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Pagenax 120 mg/ml Injection 1's is used to treat eye conditions like wet age-related macular degeneration (AMD) and diabetic macular edema (DME). It helps by inhibiting VEGF, a protein that contributes to abnormal blood vessel growth in the eye. This reduces fluid leakage and helps improve vision. Pagenax 120 mg/ml Injection 1's may cause certain side effects like eye discomfort, pain, and increased intraocular pressure. Inform your doctor if you have a history of eye conditions or if you're pregnant or breastfeeding.

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Reviewed By Lakshmithulasi Yarragunta ,
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More about the Product

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Pagenax 120 mg/ml Injection 1's

Pagenax 120 mg/ml Injection 1's is used to treat eye conditions that may affect your vision, such as neovascular (wet) age-related macular degeneration (AMD) and diabetic macular edema (DME). AMD is a condition that leads to vision loss due to the formation of abnormal blood vessels in the retina. DME is a complication of diabetes that causes swelling in the macula, the part of the retina responsible for sharp, central vision.

Pagenax 120 mg/ml Injection 1's contains brolucizumab, which is a monoclonal antibody. It blocks VEGF (vascular endothelial growth factor), a protein involved in the formation of abnormal blood vessels in the retina. This helps reduce fluid leakage, prevent further vision loss, and improve vision in patients with these eye conditions. 

A healthcare professional will administer Pagenax 120 mg/ml Injection 1's. This medicine may sometimes cause side effects, such as eye discomfort, redness, or increased intraocular pressure. Most of these side effects do not require medical treatment and will subside with time. However, if they persist or worsen, see a doctor.

Pagenax 120 mg/ml Injection 1's should not be received if you are allergic to it. Let your doctor know if you have ever had any eye diseases such as glaucoma, dark floating spots, retinal vascular occlusion, retinal vasculitis, or any previous eye treatments before receiving Pagenax 120 mg/ml Injection 1's. If you are pregnant or breastfeeding, please consult a doctor before taking Injection. Pagenax 120 mg/ml Injection 1's is not recommended for children, as its safety and efficacy have not been established.

Uses of Pagenax 120 mg/ml Injection 1's

Pagenax 120 mg/ml Injection 1's is used to treat wet age-related macular degeneration (AMD) and diabetic macular edema (DME). The detailed uses of Pagenax 120 mg/ml Injection 1's are as follows:

  • Wet Age-Related Macular Degeneration (AMD) Treatment: Pagenax 120 mg/ml Injection 1's treats wet AMD by blocking VEGF-A, reducing abnormal blood vessel growth and leakage, slowing disease progression, and preserving vision.
  • Diabetic Macular Edema (DME) Treatment: Pagenax 120 mg/ml Injection 1's treats diabetic macular edema (DME) by blocking VEGF-A, reducing fluid leakage and swelling in the retina, and improving vision.

Key Benefits

Pagenax 120 mg/ml Injection 1's provides significant benefits for patients with wet AMD and DME because it reduces abnormal blood vessel formation and fluid leakage. This helps to prevent vision loss and improve vision. The drug is supplied directly into the eye via pre-filled injection, usually on a predetermined schedule that changes based on the patient's response. Pagenax 120 mg/ml Injection 1's blocks VEGF (vascular endothelial growth factor), a protein involved in the formation of abnormal blood vessels in the retina. This helps reduce fluid leakage, prevent further vision loss, and improve vision in patients with these eye conditions.

Side effects of Pagenax 120 mg/ml Injection
  • Talk to the doctor if you notice any visual disturbances.
  • Do not drive or operate machinery unless you have a clear vision.
  • Lubricate the eyes and use a warm compress to gently massage the eyes.
  • Keep your eyes protected from harmful sun rays by wearing sunglasses and a hat.
  • Rest well and eat a balanced diet.
  • Use a humidifier and increase fluid intake.
  • Eating foods high in vitamins C (like oranges, peppers, and tomatoes) and E (like peanuts, spinach, and broccoli) may help protect your eyes from cataracts or slow them down.
  • Quit smoking and cut back on alcohol.
  • Wear sunglasses when you are outside to protect your eyes from the sun.
  • Keep your blood sugar under control, because high blood sugar can cause changes in the eye lens that lead to cataracts.
  • Have regular eye checkups to catch any problems early.
  • Maintain a balanced diet with leafy greens, carrots, and citrus fruits.
  • Ensure you drink enough water throughout the day to stay hydrated.
  • Protect your eyes by wearing sunglasses and protective eyewear when necessary.
  • Rest your eyes by blinking often and taking regular breaks from screens to reduce strain.
  • Quit smoking to minimize eye damage and improve overall eye health significantly.
  • Consult an eye doctor if you notice a sudden increase or worsening of floaters.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Pagenax 120 mg/ml Injection 1's should be administered by a nurse or doctor to ensure proper dosage, technique, and monitoring for any potential side effects or complications.
  • Do not self-administer.

