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compositionComposition:LEVOCETIRIZINE-2.5MG/5ML+MONTELUKAST-4MG/5ML
prescription
Prescription Medicine
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Nixzine M Syrup is used to relieve allergic rhinitis. It contains Montelukast and Levocetirizine, which work by blocking the chemical messengers responsible for allergy. In some cases, this medicine may cause side effects like abdominal pain, dizziness, headache, fatigue, and sleepiness. Let the doctor know if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LEVOCETIRIZINE-2.5MG/5ML+MONTELUKAST-4MG/5ML

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Nixzine M Syrup

Nixzine M Syrup is a medicine used to relieve symptoms of allergic rhinitis, such as sneezing, runny nose, and itchy eyes. It is also prescribed to manage allergy symptoms associated with asthma. This combination helps keep your airway passage clear and reduces discomfort.

For the best results, take this medicine once daily at the same time every day, with or without food. Consistency is key to keeping allergy symptoms under control throughout the day and night. Staying hydrated and keeping indoor environments dust-free can further support your recovery.

While taking Nixzine M Syrup, you may experience mild side effects like drowsiness, dry mouth, or headache. If you experience any severe symptoms, such as mood changes, severe dizziness, or breathing difficulties, you must consult your doctor immediately.

Before starting Nixzine M Syrup, talk to your doctor if you have kidney disease or liver damage. Do not take this medicine if you have severe kidney failure or are undergoing kidney dialysis.

Avoid consuming alcohol while taking this medicine, as it can increase drowsiness and affect your coordination. If you are pregnant, breastfeeding, or an elderly patient, consult your healthcare provider to ensure this treatment is safe for you.

Uses of Nixzine M Syrup

Your doctor may prescribe Nixzine M Syrup to treat several conditions, including:

  • Allergic Rhinitis: Helps relieve seasonal and year-round allergy symptoms like sneezing, runny nose, nasal congestion, and itchy, watery eyes.
  • Asthma with Allergies: Assists in managing allergy symptoms in patients who also have mild to moderate asthma, helping to keep airways clear.
  • Hives (Urticaria): Reduces skin itching, swelling, and redness associated with chronic allergic skin conditions.

Key Benefits

Nixzine M Syrup provides comprehensive allergy relief by targeting multiple pathways involved in nasal and eye allergy symptoms. By controlling inflammation and allergy responses, this medicine offers several key health benefits:

  • Complete Relief from Nasal and Eye Allergy Symptoms: Nixzine M Syrup works through dual-action effects to reduce symptoms such as sneezing, nasal congestion, and eye irritation, providing relief where it is needed most.
  • Improved Sleep and Daily Comfort: By reducing persistent allergy symptoms, Nixzine M Syrup helps support better sleep quality, improved focus, and greater comfort during daily activities.
  • Long-Lasting 24-Hour Allergy Protection: With a convenient once-daily dose, Nixzine M Syrup provides continuous symptom control, helping prevent allergy triggers from disrupting your routine throughout the day.
     
Side effects of Nixzine M Syrup
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Directions for Use

Follow these steps to apply Nixzine M Syrup safely and effectively:

  • Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
  • You can take this medicine with or without food, but taking it at the same time each day helps maintain a steady level in your body.
  • Always follow your doctor's exact instructions regarding how long to continue this treatment, even if you start feeling better.

How Nixzine M Syrup Works

Nixzine M Syrup contains two active ingredients that work together to stop allergy symptoms in their tracks. The first active ingredient, levocetirizine, is an antihistamine. It blocks histamine, a natural chemical your body releases during an allergic reaction that causes itching, runny nose, and watery eyes. The second active ingredient, montelukast, is a leukotriene receptor antagonist. It blocks leukotrienes, which are chemicals that cause swelling, narrowing, and mucus buildup in your airways. Together, these two ingredients soothe irritation in both your nose and chest.
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Alcohol

Unsafe

It is not advised to consume alcohol while taking Nixzine M Syrup as it leads to excessive drowsiness.

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Pregnancy

Caution

Please consult the doctor. There are no adequate and well-controlled studies on pregnant women. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

It is not known if Nixzine M Syrup passes into breastmilk. Consult your doctor if you are breastfeeding.

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Driving

Caution

Nixzine M Syrup should be used with caution while driving as it may interfere with driving capabilities. You may feel drowsy or sleepy after taking Nixzine M Syrup.

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Liver

Caution

If you have a history of liver diseases or conditions, inform your doctor. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Nixzine M Syrup is not recommended in patients with severe renal impairment. Inform your doctor if you have a history of kidney diseases/conditions.

