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compositionComposition:DISOPYRAMIDE-100MG
prescription
Prescription Medicine
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Norpace Capsule is used to treat irregular heartbeat. It contains disopyramide which helps correct irregular heartbeats by blocking certain electrical signals in the heart. In some cases, this medicine may cause side effects such as blurred or double vision, stomach pain, little or no urinating, and low blood sugar. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DISOPYRAMIDE-100MG

Manufacturer/Marketer :

RPG Life Sciences Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Norpace Capsule

Norpace Capsule is an oral prescription medication used to treat and manage certain types of serious, life-threatening irregular heartbeats (arrhythmias). It helps keep your heart beating in a normal, steady rhythm. This medicine is typically prescribed for individuals who have serious heart rhythm issues starting in the lower chambers of the heart.

To work effectively, Norpace Capsule must be taken consistently at the exact times prescribed by your doctor, usually multiple times throughout the day. You can take this medicine with or without food, but it is best to choose one way and stick to it with every dose to maintain stable levels in your body. Your doctor may also suggest certain lifestyle changes, such as limiting caffeine and getting regular, gentle exercise, to support your heart health.

Some people taking Norpace Capsule may experience side effects like dry mouth, blurred vision, constipation, or difficulty urinating. While these are usually mild, you must consult your doctor immediately if you face serious issues such as sudden shortness of breath, unexplained swelling in your legs, or chest pain.

Before starting Norpace Capsule , tell your doctor about your complete medical history, especially if you have glaucoma, liver damage, kidney issues, or myasthenia gravis. Do not take this if you have certain severe heart conditions, such as cardiogenic shock or specific types of heart block, unless you have a working pacemaker.

This medication can interact with other substances, including alcohol, which can worsen dizziness and lower your blood pressure dangerously. If you are pregnant, breastfeeding, or an older adult, you should consult your doctor or pharmacist to discuss the risks and benefits before starting this treatment.

Uses of Norpace Capsule

Norpace Capsule is used to treat and manage certain types of serious, life-threatening irregular heartbeats (arrhythmias). The detailed uses of Norpace Capsule are as follows:

  • Serious irregular heartbeats: Norpace Capsule is prescribed to control and prevent severe, abnormal heart rhythms in the lower chambers of the heart (ventricular arrhythmias), helping to keep the heartbeat stable.
  • Maintaining normal heart rhythm: It helps keep the heart beating normally in patients who have recently had their irregular heartbeats corrected by other medical treatments.

Key Benefits

Norpace Capsule helps manage abnormal heart rhythms by restoring and maintaining a regular heartbeat. By improving the heart's electrical activity, it supports efficient blood circulation and helps reduce symptoms associated with arrhythmias.

  • Helps Maintain a Normal Heart Rhythm: By stabilising the heart's electrical signals, Norpace Capsule helps prevent episodes of rapid or irregular heartbeat, allowing the heart to pump blood more effectively.
  • Relieves Symptoms of Arrhythmia: By improving heart rhythm, Norpace Capsule helps reduce symptoms such as palpitations, dizziness, lightheadedness, fatigue, and weakness, improving day-to-day comfort.
  • Supports Better Cardiovascular Function: Maintaining a steady heart rhythm helps improve blood flow throughout the body and reduces the risk of complications associated with uncontrolled heart rhythm disorders when used as prescribed.
Side effects of Norpace Capsule
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Managing Medication-Triggered Urinary hesitancy (Difficulty passing urine): A Step-by-Step Guide:
  • Consult Your Doctor: If you experience urinary difficulties after taking medication, consult your doctor immediately and share your symptoms, medication regimen, and medical history.
  • Your doctor will assess your medication regimen to determine if it contributes to urinary hesitancy. This assessment will help identify the best course of action to manage your condition and prevent further complications.
  • Your doctor may recommend changes to your daily habits, such as drinking more water, limiting caffeine and alcohol, and exercising regularly. Additionally, your doctor may prescribe medications to help relax the muscles in the bladder and urethra, improve urine flow, or reduce symptoms.
  • If your condition does not improve or persists, consult your doctor and report your condition. Your doctor will assess your progress, adjust your treatment plan if necessary, and provide appropriate advice to ensure the best possible outcome.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Quit smoking as smoking impairs erectile function by significantly damaging blood vessels.
  • Maintain a healthy weight as overweight can cause erectile dysfunction.
  • Exercise regularly as physical activity enhances blood flow and overall health, benefiting erectile function.
  • Consume a healthy diet loaded with whole grains, fruits and vegetables.
  • Limit alcohol consumption as excessive alcohol intake can impair erectile function.
  • Manage stress by practicing techniques such as yoga, relaxation exercises or meditation.
  • In case erectile dysfunction is due to psychological factors, consider couple counselling or sex therapy to address relationship and anxiety issues.
  • Openly discuss your concerns with your partner.
  • Stay hydrated by drinking water, herbal tea, or warm soup to keep your throat moist.
  • Gargle with warm salt water (1/4 teaspoon of salt per glass) several times daily to soothe your throat.
  • Avoid smoke, dust, and other irritants that can dry out your throat.
  • Avoid caffeine and alcohol, as they can dehydrate you and dry out your throat.
  • You can moisten and calm your throat with throat lozenges.
  • Consult a doctor if your dry throat persists or worsens to rule out underlying conditions.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.

