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compositionComposition:THALIDOMIDE-100MG
prescriptionPrescription Medicine
Oncothal 100 mg Capsule 10's

Oncothal 100 mg Capsule is used to treat multiple myeloma (a type of cancer) and erythema nodosum leprosum (an inflammatory complication). It helps slow the growth of cancer cells and supports the body’s immune response. It also helps reduce inflammation and related symptoms.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

THALIDOMIDE-100MG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Oncothal 100 mg Capsule

Oncothal 100 mg Capsule is used to treat multiple myeloma (a type of cancer). It is also used to treat and prevent symptoms of erythema nodosum leprosum (ENL) and as maintenance therapy for the prevention and suppression of erythema nodosum leprosum recurrence. ENL is an immune-mediated inflammatory complication of leprosy.

Oncothal 100 mg Capsule contains thalidomide, which helps control the growth of cancer cells. It supports the body’s immune response and slows the spread of cancer. It also helps reduce the blood supply that tumours need to grow. This helps manage multiple myeloma.

Take Oncothal 100 mg Capsule as prescribed by your doctor. You may experience common side effects such as constipation, dizziness, sleepiness, tiredness, tremors (shaking movements), dysaesthesia (abnormal sensation), low blood cell count, nausea, vomiting, and swelling of hands and feet. Talk to your doctor if you experience any of these side effects persistently.

Do not take Oncothal 100 mg Capsule if you are pregnant, as it might cause severe birth defects or the death of an unborn baby. Avoid taking Oncothal 100 mg Capsule if you are breastfeeding. Oncothal 100 mg Capsule may cause dizziness, sleepiness, and blurred vision, so drive only if you are alert. Oncothal 100 mg Capsule is not recommended for children under 18 years old.

Uses of Oncothal 100 mg Capsule

Oncothal 100 mg Capsule is used to treat specific cancers and inflammatory complications of leprosy. The detailed uses of Oncothal 100 mg Capsule include:

  • Treatment of multiple myeloma: Oncothal 100 mg Capsule is used in combination with other medicines to treat multiple myeloma, a type of blood cancer affecting plasma cells in the bone marrow.
  • Management of erythema nodosum leprosum (ENL): Oncothal 100 mg Capsule is effective in managing ENL, a painful inflammatory complication of leprosy, by reducing swelling, redness, and discomfort.

Key Benefits

Oncothal 100 mg Capsule , when used as prescribed, may provide the following benefits:

For Multiple Myeloma:

  • Helps control the growth of cancer cells in the bone marrow.
  • Supports treatment when used along with other cancer medicines.
  • Helps improve disease control and overall treatment response.

For Erythema Nodosum Leprosum (ENL):

  • Helps reduce swelling, redness, and pain associated with this inflammatory condition.
  • Calms immune-related inflammation.
  • Improves comfort and quality of life during flare-ups.
Side effects of Oncothal 100 mg Capsule
Managing Medication-Triggered Hypocalcemia (Calcium deficiency or Low Calcium Levels In Blood): A Step-by-Step Guide:
  • Consult Your Doctor: If you experience symptoms such as muscle cramps, tingling, numbness, weakness, or spasms, which may indicate low calcium levels (hypocalcemia), consult your doctor to determine if your medication is the cause.
  • Your doctor will assess your medication regimen and adjust it if necessary to minimize the risk of hypocalcemia.
  • Your doctor may order blood tests to check your calcium levels and monitor for any changes.
  • To manage hypocalcemia, your doctor recommends dietary and lifestyle modifications. This may include increasing your intake of calcium-rich foods to support bone health and calcium levels. If necessary, your doctor may also prescribe calcium and vitamin D supplements to help stabilize your calcium levels.
  • If your condition does not improve or worsens, consult your doctor immediately for further evaluation and treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Muscle weakness can be due to tiredness, which can be managed by eating often.
  • Observe your movements and understand why the muscle is weakening.
  • Regularly do strengthening exercises to improve blood flow throughout the body and reduce weakness.
  • Sleep well and give enough rest to your body.
  • Take a balanced diet, quit smoking and intake of alcohol.
  • Practice yoga and meditation to improve inner strength and stay healthy.

Directions for Use

  • Oncothal 100 mg Capsule should be taken at least one hour after meals.
  • It is usually taken once daily, preferably at bedtime, or as prescribed by your doctor.
  • Swallow Oncothal 100 mg Capsule as a whole with a glass of water.
  • Do not crush, chew, or open it.

How Oncothal 100 mg Capsule Works

Oncothal 100 mg Capsule contains Thalidomide. It works in multiple myeloma by slowing cancer cell growth and supporting the body’s immune response. In erythema nodosum leprosum (ENL), it helps reduce skin inflammation and control moderate to severe flare-ups.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Oncothal 100 mg Capsule as it might cause increased sleepiness.

