Nucala 100 mg Injection 1 ml belongs to the class of 'immunomodulators', primarily used to treat asthma. Asthma is a respiratory condition in which airways narrow, swell, and produce extra mucus, leading to difficulty in breathing. Nucala 100 mg Injection 1 ml is used as an add-on maintenance treatment in severe asthma patients above six years of age and in patients with chronic rhinosinusitis with nasal polyps. It is also used in the treatment of hypereosinophilic syndrome and eosinophilic granulomatosis.

Nucala 100 mg Injection 1 ml consists of Mepolizumab as an active ingredient, which binds itself to interleukin-5 (IL-5) and stops it from attaching to its receptor on the surface of eosinophil white blood cells, specifically the alpha subunit of the receptor. It works by preventing the body's natural production of certain chemicals that increase asthma symptoms, like coughing, wheezing, chest pain, and breathing difficulties.

Nucala 100 mg Injection 1 ml may cause common side effects such as fever, back pain, itching, headache, sore throat, and breathing difficulty. These side effects resolve over time. Inform your doctor if any of these side effects bother you. Nucala 100 mg Injection 1 ml will be administered by a healthcare professional. Do not self-administer

Avoid taking Nucala 100 mg Injection 1 ml and inform your doctor if you are allergic to any component present in it. Before starting Nucala 100 mg Injection 1 ml, inform your doctor if you have any liver or kidney disease or active parasitic infections and are taking any inhaled corticosteroids. Pregnant and breastfeeding mothers should inform the physician before starting treatment with Nucala 100 mg Injection 1 ml. This medicine is contraindicated in cases of bronchospasm or status asthmaticus.

Nucala 100 mg Injection 1 ml is used in the treatment of Asthma. The detailed uses of Nucala 100 mg Injection 1 ml are as follows:

• Severe eosinophilic asthma: Nucala 100 mg Injection 1 ml is used as an add-on maintenance treatment for patients aged 6 years and older with severe asthma characterized by high levels of eosinophils. It helps reduce inflammation in the airways and lowers the frequency of asthma attacks.
• Chronic obstructive pulmonary disease (COPD): Nucala 100 mg Injection 1 ml is used in adults with eosinophilic COPD whose symptoms are not adequately controlled with standard inhalers. It works by reducing eosinophil-driven inflammation, improving breathing and quality of life.
• Chronic rhinosinusitis with nasal polyps (CRSwNP): Nucala 100 mg Injection 1 ml is used in adults whose nasal polyps are not controlled with corticosteroids. It helps reduce nasal congestion, discharge, and the need for surgery.
• Eosinophilic granulomatosis with polyangiitis (EGPA): Nucala 100 mg Injection 1 ml is used to treat this rare autoimmune condition that involves asthma, high eosinophil counts, and blood vessel inflammation. It helps reduce flare-ups and steroid dependence.
• Hypereosinophilic syndrome (HES): Nucala 100 mg Injection 1 ml is used in adults and children aged 12 and older who have had HES for at least 6 months without a known secondary cause. It helps lower eosinophil counts and control symptoms.

• Follow your doctor’s recommendations for the correct dosage and timing of this medication.
• The first dose of Nucala 100 mg Injection 1 ml may be administered by the doctor. After that, your doctor may allow you or a caregiver to administer it at home. Check the label for directions and use it as advised by the doctor. Choose an injection site such as the thigh or abdomen; pinch the skin and inject the advised dose slowly and steadily.
• Rotate the injection site each time. Do not inject into skin that is red, bruised, or hard.

Nucala 100 mg Injection 1 ml contains Mepolizumab, which is a humanized recombinant IgG1 (Immunoglobulin G1) monoclonal antibody. It works by preventing the body's natural production of certain chemicals that increase asthma symptoms, like coughing, wheezing, chest pain, and breathing difficulties.

To treat your condition effectually, continue taking Nucala 100 mg Injection 1 ml for the period that your doctor has prescribed. Avoid taking Nucala 100 mg Injection 1 ml if you are allergic to it or any other components present in it. Inform your doctor if you have any liver or kidney diseases, active parasitic infections, and are taking any inhaled corticosteroids before receiving Nucala 100 mg Injection 1 ml. Avoid close contact with people who have infections that can be easily spread. Nucala 100 mg Injection 1 ml is not recommended in children below six years of age as safety and efficacy are not established. Nucala 100 mg Injection 1 ml may cause severe allergic reactions, herpes zoster infections, and parasitic infections and reduce the effect of corticosteroid medicines. Hence, inform your doctor about your complete medication and medical history before taking Nucala 100 mg Injection 1 ml.