

Consult your doctor

Nitrobest Tablet is excreted in breast milk. Caution should be exercised, and it is advisable to consult a doctor before using it.

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Driving

Unsafe

Nitrobest Tablet may cause dizziness and drowsiness, and the patient should not drive or operate machinery.

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Liver

Consult your doctor

If you have or had a history or evidence of any liver-related diseases, please consult the doctor before taking medicine.

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Kidney

Consult your doctor

Nitrobest Tablet is contraindicated in patients with renal dysfunction and patients with an eGFR of less than 45 ml/minute. It is advisable to consult a doctor before using it.

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Children

Safe if prescribed

Nitrobest Tablet can be given to children but under child specialist medical supervision. Nitrobest Tablet is prescribed to the children to treat complicated urinary tract infections.

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Heart

Safe if prescribed

Nitrobest Tablet is safe for use in heart patients if recommended by the physician.

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Geriatrics

Caution

Nitrobest Tablet should be used under caution in geriatric patients as it can lead to adverse effects. Please consult your physician.

What if I have taken an overdose of Nitrobest Tablet

Do not take more than the prescribed dose of Nitrobest Tablet as it may cause serious adverse effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Drink plenty of water: Aim to drink at least 8 to 10 glasses of water daily to flush bacteria out of your urinary tract naturally.
  • Take with food or milk: Always schedule your doses around meals or snacks to maximise absorption and prevent nausea.
  • Avoid irritating foods and drinks: Limit caffeine, alcohol, spicy foods, and acidic fruits (like oranges or lemons) while you have active symptoms, as these can irritate your bladder.
  • Do not use magnesium-containing antacids: If you need an antacid, choose one without magnesium, as magnesium binds to the medicine and stops it from working.
     

Health Queries

Have a query?

How Soon It Starts Working

  • The time required for Nitrobest Tablet to start to work: The time required for Nitrobest Tablet to show its action is unknown.
  • The time for which the effects of Nitrobest Tablet last: The effect of Nitrobest Tablet lasts for 1 to 3 hours.

What if you forget to take Nitrobest Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time.

Storage

• Store Nitrobest Tablet tablets or capsules at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original container, tightly closed, and protected from direct light, moisture, and extreme heat.

Drug Warnings

  • Complete the full course: Never stop taking this medicine early, even if you feel completely better, as the infection can return and become harder to treat.
  • Watch your urine colour: Do not be alarmed if your urine turns a dark yellow or brown colour; this is a harmless and temporary side effect of the medicine.
  • Avoid magnesium antacids: Check the label of any over-the-counter heartburn medicine you take; avoid any that list magnesium trisilicate, as it reduces the effectiveness of Nitrobest Tablet .
  • Monitor your breathing: Contact your doctor immediately if you develop any new lung symptoms, such as a dry cough or shortness of breath, especially if you are taking this medicine long-term.
  • Report nerve tingling: Tell your healthcare provider right away if you feel any unusual numbness, tingling, or weakness in your hands or feet.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Antacids containing magnesium trisilicate: These can significantly lower how much medicine your body absorbs, making the antibiotic less effective.
  • Gout medications (like probenecid or sulfinpyrazone): These can block your kidneys from passing Nitrobest Tablet into your urine, which reduces its effectiveness and increases the risk of side effects in your blood.
  • Live typhoid vaccine: This antibiotic may stop the oral typhoid vaccine from working properly. Do not get vaccinations while taking this medicine without consulting your doctor.

Drug-Food Interactions

  • Food and dairy products: Taking this medicine with food or milk actually improves how well your body absorbs it and helps prevent an upset stomach.
  • Alcohol: Drinking alcohol while taking this medicine can increase your risk of side effects like dizziness, headache, and stomach irritation.

Drug-Disease Interactions

  • Kidney disease: If your kidneys do not work well, the medicine cannot reach high enough levels in your urine to fight the infection, and it can build up dangerously in your body.
  • Liver disease: People with a history of liver problems should use this medicine with caution, as it can occasionally cause liver damage.
  • Lung conditions: If you have asthma or other chronic lung issues, your doctor will monitor you closely, as this medicine can cause lung reactions.
  • G6PD deficiency: People with this genetic condition may develop a serious blood disorder (haemolytic anaemia) if they take this medicine.
NitrofurantoinPrilocaine
Severe
NitrofurantoinLevobupivacaine
Severe

Drug-Drug Interactions

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NitrofurantoinPrilocaine
Severe
How does the drug interact with Nitrobest Tablet:
Coadministration of Nitrobest Tablet with Prilocaine can increase the risk of methemoglobinemia, a condition that can lead to oxygen deprivation in tissues and vital organs due to the reduced oxygen-carrying capacity of the blood.

