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compositionComposition:PEFLOXACIN-400MG
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Prescription Medicine
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Pefran 400mg Tablet is used to treat bacterial infections. It contains Pefloxacin, which kills infection-causing bacteria. In some cases, this medicine may cause side effects such as nausea, headache, diarrhoea, vomiting, itching, and dizziness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PEFLOXACIN-400MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Pefran 400mg Tablet

Pefran 400mg Tablet is a prescription oral antibiotic used to treat a wide range of bacterial infections. It is clinically prescribed to resolve serious conditions such as urinary tract infections, respiratory tract infections, and infections of the bones and joints. By targeting and eliminating the bacteria responsible for these illnesses, this medicine helps restore your health and prevent the infection from spreading.

To ensure the medication works effectively, you must take Pefran 400mg Tablet at regular, evenly spaced intervals exactly as prescribed by your doctor. The tablets should be swallowed whole with a full glass of water, and they can be taken with or without food. Drinking plenty of fluids and getting adequate rest during your recovery will further support the healing process.

While taking Pefran 400mg Tablet, some people may experience mild side effects, such as a temporary upset stomach, nausea, or a mild headache. However, you should contact your doctor or pharmacist immediately if you experience severe symptoms like sudden joint pain, nerve tingling, or an unexpected skin rash.

Before starting this medicine, talk to your doctor if you have a history of kidney disease, epilepsy, or nerve problems. Do not take this if you have previously had tendon damage caused by similar antibiotics, or if you are allergic to this class of medication.

This medicine can interact with certain other substances, such as mineral supplements, blood thinners, and caffeine, which can reduce its effectiveness or increase side effects. It is also recommended to avoid alcohol and smoking during treatment to help your body recover more efficiently. Pregnant women, breastfeeding mothers, and elderly individuals should always consult their doctor to ensure this medication is safe for their specific needs.

Uses of Pefran 400mg Tablet

Pefran 400mg Tablet is used in the treatment of bacterial infections. The detailed uses of Pefran 400mg Tablet are as follows:

  • Urinary tract infections (UTIs): Pefran 400mg Tablet helps by clearing bacterial infections in the bladder and kidneys, helping to relieve painful urination.
  • Respiratory tract infections: It targets bacteria in the lungs and airways, helping to resolve infections like bronchitis.
  • Bone and joint infections: The medicine penetrates deep into tissues to eliminate persistent bacterial infections in the bones.
  • Abdominal infections: It treats bacterial infections within the abdominal cavity, preventing further complications.

Key Benefits

Pefran 400mg Tablet offers highly effective relief from the painful and disruptive symptoms of bacterial infections. By targeting the root cause of your illness, it helps your body recover quickly, allowing you to regain your energy and return to your daily activities. The benefits of this medication include:

  • Quickly reduces the bacterial load in your body, which helps ease fever, pain, and localised inflammation.
  • Stops bacteria from growing and multiplying, helping prevent the infection from spreading to other organs or becoming more severe.
  • The oral tablet form allows you to treat serious bacterial infections effectively at home, reducing the need for injectable therapy.

Directions for Use

  • Pefran 400mg Tablet should be taken with food. However, avoid taking it with dairy products, as they may reduce its effectiveness.
  • It is usually taken 1-2 times a day or as advised by your doctor.
  • Swallow Pefran 400mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Pefran 400mg Tablet Works

Pefran 400mg Tablet belongs to a class of antibiotics known as fluoroquinolones. It works by targeting and blocking specific enzymes inside the bacteria that are essential for their survival, namely DNA gyrase and topoisomerase IV. These enzymes are responsible for copying, repairing, and replicating the bacterial DNA. When these enzymes are blocked, the bacteria can no longer duplicate their genetic material or repair themselves. As a result, the bacteria stop multiplying and quickly die off. This reduction in bacteria allows your body's natural immune system to easily clear the remaining infection and fully restore your health.
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Alcohol

Unsafe

Alcohol may cause unpleasant, serious side effects if consumed while on treatment with Pefran 400mg Tablet. So, consumption of alcohol should be avoided while using Pefran 400mg Tablet.

