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compositionComposition:OXALIPLATIN-2MG
prescription
Prescription Medicine
info
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Oxashil 100 mg Injection 50 ml is used to treat Colon and rectal cancer. It contains Oxaliplatin, which works by killing the cancer cells. Thereby, it helps treat cancer. Sometimes, Oxashil 100 mg Injection 50 ml may cause side effects such as mild nausea, vomiting, diarrhoea, fever, and headache. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

OXALIPLATIN-2MG

Manufacturer/Marketer :

Shilpa Medicare Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-29

Return Policy :

Not Returnable

About Oxashil 100 mg Injection 50 ml

Oxashil 100 mg Injection 50 ml is a prescription cancer medication given as an injection into a vein to treat cancer of the colon or rectum. This medicine is designed to target and stop the growth of rapidly dividing cancer cells in the body. It is typically prescribed either after surgery to prevent the cancer from returning, or to manage advanced stages of the disease.

This treatment is given in scheduled cycles, usually once every two weeks, to allow your body time to recover between doses. Since it is given as an intravenous infusion, you do not need to worry about taking it with food, but staying well-hydrated is crucial. Making simple lifestyle adjustments, such as eating small, frequent meals and avoiding cold foods or drinks, can significantly help manage treatment-related side effects.

Many patients experience temporary side effects during treatment, including tiredness, nausea, and a unique sensitivity to cold temperatures. However, you must consult your doctor immediately if you experience serious symptoms such as severe numbness in your hands or feet, difficulty breathing, or signs of an infection like a fever.

Before starting therapy, talk to your doctor if you have a history of kidney disease, nerve disorders, or heart conditions. Do not take this medicine if you have previously had a severe allergic reaction to similar platinum-based chemotherapy drugs.

This medicine can interact with other drugs that affect your kidneys or heart rhythm, as well as alcohol, which can worsen liver stress and dehydration. If you are pregnant, breastfeeding, or planning a pregnancy, consult your doctor immediately, as this medicine can cause harm to a developing baby; elderly patients should also be closely monitored.

Uses of Oxashil 100 mg Injection 50 ml

Your doctor may prescribe this medicine to help manage the following conditions:

  • Colorectal Cancer (after surgery): Oxashil 100 mg Injection 50 ml is used after surgery to remove a tumor in the colon (stage III colon cancer) to help lower the risk of the cancer returning.
  • Advanced Colorectal Cancer: Oxashil 100 mg Injection 50 ml is used to treat colon or rectal cancer that has spread to other parts of the body, helping to shrink tumours and slow down the progression of the disease.

Key Benefits

When used as prescribed, Oxashil 100 mg Injection 50 ml offers several important benefits in the treatment of cancer.

  • Reduces the risk of cancer recurrence: After surgery, Oxashil 100 mg Injection 50 ml helps destroy microscopic cancer cells that may remain in the body, lowering the risk of the cancer returning.
  • Slows tumour growth: In patients with advanced or metastatic cancer, this medicine helps slow the growth and spread of cancer cells, helping keep the disease under control.
  • Helps shrink tumours: By reducing tumour size in some patients, Oxashil 100 mg Injection 50 ml may relieve cancer-related symptoms caused by pressure on surrounding tissues or organs.
  • Supports quality of life: By controlling cancer progression and reducing tumour-related symptoms, this medicine may help improve comfort and enable many patients to maintain their daily activities for longer.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Oxashil 100 mg Injection 50 ml will be administered by a nurse or doctor.
  • Do not self-administer.

How Oxashil 100 mg Injection 50 ml Works

Oxashil 100 mg Injection 50 ml contains oxaliplatin, which works by interfering with the genetic material (DNA) inside cancer cells. It binds to the DNA, creating cross-links that prevent the cells from duplicating their genetic code. Because cancer cells grow and divide much faster than normal cells, they are highly sensitive to this DNA damage. Once the DNA is damaged and cannot replicate, the cancer cells are unable to multiply and eventually die off. This action helps to shrink existing tumours and prevent the disease from spreading further throughout the body.
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Alcohol

Consult your doctor

It is not known if alcohol affects Oxashil 100 mg Injection 50 ml. Please consult your doctor.