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Pregnancy

Unsafe

Oncothal 100 mg Capsule belongs to pregnancy category X. Oncothal 100 mg Capsule should not be taken during pregnancy as it causes severe birth defects or death to an unborn baby. Use highly effective contraception if you are a woman of child-bearing age. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Oncothal 100 mg Capsule as it is unknown if Oncothal 100 mg Capsule passes into breastmilk.

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Driving

Unsafe

Oncothal 100 mg Capsule may cause dizziness, sleepiness, and blurred vision. Do not drive or operate heavy machinery unless you are alert.

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Liver

Caution

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Oncothal 100 mg Capsule is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Caution

Oncothal 100 mg Capsule should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Oncothal 100 mg Capsule .

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Geriatrics

Caution

Oncothal 100 mg Capsule should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Oncothal 100 mg Capsule .

What if I have taken an overdose of Oncothal 100 mg Capsule

Take Oncothal 100 mg Capsule only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

Diet:

  • Maintain a healthy, balanced diet to achieve an appropriate weight.
  • Include iron-rich foods like lean meat, raisins, and green vegetables.
  • Include fibre-rich foods, such as whole grains, fruits, and beans, to prevent constipation.
  • Drink plenty of water to support digestion and reduce the risk of constipation.

Physical Activity:

  • Do light to moderate exercise regularly to maintain strength and circulation.
  • Avoid activities that increase the risk of injury if feeling weak or dizzy.

Habits & Safety:

  • Avoid smoking and alcohol consumption.
  • Use effective birth control as advised, as Oncothal 100 mg Capsule can cause serious birth defects.
  • Do not donate blood during treatment.
  • Take the medicine at night if it causes drowsiness and avoid driving if feeling sleepy.

Have a query?

How Soon It Starts Working

  • The time required for Oncothal 100 mg Capsule to start to work: The time required for Oncothal 100 mg Capsule to show its action is unknown.
  • The time for which the effects of Oncothal 100 mg Capsule last: The duration of action for Oncothal 100 mg Capsule is clinically unknown.

What if you forget to take Oncothal 100 mg Capsule

If you forget to take a dose of Oncothal 100 mg Capsule , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not double the dose to make up for the missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Oncothal 100 mg Capsule out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not take Oncothal 100 mg Capsule if you are allergic to any of its components.
  • Inform your doctor if you have/had blood clots, a heart attack, neuropathy, a slow heart rate, high blood pressure, low blood pressure, infections, a viral infection, HIV, hepatitis B, epilepsy, liver or kidney problems.
  • Do not take Oncothal 100 mg Capsule if you are pregnant, as it might cause severe birth defects or the death of the unborn baby.
  • Avoid taking Oncothal 100 mg Capsule if you are breastfeeding, as it is not known if it passes into breastmilk.
  • Oncothal 100 mg Capsule may cause dizziness, sleepiness, and blurred vision; therefore, drive only if you are alert.
  • Oncothal 100 mg Capsule is not recommended for children under 18 years, as safety and efficacy have not been established.
  • Avoid consuming alcohol with Oncothal 100 mg Capsule as it could lead to increased dizziness and sleepiness.
  • Oncothal 100 mg Capsule , when taken with dexamethasone, increases the risk of deep vein thrombosis and pulmonary embolism.
  • Stop taking Oncothal 100 mg Capsule and consult a doctor immediately if you think you are pregnant, if you have irregular periods, missed a period, have any change in menstrual bleeding, or if you have had sex without using two forms of birth control.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Inform your doctor if you are taking any of the following medicines, as there may be an interaction.

  • Anticancer medicines (Thiotepa, Vincristine)
    • Potential effect: May increase the risk of blood clots and other serious complications.
  • Hormone-related medicine (Ethinylestradiol)
    • Potential effect: May increase the risk of blood clots and raise the chance of serious complications.
  • Immunity-lowering medicines (Tofacitinib, Baricitinib)
    • Potential effect: May increase the risk of infections due to added immune suppression.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have a history of the following conditions before taking Oncothal 100 mg Capsule .

  • Seizures (fits)
  • HIV infection
  • Hypotension (low blood pressure)
  • Neuropathy (nerve damage)
  • Neutropenia (low levels of neutrophils)
ThalidomideDexamethasone
Severe
ThalidomideDacarbazine
Severe

Drug-Drug Interactions

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ThalidomideDexamethasone
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Dexamethasone with Oncothal 100 mg Capsule may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction, Dexamethasone can be taken with Oncothal 100 mg Capsule if prescribed by the doctor. Consult the doctor immediately if you experience signs and symptoms of blood clots such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness, or swelling in an arm or leg. Do not discontinue the medication without consulting a doctor.
ThalidomideDacarbazine
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Oncothal 100 mg Capsule together with dacarbazine may increase the risk of blood clots.