How Pagenax 120 mg/ml Injection 1's Works

Vascular endothelial growth factor (VEGF) is a protein that helps new blood vessels grow. Sometimes, abnormal blood vessels start growing under the retina in certain eye conditions. These abnormal vessels can leak fluid and bleed, causing damage to the macula, the central part of the retina responsible for sharp vision. This can lead to severe vision loss and blurry vision in the centre of your sight. Pagenax 120 mg/ml Injection 1's works by blocking the VEGF protein. Doing this helps reduce the growth and leakage of these abnormal blood vessels in the retina, protecting your vision.
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Alcohol

Consult your doctor

It is unknown if alcohol interacts with Pagenax 120 mg/ml Injection 1's. Please consult a doctor if you have any concerns.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform the doctor before receiving Pagenax 120 mg/ml Injection 1's. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Limited data exist on the use of Pagenax 120 mg/ml Injection 1's during breastfeeding. Consult your healthcare provider to assess the risks and benefits.

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Driving

Unsafe

Pagenax 120 mg/ml Injection 1's may affect vision temporarily. Avoid driving or operating heavy machinery if you experience visual disturbances after the injection.

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Liver

Caution

Dose adjustment may be needed in case of moderate to severe liver impairment patients. Hence, inform your doctor if you have kidney disease before receiving Pagenax 120 mg/ml Injection 1's. Your doctor will prescribe Pagenax 120 mg/ml Injection 1's only if the benefits overweigh risks.

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Kidney

Caution

Dose adjustment may be needed in case of moderate to severe kidney impairment patients. Hence, inform your doctor if you have kidney disease before receiving Pagenax 120 mg/ml Injection 1's. Your doctor will prescribe Pagenax 120 mg/ml Injection 1's only if the benefits overweigh risks.

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Children

Unsafe

Pagenax 120 mg/ml Injection 1's is not recommended for children below 18 years, as its safety and efficacy have not been established.

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Heart

Consult your doctor

Inform your doctor if you have heart problems before using Pagenax 120 mg/ml Injection 1's.

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Geriatrics

Consult your doctor

Pagenax 120 mg/ml Injection 1's can be given to geriatrics. If you have any concerns regarding the use of Pagenax 120 mg/ml Injection 1's, please consult a doctor.

What if I have taken an overdose of Pagenax 120 mg/ml Injection 1's

Pagenax 120 mg/ml Injection 1's is administered in a hospital setting by a healthcare professional, and the likelihood of an overdose is much less. However, if you suspect an overdose or experience any adverse effects, seek medical attention immediately.

Diet & Lifestyle Advise

  • Consume a balanced diet high in leafy greens, seafood, nuts, and citrus fruits.
  • Stay hydrated for better general and eye health.
  • Control your blood sugar and blood pressure to avoid worsening eye issues.
  • To decrease retinal damage, avoid smoking and consuming alcohol.
  • Regular exercise improves circulation and overall well-being.
  • Wear UV-blocking sunglasses to protect your eyes.
  • Schedule regular eye exams to monitor your condition.

Have a query?

How Soon It Starts Working

The time required for Pagenax 120 mg/ml Injection 1's to start to work: The onset time for Pagenax 120 mg/ml Injection 1's is clinically unknown. The time for which the effects of Pagenax 120 mg/ml Injection 1's last: The duration of Pagenax 120 mg/ml Injection 1's effect is clinically unknown.

What if you forget to take Pagenax 120 mg/ml Injection 1's

As this medication is administered in a hospital by your healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight. • Keep Pagenax 120 mg/ml Injection 1's out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.

Drug Warnings

Let the doctor know if you are allergic to the Pagenax 120 mg/ml Injection 1's. Before starting treatment with Pagenax 120 mg/ml Injection 1's, inform your doctor about any other medications or herbal products you are taking. If you are pregnant or nursing, speak with your doctor. Pagenax 120 mg/ml Injection 1's is not recommended for use in conditions like ocular/periocular infections and active intraocular infections. Tell your doctor if you have a history of eye disorders such as glaucoma, dark floating spots, retinal vascular occlusion, retinal vasculitis, or any past eye treatments. Pagenax 120 mg/ml Injection 1's is not recommended for children under 18 years old.

Drug-Drug Interactions

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Drug-Drug Interactions: No significant medication interactions are currently recognized. However, inform your doctor about your previous medical history, including herbal and vitamin supplements.
Drug-Food Interactions: No known significant interactions.
Drug-Disease Interactions: Inform your doctor if you have ever had any eye diseases such as glaucoma, dark floating spots, retinal vascular occlusion, or retinal vasculitis before receiving medication.

No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[OPHTHALMOLOGIC AGENTS]

FAQs

Pagenax 120 mg/ml Injection 1's is used to treat wet age-related macular degeneration (AMD) and diabetic macular edema (DME).

Pagenax 120 mg/ml Injection 1's works by targeting and blocking VEGF (vascular endothelial growth factor). VEGF promotes the growth of abnormal blood vessels in the eye, which can lead to fluid leakage and vision impairment. By inhibiting VEGF, Pagenax 120 mg/ml Injection 1's reduces fluid buildup and maintains retinal health.

Common side effects include eye discomfort, redness, and increased intraocular pressure. If the symptoms persist or worsen, seek medical attention.

Pregnant or breastfeeding women should consult their healthcare provider before using Pagenax 120 mg/ml Injection 1's, as its safety during pregnancy and breastfeeding is not fully established.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - PAG0011
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