Directions for Use

  • Take Norpace Capsule with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew or break it.

How Norpace Capsule Works

Norpace Capsule contains disopyramide, which belongs to a group of medicines known as antiarrhythmics. It works directly on the muscle cells of your heart to co-stabilise its electrical system. In a healthy heart, orderly electrical signals tell the heart muscle when to contract and pump blood. In people with arrhythmias, these signals become chaotic, causing the heart to beat too quickly or irregularly. This medicine works by blocking specific channels (called sodium channels) in the heart's cells. By slowing down the electrical impulses that cause rapid beats, Norpace Capsule calms the overactive areas of the heart muscle. This allows the heart to maintain a steady, predictable rhythm, ensuring a safe and consistent flow of blood to your vital organs.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption with Norpace Capsule as it may increase drowsiness and reduce the amount of Norpace Capsule in the blood leading to abnormal heart function.

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Pregnancy

Consult your doctor

Norpace Capsule should not be taken until prescribed. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Breast Feeding

Consult your doctor

Norpace Capsule should not be taken until prescribed. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Driving

Unsafe

Norpace Capsule may cause dizziness and blurred vision in some people. So, make sure you are not affected before driving or operating machinery.

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Liver

Caution

Take Norpace Capsule with caution, especially if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Norpace Capsule with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Norpace Capsule is not recommended for use in children.

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Heart

Caution

Please inform your doctor if you have a history of heart disease before using Norpace Capsule . Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Caution

Norpace Capsule should be given with caution in elderly patients due to an increased risk of side effects. Dose adjustment may be required based on their health condition.

What if I have taken an overdose of Norpace Capsule

In case of an accidental overdose, seek emergency medical attention immediately. Symptoms of an overdose may include severe dizziness, difficulty breathing, loss of consciousness, or a dangerously slow heartbeat.

Diet & Lifestyle Advise

  • Limit caffeine and alcohol: Both caffeine and alcohol can trigger irregular heartbeats and reduce the effectiveness of Norpace Capsule . Talk to your doctor about safe limits.
  • Stay properly hydrated: Because this medicine can cause dry mouth and constipation, drink plenty of water throughout the day. However, if you have a history of heart failure, consult your doctor about how much fluid is safe for you to drink.
  • Avoid grapefruit and grapefruit juice: Grapefruit can increase the amount of Norpace Capsule in your blood, raising your risk of experiencing serious side effects.
  • Eat a high-fiber diet: To help prevs medicine, try to include fibre-rich foods like whole grains, fruits, and vegetables in your meent constipation caused by thials, unless advised otherwise by your doctor.

Health Queries

What is the role of Disopyramide tablets in HOCM associated with mitral regurgitation, and how effective is this treatment for symptom control?

Vikas Singh

Vikas Singh

M Pharmacy

Disopyramide tablets are sometimes used in hypertrophic obstructive cardiomyopathy (HOCM) to help reduce obstruction inside the heart and improve symptoms such as chest discomfort, breathlessness, palpitations, dizziness, or fatigue. In HOCM, the heart muscle becomes abnormally thick and can block blood flow, leaving the heart. This blockage may also worsen mitral regurgitation by affecting the movement of the mitral valve. Disopyramide works by reducing the force of heart muscle contraction, which may decrease the obstruction and indirectly reduce leakage through the mitral valve in some patients. Many people experience improvement in symptoms and exercise tolerance when the medicine is combined with other heart medications. However, the response can vary depending on the severity of the obstruction and valve leakage. Dry mouth, constipation, difficulty passing urine, or rhythm-related side effects may occur in some people, so regular heart monitoring is important during treatment. Worsening breathlessness, fainting, chest pain, or irregular heartbeat may suggest the condition needs closer cardiac evaluation and treatment adjustment.
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How Soon It Starts Working

  • The time required for Norpace Capsule to start to work: Norpace Capsule starts to show its action within 1 to 3 hours of administration.
  • The time for which the effects of Norpace Capsule last: Norpace Capsule effect lasts for 24 hours.