How to manage the interaction:
Although taking Oncothal 100 mg Capsule and dacarbazine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideErythropoietin
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Oncothal 100 mg Capsule with erythropoietin may increase the risk or severity of thromboembolism(a circulating blood clot that gets stuck and causes an obstruction).

How to manage the interaction:
Although taking Erythropoietin and Oncothal 100 mg Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideTofacitinib
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Oncothal 100 mg Capsule with Tofacitinib may increase the risk of infection.

How to manage the interaction:
Although taking Oncothal 100 mg Capsule and tofacitinib together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
ThalidomideEtanercept
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Oncothal 100 mg Capsule with Etanercept may increase the risk of serious infection.

How to manage the interaction:
Although taking Oncothal 100 mg Capsule and etanercept together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
ThalidomideAnastrozole
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Using Oncothal 100 mg Capsule together with anastrozole can increase the risk of dangerous blood clots.

How to manage the interaction:
Although taking Oncothal 100 mg Capsule with Anastrozole together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience shortness of breath, difficulty breathing, chest pain, coughing up blood, sudden loss of vision, and/or pain, redness or swelling in an arm or leg, contact a doctor immediately. Do not stop taking any medication without doctors advise.
ThalidomidePrednisolone
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Co-administration of Oncothal 100 mg Capsule and Prednisolone use may increase the possibility of serious blood clots.

How to manage the interaction:
Although taking Prednisolone and Oncothal 100 mg Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ThalidomideCapecitabine
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Co-administration of Oncothal 100 mg Capsule with Capecitabine may increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction, Capecitabine can be taken with Oncothal 100 mg Capsule if prescribed by the doctor. Consult the prescriber if you experience signs and symptoms of blood clots such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness, or swelling in an arm or leg. Do not discontinue the medication without consulting a doctor.
ThalidomideCyclophosphamide
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Cyclophosphamide with Oncothal 100 mg Capsule may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction, Cyclophosphamide can be taken with Oncothal 100 mg Capsule if prescribed by the doctor. However, consult the doctor if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness, or swelling in an arm or leg. Do not discontinue any medications without a doctor's advice.
ThalidomideBaricitinib
Severe
How does the drug interact with Oncothal 100 mg Capsule:
Taking Oncothal 100 mg Capsule with Baricitinib together can increase the risk of infection.

How to manage the interaction:
Although taking Oncothal 100 mg Capsule and baricitinib together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTILEPROTICS]

FAQs

Oncothal 100 mg Capsule belongs to the group of medicines called immunomodulatory agents used to treat multiple myeloma. Oncothal 100 mg Capsule is also used to treat and prevent symptoms of erythema nodosum leprosum (ENL) and as maintenance therapy for the prevention and suppression of erythema nodosum leprosum recurrence.

Oncothal 100 mg Capsule stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Oncothal 100 mg Capsule helps treat multiple myeloma.

Do not stop taking Oncothal 100 mg Capsule on your own. You are advised to take Oncothal 100 mg Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. Do not hesitate to speak with your doctor if you experience any difficulties while taking Oncothal 100 mg Capsule .

Orthostatic hypotension could be a side-effect of Oncothal 100 mg Capsule . Orthostatic hypotension is a sudden lowering of blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better.

No, it is not safe to father a child while taking Oncothal 100 mg Capsule . Thalidomide is present in the semen of male patients taking Oncothal 100 mg Capsule ; it could cause severe birth defects or death of the unborn baby. During sexual activity with females of reproductive potential, always use effective contraception such as latex or synthetic condom while taking Oncothal 100 mg Capsule and for at least 4weeks after discontinuing Oncothal 100 mg Capsule , even if you have undergone a successful vasectomy. Male patients taking Oncothal 100 mg Capsule must not donate semen.

Patients taking Oncothal 100 mg Capsule must not donate blood during the treatment with Oncothal 100 mg Capsule and for 4weeks after discontinuation of Oncothal 100 mg Capsule as the donated blood might be given to pregnant women whose foetus should not be exposed to thalidomide since it causes severe birth defects or death of the unborn baby.

People with multiple myeloma taking Oncothal 100 mg Capsule may have an increased risk for blood clots in veins, arteries, and lungs. The risk is higher if you take dexamethasone with Oncothal 100 mg Capsule for treating multiple myeloma. Consult your doctor immediately if you notice symptoms such as shortness of breath, chest pain, and swelling in the legs or arm.

Oncothal 100 mg Capsule may cause side effects such as nausea, vomiting, indigestion, dizziness, heartburn, constipation, tiredness, tremor or swelling of hands and feet. If these side effects persist or worsen, please consult your doctor.

If you forget to take a dose of Oncothal 100 mg Capsule , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one, as this may increase the risk of side effects.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

D' Block, 3Rd Floor, Gillander House, Netaji Subhas Road, Kolkata - 700001 (Wb)
Other Info - ONC0020
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