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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Palbinas 100 Capsule is an anti-cancer medicine used in the treatment of certain types of breast cancer. This medicine contains palbociclid which works by blocking proteins necessary for cell growth, thereby causing cell death and arresting the uncontrolled production of new cells. Common side effects include weakness, loss of appetite, infections and dry skin.
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Whats That

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Composition :

PALBOCICLIB-100MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Palbinas 100 Capsule

Palbinas 100 Capsule belongs to the group of anti-cancer drugs used to treat certain types of breast cancer. Cancer is the uninhibited and uncontrolled growth of cells in the body. Breast cancer is cancer that forms in the cells of the breast. It can form in the lobules, ducts or tubules of the breast or in the breast tissue itself.

Palbinas 100 Capsule contains Palbociclib that works by blocking proteins necessary for cell growth, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Palbinas 100 Capsule is effective in controlling cancer cells from multiplying and is used in the treatment of breast cancer. 

Take Palbinas 100 Capsule as prescribed. In some cases, Palbinas 100 Capsule may cause certain common side effects such as weakness, loss of appetite, infections and dry skin. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist or worsen. 

It is advisable to inform the doctor if you are allergic to any of its components. Do not take Palbinas 100 Capsule if you are pregnant or breastfeeding. Palbinas 100 Capsule may cause tiredness, so drive only if you are alert. Palbinas 100 Capsule is not recommended for use in children below 18years. Keep your doctor informed about your health condition and medications to rule out any interactions.

Uses of Palbinas 100 Capsule

Treatment of Breast Cancer

Directions for Use

Take Palbinas 100 Capsule preferably with a meal. Swallow it as a whole with water. Do not crush, chew or break it.

Medicinal Benefits

Palbinas 100 Capsule is an anti-cancer drug used in the treatment of a particular type of breast cancer that is hormone receptor-positive and human epidermal growth factor receptor-2-negative. Palbinas 100 Capsule works by blocking the production of proteins called cyclin-dependent kinase 4 and 6 that are responsible for cell growth and division. By blocking them, Palbinas 100 Capsule nips cell growth in the bud and prevents cancer cells from spreading further. Thus, Palbinas 100 Capsule helps treat breast cancer.

How Palbinas 100 Capsule Works

Palbinas 100 Capsule contains Palbociclib that works by blocking proteins necessary for cell growth, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Palbinas 100 Capsule is effective in controlling cancer cells from multiplying and is used in the treatment of breast cancer.

Storage

Store in a cool and dry place away from sunlight
Side effects of Palbinas 100 Capsule
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • Prefer liquid food like juices and soups when you are not likely to eat.
  • Avoid spicy, fatty and fried foods as they cause stomach upset.
  • Eat small and frequent meals, avoiding large meals at a time.
  • Add healthy foods in your diet like fruits and vegetables.
  • Take starchy food like cereals, bread and potatoes etc.

What if I have taken an overdose of Palbinas 100 Capsule

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include nausea, vomiting, and neutropenia (low neutrophil levels). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take St. John's wort or grapefruit/grapefruit juice with Palbinas 100 Capsule . It is advisable to inform the doctor if you are allergic to any of its components. Do not take Palbinas 100 Capsule if you are pregnant or breastfeeding. Palbinas 100 Capsule may cause tiredness, so drive only if you are alert. Palbinas 100 Capsule is not recommended for use in children below 18years. If you experience any signs or symptoms of infections, inform your doctor. Keep your doctor informed about your health condition and medications to rule out any interactions. Consult your doctor immediately if you experience symptoms such as dry cough, chest pain, difficulty breathing or shortness of breath as it could be an indication of lung inflammation

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Palbinas 100 Capsule:
Coadministration of Ketoconazole and Palbinas 100 Capsule may increase the blood level of Palbinas 100 Capsule.

How to manage the interaction:
Although taking Ketoconazole and Palbinas 100 Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience nausea, vomiting, diarrhea, loss of appetite, mouth sores, hair loss, weakness, pain, numbness, or tingling in the hands and feet, more severely, consult a doctor. Without consulting a doctor, never stop taking any drugs.
How does the drug interact with Palbinas 100 Capsule:
Co-administration of Palbinas 100 Capsule with Morphine may increase the blood levels and side effects of morphine.

How to manage the interaction:
Taking Morphine with Palbinas 100 Capsule can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.
How does the drug interact with Palbinas 100 Capsule:
When Palbinas 100 Capsule is taken with Posaconazole can increase the blood levels of Palbinas 100 Capsule.

