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  3. Ondasal 4mg Injection

Ondasal 4mg Injection, Pack of 1 Injection
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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy

Ondasal 4mg Injection is an antiemetic medication used in the treatment and prevention of nausea and vomiting during chemotherapy. This medication contains ondansetron which functions by inhibiting the activity of serotonin, a neurotransmitter that activates the brain's vomiting center (chemoreceptor trigger zone, or CTZ).

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Composition :

ONDANSETRON-4MG/2ML

Manufacturer/Marketer :

Salveo Lifecare

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Ondasal 4mg Injection

Ondasal 4mg Injection is used to prevent and treat nausea and vomiting during chemotherapy. Nausea is an uneasy feeling in which a person feels an urge to vomit, while vomiting is the natural response of the body to expel the stomach contents from the mouth forcefully.

Ondasal 4mg Injection contains Ondansetron, which works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting.

In some cases, Ondasal 4mg Injection may cause headache, constipation, a feeling of warmth or flushing, redness, and irritation at the site of injection. If the side effects persist or worsen, please consult your doctor.

If you are allergic to Ondasal 4mg Injection or any other medicines, please tell your doctor. It should be given to children only in doses advised by the doctor based on the child’s body weight or body surface area. If you are pregnant or breastfeeding, you must inform your doctor before taking Ondasal 4mg Injection.

Uses of Ondasal 4mg Injection

Ondasal 4mg Injection is used to prevent and treat nausea and vomiting caused by various medical conditions. The detailed uses of Ondasal 4mg Injection are as follows:

  • Chemotherapy-induced nausea and vomiting (CINV) : Ondasal 4mg Injection is used in adults and children to prevent and manage nausea and vomiting caused by cancer chemotherapy.
  • Post-operative nausea and vomiting (PONV): Ondasal 4mg Injection helps prevent and treat nausea and vomiting that may occur after surgery.
  • Radiotherapy-induced nausea and vomiting: In adults receiving radiation treatment for cancer, Ondasal 4mg Injection is used to reduce or prevent nausea and vomiting associated with therapy.

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Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Ondasal 4mg Injection will be administered by the doctor.
  • Do not self-administer.

Medicinal Benefits

  • Ondasal 4mg Injection contains Ondansetron that blocks the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain.
  • Thus, it prevents nausea and vomiting caused by chemotherapy in adults and children, as well as after surgery.
  • Additionally, Ondasal 4mg Injection can be used to prevent nausea and vomiting caused by radiotherapy for cancer in adults.

How Ondasal 4mg Injection Works

Ondasal 4mg Injection contains Ondansetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting center (chemoreceptor trigger zone CTZ) located in the brain. Thus, it prevents nausea and vomiting.

Storage

• Store in a cool and dry place away from sunlight.• Keep Ondasal 4mg Injection out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Ondasal 4mg Injection
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink plenty of fluids to stay hydrated and replace the lost electrolytes.
  • Eat small, frequent meals of bland foods like crackers, toast, or plain rice.
  • Avoid heavy or fatty foods that can worsen nausea.
  • Use relaxation techniques like deep breathing or meditation to manage stress and anxiety.
  • Minimize exposure to strong smells or odors that can trigger nausea.
  • Ensure good airflow in the room by keeping it well-ventilated and maintaining a comfortable temperature.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

What if I have taken an overdose of Ondasal 4mg Injection

Ondasal 4mg Injection is administered by a health care professional in a hospital setting. Hence, the chances of overdose are less. Symptoms of overdose may include sudden loss of vision, severe constipation, feeling light-headed, or fainting. There is no specific antidote for Ondansetron overdose. Your doctor may take necessary measures if an overdose is suspected.

Drug Warnings

  • If you are allergic to Ondansetron, Palanosetron, Granisetron, or any other medicines, please tell your doctor.
  • Ondasal 4mg Injection should be given to children only in doses as advised by the doctor based on the child’s body weight or body surface area.
  • Ondasal 4mg Injection should be used during pregnancy or breastfeeding after consultation with a doctor.
  • If you have problems with levels of sodium, magnesium, and potassium salts in your blood, inform your doctor before taking Ondasal 4mg Injection.

