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Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml belongs to the class of medicine called hematopoietic agents used in the treatment of neutropenia. It helps reduce the chances of infection in cancer patients by stimulating the formation of white blood cells. Common side effects include nausea, headaches, bone pain, pain in the extremity, and injection site reactions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

PEGFILGRASTIM-6MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-29

Return Policy :

Not Returnable

About Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml

Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml is a prescription injection used to lower the risk of infection in patients with non-myeloid cancers who are receiving strong chemotherapy. It helps prevent a severe drop in certain infection-fighting white blood cells, known as neutrophils, which can often occur after chemotherapy treatments. By stimulating your body to produce more of these protective cells, this medicine shields you from potentially dangerous infections.

This medicine is typically given as a single injection during each chemotherapy cycle, usually 24 hours after your chemotherapy session. Staying highly consistent with your scheduled injection dates is critical for maintaining your body's immune defense throughout your cancer treatment. Because this is an injection, food intake does not affect how it works. Making simple lifestyle adjustments, such as staying thoroughly hydrated and practising strict hand hygiene, can significantly support your body during this treatment.

The most common side effect you may experience is temporary bone pain, which indicates that your bone marrow is actively producing new white blood cells. However, you must contact your doctor immediately if you experience severe left upper stomach pain, shoulder pain, or sudden breathing difficulties, as these are signs of serious complications. Always consult your healthcare provider if any side effect becomes severe or bothersome.

Before you begin using this medicine, it is important to talk to your doctor if you have a history of sickle cell disorders, kidney disease, or lung problems. Do not take this if you have had a severe allergic reaction to human granulocyte colony-stimulating factors or acrylic adhesives. Sharing your medical history helps ensure this therapy is safe for your specific condition.

This medicine does not have direct interactions with food, alcohol, or smoking, but consuming alcohol should be avoided as it can dehydrate your body and weaken your recovering immune system. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly patient, you should consult your healthcare provider to discuss the benefits and risks of using this injection.

Uses of Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml

Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml helps increase white blood cell production to reduce the risk of serious infections in people with low neutrophil counts. It may be used for:

  • Febrile neutropenia prevention in chemotherapy patients: Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml helps by stimulating your bone marrow to quickly produce more white blood cells, lowering your risk of developing a severe infection and fever while receiving chemotherapy.
  • Radiation-induced bone marrow suppression: In cases of accidental or high-dose radiation exposure, Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml helps speed up the recovery of damaged white blood cells to protect the body against life-threatening infections.
     

Key Benefits

Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml helps reduce the risk of serious infections, supports uninterrupted cancer treatment, and promotes faster recovery of white blood cells. Key benefits include:

  • Reduces the risk of infection: Increases neutrophil levels, helping lower the risk of serious infections and febrile neutropenia during chemotherapy.
  • Supports uninterrupted chemotherapy: Helps maintain adequate white blood cell counts, reducing the need to delay or reduce chemotherapy doses.
  • May reduce hospitalisation: Lowers the likelihood of severe infections that require emergency hospital care or intravenous antibiotics.
  • Provides long-lasting protection: A single injection offers prolonged support throughout the chemotherapy cycle, reducing the need for frequent injections.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml may be administered by your doctor, or you may be told to inject the medication yourself at home. Your doctor will train you on how to use Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml at home.
  • Check the label for directions and use it as advised by the doctor.
  • Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml should be administered subcutaneously (under the skin) in the thighs, abdomen, buttocks, or upper arm.
  • Rotate the injection site each time.
  • Do not inject into the areas where the skin is tender, red, bruised, hard, scarred, or has stretch marks.

How Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml Works

Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml contains pegfilgrastim, which works by stimulating the bone marrow to produce more neutrophils (a type of white blood cell), helping reduce the risk of serious infections during chemotherapy. Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml is a long-acting form of granulocyte colony-stimulating factor (G-CSF). It binds to receptors in the bone marrow and stimulates the production, maturation, and release of neutrophils into the bloodstream. This helps restore low white blood cell counts caused by chemotherapy or radiation exposure, providing prolonged protection against infection with a single injection per chemotherapy cycle.
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Alcohol

Caution

It is unknown whether consuming alcohol with Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml is safe. However, as a precaution, it is best to avoid or limit alcohol consumption.

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Pregnancy

Caution

Pregnancy Category C. It should be used in pregnant women only if clinically needed, and the benefits outweigh the risks. Please consult your doctor.

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Breast Feeding

Caution

It is unknown whether Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml passes into the breast milk. Please seek medical advice from your doctor if you are breastfeeding before taking Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml.

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Driving

Safe if prescribed

The ability to drive or utilize machines is unaffected by Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml.

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Liver

Caution

Consult your doctor if you have liver problems.

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Kidney

Caution

Caution should be exercised while using Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml in patients with renal dysfunction. Monitoring of patients with renal dysfunction is recommended.

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Children

Caution

Please consult your doctor if you have any concerns regarding the usage of Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml in children.

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Heart

Caution

Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml should be used with caution in patients with heart conditions, as it may increase the risk of side effects. Please inform your doctor if you have any heart problems before receiving Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml.

