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compositionComposition:CEFIXIME-50MG+OFLOXACIN-50MG
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Prescription Medicine
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Office 50 DS Syrup is used for the treatment of a wide range of bacterial infections of the skin, ears, lungs, prostate and urinary tract. Besides this, it also treats typhoid fever and STDs (sexually transmitted diseases) like chlamydia and gonorrhoea. It contains Cefixime and Ofloxacin, which works by preventing the formation of the outer covering of the bacteria (cell wall) required for their survival. It prevents the release of a chemical messenger (mucopeptides) by the bacteria, thereby weakening and destroying the bacterial cell wall. It may cause some common side effects such as diarrhoea, indigestion, nausea, loose stools, abdominal pain, and vomiting.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CEFIXIME-50MG+OFLOXACIN-50MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Office 50 DS Syrup

Office 50 DS Syrup is a combination antibiotic prescribed to treat a wide range of bacterial infections. This medicine is commonly used to clear infections in the urinary tract, lungs, and airways, as well as complex conditions like typhoid fever. It works by stopping bacterial growth and clearing the infection from your body.

To get the best results, you must take Office 50 DS Syrup consistently at the same times each day as directed by your healthcare provider. You can take this tablet with or without food, though taking it with a meal is often recommended to help prevent a mild upset stomach. Drinking plenty of water and getting extra rest will also help support your immune system during your recovery.

While taking Office 50 DS Syrup, some people may experience mild side effects like nausea, headache, or temporary changes in digestion. However, you must contact your doctor immediately if you develop serious symptoms, such as severe watery diarrhoea, sudden joint pain, or an unexpected skin rash. Seeking medical advice early ensures your treatment remains safe and effective.

Talk to your doctor before starting this medicine if you have a history of kidney disease, liver damage, tendon problems, or regular bowel inflammation. Do not take this if you have had an allergic reaction to cephalosporins, fluoroquinolones, or similar antibiotic medications in the past. Your doctor will evaluate your medical history to ensure this is the right option for you.

Certain medications, such as stomach antacids and iron supplements, can interfere with how your body absorbs Office 50 DS Syrup, so they should not be taken at the same time. You should avoid drinking alcohol during your treatment, as it can worsen dizziness and stomach discomfort. If you are pregnant, breastfeeding, or managing health conditions in your elderly years, always consult your healthcare provider before taking this medicine.
 

Uses of Office 50 DS Syrup

Office 50 DS Syrup may be prescribed for the following bacterial infections: 

  • Typhoid Fever: Office 50 DS Syrup helps clear the severe systemic bacterial infection responsible for typhoid, reducing high body temperature and restoring digestive comfort.
  • Urinary Tract Infections (UTIs): This medicine targets and eliminates bacteria causing painful, burning, or frequent urination, clearing the infection from the bladder or kidneys.
  • Respiratory Tract Infections: It treats infections like bronchitis and pneumonia by clearing bacteria from your lungs and airways, making it easier to breathe.
  • Prostate and Genital Infections: Office 50 DS Syrup penetrates deep into pelvic tissues to resolve bacterial infections and ease swelling or localised pain.
  • Abdominal Infections: It targets complex bacterial strains within the stomach and intestines, helping to relieve abdominal pain and prevent complications.
     

Key Benefits

Office 50 DS Syrup combines two antibiotics that work together to treat bacterial infections effectively. This combination helps eliminate infection-causing bacteria and supports a faster recovery.

  • Treats Bacterial Infections: Helps eliminate a wide range of bacteria responsible for infections affecting different parts of the body.
  • Provides Rapid Symptom Relief: Helps reduce infection-related symptoms such as fever, pain, inflammation, and discomfort as the infection improves.
  • Offers Broad-Spectrum Protection: The combination of two antibiotics helps target susceptible bacteria through different mechanisms, supporting effective treatment.
  • Supports Recovery: By helping control the infection, it may promote faster improvement in overall health and well-being.
  • Convenient At-home Treatment: The oral tablet formulation allows many infections to be treated effectively without the need for injectable antibiotics.
     

