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compositionComposition:ONDANSETRON-2MG
prescriptionPrescription Medicine
Onsett Injection 2 ml

Onsett Injection 2 ml is an antiemetic medication used in the treatment and prevention of nausea and vomiting during chemotherapy. This medication contains ondansetron which functions by inhibiting the activity of serotonin, a neurotransmitter that activates the brain's vomiting center (chemoreceptor trigger zone, or CTZ).

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

ONDANSETRON-2MG

Manufacturer/Marketer :

Cadila Healthcare Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Onsett Injection 2 ml

Onsett Injection 2 ml is used to prevent and treat nausea and vomiting during chemotherapy. Nausea is an uneasy feeling in which a person feels an urge to vomit, while vomiting is the natural response of the body to expel the stomach contents from the mouth forcefully.

Onsett Injection 2 ml contains Ondansetron, which works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting.

In some cases, Onsett Injection 2 ml may cause headache, constipation, a feeling of warmth or flushing, redness, and irritation at the site of injection. If the side effects persist or worsen, please consult your doctor.

If you are allergic to Onsett Injection 2 ml or any other medicines, please tell your doctor. It should be given to children only in doses advised by the doctor based on the child’s body weight or body surface area. If you are pregnant or breastfeeding, you must inform your doctor before taking Onsett Injection 2 ml.

Uses of Onsett Injection 2 ml

Onsett Injection 2 ml is used to prevent and treat nausea and vomiting caused by various medical conditions. The detailed uses of Onsett Injection 2 ml are as follows:

  • Chemotherapy-induced nausea and vomiting (CINV) : Onsett Injection 2 ml is used in adults and children to prevent and manage nausea and vomiting caused by cancer chemotherapy.
  • Post-operative nausea and vomiting (PONV): Onsett Injection 2 ml helps prevent and treat nausea and vomiting that may occur after surgery.
  • Radiotherapy-induced nausea and vomiting: In adults receiving radiation treatment for cancer, Onsett Injection 2 ml is used to reduce or prevent nausea and vomiting associated with therapy.

Key Benefits

  • Onsett Injection 2 ml contains Ondansetron that blocks the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain.
  • Thus, it prevents nausea and vomiting caused by chemotherapy in adults and children, as well as after surgery.
  • Additionally, Onsett Injection 2 ml can be used to prevent nausea and vomiting caused by radiotherapy for cancer in adults.
Side effects of Onsett Injection 2 ml
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink plenty of fluids to stay hydrated and replace the lost electrolytes.
  • Eat small, frequent meals of bland foods like crackers, toast, or plain rice.
  • Avoid heavy or fatty foods that can worsen nausea.
  • Use relaxation techniques like deep breathing or meditation to manage stress and anxiety.
  • Minimize exposure to strong smells or odors that can trigger nausea.
  • Ensure good airflow in the room by keeping it well-ventilated and maintaining a comfortable temperature.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Onsett Injection 2 ml will be administered by the doctor.
  • Do not self-administer.

How Onsett Injection 2 ml Works

Onsett Injection 2 ml contains Ondansetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting center (chemoreceptor trigger zone CTZ) located in the brain. Thus, it prevents nausea and vomiting.
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Alcohol

Unsafe

Avoid consuming alcohol while taking Onsett Injection 2 ml as this medicine can interact with alcohol and may worsen the side effects.

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Pregnancy

Consult your doctor

If you are pregnant, inform your doctor before taking Onsett Injection 2 ml. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Breast Feeding

Consult your doctor

If you are a nursing mother, inform your doctor before taking Onsett Injection 2 ml. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Driving

Caution

Onsett Injection 2 ml usually does not affect your driving ability. However, do not drive if you feel any discomfort.

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Liver

Caution

Take Onsett Injection 2 ml with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Safe if prescribed

Onsett Injection 2 ml may be safe to use in patients with kidney problems if prescribed by a doctor.

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Children

Consult your doctor

Onsett Injection 2 ml should be used in children only in doses advised by the doctor based on child’s body weight or body surface area.

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Heart

Caution

Onsett Injection 2 ml may be used in heart patients but requires caution due to risk of QT prolongation. ECG monitoring is advised to prevent serious arrhythmias, especially in those with existing cardiac conditions.

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Geriatrics

Caution

Onsett Injection 2 ml can be used in geriatric patients, but with caution. Older adults may be more sensitive to side effects like QT prolongation, so ECG monitoring is often recommended during treatment.

What if I have taken an overdose of Onsett Injection 2 ml

Onsett Injection 2 ml is administered by a health care professional in a hospital setting. Hence, the chances of overdose are less. Symptoms of overdose may include sudden loss of vision, severe constipation, feeling light-headed, or fainting. There is no specific antidote for Ondansetron overdose. Your doctor may take necessary measures if an overdose is suspected.

Diet & Lifestyle Advise

  • Eat a healthy and low-fat diet, especially in small portions, as it will be easy to digest. Avoid eating overly sweet food and include more salty food, especially if you have been vomiting.
  • Drink any other liquid at least 30 minutes after eating food.
  • If the smell of food makes you feel sick (vomit), do not cook food as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Have a query?

How Soon It Starts Working

  • The time required for Onsett Injection 2 ml to start to work: Onsett Injection 2 ml ideally shows its action within 30 minutes after administration. 
  • The time for which the effects of Onsett Injection 2 ml last: The duration of action for Onsett Injection 2 ml is unknown.