What if you forget to take Norpace Capsule

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is less than 4 hours away, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Norpace Capsule capsules at room temperature, ideally between 68°F and 77°F (20°C to 25°C). •Keep the medication in its original bottle, tightly closed, to protect it from direct light and moisture.

Drug Warnings

  • Check your pulse regularly: Learn how to take your own pulse and keep a daily log. Share this information with your doctor at your checkups.
  • Avoid overheating: Norpace Capsule can decrease your body's ability to sweat, making you more sensitive to hot weather or intense exercise. Stay in cool areas and drink plenty of water.
  • Be careful when driving: Because this medicine can cause blurred vision and mild dizziness, avoid driving or operating machinery until you are sure you can do so safely.
  • Tell all your healthcare providers: Ensure that your dentists, surgeons, and other doctors know you are taking Norpace Capsule before any procedure or before starting any new prescriptions.
  • Keep your medical appointments: You will need regular blood tests and electrocardiograms (ECGs) so your doctor can monitor your heart and kidney function while you are on this medicine.

Drug-Drug Interactions

verifiedApollotooltip
  • Medicines that affect heart rhythm (e.g., beta-blockers or other antiarrhythmic medicines): Taking Norpace Capsule together with these medicines may slow your heart rate excessively or increase the risk of heart-rhythm disturbances. Your doctor may recommend closer monitoring or dose adjustments.
  • Certain antibiotics or antifungal medicines: Some antibiotics and antifungal medicines may increase the levels of Norpace Capsule in your bloodstream, raising the risk of side effects and toxicity. Inform your doctor about all medicines you are taking before starting treatment.
  • Anticholinergic medicines: Taking Norpace Capsule with other medicines that have anticholinergic effects may worsen side effects such as dry mouth, constipation, blurred vision, and difficulty passing urine (urinary retention).
DisopyramideCisapride
Critical
DisopyramideOfloxacin
Critical

Drug-Drug Interactions

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DisopyramideCisapride
Critical
How does the drug interact with Norpace Capsule:
Combining Norpace Capsule with Cisapride can increase the risk an irregular heart rhythm .

How to manage the interaction:
Taking Norpace Capsule with Cisapride is not recommended, as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, diarrhea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DisopyramideOfloxacin
Critical
How does the drug interact with Norpace Capsule:
Coadministration of Ofloxacin with Norpace Capsule can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Ofloxacin with Norpace Capsule together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DisopyramideZiprasidone
Critical
How does the drug interact with Norpace Capsule:
Coadministration of Norpace Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Norpace Capsule with Ziprasidone is not recommended, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, diarrhea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DisopyramideIbutilide
Critical
How does the drug interact with Norpace Capsule:
Combining Norpace Capsule and Ibutilide can increase the arrhythmogenic activities( producing or tending to produce cardiac arrhythmia) of Ibutilide.

How to manage the interaction:
Taking Norpace Capsule with Ibutilide together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - chest pain, discomfort, trouble breathing, or feeling lightheaded, make sure to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
DisopyramideLevofloxacin
Critical
How does the drug interact with Norpace Capsule:
Combining Levofloxacin with Norpace Capsule can increase the risk of irregular heart rhythm .

How to manage the interaction:
Taking Levofloxacin with Norpace Capsule is not recommended, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DisopyramidePotassium chloride
Critical
How does the drug interact with Norpace Capsule:
Taking Norpace Capsule and Potassium chloride together can increase the risk of stomach ulcers.