Directions for Use

To use this medicine safely and effectively, please follow these step-by-step instructions:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can alter how the medicine is absorbed in your body.
  • Take your doses at evenly spaced intervals throughout the day to keep a steady level of the medicine in your bloodstream.
  • Always complete the entire course of treatment prescribed by your doctor, even if your symptoms improve after a few days. Stopping
  • early can cause the remaining bacteria to multiply again.

Always follow your doctor's exact instructions regarding how many tablets to take and how many days to continue the treatment.
 

How Office 50 DS Syrup Works

This medicine contains cefixime and ofloxacin, which work together to help treat bacterial infections by attacking bacteria through different mechanisms. Cefixime is a cephalosporin antibiotic that works by interfering with the formation of the bacterial cell wall, an essential structure that protects bacteria and maintains their shape. Without a properly functioning cell wall, the bacteria become weakened and eventually die. Ofloxacin is a fluoroquinolone antibiotic that works by blocking enzymes required for bacterial DNA replication, repair, and cell division. This prevents the bacteria from multiplying and spreading within the body. Together, these actions help eliminate susceptible bacteria, control the infection, and support recovery from bacterial illnesses.
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Alcohol

Unsafe

Avoid consumption of alcohol as it may worsen the side effects of Office 50 DS Syrup.

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Pregnancy

Unsafe

If you are pregnant or planning pregnancy, avoid taking Office 50 DS Syrup. If you become pregnant while on treatment with Office 50 DS Syrup, stop taking it and contact your doctor immediately.

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Breast Feeding

Unsafe

If you are a breastfeeding mother, avoid taking Office 50 DS Syrup.

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Driving

Unsafe

Office 50 DS Syrup may cause sleepiness, dizziness or may affect your eyesight. Therefore, avoid driving if you are not alert after taking Office 50 DS Syrup.

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Liver

Caution

Office 50 DS Syrup should be taken with caution in patients having a history of liver diseases/conditions. The doctor may suggest lower doses initially.

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Kidney

Caution

Office 50 DS Syrup to be taken with caution, especially in persons having a history of Kidney disorders. The doctor may initially suggest a lower dose of initially.

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Children

Unsafe

Office 50 DS Syrup is not recommended for children below 18 years of age.

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Heart

Unsafe

Office 50 DS Syrup is not recommended for use in heart patients as it can lead to cardiovascular effects.

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Geriatrics

Unsafe

Office 50 DS Syrup is not recommended for use in elderly patients as it can lead to side effects.

What if I have taken an overdose of Office 50 DS Syrup

Do not take more than the prescribed dose of Office 50 DS Syrup as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Stay Well-Hydrated: Drink plenty of water throughout the day to support recovery and maintain hydration.
  • Support Gut Health: Consume probiotic-rich foods such as yoghurt or kefir a few hours after taking the medicine to help maintain healthy gut bacteria.
  • Be Mindful of Dairy and Calcium-Rich Products: The ofloxacin component may interact with calcium-containing foods and beverages, potentially reducing absorption. Consider taking dairy products, calcium-fortified drinks, or calcium supplements a few hours apart from your dose, and follow your doctor's or pharmacist's advice.
  • Protect Your Skin from Sunlight: Wear protective clothing and sunscreen when outdoors, as this medicine may increase sensitivity to sunlight.
  • Get Adequate Rest: Allow your body sufficient rest to support your immune system and recovery process.
     
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How Soon It Starts Working

  • The time required for Office 50 DS Syrup to start to work: Office 50 DS Syrup ideally shows its action within 1 to 3 hours after administration.
  • The time for which the effects of Office 50 DS Syrup last: The effect of Office 50 DS Syrup lasts for 16 to 20 hours.

What if you forget to take Office 50 DS Syrup

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular schedule. Avoid taking two doses at once.

Storage

•Store Office 50 DS Syrup at room temperature, ideally between 20°C and 25°C (68°F to 77°F). • Keep the tablets in their original blister packaging to protect them from moisture and direct light.

