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  3. Peg L-Aspatero 3750IU Injection 5 ml

Peg L-Aspatero 3750IU Injection 5 ml, Pack of 1 INJECTION
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Written By ,
Reviewed By Santoshini Reddy G , M Pharmacy

Peg L-Aspatero 3750IU Injection 5 ml is used to treat Acute Lymphoblastic Leukaemia, mainly as a first-line treatment. It is also beneficial for patients who are allergic to asparaginase. It works by lowering plasma asparagine, a necessary component for leukaemia cells to survive. Common side effects include nausea, vomiting, diarrhoea, fever, tiredness, and dizziness. Let the doctor know if you are pregnant, breastfeeding, taking other medicines or have pre-existing medical conditions.

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Composition :

PEG L ASPARAGINASE-3750IU

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Peg L-Aspatero 3750IU Injection 5 ml

Peg L-Aspatero 3750IU Injection 5 ml is used in the treatment of Acute Lymphoblastic Leukaemia (ALL) and hypersensitivity to asparaginase. Acute lymphoblastic leukaemia is a type of cancer where the body makes too many abnormal white blood cells. These cells proliferate quickly and interfere with normal blood cell production, causing symptoms such as fatigue and easy bruising. It is more common in children but can also affect adults.

Peg L-Aspatero 3750IU Injection 5 ml contains Pegylated L-asparaginase. It works by reducing asparagine, which is necessary for leukaemia cells to survive. L-asparaginase breaks down asparagine in the blood. Since leukaemia cells cannot produce it on their own, they rely on an external source. With the reduction of asparagine, the leukaemia cells are unable to proliferate and eventually die.

A healthcare professional will administer Peg L-Aspatero 3750IU Injection 5 ml. In some cases, this medicine may cause side effects like nausea, vomiting, diarrhoea, fever, tiredness, and dizziness. The majority of these side effects may not require medical treatment and will subside with time. However, if the side effects persist or worsen, see a doctor.

Before starting treatment, be sure to inform your doctor about any other medications or herbal products you are currently taking. Peg L-Aspatero 3750IU Injection 5 ml is contraindicated for patients with a history of severe allergic reactions, pancreatitis, blood clots, or serious bleeding caused by prior L-asparaginase treatment. Pregnant and breastfeeding women should consult their doctor before receiving Peg L-Aspatero 3750IU Injection 5 ml. This medicine is given to children in doses as advised by the doctor, depending on the age. Peg L-Aspatero 3750IU Injection 5 ml should be stored in cold places at 2°C to 8°C.

Uses of Peg L-Aspatero 3750IU Injection 5 ml

First-line Treatment of Acute Lymphoblastic Leukaemia (ALL): Peg L-Aspatero 3750IU Injection 5 ml is used as the first-line treatment for Acute Lymphoblastic Leukaemia. It works by breaking down the amino acid asparagine, which is required for leukaemia cell survival, thereby reducing proliferation and promoting recovery.
Treatment of Acute Lymphoblastic Leukemia (ALL): Peg L-Aspatero 3750IU Injection 5 ml is also used in the general management of Acute Lymphoblastic Leukemia.
Patients with Hypersensitivity to Asparaginase: Peg L-Aspatero 3750IU Injection 5 ml is used as an alternative in patients who have developed hypersensitivity reactions to other forms of asparaginase. Its PEGylated formulation reduces the risk of immune responses and allows for prolonged therapeutic activity.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • A healthcare professional will administer Peg L-Aspatero 3750IU Injection 5 ml in a medical setting.
  • Do not self-administer.

Medicinal Benefits

Peg L-Aspatero 3750IU Injection 5 ml is a pegylated form of L-asparaginase, an enzyme that breaks down L-asparagine. This enzyme specifically targets leukaemia cells in acute lymphoblastic leukaemia (ALL), which cannot produce enough L-asparagine on their own and depend on it from the blood for protein production. It works by breaking down the amino acid asparagine, which leukaemia cells need to proliferate. Its pegylated form reduces the risk of hypersensitivity reactions and provides a longer duration of action, allowing for less frequent dosing. This makes it more tolerable for patients, especially those who have experienced allergic reactions to other forms of asparaginase.