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Pregnancy

Caution

Avoid taking Pefran 400mg Tablet if you are pregnant unless prescribed by a doctor. Please consult your doctor before taking this medicine. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Pefran 400mg Tablet is not recommended for using in breastfeeding unless prescribed by a doctor. If you are breastfeeding, consult your doctor before taking this medicine. Your doctor will prescribe only if the benefits outweigh the risks.

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Driving

Unsafe

Pefran 400mg Tablet may cause dizziness. So, it is not recommended to drive or operate heavy machinery when you take Pefran 400mg Tablet.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor before taking Pefran 400mg Tablet if you have liver disease.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney problems before taking Pefran 400mg Tablet.

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Children

Unsafe

Pefran 400mg Tablet should not be given to children below 12 years due to the increased risk of serious side effects.

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Heart

Caution

Pefran 400mg Tablet should be used with extreme caution due to the risk of cardiovascular problems. Please inform your physician if you have any concerns.

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Geriatrics

Caution

Pefran 400mg Tablet can be given in elderly patients with extreme caution, due to the cause of adverse effects.

What if I have taken an overdose of Pefran 400mg Tablet

If you take more than your prescribed dose, seek immediate medical attention or contact a poison control centre right away. Overdose symptoms may include severe dizziness, hand tremors, confusion, or seizures.

Diet & Lifestyle Advise

  • Avoid dairy and calcium-rich foods close to your dose: Do not consume milk, cheese, yoghurt, or calcium-fortified juices at the same time as Pefran 400mg Tablet. Calcium can bind to the medicine in your stomach and significantly decrease its absorption. Take your dose at least 2 hours before or 4 to 6 hours after eating these foods.
  • Stay well hydrated: Drink plenty of water throughout the day while taking this medicine. Proper hydration helps flush the medicine through your kidneys and prevents crystals from forming in your urine.
  • Protect your skin from the sun: This medicine makes your skin highly sensitive to sunlight and UV rays. Wear protective clothing, use a high-SPF sunscreen, and avoid direct sun exposure or tanning beds during your treatment.
  • Limit your caffeine intake: This antibiotic can slow down the rate at which your body processes caffeine. To avoid feeling jittery, anxious, or experiencing a rapid heartbeat, limit your intake of coffee, tea, and energy drinks.
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Have a query?

How Soon It Starts Working

The time required for Pefran 400mg Tablet to start to work: The time required for Pefran 400mg Tablet to show its action is unknown. The time for which the effects of Pefran 400mg Tablet last: The duration of action for Pefran 400mg Tablet is clinically unknown.

What if you forget to take Pefran 400mg Tablet

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and continue with your normal routine. Do not take a double dose to make up for a missed one.

Storage

• Store Pefran 400mg Tablet tablets at controlled room temperature, safely between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Monitor for tendon pain: Stop taking the medicine and seek immediate medical help at the very first sign of tendon pain, swelling, or stiffness.
  • Do not drive if dizzy: Avoid driving, riding a bicycle, or operating heavy machinery if you feel dizzy, lightheaded, or less alert after taking this medicine.
  • Complete the entire prescription: Finish the full course of treatment exactly as prescribed, even if you feel completely recovered. This prevents the bacteria from becoming resistant to antibiotics.
  • Watch for nerve symptoms: Alert your doctor immediately if you experience any numbness, tingling, or pins and needles sensations in your arms or legs.
  • Fluoroquinolone allergy: Do not take Pefran 400mg Tablet if you have had a serious allergic reaction to this medicine or other fluoroquinolone antibiotics in the past.
  • Children and adolescents: Pefran 400mg Tablet is usually not recommended for children and teenagers with developing bones. Your doctor may prescribe it only if the benefits are greater than the possible risks.

