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compositionComposition:HYDRALAZINE-37.5MG+ISOSORBIDE DINITRATE-20MG
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Prescription Medicine
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Nitrolazine Tablet 10's is used to treat heart failure. It contains Isosorbide dinitrate and Hydralazine, which relax the heart's muscles and widen the heart's veins and arteries for easy flow of blood to every part of the body. Thus, it helps lower high blood pressure and treat heart failure. It may cause side effects like headache, nausea, dizziness, and lightheadedness (feeling faint). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

HYDRALAZINE-37.5MG+ISOSORBIDE DINITRATE-20MG

Manufacturer/Marketer :

Wellness Inc

Consume Type :

Oral

Return Policy :

Not Returnable

About Nitrolazine Tablet 10's

Nitrolazine Tablet 10's is an oral prescription medicine used to treat heart failure. It is typically prescribed alongside other standard heart failure medications to help manage symptoms and improve survival. This combination may be particularly useful in certain patients who cannot tolerate ACE inhibitors or angiotensin receptor blockers (ARBs), or when additional symptom control is needed as part of a comprehensive heart failure treatment plan. By helping blood vessels relax and improving blood flow, this medicine reduces the workload on the heart and supports long-term heart health.

For this medicine to work effectively, it must be taken consistently every day exactly as your doctor directs. You can take this medicine with or without food, but choosing one way and sticking to it with every dose helps keep medication levels steady in your body. Making healthy changes, such as eating a low-salt diet and staying moderately active, will also help you get the best results from your treatment.

Like all medications, Nitrolazine Tablet 10's can cause some side effects, with headaches and dizziness being the most common, especially when you first start taking it. While these mild issues often improve over time, you should contact your doctor immediately if you experience serious symptoms such as severe lightheadedness, fainting, or a fast heartbeat.

Talk to your doctor before starting Nitrolazine Tablet 10's if you have a history of low blood pressure, lupus, or severe kidney or liver problems. Do not take this medicine if you are currently taking certain medications for erectile dysfunction or high blood pressure in the lungs, as this combination can cause a dangerous, sudden drop in blood pressure.

This medicine can interact with alcohol, which may increase your risk of dizziness and low blood pressure. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor or pharmacist to discuss whether this treatment is safe and appropriate for your specific situation.

Uses of Nitrolazine Tablet 10's

Nitrolazine Tablet 10's is used in the treatment of heart failure. The detailed uses of Nitrolazine Tablet 10's are as follows:

  • Heart Failure Management: Helps reduce the workload on the heart by relaxing blood vessels, improving blood flow, and reducing symptoms such as shortness of breath and fatigue.
  • Adjunctive Therapy in Chronic Heart Failure: May be prescribed alongside other heart failure medicines to improve symptom control, support physical activity, and reduce the risk of hospitalisation.
  • Alternative Treatment Option for Certain Patients: May be used in patients who cannot tolerate ACE inhibitors or ARBs, or when additional treatment is needed as determined by a healthcare provider.

Key Benefits

Nitrolazine Tablet 10's helps improve heart function in people with heart failure by relaxing and widening blood vessels, making it easier for the heart to pump blood throughout the body. This helps reduce symptoms and supports better day-to-day functioning. Benefits may include:

  • Reduces the workload and strain on the heart.
  • Improves blood flow and oxygen delivery to body tissues.
  • Helps reduce shortness of breath and fatigue associated with heart failure.
  • Improves the ability to perform daily activities and physical tasks.
  • May reduce the risk of hospitalisation due to worsening heart failure symptoms.
  • Supports better long-term management of heart failure and overall quality of life.

Directions for Use

Follow these steps to take your medicine safely and effectively:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can change how the medicine is absorbed into your body.
  • Take this medicine at the same times every day to keep a steady amount of the drug in your system.
  • You may take this medication with or without food, but be consistent with how you take it.

Always follow your doctor's exact instructions regarding how and when to take Nitrolazine Tablet 10's. Do not stop taking this medication suddenly without consulting your healthcare provider, even if you feel better.

How Nitrolazine Tablet 10's Works

Nitrolazine Tablet 10's contains Isosorbide Dinitrate and Hydralazine. • Isosorbide Dinitrate: It helps relax and widen the blood vessels, especially the veins. This reduces the amount of blood returning to the heart, lowering the strain on the heart and helping it work more efficiently. • Hydralazine: It helps relax and widen the arteries, allowing blood to flow more easily through the body. This reduces the workload on the heart and improves blood circulation.
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Alcohol

Unsafe

Consuming alcohol with the Nitrolazine Tablet 10's is not advisable as it may cause unpleasant side effects, or you may become more sensitive to the effects of alcohol.

