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  3. Pazotab 400 mg Tablet 30's

Pazotab 400 mg Tablet 30's, Pack of 1 Tablet
Pazotab 400 mg Tablet 30's, Pack of 1 Tablet
Pazotab 400 mg Tablet 30's, Pack of 1 Tablet
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Pazotab 400 mg Tablet is an anti-cancer drug used in the treatment of kidney and soft tissue cancer. It contains Pazopanib, which works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. Thus, it stops the spread of cancerous cells. It may cause common side effects such as itching or skin rash, acne, dry skin, vomiting, diarrhea and loss of appetite.
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Composition :

PAZOPANIB-400MG

Manufacturer/Marketer :

Adley Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Pazotab 400 mg Tablet

Pazotab 400 mg Tablet belongs to the group of medicine called ‘anti-cancer’ that is primarily indicated in the treatment of kidney and soft tissue cancer.  Kidney cancer also known as renal cancer is a disease in which healthy cells of the kidney become malignant (cancerous), grow in an uncontrolled manner and forms a tumor. When a group of cancer occurs in different parts of the body such as bones, muscles, deep layers of skin, and fat then it is known as soft tissue sarcomas. This type of cancer may also form in nerves, blood vessels or connective tissues that support organs of the body.

Pazotab 400 mg Tablet contains 'Pazopanib' which falls in the category of medicines known as 'kinase inhibitors'. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Take Pazotab 400 mg Tablet as prescribed by your doctor. You are suggested to take Pazotab 400 mg Tablet as long as your doctor has prescribed it after checking your medical condition.  In some cases, you may experience certain common side effects such as itching or skin rash, acne, dry skin, vomiting, diarrhea and loss of appetite. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Pazotab 400 mg Tablet for as long as your doctor has prescribed. Do not take Pazotab 400 mg Tablet if you are pregnant or planning for pregnancy as Pazotab 400 mg Tablet causes serious birth defects. Pazotab 400 mg Tablet should not be taken by breastfeeding mothers as it passes into breast milk and may cause possible risk to the infant. Elderly people are more sensitive to medicine so the doctor may adjust the dosage according to the condition. Avoid consuming alcohol along with Pazotab 400 mg Tablet as it could lead to increased dizziness.

Uses of Pazotab 400 mg Tablet

Treatment of Kidney cancer, Soft tissue cancer

Directions for Use

• Pazotab 400 mg Tablet should be taken without food, preferably on an empty stomach, at least 1–2 hours before a meal. • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.• Swallow it as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

Pazotab 400 mg Tablet is a ' tyrosine kinase inhibitor (TKI)', that stops the uncontrolled growth and spread of cancerous cells. Pazotab 400 mg Tablet is effective in treating thyroid, liver and kidney cancer. It acts by stopping the action of the abnormal protein that is responsible for the multiplication of cancerous cells. Whenever a new healthy cell is formed it undergoes a usual process of maturity. Cancerous cells form new cells more quickly so Pazotab 400 mg Tablet targets cancerous cells and blocks the action of Tyrosine kinases enzymes (responsible for causing cancer). It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Pazotab 400 mg Tablet stops the production, spread and growth of cancerous cells in the body.

How Pazotab 400 mg Tablet Works

Pazotab 400 mg Tablet contains 'Pazopanib' which falls in the category of medicines known as 'kinase inhibitors'. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Storage

Keep Pazotab 400 mg Tablet out of reach and sight of children.
Side effects of Pazotab 400 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Consult your doctor for dose adjustment or alternative medicine if you notice hair color changes.
  • To avoid further scalp irritation, use a mild shampoo and conditioner.
  • Avoid harsh styling techniques such as tight hairstyles and excessive heat styling.
  • Discuss your concerns with a professional hairstylist who can recommend color techniques to manage the look of hair color changes.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of Pazotab 400 mg Tablet

Do not take more than the prescribed dose of Pazotab 400 mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Pazotab 400 mg Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising. Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Inform your doctor about your health condition and medicines to rule out any unpleasant side-effects. Before your doctor prescribes you Pazotab 400 mg Tablet , tell them if you have heart problems, high blood pressure, bleeding issues, surgery or an electrolyte imbalance (like abnormal levels of magnesium, calcium  or potassium in the blood). Pazotab 400 mg Tablet is restricted to use in persons who are sensitive to any of its constituents or have squamous cell lung cancer or already taking carboplatin and paclitaxel.

Drug-Drug Interactions

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PazopanibCisapride
Critical
PazopanibSparfloxacin
Critical

Drug-Drug Interactions

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PazopanibCisapride
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Using cisapride together with Pazotab 400 mg Tablet can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Cisapride is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibSparfloxacin
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Using Pazotab 400 mg Tablet together with sparfloxacin can increase the risk of abnormal heart rhythm

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Sparfloxacin is not recommended, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PazopanibThioridazine
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Taking Pazotab 400 mg Tablet with Thioridazine can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibPimozide
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Taking Pimozide with Pazotab 400 mg Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Pimozide is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibAluminium hydroxide
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Co-administration of Pazotab 400 mg Tablet with aluminium hydroxide can reduce the blood levels and effects of Pazotab 400 mg Tablet.

How to manage the interaction:
Although there is an interaction between Pazotab 400 mg Tablet and Aluminium hydroxide, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
PazopanibHalofantrine
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Using Pazotab 400 mg Tablet together with halofantrine can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Halofantrine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibZiprasidone
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Taking Pazotab 400 mg Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Pazotab 400 mg Tablet and Ziprasidone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibYellow fever vaccine
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Coadministration of Yellow fever vaccine with Pazotab 400 mg Tablet can increase the risk of infection.