Drug Warnings

  • Check Before Use: Inspect the blister pack before taking a dose and do not use the medicine if the packaging is damaged.
  • Use Caution During Activities: Avoid driving or operating machinery if you experience dizziness or lightheadedness after taking the medicine.
  • Report Joint or Tendon Problems: Contact your doctor immediately if you develop sudden joint pain, tendon pain, swelling, or a snapping sensation.
  • Monitor Treatment Response: Consult your doctor if your symptoms do not begin to improve within 3 to 4 days of starting treatment.
  • Do Not Share Your Medicine: Never share antibiotics with others, even if they have similar symptoms, as inappropriate antibiotic use may contribute to antibiotic resistance.
     

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact with Office 50 DS Syrup: 

  • Antacids: Stomach remedies containing magnesium, aluminium, or calcium can lower the absorption of Office 50 DS Syrup. Take them at least 2 hours before or 2 hours after your antibiotic.
  • Blood Thinners: Taking this medicine with medications like warfarin may increase the risk of bleeding.
  • Pain Relievers (NSAIDs): Using certain pain relievers like ibuprofen with this medicine may increase the risk of central nervous system stimulation and seizures.
  • Iron and Zinc Supplements: Mineral supplements can bind with the medicine in your stomach, making it less effective.


Drug-Food Interactions

Certain foods and beverages may affect how Office 50 DS Syrup works or increase the risk of side effects: 

  • Dairy Products and Calcium-Rich Foods: The ofloxacin component may bind to calcium and reduce absorption. This interaction is mainly associated with ofloxacin rather than cefixime. If advised by your healthcare provider, take dairy products, calcium-fortified beverages, or calcium supplements a few hours apart from your dose.
  • Caffeine: This medicine can slow down how your body processes caffeine, which may lead to feelings of jitteriness, anxiety, or a rapid heart rate.


Drug-Disease Interactions

Inform your doctor if you have any of the following medical conditions before taking Office 50 DS Syrup, as dose adjustments or additional monitoring may be required: 

  • Myasthenia Gravis: This medicine can worsen muscle weakness, so it should be used with extreme caution.
  • Kidney Impairment: If your kidneys do not filter properly, your doctor may need to adjust your dose to prevent the medicine from building up in your body.
  • Seizure Disorders: This medicine can lower the seizure threshold, meaning it should be used cautiously if you have a history of seizures.
  • Tendonitis: If you have a history of tendon inflammation or injury, taking this medicine can increase the risk of a tendon tear.
  • Heart Rhythm Disorders (QT Prolongation): The ofloxacin component may affect the heart's electrical activity and increase the risk of abnormal heart rhythms in susceptible individuals. Use with caution if you have a history of QT prolongation, irregular heart rhythms, low potassium levels, or are taking medicines that can affect heart rhythm. 
     

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Habit Forming

No

Therapeutic Class

[ANTI- BACTERIALS]