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Pregnancy

Consult your doctor

Nitrolazine Tablet 10's is not recommended during pregnancy. Please discuss with the doctor if you have any concerns.

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Breast Feeding

Consult your doctor

Nitrolazine Tablet 10's is not recommended during nursing. Please discuss with the doctor if you have any concerns.

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Driving

Unsafe

Nitrolazine Tablet 10's may cause dizziness in some people, so it may affect your ability to drive.

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Liver

Caution

Nitrolazine Tablet 10's to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Nitrolazine Tablet 10's to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

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Children

Unsafe

The safety and effectiveness of Nitrolazine Tablet 10's in children have not been established.

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Heart

Caution

Nitrolazine Tablet 10's can be used in heart patients if prescribed by the physician in heart failure patients. Please consult your physician if you have any concerns.

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Geriatrics

Caution

Exercise caution while giving Nitrolazine Tablet 10's in geriatric patients. Close monitoring of the individual is required.

What if I have taken an overdose of Nitrolazine Tablet 10's

In case of an accidental overdose, seek emergency medical help or contact a poison control centre immediately. Symptoms of an overdose may include severe dizziness, fainting, a very fast heartbeat, confusion, or cold, sweaty skin.

Diet & Lifestyle Advise

  • Limit your sodium intake: Eat a low-salt diet as recommended by your doctor, as excess salt causes your body to hold onto fluid, putting extra stress on your heart.
  • Monitor your weight daily: Weigh yourself every morning after using the bathroom but before eating. Report any sudden weight gain (such as 2 to 3 pounds in a day or 5 pounds in a week) to your doctor, as this can be a sign of fluid buildup.
  • Avoid alcohol: Limit or avoid alcoholic beverages, as alcohol can interact with this medicine to cause severe dizziness or dangerously low blood pressure.
  • Stay active safely: Engage in light, doctor-approved physical activity, such as walking, to help strengthen your cardiovascular system.
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How Soon It Starts Working

  • The time required for Nitrolazine Tablet 10's to start to work: Nitrolazine Tablet 10's ideally shows its action within 1 hour after administration.
  • The time for which the effects of Nitrolazine Tablet 10's last: The effect of Nitrolazine Tablet 10's lasts for 4 to 6 hours.

What if you forget to take Nitrolazine Tablet 10's

If you miss a dose of Nitrolazine Tablet 10's, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Change positions slowly: Stand up gradually from a sitting or lying position to help prevent dizziness and reduce the risk of falls.
  • Avoid certain medicines without medical advice: Do not take medicines used for erectile dysfunction while using Nitrolazine Tablet 10's, as this combination may cause a severe drop in blood pressure.
  • Monitor your blood pressure regularly: Check your blood pressure and heart rate at home as advised by your doctor and report any unusual changes.
  • Protect your skin from sunlight: This medicine may increase your sensitivity to the sun. Wear protective clothing and apply sunscreen when spending time outdoors.
  • Inform healthcare providers before procedures: Tell your surgeon, dentist, or healthcare provider that you are taking Nitrolazine Tablet 10's before undergoing any medical or dental procedure.
  • Do not take Nitrolazine Tablet 10's: Unless specifically advised by your doctor, if you are allergic to its ingredients, have severe low blood pressure, are taking erectile dysfunction medicines, have certain serious heart conditions, or have had a serious reaction to nitrate medicines. Inform your doctor about your complete medical history before starting treatment.
  • Watch for worsening heart failure symptoms: Contact your doctor if you notice increasing shortness of breath, swelling of the feet or ankles, sudden weight gain, unusual fatigue, or reduced ability to perform normal activities.

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Drug-Drug Interactions

  • Erectile dysfunction medications (e.g., sildenafil, tadalafil, or vardenafil): Taking these with Nitrolazine Tablet 10's can cause an extremely dangerous, rapid drop in blood pressure.
  • Other blood pressure medicines (e.g., diuretics or beta-blockers): Combining these can increase the risk of excessively low blood pressure and dizziness.
  • Certain migraine medications: May interact with this medicine and alter its blood-vessel-relaxing effects.

Drug-Food Interactions

  • Alcohol: Drinking alcohol while taking this medicine can increase the risk of severe dizziness, lightheadedness, and fainting by further lowering your blood pressure.