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Geriatrics

Caution

Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml should be administered with caution in elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.

What if I have taken an overdose of Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml

If you accidentally inject more than the prescribed dose of Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml, seek immediate medical attention. Even if you do not have any symptoms, contact your doctor or go to the nearest emergency department as soon as possible.

Diet & Lifestyle Advise

  • Practice strict hand hygiene: Wash your hands thoroughly with soap and water throughout the day, especially before eating and after using public spaces, to minimize your exposure to bacteria.
  • Eat fully cooked foods: Avoid raw meats, raw seafood, runny eggs, and unpasteurized dairy products, as these can carry bacteria that your recovering immune system might struggle to fight.
  • Avoid crowded places: Limit your exposure to large crowds and individuals showing symptoms of cold, flu, or other contagious illnesses during your chemotherapy cycles.
  • Stay well-hydrated: Drink plenty of water and clear fluids daily to support your kidneys and help your body process your treatments effectively.
  • Engage in gentle movement: Light stretching or walking can help ease the temporary bone and joint pain that often occurs as your bone marrow works to produce new cells.
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How Soon It Starts Working

The time required for Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml to start to work: Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml ideally shows its action within 24 hours after administration. The time for which the effects of Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml last: The effect of Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml lasts for several days.

What if you forget to take Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml

If you miss your scheduled injection, contact your doctor or pharmacist immediately. Because this medicine must be carefully timed in relation to your chemotherapy sessions, your healthcare team will advise you on the safest time to receive your missed dose. Do not take a double dose to make up for a missed one.

Storage

•Store Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml in a refrigerator between 2°C and 8°C in its original carton to protect it from light.•Do not freeze this medicine. If the syringe has been frozen, do not use it.

Drug Warnings

  • Check the expiry date: Always check the expiry date before using Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml. Do not use it if it has expired.
  • Do not shake the syringe: Never shake the prefilled syringe, as this may damage the medicine.
  • Rotate injection sites: Use a different injection site each time and avoid injecting into skin that is bruised, tender, red, or hard.
  • Never reuse injection equipment: Use a new needle or prefilled syringe for each injection and dispose of it safely after use.
  • Follow the correct timing: Inject Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml at least 24 hours after completing chemotherapy and not within 14 days before your next chemotherapy session.

verifiedApollotooltip
  • Lithium: Taking Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml with lithium may further increase white blood cell counts and requires careful monitoring by your doctor.
  • Other bone marrow-stimulating medicines: Using Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml with other granulocyte colony-stimulating factors (G-CSFs) or medicines that stimulate bone marrow may increase the risk of excessively high white blood cell counts.

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verifiedApollotooltip

No clinically significant food interactions are known with Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml when used as directed. 

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Habit Forming

No

Therapeutic Class

[HEMATOPOIETIC]

FAQs

Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml belongs to the class of medicine called 'hematopoietic agent' used to treat neutropenia, a deficiency of specific white blood cells caused by cancer, bone marrow transplant, chemotherapy, or other diseases.
Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml contains 'Pegfilgrastim,' which is a growth factor that stimulates the formation of white blood cells and helps to reduce the chances of infection in cancer patients receiving chemotherapy.
This medication should not be used in individuals who have a known allergy to filgrastim, pegfilgrastim, or any of the inactive components present in it.
Yes, Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml may interfere with certain lab tests, such as bone imaging and blood testing, potentially resulting in incorrect test findings. Make sure your doctor and laboratory personnel are aware that you take Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml.
Peg-Grafeel+ Pfs 6 mg Injection 0.6 ml may sometimes cause capillary leak syndrome, a condition that causes blood leakage from small blood vessels. Inform your doctor immediately if you notice difficulty breathing, swelling, a feeling of fullness, and tiredness.
Yes, you can self-inject if your healthcare provider trains you on proper technique, safety, and disposal. Do not attempt to inject yourself until you feel completely confident in doing so. Talk to your doctor or pharmacist if you need a demonstration.
Bone pain is a common sign that the medicine is working. It stimulates your bone marrow to quickly produce a large number of new white blood cells, which can create temporary pressure and pain inside your bones. Talk to your doctor about safe over-the-counter pain relievers you can use.
Because this medicine must be precisely timed with your chemotherapy cycle, missing a dose requires immediate guidance. Contact your healthcare provider right away to reschedule. Talk to your doctor or pharmacist for custom advice on your chemotherapy schedule.
The safety of this medicine during pregnancy or breastfeeding is not fully established. It should only be used if the potential benefit justifies the risk to the baby. Talk to your doctor to evaluate your options safely.
When traveling, keep the medicine in its original packaging inside a cool travel pack with ice packs, ensuring it does not freeze. Avoid exposing it to extreme heat or direct light. Talk to your pharmacist for specific travel storage tips.
While there is no direct interaction between this medicine and alcohol, alcohol can dehydrate you and strain your recovery during chemotherapy. Talk to your doctor before consuming alcohol during your treatment.
No, this medicine does not treat or cure cancer itself. It is a supportive therapy designed to protect your immune system and prevent life-threatening infections while you undergo cancer treatments. Talk to your doctor to learn more about how it fits into your overall treatment plan.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy'S Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, India.
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