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compositionComposition:FLUOXETINE-20MG+OLANZAPINE-10MG
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Prescription Medicine
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Olapin Forte Tablet is used to treat schizophrenia and bipolar disorder (manic depression). It contains Fluoxetine and Olanzapine which work by restoring the balance of certain natural substances in the brain. In some cases, this medicine may cause side effects such as drowsiness, lightheadedness, restlessness, irritability, tremors, dry mouth, constipation, and increased appetite. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

FLUOXETINE-20MG+OLANZAPINE-10MG

Manufacturer/Marketer :

Crescent Therapeutics Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Olapin Forte Tablet

Olapin Forte Tablet is a combination prescription medicine used to treat depressive episodes associated with bipolar I disorder. It is also prescribed for treatment-resistant depression, which is depression that has not improved after trying other antidepressant medicines.

For the best results, you must take this medicine consistently once daily, usually in the evening, exactly as your healthcare provider instructs. You can take this medication with or without food. Making healthy lifestyle choices, such as eating a balanced diet, keeping a regular sleep schedule, and engaging in light physical activity, can also support your treatment outcomes.

Like many medications that affect brain chemistry, Olapin Forte Tablet can cause side effects. Some of the most common ones include sleepiness, dry mouth, tiredness, and an increased appetite that may lead to weight gain. While these are usually manageable, you must monitor your body and contact your doctor immediately if you experience serious symptoms like extreme mood changes, severe muscle stiffness, or signs of high blood sugar.

Do not take this if you have certain pre-existing health conditions without discussing them with your healthcare provider first. Be sure to tell your doctor if you have a history of heart issues, diabetes, seizures, or liver damage. This medicine is not suitable for everyone, and certain individuals should not take it, especially those who have recently taken specific types of antidepressants known as monoamine oxidase inhibitors (MAOIs).

This medicine can interact with alcohol, smoking, and other medications. For example, drinking alcohol while taking this medicine can cause severe drowsiness, while smoking can change how the medicine is processed in your body. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor to discuss whether this medication is safe for you.

Uses of Olapin Forte Tablet

Olapin Forte Tablet is used to treat depressive episodes associated with bipolar I disorder. The detailed uses of Olapin Forte Tablet are as follows:

  • Depressive episodes associated with Bipolar I disorder: This medicine helps balance mood levels, relieving the severe lows and depressive states associated with bipolar disorder.
  • Treatment-resistant depression: It helps relieve symptoms of major depressive disorder in adults whose symptoms have not improved after trying other antidepressant treatments.
     

Key Benefits

name helps manage symptoms of depression by acting on multiple chemical pathways in the brain to improve mood and emotional well-being. With regular use, it supports emotional balance, improves daily functioning, and enhances overall quality of life.

  • Effective Mood Stabilisation: By targeting multiple chemical pathways in the brain, this medicine helps stabilise mood and restore interest in daily activities, providing effective relief from symptoms of depression.
  • Relieves Depression and Anxiety Symptoms: This medicine helps reduce feelings of severe sadness and anxiety while promoting more regular sleep patterns, supporting better emotional and physical well-being.
  • Improves Daily Functioning: Over time, this medicine helps restore emotional balance, making it easier to engage in personal, social, and professional activities with greater confidence and comfort.
Side effects of Olapin Forte Tablet
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Eat a balanced diet containing enough proteins, fibre, healthy fats, vegetables and fruits.
  • Get quality sleep for about 7-9 hours.
  • Try to manage stress with meditation or yoga.
  • Drink enough water.
  • Exercise regularly as it helps regulate appetite.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

Directions for Use

  • Take Olapin Forte Tablet with or without food as advised by your doctor.
  • It is advised to take Olapin Forte Tablet once daily; however, follow your doctor's recommendation regarding the dosage and duration.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew or break it.