verifiedApollotooltip
  • Antacids and mineral supplements (e.g., Magnesium hydroxide, Aluminium hydroxide, Iron, Zinc): These medicines can bind to Pefran 400mg Tablet in your gut, stopping it from being absorbed. Take these supplements at least 2 hours before or 6 hours after your antibiotic.
  • Blood thinners (e.g., Warfarin): Combining this medicine with blood thinners can increase the risk of bleeding.
  • Nonsteroidal anti-inflammatory drugs (e.g., Ibuprofen, Naproxen): Taking pain relievers alongside this antibiotic may increase the risk of central nervous system stimulation and seizures.
  • Corticosteroids (e.g., Prednisolone): Taking steroid medications while using this antibiotic can significantly increase the risk of tendon injury or rupture.

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verifiedApollotooltip
  • Dairy and calcium-fortified foods: Eating dairy products or drinking calcium-enriched beverages close to your dose may reduce the absorption of Pefran 400mg Tablet. Follow your doctor's advice or the product instructions regarding the recommended timing between these products and your medicine.
  • Caffeinated drinks: This medicine can prolong the effects of caffeine, which may cause nervousness, sleep issues, or a fast heartbeat.

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Habit Forming

No

Therapeutic Class

[ANTI- BACTERIALS]

FAQs

No. Avoid taking Pefran 400mg Tablet together with milk, yoghurt, or other dairy products because the calcium can reduce how much of the medicine your body absorbs, making it less effective. Take Pefran 400mg Tablet at least 2 hours before or 4–6 hours after consuming dairy products. If you need help planning your doses, speak with your doctor or pharmacist.
Pain, swelling, or tenderness in a joint or tendon—especially around the Achilles tendon—may be a sign of tendon inflammation or rupture, a rare but serious side effect of Pefran 400mg Tablet. Stop taking the medicine, avoid exercising or putting weight on the affected area, and contact your doctor immediately. Your doctor may recommend an alternative antibiotic if needed.
Diarrhoea can occur while taking antibiotics because they affect both harmful and beneficial bacteria in the gut. However, if you develop severe, persistent, watery, or bloody diarrhoea, contact your doctor immediately, as this may indicate a serious bowel infection. Do not take over-the-counter anti-diarrhoeal medicines unless your doctor advises you to.
This medicine can make your skin highly sensitive to sunlight and UV rays, a condition called photosensitivity. This means you could get a severe sunburn, skin rash, or blisters much faster than usual. When outdoors, wear long sleeves, a hat, and use a high-SPF sunscreen. Talk to your doctor or pharmacist if you develop a severe skin reaction.
You should limit your caffeine intake while taking Pefran 400mg Tablet. This medicine slows down how quickly your body breaks down caffeine, which can make you feel jittery, anxious, or cause your heart to beat unusually fast. If you experience these symptoms, try switching to decaffeinated beverages. Talk to your doctor or pharmacist if you have concerns.
Pefran 400mg Tablet is generally not recommended during pregnancy or while breastfeeding unless your doctor determines that the benefits outweigh the potential risks. Concerns about its effects on developing joints and bones are based mainly on animal studies, and the risk in humans has not been clearly established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss your treatment options with your doctor before taking this medicine.
No, you must finish the entire course of Pefran 400mg Tablet prescribed by your doctor, even if you feel completely better after a few days. Stopping the antibiotic too early can allow the strongest bacteria to survive, which can cause the infection to return and make the bacteria resistant to future treatments. Talk to your doctor or pharmacist if you feel the medication is not agreeing with you.
You should check with your doctor before taking nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen while taking Pefran 400mg Tablet. Taking these medications together can sometimes increase the risk of central nervous system side effects, including seizures. Talk to your doctor or pharmacist for safe pain relief recommendations.

Disclaimer

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Country of origin

India
Other Info - PE58085
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