FAQs

Office 50 DS Syrup is used for the treatment of a wide range of bacterial infections of the skin, ears, lungs, prostate and urinary tract. Besides this, it also treats typhoid fever and STDs (sexually transmitted diseases) like chlamydia and gonorrhoea.
No, you should not double the dose if you forget to take Office 50 DS Syrup, then take it as soon as you remember or skip it if it is time for the next dose.
Yes, this medicine is prescribed for the treatment of urinary tract infection (UTI). Take Office 50 DS Syrup only if the doctor has prescribed you this medicine.
You should avoid driving as this medicine may cause impaired vision or affect the thinking ability so avoid such a task that needs a clear vision.
You should avoid taking Office 50 DS Syrup if you have peripheral neuropathy (nerve damage in legs), tendinitis (swelling or tearing of a tendon), myasthenia gravis (skeletal muscle weakness), respiratory issues like bronchitis, sinusitis, diabetes, central nervous system disorder, or epilepsy (fits).
Yes, cefix contains cefixime as its active substance and is an antibiotic used to treat bacterial infections of urinary tract, lungs, throat, airways, tonsils, middle ear, and cervical or urethral regions.
Take Office 50 DS Syrup as recommended by your doctor. Taking Office 50 DS Syrup with milk may potentially affect its effectiveness.
No, do not take Office 50 DS Syrup for stomach infections as it could be due to various reasons. Also, avoid taking Office 50 DS Syrup for any infection without doctor’s advice.
Yes, Office 50 DS Syrup is a strong antibiotic that can treat various bacterial infections. Do not self-medicate.
Office 50 DS Syrup can be used for sinus infections (sinusitis) if caused by bacteria and if it is advised by a doctor. However, please consult a doctor as it varies for everyone based on your health condition.
No, do not take Office 50 DS Syrup on your own as inappropriate usage of antibiotics may cause failure of the treatment in future.
The dosage of Office 50 DS Syrup treatment vary based on the specific condition and patient response to the medication. If you do not notice any improvement within 3-4 days of starting the treatment, please consult your doctor. Do not self-medicate.
Office 50 DS Syrup contains Cefixime (cephalosporin antibiotic) and Ofloxacin (fluoroquinolone antibiotic) as its active substances.
Consult your doctor if you don’t get better after using Office 50 DS Syrup. Also, inform about the unwanted effects and the symptoms that worsen while using Office 50 DS Syrup.
Store Office 50 DS Syrup at room temperature. Protect from light. Keep it out of reach from children. Disposal of Office 50 DS Syrup is done by following the local guidelines.
No, you should never stop taking Office 50 DS Syrup early, even if you feel completely better. Stopping your antibiotic treatment prematurely can allow surviving bacteria to multiply and develop resistance, making future infections harder to treat. Always complete the entire course prescribed by your healthcare provider. Talk to your doctor if you have concerns.
This medicine is generally not recommended during pregnancy or breastfeeding unless your doctor decides it is absolutely necessary. It is important to weigh the benefits against potential risks to the developing baby. Talk to your doctor before starting this medication.
You can take Office 50 DS Syrup with or without food. Taking it with a meal can help reduce the chances of developing a mild upset stomach or nausea. However, avoid taking it with dairy-heavy meals or calcium-rich drinks. Talk to your doctor or pharmacist for personalised advice.
Mild diarrhoea is a common side effect of antibiotics. However, if you experience severe, watery, or bloody diarrhoea accompanied by stomach cramps, stop taking the medication and seek medical help immediately, as this could be a sign of a serious bowel condition. Talk to your doctor before taking any anti-diarrhoeal medicines.
It is highly recommended to avoid alcohol while taking Office 50 DS Syrup. Alcohol can increase the risk of experiencing side effects such as dizziness, lightheadedness, and stomach upset, which can delay your recovery. Talk to your doctor if you have questions about alcohol use.
No, Office 50 DS Syrup is an antibiotic and is only effective against bacterial infections. It will not work for viral infections like colds, flu, or acute bronchitis caused by viruses. Using antibiotics unnecessarily can make them less effective for future bacterial infections. Talk to your doctor for a proper diagnosis.
Yes, the ofloxacin component belongs to a group of antibiotics called fluoroquinolones, which have been associated with an increased risk of tendonitis and tendon rupture, particularly involving the Achilles tendon. The risk is higher in older adults, people taking corticosteroids, and those with a history of tendon disorders. If you develop sudden tendon pain, swelling, or difficulty moving a joint, stop strenuous activity and contact your doctor promptly.
No, you should avoid taking antacids, iron supplements, or multivitamins containing zinc or calcium at the same time as Office 50 DS Syrup. These products can bind to the medicine and prevent your body from absorbing it properly. Space them at least 2 hours before or after taking your antibiotic. Talk to your doctor or pharmacist to help plan your dosing schedule.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

7-2-A2, Hetero Corporate Indl Estates, Sanath Nagar Hyderabad, 500 018
Other Info - OFF0020
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