How to manage the interaction:
Taking Nitrobest Tablet with Prilocaine together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NitrofurantoinLevobupivacaine
Severe
How does the drug interact with Nitrobest Tablet:
Combining Nitrobest Tablet with Levobupivacaine can increase the risk of methemoglobinemia (a condition in which the iron in the hemoglobin molecule (the red blood pigment) is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
There may be a possibility of interaction between Nitrobest Tablet and Levobupivacaine, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include a condition called methemoglobinemia, problems with your heart or lungs, your skin turning gray, feeling sick to your stomach, having a headache, feeling dizzy or lightheaded, being very tired, having trouble breathing, breathing quickly or not deeply enough, a fast heartbeat, feeling your heart pounding, feeling anxious or confused. Do not stop using any medications without a doctor's advice.
NitrofurantoinTetracaine
Severe
How does the drug interact with Nitrobest Tablet:
Combining Nitrobest Tablet with Tetracaine can increase the risk of methemoglobinemia (a condition in which the iron in the hemoglobin molecule is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Nitrobest Tablet and Tetracaine together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms, it's important to contact a doctor right away if you experience your skin turning gray, feeling sick to your stomach, having a headache, feeling dizzy or lightheaded, being very tired, having trouble breathing, breathing quickly or not deeply enough, a fast heartbeat, feeling your heart pounding, feeling anxious or confused. Do not stop using any medications without talking to a doctor.
NitrofurantoinLeflunomide
Severe
How does the drug interact with Nitrobest Tablet:
Coadministration of Nitrobest Tablet with leflunomide can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between Nitrobest Tablet and leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NitrofurantoinMepivacaine
Severe
How does the drug interact with Nitrobest Tablet:
Combining Nitrobest Tablet with Mepivacaine can increase the risk of methemoglobinemia (a condition in which the iron in the hemoglobin molecule is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Nitrobest Tablet and Mepivacaine together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms, it's important to contact a doctor right away: gray skin color, feeling sick, headache, feeling dizzy or lightheaded, tiredness, trouble breathing, fast or shallow breathing, a fast heartbeat, feeling your heart pounding, feeling anxious or confused. Do not discontinue any medications without consulting a doctor.
NitrofurantoinMipomersen
Severe
How does the drug interact with Nitrobest Tablet:
Coadministration of Mipomersen with Nitrobest Tablet may increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Nitrobest Tablet and Mipomersen, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include liver problems, fever, rash, itching, loss of appetite, feeling sick, throwing up, feeling tired, feeling unwell, pain in the upper right side of your belly, dark urine, yellowing of the skin or eyes, chills, joint pain, swelling, bruising, not wanting to eat, belly pain, liver damage, bleeding, or throwing up. Do not discontinue any medications without consulting a doctor.
NitrofurantoinBCG vaccine
Severe
How does the drug interact with Nitrobest Tablet:
When BCG vaccine is used with Nitrobest Tablet, its effectiveness may be reduced.

How to manage the interaction:
Taking Nitrobest Tablet with BCG vaccine together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice. Do not stop using any medications without consulting a doctor.
NitrofurantoinEtidocaine
Severe
How does the drug interact with Nitrobest Tablet:
Coadministration of Nitrobest Tablet with Etidocaine may cause methemoglobinemia (a condition in which the iron in the hemoglobin molecule is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Co-administration of Nitrobest Tablet with Etidocaine can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include a condition called methemoglobinemia, problems with your heart or lungs, your skin turning gray, feeling sick to your stomach, having a headache, feeling dizzy or lightheaded, being very tired, having trouble breathing, breathing quickly or not deeply enough, a fast heartbeat, feeling your heart pounding, feeling anxious or confused. Do not discontinue any medications without consulting a doctor.
NitrofurantoinBupivacaine
Severe
How does the drug interact with Nitrobest Tablet:
Taking Bupivacaine and Nitrobest Tablet may cause methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Taking bupivacaine and Nitrobest Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
NitrofurantoinKetoconazole
Severe
How does the drug interact with Nitrobest Tablet:
Coadministration of Ketoconazole and Nitrobest Tablet may increase the risk of liver injury.