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Yellow fever vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
PazopanibChloroquine
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Taking Pazotab 400 mg Tablet with chloroquine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Chloroquine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibBCG vaccine
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Taking BCG vaccine with Pazotab 400 mg Tablet can increase the risk of infection.

How to manage the interaction:
Taking Pazotab 400 mg Tablet with BCG vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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PAZOPANIB-400MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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PAZOPANIB-400MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Coadministration of Pazotab 400 mg Tablet with grapefruit juice can increase the blood levels of Pazotab 400 mg Tablet, which may lead to an increased risk of serious side effects such as liver problems, irregular heart rhythm, bleeding, and high blood pressure. Avoid taking grapefruit juice along with Pazotab 400 mg Tablet, as it can lead to an interaction.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles reduce fatigue, helps in weight loss and give strength. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga and other relaxation techniques may also help in improving physical and mental health and may reduce your stress levels.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting helps in improving your health, mental ability, and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listen to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing fiber help in better digestion. These include beans, peas, lentils, whole grains,  nuts, and seeds.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Pazotab 400 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption with Pazotab 400 mg Tablet as it may increase the risk of side effects such as dizziness, drowsiness or difficulty in concentrating.

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Pregnancy

Unsafe

Pazotab 400 mg Tablet is restricted to use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or for at least 6 months after taking the last dose of Pazotab 400 mg Tablet .

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Breast Feeding

Unsafe

Pazotab 400 mg Tablet should not be taken by breastfeeding mothers as it passes into breast milk and may cause possible risk to the infant.

bannner image

Driving

Caution

It is not known if Pazotab 400 mg Tablet may affect your driving ability or not.

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Liver

Safe if prescribed

Pazotab 400 mg Tablet should be taken with caution in patients dealing with the liver disease. The dose may be adjusted by the doctor according to the medical condition of the patient.

bannner image

Kidney

Safe if prescribed

Pazotab 400 mg Tablet is safe to take by patients dealing with kidney cancer as prescribed by their doctor. The dose may be adjusted by the doctor according to the medical condition of the patient.

bannner image

Children

Unsafe

Pazotab 400 mg Tablet is not recommended for children below 18 years as the safety and effectiveness were not established.

Have a query?

FAQs

Pazotab 400 mg Tablet is used in the treatment of kidney and soft tissue cancer.

Pazotab 400 mg Tablet is safe to be taken by a diabetic person. However, take Pazotab 400 mg Tablet only after asking with a doctor as they may adjust the dosing according to the condition of the patient.

Pazotab 400 mg Tablet is restricted to use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or for at least 6 months after taking the last dose of Pazotab 400 mg Tablet .

Pazotab 400 mg Tablet should be stopped in cases where a person faces serious side effect that affects the quality of life. Otherwise, you need to keep taking Pazotab 400 mg Tablet until your doctor asks you to stop it.

Before your doctor prescribes you Pazotab 400 mg Tablet , tell them if you have heart problems, high blood pressure, bleeding issues, surgery or an electrolyte imbalance (like abnormal levels of magnesium, calcium, or potassium in the blood).

Pazotab 400 mg Tablet is restricted to use in persons who are sensitive to any of its constituents or have squamous cell lung cancer or already taking carboplatin and paclitaxel.

Pazotab 400 mg Tablet is not a chemotherapy medicine. It belongs to an anti-cancer group of medicines called protein kinase inhibitors. Pazotab 400 mg Tablet works by preventing the activity of proteins that are involved in the growth and spread of cancer cells.

Take Pazotab 400 mg Tablet by orally as prescribed by your physician. Consume it whole with water. Breaking or crushing it will interfere with Pazotab 400 mg Tablet 's absorption and raise the chance of adverse effects.

No, Pazotab 400 mg Tablet should not be taken with food as it increases the amount of Pazotab 400 mg Tablet absorbed into the body and may increase the risk of side effects. It is best to take it on an empty stomach, either 1 hour before or 2 hours after a meal. However, always take Pazotab 400 mg Tablet as advised by your doctor.

It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Regular check-ups and imaging tests will help your doctor assess the effectiveness of the treatment. However, it is important to monitor for side effects like diarrhoea, high blood pressure, and fatigue, and consult your doctor if you have any concerns.

Yes, there are some food restrictions while taking Pazotab 400 mg Tablet . You are recommended to avoid grapefruit and grapefruit juice, as it may increase the risk of side effects. If you have any concerns about foods to avoid while taking Pazotab 400 mg Tablet , please discuss with your doctor.

The duration for taking Pazotab 400 mg Tablet can vary depending on your specific condition, the severity of your disease, and how well you respond to the treatment. It is important to follow your doctor's instructions regarding the duration of treatment. Do not stop unless your doctor advises you to.

Some important things you should know about Pazotab 400 mg Tablet are side effects it may cause such as serious or life-threatening liver damage. If you experience any of the following symptoms like yellowing of the skin or eyes, dark urine , extreme tiredness , nausea, vomiting , loss of appetite, pain in the upper right part of the stomach, unusual bleeding or bruising, inform your doctor. Pazotab 400 mg Tablet should be used with caution in patients with liver disease.

Country of origin

India

Manufacturer/Marketer address

2/236, KAMBRATH THAZAM, PULLALUR, KURUVATTOOR PO, NA KOZHIKODE Kozhikode Kerala 673012
Other Info - PAZ0063

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:46 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022465s-010S-012lbl.pdf
  2. https://www.cancer.org/cancer/soft-tissue-sarcoma/about/soft-tissue-sarcoma.html

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