How Olapin Forte Tablet Works

This medicine is a combination of two active components that work together to balance brain chemistry. Because it addresses multiple pathways at once, it helps relieve complex mood symptoms more effectively than either component could alone. The first active component, olanzapine, works by blocking receptors for certain chemical messengers in the brain, specifically dopamine and serotonin. By balancing these pathways, it helps improve thinking, mood, and behaviour. The second active component, fluoxetine, prevents the brain from reabsorbing serotonin, a chemical messenger responsible for maintaining emotional balance. This increases the amount of active serotonin available, which helps lift your mood and reduce anxiety.
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Alcohol

Unsafe

Patients taking Olapin Forte Tablet should avoid taking alcohol as it may increase drowsiness.

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Pregnancy

Caution

Olapin Forte Tablet should be used in pregnant women only when prescribed by a doctor.

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Breast Feeding

Unsafe

Olapin Forte Tablet should not be given to breastfeeding mothers.

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Driving

Unsafe

Olapin Forte Tablet causes drowsiness. So, avoid driving or operating heavy machinery after taking Olapin Forte Tablet .

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Liver

Caution

Olapin Forte Tablet should be used with caution in patients with liver diseases.

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Kidney

Caution

Olapin Forte Tablet should be used in patients with kidney diseases only when prescribed by a doctor. Dose adjustments and regular monitoring of electrolytes may be required as it may alter electrolyte levels in the body.

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Children

Unsafe

Olapin Forte Tablet should not be prescribed in children below 12 years of age.

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Heart

Caution

Olapin Forte Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems.

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Geriatrics

Caution

Olapin Forte Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Olapin Forte Tablet .

What if I have taken an overdose of Olapin Forte Tablet

If you suspect an overdose, seek emergency medical attention immediately. Symptoms of an overdose may include extreme sleepiness, rapid heartbeat, slurred speech, or severe shakiness.

Diet & Lifestyle Advise

  • Monitor your weight and diet: Because this medicine can increase appetite and cause weight gain, focus on a diet rich in vegetables, fruits, lean proteins, and whole grains.
  • Stay hydrated: Drink plenty of water throughout the day to help manage dry mouth and support overall digestion.
  • Establish a regular sleep routine: Go to bed and wake up at the same time each day to help manage sleepiness and support your mental health.
  • Avoid alcohol: Do not drink alcohol while taking this medicine, as it can worsen drowsiness and increase the risk of coordination problems.
  • Incorporate light exercise: Gentle physical activities like walking can help support your mood and assist with weight management.
health query

Have a query?

How Soon It Starts Working

The time required for Olapin Forte Tablet to start to work: The time required for Olapin Forte Tablet to show its action is unknown. The time for which the effects of Olapin Forte Tablet last: The duration of action for Olapin Forte Tablet is clinically unknown.

What if you forget to take Olapin Forte Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store Olapin Forte Tablet at room temperature, between 20°C and 25°C (68°F to 77°F). • Keep the medicine in its original container to protect it from light and excess moisture.

Drug Warnings

  • Do not drive, operate machinery, or perform hazardous tasks until you know how this medicine affects your alertness.
  • Do not stop taking this medicine suddenly, as doing so can cause your symptoms to return or lead to withdrawal-like reactions; your doctor will help you by gradually decreasing the dose.
  • Rise slowly from a sitting or lying position to prevent a sudden drop in blood pressure, which can cause dizziness or fainting.
  • Pay close attention to any sudden changes in your mood, thoughts, or behaviour, especially when you first start taking this medicine or when your dose changes.
  • Attend all scheduled medical appointments so your doctor can check your progress, blood sugar, and cholesterol levels.

Drug-Drug Interactions

verifiedApollotooltip
  • Monoamine Oxidase Inhibitors (MAOIs): Do not take this medicine with MAOIs or within 14 days of stopping them, as this can cause a life-threatening reaction. At least 5 weeks should pass after stopping Olapin Forte Tablet before starting an MAOI.
  • Sedatives and Sleep Medicines: Taking this medicine with other drugs that cause drowsiness can worsen coordination and cause severe sleepiness.
  • Medicines affecting heart rhythm: Combining this medicine with drugs that alter your heart rate can increase the risk of serious heart rhythm problems.
  • Serotonergic drugs: Taking other medicines that increase serotonin (such as certain migraine drugs or other antidepressants) can cause a dangerous buildup of serotonin in the body.
Olanzapine + FluoxetinePotassium citrate
Critical
Olanzapine + FluoxetinePotassium chloride
Critical