What if you forget to take Onsett Injection 2 ml

As this medicine is administered in a hospital by your healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight.• Keep Onsett Injection 2 ml out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • If you are allergic to Ondansetron, Palanosetron, Granisetron, or any other medicines, please tell your doctor.
  • Onsett Injection 2 ml should be given to children only in doses as advised by the doctor based on the child’s body weight or body surface area.
  • Onsett Injection 2 ml should be used during pregnancy or breastfeeding after consultation with a doctor.
  • If you have problems with levels of sodium, magnesium, and potassium salts in your blood, inform your doctor before taking Onsett Injection 2 ml.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interaction: Onsett Injection 2 ml may interact with anticonvulsants (phenytoin, carbamazepine), antituberculosis drug (rifampicin), antibiotics (erythromycin), antifungal (ketoconazole), narcotic analgesics (tramadol, methadone), beta-blockers, anti-arrhythmic medicines, antidepressants (citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, escitalopram, duloxetine, venlafaxine), chemotherapy drugs (anthracyclines, trastuzumab) and antipsychotic (haloperidol).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: If you have a blockage in the gut, liver or heart problems, an imbalance of potassium, sodium and magnesium in the blood, inform your doctor before taking Onsett Injection 2 ml.

OndansetronZiprasidone
Critical
OndansetronPentazocine
Severe

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
How does the drug interact with Onsett Injection 2 ml:
Taking Onsett Injection 2 ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Onsett Injection 2 ml with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
OndansetronPentazocine
Severe
How does the drug interact with Onsett Injection 2 ml:
Taking Pentazocine with Onsett Injection 2 ml may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in body).

How to manage the interaction:
Taking Onsett Injection 2 ml with Pentazocine together can result in an interaction but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
OndansetronProcarbazine
Severe
How does the drug interact with Onsett Injection 2 ml:
When Onsett Injection 2 ml, is taken with procarbazine it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Onsett Injection 2 ml along with procarbazine can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, and diarrhea, see a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronFluvoxamine
Severe
How does the drug interact with Onsett Injection 2 ml:
When Onsett Injection 2 ml is taken with fluvoxamine, can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Onsett Injection 2 ml along with fluvoxamine can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not discontinue any medications without a doctor's advice.
OndansetronMirtazapine
Severe
How does the drug interact with Onsett Injection 2 ml:
Using Onsett Injection 2 ml with mirtazapine might raise serotonin hormone levels in the body, affects the brain and nerve cells.

How to manage the interaction:
Co-administration of Onsett Injection 2 ml along with mirtazapine can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not discontinue any medications without a doctor's advice.
OndansetronDisopyramide
Severe
How does the drug interact with Onsett Injection 2 ml:
Taking Onsett Injection 2 ml with disopyramide increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking Onsett Injection 2 ml along with disopyramide can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronHydroxychloroquine
Severe
How does the drug interact with Onsett Injection 2 ml:
Taking Onsett Injection 2 ml with hydroxychloroquine increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Onsett Injection 2 ml along with hydroxychloroquine can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronImipramine
Severe
How does the drug interact with Onsett Injection 2 ml:
Coadministration of Onsett Injection 2 ml along with imipramine can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Taking Onsett Injection 2 ml along with imipramine together can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not discontinue any medications without consulting a doctor.
OndansetronLithium
Severe
How does the drug interact with Onsett Injection 2 ml:
Taking Onsett Injection 2 ml with lithium can increase the risk of serotonin syndrome a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Although taking Onsett Injection 2 ml along with lithium can result in an interaction but can be taken together if prescribed by a doctor. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools, or fast or rapid heartbeats during therapy, consult a doctor. Do not stop using any medications without talking to a doctor.
OndansetronSotalol
Severe
How does the drug interact with Onsett Injection 2 ml:
Taking Onsett Injection 2 ml and Sotalol can increase the risk or severity of irregular heart rhythms which can be severe.

How to manage the interaction:
Although taking Onsett Injection 2 ml and Sotalol can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIEMETICS]

FAQs

Onsett Injection 2 ml belongs to a class of drugs called antiemetics used to prevent nausea and vomiting during chemotherapy.

Onsett Injection 2 ml works by blocking the action of serotonin, a chemical that stimulates the vomiting center (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.

You are not recommended to take erythromycin with Onsett Injection 2 ml as it may increase the risk of severe irregular heart rhythm. However, please consult your doctor before taking other medicines with Onsett Injection 2 ml.

Onsett Injection 2 ml may cause constipation as a side effect. It is not necessary for everyone taking Onsett Injection 2 ml to experience this side effect. However, if the condition persists or worsens, please consult a doctor.

Onsett Injection 2 ml should be used with caution in patients suffering from liver problems. However, inform your doctor if you have any liver problems before taking Onsett Injection 2 ml so that the dose may be adjusted appropriately.

Yes, Onsett Injection 2 ml may be used to prevent nausea and vomiting after surgery. Onsett Injection 2 ml blocks serotonin (a chemical) action which is responsible for causing nausea and vomiting.

Disclaimer

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Author Details

Veda MaddalaDoctor badge

Written By

  • Veda Maddala

    M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

  • Santoshini Reddy G

    M Pharmacy

Last Updated

Doctor imageWe provide you with authentic, trustworthy and relevant information

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads, Ahmedabad 380015, Gujarat, India.
Other Info - ONS0040
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