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
OndansetronBupropion
Severe

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
How does the drug interact with Ondasal 4mg Injection:
Taking Ondasal 4mg Injection with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ondasal 4mg Injection with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
OndansetronBupropion
Severe
How does the drug interact with Ondasal 4mg Injection:
When bupropion, is combined with Ondasal 4mg Injection it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Ondasal 4mg Injection along with bupropion can lead to interaction, it can be taken if recommended by a doctor. If you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, and diarrhea consult a doctor. Do not discontinue any medications without consulting a doctor.
OndansetronCitalopram
Severe
How does the drug interact with Ondasal 4mg Injection:
When Ondasal 4mg Injection, is taken with citalopram, the risk of serotonin syndrome increases. (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Ondasal 4mg Injection along with citalopram can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach pain, nausea, vomiting, and diarrhea while taking these medications, consult the doctor. Do not discontinue any medications without a doctor's advice.
OndansetronVenlafaxine
Severe
How does the drug interact with Ondasal 4mg Injection:
When Ondasal 4mg Injection is taken with venlafaxine, it can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Although taking Ondasal 4mg Injection along with venlafaxine can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking these medications. Do not discontinue any medications without a doctor's advice.
OndansetronBuspirone
Severe
How does the drug interact with Ondasal 4mg Injection:
Using Buspirone together with Ondasal 4mg Injection can increase the risk of a serious condition called serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a chemical that plays a role in overall wellbeing and especially a mood stabilizer).

How to manage the interaction:
Co-administration of Ondasal 4mg Injection with buspirone can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.
OndansetronIloperidone
Severe
How does the drug interact with Ondasal 4mg Injection:
Taking Ondasal 4mg Injection with Iloperidone increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Ondasal 4mg Injection along with Iloperidone can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronMaprotiline
Severe
How does the drug interact with Ondasal 4mg Injection:
When Ondasal 4mg Injection is taken with maprotiline, can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Ondasal 4mg Injection along with maprotiline can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not stop using any medications without talking to a doctor.
OndansetronAmiodarone
Severe
How does the drug interact with Ondasal 4mg Injection:
Coadministration of Ondasal 4mg Injection with amiodarone can lead to or increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Ondasal 4mg Injection with amiodarone together can result in interaction, it should be taken only if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without a doctor's advice.
OndansetronEfavirenz
Severe
How does the drug interact with Ondasal 4mg Injection:
Taking Ondasal 4mg Injection with efavirenz increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Ondasal 4mg Injection along with efavirenz can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronChloroquine
Severe
How does the drug interact with Ondasal 4mg Injection:
Using chloroquine together with Ondasal 4mg Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Ondasal 4mg Injection and chloroquine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and low-fat diet, especially in small portions, as it will be easy to digest. Avoid eating overly sweet food and include more salty food, especially if you have been vomiting.
  • Drink any other liquid at least 30 minutes after eating food.
  • If the smell of food makes you feel sick (vomit), do not cook food as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Ondasal 4mg Injection Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid consuming alcohol while taking Ondasal 4mg Injection as this medicine can interact with alcohol and may worsen the side effects.

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Pregnancy

Consult your doctor

If you are pregnant, inform your doctor before taking Ondasal 4mg Injection. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Breast Feeding

Consult your doctor

If you are a nursing mother, inform your doctor before taking Ondasal 4mg Injection. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Driving

Caution

Ondasal 4mg Injection usually does not affect your driving ability. However, do not drive if you feel any discomfort.

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Liver

Caution

Take Ondasal 4mg Injection with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Safe if prescribed

Ondasal 4mg Injection may be safe to use in patients with kidney problems if prescribed by a doctor.

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Children

Consult your doctor

Ondasal 4mg Injection should be used in children only in doses advised by the doctor based on child’s body weight or body surface area.

FAQs

Ondasal 4mg Injection belongs to a class of drugs called antiemetics used to prevent nausea and vomiting during chemotherapy.

Ondasal 4mg Injection works by blocking the action of serotonin, a chemical that stimulates the vomiting center (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.

You are not recommended to take erythromycin with Ondasal 4mg Injection as it may increase the risk of severe irregular heart rhythm. However, please consult your doctor before taking other medicines with Ondasal 4mg Injection.

Ondasal 4mg Injection may cause constipation as a side effect. It is not necessary for everyone taking Ondasal 4mg Injection to experience this side effect. However, if the condition persists or worsens, please consult a doctor.

Ondasal 4mg Injection should be used with caution in patients suffering from liver problems. However, inform your doctor if you have any liver problems before taking Ondasal 4mg Injection so that the dose may be adjusted appropriately.

Yes, Ondasal 4mg Injection may be used to prevent nausea and vomiting after surgery. Ondasal 4mg Injection blocks serotonin (a chemical) action which is responsible for causing nausea and vomiting.

Country of origin

India
Other Info - ON60298

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Sep 18, 2025 | 1:09 PM IST

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Reference

  1. https://www.hpra.ie/img/uploaded/swedocuments/5222449c-5347-4bed-8bf1-14edbf40c23d.pdf
  2. https://www.nps.org.au/assets/medicines/bb5dfa0a-c759-49c8-97ac-a53300ff3381.pdf
  3. https://extranet.who.int/pqweb/sites/default/files/documents/HA607part3v1.pdf
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