How to manage the interaction:
Taking Potassium chloride and Norpace Capsule is not recommended, as it can lead to an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
DisopyramidePotassium citrate
Critical
How does the drug interact with Norpace Capsule:
Taking Norpace Capsule and Potassium citrate together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Although taking Norpace Capsule and Potassium citrate together is not recommended as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
DisopyramideMoxifloxacin
Critical
How does the drug interact with Norpace Capsule:
Using Norpace Capsule together with Moxifloxacin can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Norpace Capsule is not recommended, please consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting your doctor.
DisopyramideNorfloxacin
Critical
How does the drug interact with Norpace Capsule:
Coadministration of Norfloxacin with Norpace Capsule can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Norfloxacin with Norpace Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
DisopyramideItraconazole
Critical
How does the drug interact with Norpace Capsule:
Coadministration of Itraconazole with Norpace Capsule can reduce the metabolism and increase the levels of Norpace Capsule in the body. This may increase the risk or severity of side effects like irregular heart rhythms.

How to manage the interaction:
Taking Itraconazole with Norpace Capsule together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, dizziness, irritation, confusion, chest pain or tightness, swelling, fatigue, palpitations, shortness of breath, or constipation, you should contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: Avoid consuming grapefruit or grapefruit juice while taking Norpace Capsule , as they may interfere with how your body processes the medicine, increasing its levels in the bloodstream and raising the risk of side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIARRHYTHMICS]

FAQs

Norpace Capsule is used to treat arrhythmia (irregular heartbeats). It helps slow the heart rate and prevent abnormal heart rhythms.
Norpace Capsule contains disopyramide that works by blocking abnormal electrical signals in the heart. Thus Norpace Capsule helps to treat uneven heartbeats and helps in normalizing the heart rhythm.
No, you are not recommended to take amiodarone with Norpace Capsule as co-administration of these two medicines may increase the levels of Norpace Capsule in the blood resulting in Norpace Capsule toxicity. However, please consult a doctor before taking other medicines with Norpace Capsule to adjust the dose appropriately.
Do not stop using Norpace Capsule even if you feel better. It should be strictly used as advised by your doctor to avoid recurring symptoms like irregular heartbeat and to worsen the disease.
Norpace Capsule should be used with caution in cases of any allergic reactions, heart problems like heart failure, slow heartbeat, QT prolongation (heart muscle takes longer than usual to recharge between beats) in the ECG (electrocardiogram), and electrolyte imbalance (low levels of potassium and magnesium).
Store Norpace Capsule away from direct sunlight and at a temperature not exceeding 30°C. Keep this medicine out of sight and reach of children.
If you missed a dose, take Norpace Capsule as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.
Yes, Norpace Capsule may cause dry mouth as a temporary side effect in some people. It is not necessary for everyone taking Norpace Capsule to experience this side effect. However, to avoid such side effects, drink plenty of water, regularly rinse your mouth, practice good oral hygiene and suck on sugarless candy. However, if the condition persists or worsens, please consult a doctor.
It is highly recommended to avoid alcohol while taking Norpace Capsule . Alcohol can increase the risk of side effects like dizziness and lightheadedness, and it can also directly interfere with your heart's rhythm. Talk to your doctor for personalised advice.
Dry mouth is a very common side effect. You can manage this by sucking on sugarless hard candies, chewing sugarless gum, or sipping water frequently. If the dry mouth becomes severe or does not go away, talk to your doctor or pharmacist.
You should only take Norpace Capsule during pregnancy or breastfeeding if your doctor determines that the benefits outweigh the potential risks to your baby. If you are pregnant or planning to become pregnant, talk to your doctor right away.
Yes, in some cases, Norpace Capsule can cause low blood sugar (hypoglycemia), especially in older adults or people with liver or kidney issues. If you experience shakiness, sweating, or confusion, check your blood sugar if possible and talk to your doctor.
Some blood pressure medicines, especially those that also slow your heart rate, can interact with Norpace Capsule . Before starting this medicine, make sure your doctor knows about all other prescriptions you are taking. Talk to your doctor or pharmacist to perform a safety check.
Yes, Norpace Capsule can cause blurred vision or difficulty focusing your eyes. Be very cautious when driving or doing tasks that require clear vision until you know how this medicine affects you. If your vision changes do not improve, talk to your doctor.
No, you must swallow Norpace Capsule capsules whole. Crushing, chewing, or opening the capsules can cause the medication to release too quickly into your body, increasing the risk of side effects. If you have trouble swallowing capsules, talk to your doctor or pharmacist for alternative options.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

463, 4 th Floor, RPG HOUSE, Dr. Annie Besant Road, Worli, Mumbai – 400 030. Maharashtra, INDIA
Other Info - NOR0078
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