How to manage the interaction:
Although taking Ketoconazole and Nitrobest Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Nitrobest Tablet is used to treat bacterial infections like urinary tract infections (UTIs), including bladder infections, cystitis and kidney infections.
Nitrobest Tablet kills bacteria by entering their cells and destroying their genetic material. As a result, it is effective against bacterial infections.
Nitrobest Tablet belongs to the class of penicillin antibiotic. Nitrobest Tablet is a broad-spectrum antibiotic effective against a wide range of bacteria. On the other hand, penicillin is a narrow-spectrum antibiotic effective against less number of bacteria.
Nitrobest Tablet does not work against viral infection. So, treating common cold and cough should not be taken.
Nitrobest Tablet makes your skin sensitive to sunlight, known as photosensitivity. So, prolonged exposure to sunlight or ultraviolet light should be avoided. In case of emergency, you should always wear sunscreen before going out.
No, Nitrobest Tablet should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.
Stay hydrated by drinking at least six glasses of water or other fluids. Keep your underwear clean, and use underwear made of cotton to avoid spreading infection. Always keep your bladder empty as much as possible by peeing regularly. Your doctor may prescribe cranberry juice with antibiotics to treat urinary tract infections.
Always follow your pharmacist's or doctor's advice and the instructions that come with your medicine.
Your dose of Nitrobest Tablet depends on whether it's to treat or prevent a medical condition, your age, and how bad the infection is.
Nitrobest Tablet can cause acute or chronic liver injury. So, inform your doctor before prescribing Nitrobest Tablet about your medical condition. Your doctor will monitor your liver with blood tests and adjust the treatment if necessary.
Never take an extra dose to make up for a forgotten one. It may lead to more prone to more adverse events.
In some cases, Nitrobest Tablet may cause blurred vision. It may be severe and, in some instances, permanent. So, seek medical attention immediately if you observe any symptoms related to this.
In some instances, Nitrobest Tablet may cause neurological adverse effects, including headache, drowsiness, vertigo, dizziness, nystagmus (involuntary eye movement), intracranial hypertension, and peripheral neuropathy.
No, Nitrobest Tablet is not a sleeping pill; it is an antibiotic medication. However, it can make you feel dizzy or sleepy.
No, Nitrobest Tablet is not intended to treat anxiety. It is an antibiotic medication.
Acidic foods, spicy foods, alcohol, and caffeine can all increase UTI symptoms and nitrofurantoin side effects, so you may want to avoid these while taking the medication.
No. Even if you start feeling better, do not skip doses or stop taking Nitrobest Tablet early. Complete the full course exactly as prescribed. Stopping treatment too soon may allow the infection to return and increase the risk of antibiotic resistance.
Nitrobest Tablet might cause weight loss as taking it makes you feel less or not hungry (loss of appetite). However, it varies from person to person.
Swallow the tablet whole with a drink of water. Do not chew or break them. Take Nitrobest Tablet with or after a meal or snack. This helps your body absorb the medicine, as well as helping to prevent stomach upset.
Nitrobest Tablet can safely turn your urine a dark yellow or rusty brown colour. This is a very common and harmless reaction as your body processes and eliminates the medicine, and your urine will return to its normal colour once you finish the treatment.
Nitrobest Tablet is generally considered safe during early and mid-pregnancy, but it should not be taken during the final weeks of pregnancy (near term) as it can cause blood issues in the newborn baby. Always talk to your doctor or pharmacist before taking any medication while pregnant.
Nitrobest Tablet begins working within a few hours of the first dose. Many people notice improvement in urinary symptoms within 24–48 hours, but it is important to complete the full prescribed course to completely clear the infection.
You should avoid taking Nitrobest Tablet on an empty stomach. Taking it with food or milk significantly improves how your body absorbs the medicine and helps prevent common side effects like nausea and stomach pain. Talk to your doctor or pharmacist for more personalised advice.
No, Nitrobest Tablet is not used to treat kidney infections. The medicine concentrates quickly in the bladder urine and does not reach high enough levels in the kidney tissues to treat a deep kidney infection. Talk to your doctor to get the correct antibiotic if you suspect a kidney infection.
You should avoid taking antacids that contain magnesium trisilicate while taking Nitrobest Tablet , as magnesium can bind to the antibiotic and prevent your body from absorbing it. If you need an antacid, ask your pharmacist to help you choose a compatible option.
If you develop a new or persistent dry cough, shortness of breath, or chest pain while taking Nitrobest Tablet , stop taking the medicine and contact your doctor immediately. These could be signs of a rare but serious lung reaction. Talk to your doctor right away for alternative treatment options.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.428 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. National Health Service (NHS). Nitrofurantoin - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  3. Nitrofurantoin Nitrofurantoin. 2008. [Accessed on 28 Mar. 2019] Check here
  4. Nitrofurantoin monohydrate/macrocrystals [Prescribing Information]. 2008. [Accessed on 06 Apr. 2023] Check here
  5. EMC Nitrofurantoin [Accessed on 27 Oct 2025] Check here
  6. Squadrito FJ, del Portal D. Nitrofurantoin. NIH National Library of Medicine, National center for biotechnology information. July 2021 [Accessed on 10th May 2022] Check here
  7. Asis Pharmaceuticals. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 10th May 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - NIT0232

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