How Peg L-Aspatero 3750IU Injection 5 ml Works

Peg L-Aspatero 3750IU Injection 5 ml contains Pegylated L-asparaginase. It works by reducing asparagine, which is necessary for leukaemia cells to survive. L-asparaginase breaks down asparagine in the blood. Since leukaemia cells cannot produce it on their own, they rely on an external source. With the reduction of asparagine, the leukaemia cells are unable to proliferate and eventually die.

Storage

Store in a cool and dry place away from sunlight
Side effects of Peg L-Aspatero 3750IU Injection 5 ml
  • If you experience or encounter any severe allergic reaction, stop using medication and consult the doctor right away.
  • Tell your doctor about the allergic reaction, including the medication taken and any symptoms experienced.
  • Your doctor will evaluate the severity of the reaction and determine the best course of action.
  • To ensure a full recovery, follow your doctor's advice, attend scheduled follow-up appointments, and undergo recommended tests to monitor progress and adjust treatment as needed.
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Managing Medication-Triggered Pancreatitis: A Step-by-Step Guide:
  • If you take medication and get severe stomach pain, feel nauseous, vomit, or have a fever, get emergency medical help right away. This could be a sign of pancreatitis, an inflammation of the pancreas.
  • Your doctor may alter your treatment plan, provide supportive therapy, or prescribe alternative medications to manage the reaction. They will also perform regular tests to monitor your progress and adjust your treatment as needed.
  • Follow your doctor's advice, including dietary recommendations and lifestyle changes, and avoid triggers like alcohol and fatty foods.
  • Monitor your condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Inform your physician if you notice redness, heat, swelling, or pus since these are infection signs.
  • Your physician can prescribe medication to reduce symptoms and promote healing.
  • Do not scratch to prevent irritation and infection.
  • Clean and dry the area to prevent infection.
  • Apply heat or cold packs to reduce pain and swelling.
  • Massage the area lightly to promote blood flow and reduce swelling.
  • Inform your physician if you notice signs of infection such as redness, swelling, or pus to prevent complications.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of Peg L-Aspatero 3750IU Injection 5 ml

Peg L-Aspatero 3750IU Injection 5 ml is administered in a controlled medical setting by a healthcare professional, and the likelihood of an overdose is much less. However, if you suspect an overdose or experience any unusual effects, seek medical attention immediately.

Drug Warnings

Inform your doctor if you have had severe allergic reactions to asparaginase, bleeding problems, or blood clots. Let your doctor know if you get a fever, have liver issues, or take medicines that could harm your liver. Peg L-Aspatero 3750IU Injection 5 ml can cause liver damage, brain problems, or pancreas issues. If you experience stomach pain, let your doctor know. Peg L-Aspatero 3750IU Injection 5 ml is contraindicated for patients with a history of severe allergic reactions, pancreatitis, blood clots, or serious bleeding caused by prior L-asparaginase treatment. If you are pregnant, planning for pregnancy, or are breastfeeding, please inform your doctor before receiving Peg L-Aspatero 3750IU Injection 5 ml. Avoid driving after receiving Peg L-Aspatero 3750IU Injection 5 ml if you experience drowsiness or dizziness.

Drug-Drug Interactions

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AsparaginaseMipomersen
Severe
AsparaginaseLeflunomide
Severe

Drug-Drug Interactions

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AsparaginaseMipomersen
Severe
How does the drug interact with Peg L-Aspatero 3750IU Injection 5 ml:
Coadministration of Peg L-Aspatero 3750IU Injection 5 ml and Mipomersen may increase the risk of liver problems.

How to manage the interaction:
Although taking Peg L-Aspatero 3750IU Injection 5 ml and Mipomersen together can evidently cause an interaction, it can be taken if your doctor has suggested it. Call a doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. Do not stop using any medications without talking to a doctor.
AsparaginaseLeflunomide
Severe
How does the drug interact with Peg L-Aspatero 3750IU Injection 5 ml:
Taking Peg L-Aspatero 3750IU Injection 5 ml with leflunomide may raise the risk of severe infections, and liver problems.