Drug-Drug Interactions

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Olanzapine + FluoxetinePotassium citrate
Critical
How does the drug interact with Olapin Forte Tablet:
Taking Olapin Forte Tablet with Potassium citrate can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Although co-administration of Olapin Forte Tablet and Potassium citrate leads to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of hunger, or black, tarry stools, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetinePotassium chloride
Critical
How does the drug interact with Olapin Forte Tablet:
Taking Olapin Forte Tablet with Potassium chloride (oral form) can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Although co-administration of Olapin Forte Tablet and Potassium chloride leads to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of hunger, or black, tarry stools, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetineMetoclopramide
Critical
How does the drug interact with Olapin Forte Tablet:
Co-administration of metoclopramide with Olapin Forte Tablet can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Olapin Forte Tablet and metoclopramide, you can take these medicines if prescribed by a doctor. However, if you experience any symptoms like muscle movements which are not controllable, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, jitteriness, restlessness, or foot tapping, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetineChloroquine
Severe
How does the drug interact with Olapin Forte Tablet:
Combining Olapin Forte Tablet with Chloroquine can increase the risk of irregular heart beat.

How to manage the interaction:
Taking Olapin Forte Tablet with Chloroquine together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of the symptoms like loose stools, vomiting, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heart beat. Do not stop using any medications without talking to a doctor.
Olanzapine + FluoxetineDesipramine
Severe
How does the drug interact with Olapin Forte Tablet:
Using Olapin Forte Tablet together with Desipramine can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Desipramine and Olapin Forte Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach pain, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetineZonisamide
Severe
How does the drug interact with Olapin Forte Tablet:
Combining Olapin Forte Tablet with Zonisamide can increase the risk of side effects.

How to manage the interaction:
Taking Olapin Forte Tablet with Zonisamide together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any symptoms like decreased sweating, fever, drowsiness, dizziness, lightheadedness, nausea, vomiting, tiredness, headache, confusion, irritability, or muscle pain, consult a doctor. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetineMorphine
Severe
How does the drug interact with Olapin Forte Tablet:
Combining Olapin Forte Tablet with Morphine can increase the risk of brain related side effects and serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although taking Olapin Forte Tablet and Morphine together can lead to an interaction, it can be taken if a doctor has suggested it. If you experience any symptoms like tiredness, difficulty in breathing, dizziness, difficulty focusing, difficulty in passing stools, stomach ache, or bloating, confusion, hallucination, fits, drowsiness, severe headache, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach pain, nausea, vomiting, or loose stools, consult a doctor. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetineMidazolam
Severe
How does the drug interact with Olapin Forte Tablet:
Taking Midazolam together with Olapin Forte Tablet can cause severe side effects.

How to manage the interaction:
Combining Olapin Forte Tablet and Midazolam can lead to an interaction, it can be taken if a doctor has suggested it. If you experience any symptoms like dizziness, fainting, drowsiness, rapid breathing, weakness or difficulty in speaking, consult a doctor. Do not stop using any medications without talking to a doctor.
Olanzapine + FluoxetineMetrizamide
Severe
How does the drug interact with Olapin Forte Tablet:
The use of Olapin Forte Tablet and Metrizamide together may raise the risk of seizures (fits).

How to manage the interaction:
Although using Olapin Forte Tablet and Metrizamide together causes an interaction, they can be taken if prescribed by a doctor. In case you experience any unusual symptoms like loss of consciousness, anxiety, starring, weakness or uncontrolled muscle jerking, consult a doctor. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetineHydromorphone
Severe
How does the drug interact with Olapin Forte Tablet:
Combining Olapin Forte Tablet with Hydromorphone can increase the risk of brain related side effects and serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although taking Olapin Forte Tablet and Hydromorphone together can lead to an interaction, it can be taken if a doctor has suggested it. If you experience any symptoms like tiredness, difficulty in breathing, difficulty focusing, difficulty in passing stools, stomach ache, or bloating, confusion, hallucination, fits, dizziness, drowsiness, severe headache, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach pain, nausea, vomiting, or loose stools, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid alcohol entirely, as it can severely increase drowsiness, dizziness, and impairment.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIPSYCHOTICS]

