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compositionComposition:GABAPENTIN-300MG+METHYLCOBALAMIN-500MCG
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Prescription Medicine
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Nuprega G 300mg/500mcg Tablet is used to treat neuropathic pain. It contains Gabapentin and Methylcobalamin, which rejuvenate and protect damaged nerve cells. In some cases, this medicine may cause side effects such as dizziness, sleepiness, tiredness, nausea and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GABAPENTIN-300MG+METHYLCOBALAMIN-500MCG

Manufacturer/Marketer :

Macwell Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Nuprega G 300mg/500mcg Tablet

Nuprega G 300mg/500mcg Tablet is used to treat nerve pain/damage, such as post-herpetic neuralgia. Neuralgia is a chronic pain condition of the nerves that occurs due to nerve damage or other neurological conditions like neuropathy, trigeminal neuralgia or shingles.

Nuprega G 300mg/500mcg Tablet contains Gabapentin and Methylcobalamin. Gabapentin calms overactive nerves and interferes with pain signals travelling through the brain and spine. Methylcobalamin rejuvenates and protects damaged nerve cells by producing a substance called myelin.

Sometimes, Nuprega G 300mg/500mcg Tablet may cause common side effects such as dizziness, sleepiness, tiredness, nausea, and vomiting. These side effects do not require medical attention and gradually resolve over time. However, talk to your doctor if you experience these side effects persistently.

Let your doctor know if you are using any prescription, non-prescription drugs, and herbal products before starting Nuprega G 300mg/500mcg Tablet. If you are a pregnant or breastfeeding mother, please consult your doctor before taking Nuprega G 300mg/500mcg Tablet.

Uses of Nuprega G 300mg/500mcg Tablet

Nuprega G 300mg/500mcg Tablet is used in the treatment of neuropathic pain (nerve pain). The detailed uses of Nuprega G 300mg/500mcg Tablet are as follows:

  • Treats Neuropathic Pain: Nuprega G 300mg/500mcg Tablet is used to relieve nerve pain caused by conditions such as diabetes (diabetic neuropathy), shingles/ herpes zoster infection (post-herpetic neuralgia), or spinal cord injury.
  • Promotes Nerve Health: Methylcobalamin (vitamin B12) in Nuprega G 300mg/500mcg Tablet supports the regeneration and repair of damaged nerves, thereby improving nerve function.

Key Benefits

  • Nuprega G 300mg/500mcg Tablet is used to treat nerve pain/damage, such as post-herpetic neuralgia.
  • Gabapentin calms overactive nerves and interferes with pain signals travelling through the brain and spine.
  • Methylcobalamin rejuvenates and protects damaged nerve cells by producing a substance called myelin.
  • Together, it helps improve nerve health.

Directions for Use

  • Nuprega G 300mg/500mcg Tablet can be taken with or without food as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Nuprega G 300mg/500mcg Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Nuprega G 300mg/500mcg Tablet Works

Nuprega G 300mg/500mcg Tablet contains Gabapentin and Methylcobalamin. Gabapentin calms overactive nerves and interferes with pain signals travelling through the brain and spine. Methylcobalamin rejuvenates and protects damaged nerve cells by producing a substance called myelin.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Nuprega G 300mg/500mcg Tablet as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Nuprega G 300mg/500mcg Tablet is not recommended during pregnancy unless prescribed by a doctor. Let your doctor know if you are pregnant or planning to conceive before taking Nuprega G 300mg/500mcg Tablet.

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Breast Feeding

Caution

Gabapentin in Nuprega G 300mg/500mcg Tablet is excreted into breast milk. Please consult your doctor before taking Nuprega G 300mg/500mcg Tablet if you are breastfeeding.

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Driving

Unsafe

Nuprega G 300mg/500mcg Tablet causes drowsiness, sleepiness and tiredness. Do not drive or operate machinery unless you are mentally and physically alert.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Nuprega G 300mg/500mcg Tablet. Dose adjustment may be needed in patients with liver impairment.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases before taking Nuprega G 300mg/500mcg Tablet. Dose adjustment may be needed in patients with kidney impairment.

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Children

Caution

Nuprega G 300mg/500mcg Tablet is not recommended in children less than three years of age. The doctor will prescribe the dosage of Nuprega G 300mg/500mcg Tablet based on the child's age and weight.

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Heart

Caution

Please inform your doctor if you have a history of heart disease before taking Nuprega G 300mg/500mcg Tablet. Your doctor will prescribe it only if the potential benefits outweigh the possible risks.

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Geriatrics

Caution

Nuprega G 300mg/500mcg Tablet should be given with caution in elderly patients due to an increased risk of side effects. Dose adjustment may be required based on their health condition.

What if I have taken an overdose of Nuprega G 300mg/500mcg Tablet

An overdose of Nuprega G 300mg/500mcg Tablet may cause unpleasant side effects. If you suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Include food rich in vitamins B and D in your diet, as they can help improve nerve health and prevent nerve pain.
  • Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
  • Exercising regularly helps in improving overall health and combating pain. 
  • Rest well; get plenty of sleep.
  • Try taking a warm bath as it can be soothing. It helps in increasing blood circulation, thereby decreases numbness and pain.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.
  • Physical relaxation and massages can help provide symptomatic relief.
  • Learn about techniques for sitting, stretching, moving, and standing from a physical or occupational therapist. These can help prevent pain.
  • Acupuncture can be helpful by stimulating pressure points.
  • Using essential oils for massages can help increase circulation and boosts healing.
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How Soon It Starts Working

The time required for Nuprega G 300mg/500mcg Tablet to start to work: The time required for Nuprega G 300mg/500mcg Tablet to show its action is unknown.