How to manage the interaction:
Although there is an interaction between Peg L-Aspatero 3750IU Injection 5 ml and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
AsparaginaseBexarotene
Severe
How does the drug interact with Peg L-Aspatero 3750IU Injection 5 ml:
The use of Peg L-Aspatero 3750IU Injection 5 ml with bexarotene may raise the risk of inflammation of the pancreas.

How to manage the interaction:
Co-administration of Peg L-Aspatero 3750IU Injection 5 ml with Bexarotene can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor if you have symptoms such as persistent nausea, vomiting, abdominal soreness, and upper abdominal pain, especially if it worsens after eating or extends to the back. Do not stop using any medications without talking to a doctor.
AsparaginaseTeriflunomide
Severe
How does the drug interact with Peg L-Aspatero 3750IU Injection 5 ml:
The use of Peg L-Aspatero 3750IU Injection 5 ml in conjunction with teriflunomide may raise the risk of severe infections, liver problems.

How to manage the interaction:
Co-administration of Peg L-Aspatero 3750IU Injection 5 ml with Teriflunomide can result in an interaction, but it can be taken if a doctor has advised it. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, consult the doctor. Do not stop using any medications without talking to a doctor.
AsparaginaseThalidomide
Severe
How does the drug interact with Peg L-Aspatero 3750IU Injection 5 ml:
Taking thalidomide together with Peg L-Aspatero 3750IU Injection 5 ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Peg L-Aspatero 3750IU Injection 5 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
AsparaginaseLomitapide
Severe
How does the drug interact with Peg L-Aspatero 3750IU Injection 5 ml:
Coadministration of Peg L-Aspatero 3750IU Injection 5 ml and Lopitamide may increase the risk of liver issues.

How to manage the interaction:
Taking Peg L-Aspatero 3750IU Injection 5 ml with Lomitapide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AsparaginaseNatalizumab
Severe
How does the drug interact with Peg L-Aspatero 3750IU Injection 5 ml:
Taking Peg L-Aspatero 3750IU Injection 5 ml with Natalizumab together can increase the risk of developing serious infections.

How to manage the interaction:
Taking Peg L-Aspatero 3750IU Injection 5 ml with Natalizumab together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, discomfort or burning when you urinate, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory, and personality, consult a doctor. Do not stop using any medications without talking to a doctor.
AsparaginaseDalteparin
Moderate
How does the drug interact with Peg L-Aspatero 3750IU Injection 5 ml:
Using dalteparin with Peg L-Aspatero 3750IU Injection 5 ml may increase your risk of blood clots or bleeding.

How to manage the interaction:
Although taking Desogestrel and Fosamprenavir together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fast heartbeat, anxiety, constipation, cough, dark urine, diarrhea, dizziness, lightheadedness, fainting, fever, hives or welts, itching skin or rash call your doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a balanced diet that includes fruits and vegetables rich in nutrients and low-fat proteins, such as lean meats, fish, and poultry.
  • Reduce your intake of sugary foods in order to control your blood sugar levels.
  • Include leafy greens and cruciferous vegetables in your diet to improve liver health.
  • Avoid alcohol consumption.
  • Engage in moderate exercise to maintain strength and reduce fatigue.
  • Get adequate sleep and rest.
  • Practice proper hygiene and prevent contact with sick persons.
  • Try relaxation techniques such as meditation or deep breathing.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC
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Alcohol

Caution

Avoid or limit alcohol consumption while on treatment with Peg L-Aspatero 3750IU Injection 5 ml as it may worsen your condition.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Peg L-Aspatero 3750IU Injection 5 ml. Your doctor will prescribe this medicine only if clearly needed.

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Breast Feeding

Caution

It is not known if Peg-L-Asparaginase passes into breast milk. Please consult the doctor if you are breastfeeding. Your doctor will advise you to discontinue breastfeeding or the medicine based on your condition.