FAQs

Olapin Forte Tablet is used to treat schizophrenia (mental illness) and bipolar disorder (manic depression). It works by restoring the balance of certain natural substances in the brain.
Olapin Forte Tablet can decrease anxiety, irritability or agitation. However, you should consult a doctor before using Olapin Forte Tablet for any condition.
Long-term use of Olapin Forte Tablet may cause dyskinesia (a movement disorder) in some cases. However, your doctor will prescribe this medication if the benefits outweigh the risks.
Olapin Forte Tablet can be used to treat mood disorders such as schizophrenia, bipolar disorder, anxiety, and depression. However, you should not take this medication without a doctor’s advice.
Olapin Forte Tablet may cause decreased libido in men and women. It can cause erectile dysfunction in men as it can alter testosterone levels. Consult a doctor if you experience erectile dysfunction after taking Olapin Forte Tablet .
Stopping Olapin Forte Tablet abruptly can cause withdrawal symptoms, and stopping it too early could make your illness come back. Please consult your doctor if you want to stop taking Olapin Forte Tablet .
Olapin Forte Tablet may cause severe side effects, such as memory loss and loss of contact with reality. It is important to know that it may raise blood sugar levels in diabetics and in patients who have never had diabetes. It can also induce weight gain and high blood fat levels which are more common in adolescents.
No, Olapin Forte Tablet is not a sleeping pill. It is an antipsychotic medication used in the treatment of schizophrenia or psychosis and bipolar disorder (manic depression).
Olapin Forte Tablet should be used by pregnant women only when prescribed by a doctor. Please consult the doctor if you are pregnant, think you may be pregnant or planning for pregnancy.
Do not discontinue Olapin Forte Tablet without consulting your doctor as stopping Olapin Forte Tablet suddenly may cause withdrawal symptoms. To treat your condition effectively, keep taking Olapin Forte Tablet for the prescribed duration.
Avoid smoking as it might interfere with the working of Olapin Forte Tablet . Do not consume alcohol while on treatment with Olapin Forte Tablet as it may cause increased drowsiness.
Common side-effects of Olapin Forte Tablet are drowsiness, lightheadedness, restlessness, irritability, tremors, dry mouth, constipation, increased appetite, extreme fatigue, decreased libido, swelling of the hands or feet, or weight gain. Inform your doctor if any of these side effects persist or worsen.
Yes, you can take this medicine with or without food. Taking it with food may help if you experience mild stomach upset when starting the treatment. Talk to your doctor if you have further questions.
You must contact your healthcare provider or seek medical help immediately if you experience worsening depression, sudden behavioural changes, or thoughts of self-harm. Talk to your doctor right away if you notice these signs.
No, you should avoid alcohol while taking this medicine. Alcohol can significantly increase drowsiness, affect your coordination, and interfere with how the medicine works. Talk to your doctor if you find it difficult to avoid alcohol.
Yes, an increase in appetite and weight gain are common side effects of this medicine. Managing your diet and staying physically active can help control this. Talk to your doctor or pharmacist for personalised lifestyle tips.
To manage dry mouth, try drinking water frequently, chewing sugarless gum, or sucking on sugar-free hard candies. If dry mouth persists or becomes severe, talk to your doctor or pharmacist for advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.3071 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Olanzapine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Olanzapine and fluoxetine hydrochloride [Prescribing Information]. 2011. [Accessed on 16 Sep. 2024]Check here
  5. Brown & Burk UK Ltd. Fluoxetine 20mg Hard Capsules. Electronic Medicines Compendium. [Revised in September 2021]. [Accessed on 21st January 2023].Check here
  6. Endo Ventures Ltd. Fluoxetine 10 mg Film-coated Tablets. Electronic Medicines Compendium. [Revised in January 2021]. [Accessed on 21st January 2023].Check here

Country of origin

INDIA

Manufacturer/Marketer address

SCO-58, 59, Sector-17D Chandigarh-160017
Other Info - OLA0024

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