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Pregnancy

Unsafe

Oxashil 100 mg Injection 50 ml may cause foetal harm. Therefore, avoid becoming pregnant during treatment with Oxashil 100 mg Injection 50 ml.

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Breast Feeding

Unsafe

Breastfeeding is not recommended during treatment with Oxashil 100 mg Injection 50 ml and for three months after the last dose.

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Driving

Caution

Oxashil 100 mg Injection 50 ml may cause dizziness or vision problems. Avoid driving or operating machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Consult your doctor

If you have a history of liver disease, inform your doctor before receiving Oxashil 100 mg Injection 50 ml.

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Kidney

Caution

Oxashil 100 mg Injection 50 ml should not be used if you have severe kidney disease. If you have mild or moderate kidney disease, inform your doctor before receiving Oxashil 100 mg Injection 50 ml.

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Children

Unsafe

Oxashil 100 mg Injection 50 ml is not recommended for children as safety and effectiveness have not been established.

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Heart

Caution

Oxashil 100 mg Injection 50 ml may increase the risk of heart problems. Therefore, please consult your doctor if you have any heart-related problems before using Oxashil 100 mg Injection 50 ml.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Oxashil 100 mg Injection 50 ml to geriatric patients. Your doctor will prescribe Oxashil 100 mg Injection 50 ml if the benefits outweigh the risks.

What if I have taken an overdose of Oxashil 100 mg Injection 50 ml

Because this medication is prepared and given by trained medical professionals, an overdose is highly uncommon. If an accidental overdose does occur, the medical staff will monitor you closely and provide immediate supportive care to manage any symptoms.

Diet & Lifestyle Advise

  • Avoid cold foods and drinks: Because this medicine causes temporary, extreme sensitivity to cold, avoid drinking ice-cold liquids, eating cold foods, or inhaling cold air during and immediately after your treatment. Use a straw if you must drink cool liquids, and wear gloves when handling items from the refrigerator.
  • Stay well-hydrated: Drink plenty of room-temperature fluids, such as water or warm broths, to help your kidneys flush the medicine out of your system and prevent dehydration from vomiting or diarrhea.
  • Eat soft, bland foods: To manage nausea or mouth sores, eat small, frequent meals consisting of soft, non-spicy, and non-acidic foods.
  • Protect your skin and stay warm: Wear warm clothing, including socks and gloves, especially in air-conditioned environments or during cold weather, to prevent nerve tingling or muscle spasms.
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Have a query?

How Soon It Starts Working

The time required for Oxashil 100 mg Injection 50 ml to start to work: The time required for Oxashil 100 mg Injection 50 ml to show its action is not clinically established. The time for which the effects of Oxashil 100 mg Injection 50 ml last: The duration of action for Oxashil 100 mg Injection 50 ml is not clinically established.

What if you forget to take Oxashil 100 mg Injection 50 ml

Since this medicine is given in a clinical setting by healthcare professionals, missing a dose is unlikely. However, if you miss a scheduled appointment for your infusion, contact your doctor or clinic immediately to reschedule your treatment.

Storage

•The unopened vials are stored at a controlled room temperature of 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the infusion setup: Before the infusion starts, ensure the liquid in the bag is clear and free of particles. If you notice any cloudiness or floating particles, point it out to your nurse immediately.
  • Report infusion site pain: Tell your healthcare provider immediately if you feel pain, burning, redness, or swelling around the injection site during the infusion, as the medicine can damage surrounding tissues if it leaks out of the vein.
  • Avoid cold air and drafts: Wear a scarf over your mouth and nose if you must go outside in cold weather immediately after your infusion to avoid throat spasms.
  • Monitor your temperature: Keep a thermometer at home and check your temperature if you feel unwell; contact your clinic immediately if you develop a fever of 100.4°F (38°C) or higher.
  • Use reliable birth control: Both men and women should use highly effective birth control during treatment and for several months after the final dose to prevent pregnancy.