The time for which the effects of Nuprega G 300mg/500mcg Tablet last: The duration of action for Nuprega G 300mg/500mcg Tablet is clinically unknown.

What if you forget to take Nuprega G 300mg/500mcg Tablet

If you miss a dose of Nuprega G 300mg/500mcg Tablet, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for the missed dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep out of sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Inform your doctor before taking Nuprega G 300mg/500mcg Tablet if you have a medical history of heart problems, bipolar disorder, and nervous system disorders.
  • Consult your doctor if you are on haemodialysis and experience muscle pain or weakness, persistent stomach pain, nausea, and vomiting.
  • Please do not stop taking Nuprega G 300mg/500mcg Tablet without consulting your doctor as it could cause withdrawal symptoms.
  • Pregnant and breastfeeding women should consult their doctor before taking Nuprega G 300mg/500mcg Tablet.
  • Consult your doctor immediately if you experience suicidal tendencies.
  • Keep Nuprega G 300mg/500mcg Tablet away from direct sunlight. Do not store Nuprega G 300mg/500mcg Tablet above 25ºC and keep it away from direct sunlight.

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Drug-Drug Interaction: Nuprega G 300mg/500mcg Tablet may interact with pain killers (hydrocodone, acetaminophen), antidepressants (duloxetine, escitalopram, sertraline), muscle relaxants (cyclobenzaprine), anti-anxiety drugs (alprazolam), fits medicines (pregabalin), antipsychotics (quetiapine), antibiotics (chloramphenicol), and anti-diabetics (metformin).

Drug-Food Interaction: Avoid alcohol consumption while taking Nuprega G 300mg/500mcg Tablet as it might cause increased dizziness and sleepiness.

Drug-Disease Interaction: Nuprega G 300mg/500mcg Tablet may interact with disease conditions such as suicidal tendencies, renal dysfunction, and haemodialysis.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Nuprega G 300mg/500mcg Tablet is used to treat nerve pain.
Nuprega G 300mg/500mcg Tablet contains Gabapentin and Methylcobalamin. Gabapentin calms overactive nerves and interferes with pain signals travelling through the brain and spine. Methylcobalamin rejuvenates and protects damaged nerve cells by producing a substance called myelin.
Nuprega G 300mg/500mcg Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a balanced diet.
People taking Nuprega G 300mg/500mcg Tablet should be closely monitored for suicidal thoughts or behaviour. Do not be reluctant to speak with your doctor immediately if you experience suicidal tendencies.
If Nuprega G 300mg/500mcg Tablet is taken along with antacid medicines containing aluminium and magnesium, it may lower the absorption of Nuprega G 300mg/500mcg Tablet from the stomach. To avoid this, maintain a gap of two hours between Nuprega G 300mg/500mcg Tablet and antacid medicines.
If you miss a dose, take it as soon as you remember. However, if it is time for the next scheduled dose, skip the missed dose and follow your usual dosage.
Neuropathic pain is a chronic progressive nerve disease that occurs due to damaged sensory nerves. Neuropathic pain is stabbing, tingling, and sharp while muscle pain is dull and steady or crampy and spasmodic.
Inform your doctor before taking Nuprega G 300mg/500mcg Tablet if you have a medical history of heart problems, bipolar syndrome, and nervous system disorders. Pregnant and breastfeeding women should consult their doctor before taking Nuprega G 300mg/500mcg Tablet.
Nuprega G 300mg/500mcg Tablet is a combination medicine containing Gabapentin (anticonvulsant) and Methylcobalamin (Mecobalamin or vitamin B12). It is used to treat neuropathic pain.
Peripheral neuropathy affects the nerves outside your brain or spinal cord. It causes tingling sensation, pain, numbness and burning sensation.
Do not discontinue Nuprega G 300mg/500mcg Tablet without consulting your doctor. To treat your condition effectively, keep taking Nuprega G 300mg/500mcg Tablet for the prescribed duration.
Nuprega G 300mg/500mcg Tablet may cause sleepiness as a side effect. Do not drive or operate machinery unless you are alert.
No, do not take a higher than the recommended dose of Nuprega G 300mg/500mcg Tablet as it might cause an overdose. Take Nuprega G 300mg/500mcg Tablet in the dose and duration prescribed by the doctor.
Store Nuprega G 300mg/500mcg Tablet at room temperature, in a dry place. Keep out of sight and reach of children.
Nuprega G 300mg/500mcg Tablet may cause side effects like dizziness, sleepiness, tiredness, nausea and vomiting. These side effects do not require medical attention and gradually resolve over time. However, you are advised to talk to your doctor if you experience these side effects for a longer duration.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 020235S064 020882S047 021129S046Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Gabapentin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Methylcobalamin Vitamin B12 Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Electronic Medicines Compendium (EMC). Pil.4636 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  5. PubChem PubChem. [Accessed on 22 Apr. 2019]Check here
  6. Ming Zhang, Wenjuan Han, Sanjue Hu and Hui Xu. Methylcobalamin: A Potential Vitamin of Pain Killer. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2013. [Accessed on 11th January 2023]Check here
  7. Milpharm Limited. Gabapentin Milpharm 100/300/400 mg capsules, hard. Electronic Medicines Compendium. [Revised in December 2022] [Accessed on 11th January 2023].Check here

Country of origin

India

Manufacturer/Marketer address

North India Sales Office, 305/10, Nrayan Ashram Gali, Near Chotu Ram Stadium, Sonepat Road, Rohtak - 124001, Haryana, India
Other Info - NUPR462
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