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Children

Caution

Nixzine M Syrup is not recommended for children below two years without the doctor's consent. However, consult your paediatrician before giving Nixzine M Syrup to your child.

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Heart

Consult your doctor

Limited data available for the use of Nixzine M Syrup in heart patients. Please consult your physician.

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Geriatrics

Safe if prescribed

Nixzine M Syrup is safe for use in geriatric patients if prescribed by the physician.

What if I have taken an overdose of Nixzine M Syrup

Do not take more than the prescribed dose of Nixzine M Syrup as it may cause overdose symptoms like headache, dizziness, fatigue, dry mouth, and nausea. If you suspect you have taken an overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Keep windows closed during high pollen seasons and use air conditioners to filter indoor air.
  • Dust and vacuum your living spaces regularly using a vacuum cleaner with a HEPA filter to minimise allergen exposure.
  • Stay well-hydrated by drinking plenty of water, which helps thin mucus in your nasal passages.
  • Avoid smoking and exposure to secondhand smoke, as tobacco smoke can worsen nasal congestion and respiratory allergy symptoms.
health query

Have a query?

How Soon It Starts Working

The time required for Nixzine M Syrup to start to work: The time required for Nixzine M Syrup to show its action is unknown. The time for which the effects of Nixzine M Syrup last: The duration of action for Nixzine M Syrup is unknown.

What if you forget to take Nixzine M Syrup

If you miss a dose of Nixzine M Syrup, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

• Store Nixzine M Syrup tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medicine in its original packaging to protect it from moisture and direct light.

Drug Warnings

  • Do not drive, operate heavy machinery, or perform dangerous tasks until you know how this medicine affects you, as it may cause drowsiness.
  • Watch closely for any unusual changes in mood, behavior, or sleep patterns, and report them to your doctor immediately.
  • Check the blister pack before use; do not take the tablet if the packaging is torn, punctured, or damaged.
  • Avoid drinking alcohol while taking Nixzine M Syrup, as it can significantly increase sleepiness and reduce alertness.
  • Inform any healthcare provider you visit that you are taking this medication, especially before undergoing any allergy skin tests, as it may affect the test results.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions:

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • May interact with medications that cause sleepiness, such as sleeping pills, muscle relaxants, pain relievers, or anti-anxiety drugs, by increasing their sedative effects.
  • Taking this medicine with phenytoin or phenobarbital (seizure medications) or rifampicin (an antibiotic) may lower the level of montelukast in your body, making it less effective.

Drug-Food Interactions:

  • Do not consume alcohol while taking Nixzine M Syrup, as it can worsen drowsiness and impair coordination.

Drug-Disease Interactions:

Inform your doctor if you have a history of the following conditions before taking Nixzine M Syrup, as it may worsen your condition or cause complications.

  • Kidney disease: May require a dose adjustment or make this medicine unsafe to take, especially in severe cases where kidney function is extremely low.
  • Liver damage: Use with caution, as liver function can affect how your body processes this medicine.
  • Psychiatric disorders: Use with caution if you have a history of anxiety, depression, or mood disorders, as this medicine can occasionally affect mood.
     
Levocetirizine + MontelukastPhenytoin
Severe
Levocetirizine + MontelukastEsketamine
Severe

Drug-Drug Interactions

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Levocetirizine + MontelukastPhenytoin
Severe
How does the drug interact with Nixzine M Syrup:
Coadministration of Montelukast and Phenytoin may reduce the blood levels and effects of Montelukast.

How to manage the interaction:
Taking Montelukast and Phenytoin may interact with one another, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
Levocetirizine + MontelukastEsketamine
Severe
How does the drug interact with Nixzine M Syrup:
Co-administration of Esketamine together with Levocetirizine may increase side effects (drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination).

How to manage the interaction:
Taking Levocetirizine with Esketamine together can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Levocetirizine + MontelukastRifabutin
Severe
How does the drug interact with Nixzine M Syrup:
Co-administration of Montelukast and Rifabutin can reduce the levels and effects of Rifabutin.

How to manage the interaction:
Taking montelukast and rifabutin together can possibly result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Levocetirizine + MontelukastPrimidone
Severe
How does the drug interact with Nixzine M Syrup:
Co-administration of Montelukast and Primidone can reduce the levels and effects of Montelukast.