verifiedApollotooltip
  • Medicines that harm the kidneys: Taking drugs like certain strong antibiotics (aminoglycosides) or water pills (loop diuretics) along with Oxashil 100 mg Injection 50 ml may increase the risk of kidney damage.
  • Blood thinners: Combining this medicine with drugs that prevent blood clots, such as warfarin or aspirin, may increase your risk of serious bleeding.
  • Medicines that affect heart rhythm: Medications that prolong the QT interval can increase the risk of dangerous heart rhythms when used alongside Oxashil 100 mg Injection 50 ml.

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verifiedApollotooltip
  • No clinically significant food interactions are known with Oxashil 100 mg Injection 50 ml when used as directed.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Oxashil 100 mg Injection 50 ml is used to treat Colon and rectal cancer.
Oxashil 100 mg Injection 50 ml works by killing the cancer cells. Thereby, it helps treat cancer.
Oxashil 100 mg Injection 50 ml may have an anti-fertility effect, which could be irreversible. Therefore, male patients should seek medical advice on the conservation of sperm prior to treatment with Oxashil 100 mg Injection 50 ml.
Avoid drinking or eating anything colder than room temperature. Do not touch any cold objects, wash your hands in cold water, go near air conditioners or freezers, or go outside in cold weather unless absolutely necessary for five days after you receive each dose of Oxashil 100 mg Injection 50 ml. Wear a hat, gloves, and a scarf, and cover your mouth and nose if you must go outside in cold weather.
Oxashil 100 mg Injection 50 ml may decrease the ability to fight infections due to reduced white blood cells. Stay away from sick people during treatment with Oxashil 100 mg Injection 50 ml.
Oxashil 100 mg Injection 50 ml is administered to you through an intravenous (IV) infusion. A healthcare professional usually gives it in a clinical setting.
The common side effects of Oxashil 100 mg Injection 50 ml are mild nausea, vomiting, diarrhoea, headache, peripheral neuropathy, fatigue, back pain, and stomach pain. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
This medicine temporarily affects the nerves in your body, particularly when they are exposed to low temperatures. This can cause sudden tingling, numbness, or muscle spasms in your hands, feet, or throat. This sensitivity usually improves a few days after each infusion. Talk to your doctor if this symptom becomes severe or does not go away.
This medicine can cause side effects like dizziness, vision changes, or extreme tiredness, which may affect your ability to drive safely. It is highly recommended to arrange for someone else to drive you home after your appointment. Talk to your doctor or nurse if you have concerns about getting home safely.
Hair thinning or hair loss can occur with this treatment, although it is usually mild compared to other chemotherapy drugs. In most cases, your hair will grow back after the treatment is completed. Talk to your doctor or nurse for tips on managing hair changes.
You should avoid getting "live" vaccines during your treatment, as your immune system will be weakened and you could develop an infection from the vaccine. Always consult your healthcare provider before scheduling any vaccinations. Talk to your doctor to determine which vaccines are safe for you.
A fever can be a sign of a serious infection, which requires immediate medical attention because this medicine lowers your white blood cell count. Contact your healthcare team or go to the nearest emergency room immediately if your temperature rises to 100.4°F (38°C) or higher. Talk to your doctor for guidance on monitoring infections.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.11052 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 021759S023Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. MedlinePlus. A607035 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  4. Oxaliplatin Oxaliplatin. 2011. [Accessed on 22 Jan. 2019]Check here
  5. Oxaliplatin Oxaliplatin. 2002. [Accessed on 26 Mar. 2019]Check here
  6. Oxaliplatin 5mg/ml concentrate for Solution for Infusion - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 02 June 2025]Check here
  7. Oxaliplatin 5mg/ml concentrate for Solution for Infusion - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 02 June 2025]Check here

Country of origin

India

Manufacturer/Marketer address

709, 7Th Floor, Palm Spring Center, Link Road, Malad West, Mumbai- 400064
Other Info - OXA0169
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