Drug-Disease Interactions

  • Low blood pressure (hypotension): This medicine can make existing low blood pressure worse.
  • Severe kidney or liver damage: May affect how your body processes and clears this medication, requiring closer monitoring by your doctor.
  • Systemic lupus erythematosus: This medicine can trigger or worsen symptoms of lupus, such as joint pain and rashes.

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Habit Forming

No

Therapeutic Class

[VASODILATORS]

FAQs

Nitrolazine Tablet 10's is used to treat heart failure, a condition that occurs when the heart does not pump enough blood for the body's needs.
Nitrolazine Tablet 10's relaxes the heart's muscles and widens the heart's veins and arteries for easy flow of blood to every part of our body. It helps lower raised blood pressure by relaxing and widening the heart's muscles.
Yes, the use of Nitrolazine Tablet 10's can make you feel dizzy. This may often occur when you suddenly rise from a sitting or lying position. To lower the chance of feeling dizzy (faint) or passing out, rise slowly if you have been lying down or sitting.
Keep this medicine tightly closed in the container or the original packaging. Store it according to the instructions mentioned on the pack or label. Dispose of unused medicine. Make sure pets, children, and other people do not consume it.
Take Nitrolazine Tablet 10's with or without food, accompanied by a glass of water. Swallow the medicine whole, without chewing, breaking, or crushing it. Follow your doctor's instructions for dose and duration, and complete the entire prescribed course.
The common side effects of the Nitrolazine Tablet 10's that may occur in some individuals are headache, nausea, dizziness, and lightheadedness (a fainting sensation). Most of these side effects of Nitrolazine Tablet 10's do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.
No, it is advisable not to drink alcohol while taking Nitrolazine Tablet 10's. Drinking alcohol during treatment may cause increased dizziness and drowsiness, or it may cause unpleasant side effects.
Yes, there are some precautions or warnings associated with Nitrolazine Tablet 10's. Exercise caution while using this medication and it is not advisable for individuals with low blood pressure. Pregnant or breastfeeding women should consult their doctor before use. Additionally, it may cause dizziness, so driving after taking this medication is not recommended.
If you miss a dose of Nitrolazine Tablet 10's, take it as soon as you remember. However, if it's close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Never take a double dose to make up for a missed one.
No, you must not take Nitrolazine Tablet 10's with erectile dysfunction medications like sildenafil, tadalafil, or vardenafil. Combining these medicines can cause a sudden, severe, and dangerous drop in blood pressure. Talk to your doctor if you have concerns about this interaction.
Mild headaches are a very common side effect when starting Nitrolazine Tablet 10's as your body adjusts to the relaxed blood vessels. These headaches often lessen over time. Do not take any over-the-counter pain relievers without checking with your healthcare provider first. Talk to your doctor if your headaches are severe or do not go away.
This medicine starts working in your body shortly after you take it, but it may take several weeks of consistent use before you notice an improvement in your overall heart failure symptoms, such as having more energy or easier breathing. Talk to your doctor if you do not feel any improvement over time.
No, you should never stop taking this medication suddenly, even if you feel completely healthy. Stopping it abruptly can cause your heart failure symptoms to worsen rapidly. Any changes to your treatment plan must be guided by your healthcare provider. Talk to your doctor before making any adjustments.
The safety of this medicine during pregnancy or breastfeeding is not fully established. It should only be used if the potential benefit justifies the potential risk to the baby. Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Yes, your doctor may recommend regular blood tests to check your kidney function, blood cell counts, and to monitor for any signs of an autoimmune or lupus-like reaction. It is important to keep all of your scheduled laboratory and doctor appointments. Talk to your doctor for more information.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Isosorbide Dinitrate Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Isosorbide Dinitrate And Hydralazine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Ferdinand KC, Elkayam U, Mancini D, et al. Use of isosorbide dinitrate and hydralazine in African-Americans with heart failure 9 years after the African-American Heart Failure Trial. Am J Cardiol. 2014;114(1):151-9Check here
  5. Cheng JW A review of isosorbide dinitrate and hydralazine in the management of heart failure in black patients, with a focus on a new fixed-dose combination. Clin Ther. 2006;28(5):666-78Check here
  6. Isosorbide dinitrate and hydralazine hydrochloride. 2005. [Accessed on 23 Jan. 2019]Check here
  7. ScienceDirect ScienceDirect. [Accessed on 28th Sept. 2023]Check here

Country of origin

India

Manufacturer/Marketer address

No.553, 5th Floor, OTC Road, Balepet Circle, Bangalore - 560 053
Other Info - NIT0491
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