How to manage the interaction:
Taking Montelukast and Primidone together can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Levocetirizine + MontelukastRifapentine
Severe
How does the drug interact with Nixzine M Syrup:
Co-administration of Rifapentine with Montelukast may reduce the blood levels and effects of Montelukast.

How to manage the interaction:
Taking Rifapentine with Montelukast together can possibly result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIALLERGIC]

FAQs

Nixzine M Syrup is used to relieve and/or prevent symptoms of allergic rhinitis (seasonal and perennial). It is also used to treat rhinitis associated with asthma and urticaria.
Nixzine M Syrup is a combination medicine containing levocetirizine (antihistamine) and montelukast (leukotriene antagonist). Montelukast works by blocking a chemical messenger (leukotriene) and reduces inflammation and swelling in the nose. Levocetirizine works by blocking the effects of a chemical messenger called histamine (responsible for allergic reactions).
Nixzine M Syrup is a non-sedative antihistamine providing instant relief from allergic conditions; however, in some people, it may cause sleepiness and induce drowsiness.
No, Nixzine M Syrup will not help in reducing general fever. Nixzine M Syrup is an antiallergic and primarily helps reduce allergic reactions, including seasonal allergies known as hay fever.
Nixzine M Syrup should be used during pregnancy only if prescribed by the doctor. Please consult the doctor if you are pregnant, planning for pregnancy or think you may be pregnant.
Take Nixzine M Syrup exactly as advised by your doctor, preferably at the same time each day. It can be taken during the day or evening. However, since it may cause drowsiness in some people, taking it in the evening may be preferred. Follow your doctor's recommendation.
Nixzine M Syrup is a combination medicine containing Levocetirizine and Montelukast. It treats sneezing, runny nose, and allergic skin conditions due to various allergies and hay fever (seasonal allergy).
Dry mouth could be a side-effect of Nixzine M Syrup. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevent drying of the mouth.
It is not advised to consume alcohol while taking Nixzine M Syrup as it leads to excessive drowsiness.
No, taking Nixzine M Syrup in higher doses will not be effective but might lead to an overdose. Therefore, avoid exceeding the recommended dosage.
Store Nixzine M Syrup at room temperature, in a dry place. Keep out of sight and reach of children.
Nixzine M Syrup can be taken if you have liver or kidney problems, if prescribed by the doctor. Consult the doctor if you have any concerns.
Nixzine M Syrup may cause side effects like abdominal pain, skin rash, sleepiness, headache, and fatigue. Most of these side effects of Nixzine M Syrup are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Tell your doctor about all medicines you are taking before starting Nixzine M Syrup. Some medicines, including certain pain relievers, sleep medicines, and other allergy medications, may interact with Nixzine M Syrup or increase side effects such as drowsiness. Consult your doctor before taking any new medicine.
Do not take more than the prescribed dose of Nixzine M Syrup as it may cause an overdose. Seek immediate medical attention if you have overdosed on Nixzine M Syrup.
Most patients begin to feel relief from allergy symptoms within a few hours of taking the first dose, though maximum benefit may take a few days of consistent use. Talk to your doctor if your symptoms do not improve.
It is highly recommended to avoid alcohol while taking this medicine. Alcohol can increase the risk of drowsiness, dizziness, and impaired concentration. Talk to your doctor for further guidance.
No, Nixzine M Syrup is not intended to treat sudden or acute asthma attacks. It helps manage allergic conditions and may be used as part of long-term asthma management, but it is not a rescue medication. Always use your prescribed rescue inhaler during an asthma attack and consult your doctor if you have concerns
You should not stop taking this medicine abruptly without consulting your doctor. Stopping too early may cause your allergy symptoms to return. Talk to your doctor before changing your routine.
Yes, in some cases, one of the active components can cause mood or behavior changes such as anxiety, irritability, or sleep problems. If you or your family notice any unusual behavior, stop taking the medicine and contact your doctor immediately. Talk to your doctor if you have concerns.

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Reference

  1. Drugs.com Clinical Review Team. Montelukast Patient Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 020829S051 020830S052 021409S028Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 022064S009Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Levocetirizine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. CiplaMed: Montelukast sodium + Levocetirizine dihydrochloride [Prescribing Information]. 2023. [Accessed on 24 Oct. 2025]Check here
  6. Adsule SM, Misra D Long term treatment with montelukast and levocetirizine combination in persistent allergic rhinitis: review of recent evidence. J Indian Med Assoc. 2010;108(6):381-382Check here
  7. Montelukast 10 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 15th September 2025]Check here

Country of origin

India
Other Info - NI90237
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