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Driving

Caution

Peg L-Aspatero 3750IU Injection 5 ml may cause drowsiness or dizziness. If you experience any such side effects, avoid driving or operating machinery.

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Liver

Caution

If you have pre-existing or a history of liver disease, inform your doctor before receiving Peg L-Aspatero 3750IU Injection 5 ml. Your doctor may recommend regular tests to monitor liver function while receiving Peg L-Aspatero 3750IU Injection 5 ml.

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Kidney

Caution

If you have pre-existing or a history of kidney disease, inform your doctor before receiving Peg L-Aspatero 3750IU Injection 5 ml. Your doctor may recommend regular tests to monitor kidney function while receiving Peg L-Aspatero 3750IU Injection 5 ml.

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Children

Safe if prescribed

The dosage for children is recommended based on their age, body weight, and the child's condition.

Have a query?

FAQs

Peg L-Aspatero 3750IU Injection 5 ml is used in the treatment of Acute Lymphoblastic Leukaemia (ALL) and hypersensitivity to asparaginase.

Peg L-Aspatero 3750IU Injection 5 ml contains Pegylated L-asparaginase. It works by reducing asparagine, which is necessary for leukaemia cells to survive. L-asparaginase breaks down asparagine in the blood, and since leukaemia cells cannot produce it on their own, they rely on an external source. With the reduction of asparagine, the leukaemia cells are unable to proliferate and eventually die. Thereby, Peg L-Aspatero 3750IU Injection 5 ml helps treat Acute Lymphoblastic Leukaemia.

Peg L-Aspatero 3750IU Injection 5 ml may cause glucose intolerance in some people. Consult the doctor if you have high/low blood glucose levels.

Peg L-Aspatero 3750IU Injection 5 ml is given as an injection, usually through an intravenous (IV) or intramuscular (IM) route. The dosage and frequency depend on your condition and doctor’s recommendation.

Peg L-Aspatero 3750IU Injection 5 ml may cause stomach pain in some patients. You are advised to inform your doctor immediately if you experience stomach pain, as it may be a sign of pancreatitis, an inflammation of the pancreas.

Do not drive or operate machinery while using this medication, as it may cause drowsiness, fatigue, or confusion, which can reduce your ability to concentrate and respond quickly.

Peg L-Aspatero 3750IU Injection 5 ml is contraindicated for patients with a history of severe allergic reactions, pancreatitis, blood clots, or serious bleeding caused by prior L-asparaginase treatment.

If you have a history of liver complications, inform your doctor before receiving Peg L-Aspatero 3750IU Injection 5 ml, as it can affect liver function. Individuals with a history of liver issues are at higher risk for liver damage. Your doctor will monitor liver function through regular tests and may adjust the dosage if necessary.

Yes, Peg L-Aspatero 3750IU Injection 5 ml can be administered to children, particularly to treat Acute Lymphoblastic Leukaemia (ALL). However, the dosage and administration are adjusted based on the child's age and weight. Always follow your doctor's recommendations for pediatric use.

During your treatment with Peg L-Aspatero 3750IU Injection 5 ml, avoid alcohol, infection risks, blood-thinning medications, and unapproved treatments. Check with your doctor before taking any new medications or supplements, and avoid high-fat foods if you experience digestive issues. Consult a doctor if you have any concerns or if any signs of infection occur.

Peg L-Aspatero 3750IU Injection 5 ml causes side effects such as nausea, vomiting, diarrhoea, fever, tiredness, and dizziness. Seek medical care if the side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

2Nd Floor, 8-3-166/7/1 Erragadda, Hyderabad-500018
Other Info - PEG0080

Disclaimer

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Keep Refrigerated. Do not freeze.

Reference

  1. https://www.heterohealthcare.com/peg-l-aspatero-injection
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/103411s5126lbl.pdf
  3. https://pdf.hres.ca/dpd_pm/00059708.PDF
  4. https://www.medicines.org.uk/emc/files/pil.10824.pdf
  5. https://www.sciencedirect.com/science/article/pii/S0959804921012260
  6. https://medlineplus.gov/druginfo/meds/a695031.html#precautions
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