How to manage the interaction:
Although there is an interaction between posaconazole and Palbinas 100 Capsule, it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, diarrhea, less desire to eat, mouth sores, hair loss, weakness, pain, numbness, or tingling in the hands and feet contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Palbinas 100 Capsule:
Taking Cladribine with Palbinas 100 Capsule can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Palbinas 100 Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water as dehydration is often seen in cancers.
  • Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY
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Alcohol

Caution

It is not recommended to use alcohol with Palbinas 100 Capsule . Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Palbinas 100 Capsule is not recommended for use in pregnancy. Please consult your doctor if you have any concerns.

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Breast Feeding

Unsafe

Palbinas 100 Capsule is not recommended during breastfeeding. Please consult your doctor in case of any concerns.

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Driving

Caution

Palbinas 100 Capsule may cause tiredness and lethargy, which may affect your ability to drive. Do not drive if you experience any side effects after using Palbinas 100 Capsule .

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Liver

Caution

Exercise caution before using Palbinas 100 Capsule in case of established liver disease. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Palbinas 100 Capsule in case of established kidney disease. Please consult your doctor to address any concerns.

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Children

Unsafe

Palbinas 100 Capsule is not recommended for use in children under 18 years of age. Please consult your doctor in case of any concerns.

Have a query?

FAQs

Palbinas 100 Capsule belongs to the group of anti-cancer drugs used to treat certain types of breast cancer.

Palbinas 100 Capsule works blocking proteins responsible for cell growth and division, thereby arresting the progression of cancer cells.

Do not stop taking Palbinas 100 Capsule on your own. You are advised to take Palbinas 100 Capsule for as long as your doctor has prescribed it for you depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Palbinas 100 Capsule .

A fibroadenoma is a benign state. Palbinas 100 Capsule is indicated only in case of cancers. Please consult your doctor in case of any concerns.

Palbinas 100 Capsule can reduce fertility in men. Therefore, consider sperm preservation before starting Palbinas 100 Capsule if you wish to father a child in the future. Effects on female fertility have not been established. Please consult your doctor before using Palbinas 100 Capsule .

Palbinas 100 Capsule may reduce white blood cell count, thereby weakening the immune system. This might increase your risk of infections. If you notice any signs or symptoms of infections, consult your doctor.

Palbinas 100 Capsule is a type of targeted cancer drug. It is a treatment for breast cancer that is oestrogen receptor-positive (ER+) and human epidermal growth factor receptor-negative (HER2 -).

The duration of taking Palbinas 100 Capsule varies from person to person. You take it in cycles (21 days on, 7 days off.), and as long as it's working and manageable, you continue the treatment. Your healthcare team will monitor your progress and adjust the treatment plan as needed.

Most side effects associated with Palbinas 100 Capsule are temporary and can be effectively managed. However, certain side effects may persist or have a lasting impact in some cases. Common reversible side effects include fatigue, nausea, and hair loss, which typically resolve once treatment is stopped. In rare instances, more serious and potentially irreversible side effects may occur, such as permanent hair loss, increased infection risk, or heart problems. Regular monitoring and open communication with your healthcare team are essential to mitigate these risks and address any concerns that may arise during treatment.

Yes, Palbinas 100 Capsule treatment requires blood count monitoring. If neutropenia is mild in the first six cycles, monitor blood counts every 3 months afterwards. This monitoring schedule helps healthcare providers track potential changes in blood counts and adjust treatment accordingly.

Take Palbinas 100 Capsule exactly as your healthcare provider tells you. Swallow the capsule whole with water on an empty stomach at the same time each day. Follow the treatment schedule.

While using Palbinas 100 Capsule , birth control is necessary to prevent pregnancy. Female patients must take a pregnancy test before starting treatment and use birth control during treatment and for at least 3 weeks after the final dose. Male patients, along with their partners, should also use birth control during treatment and for 3 months after the final dose. It's crucial to inform your doctor if you're pregnant, plan to become pregnant, or plan to father a child so they can guide you on the appropriate measures to take.

While women's fertility may not be affected, Palbinas 100 Capsule can decrease fertility in men. Men taking palbociclib may want to talk to their treatment team about sperm preservation before starting treatment.

In some cases, side effects can be serious. If you experience any of the following symptoms, call your doctor immediately or seek emergency medical treatment: fever, chills, or signs of infection; difficulty breathing or shortness of breath; cough with or without mucus; chest pain; dizziness; fast, irregular, or pounding heartbeat; weakness; unusual bleeding or bruising; nosebleeds; or redness, pain, swelling, or blisters on the palms of your hands or soles of your feet, as well as skin blistering, peeling, or redness.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai €“ 400 026.
Other Info - PAL0251

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