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compositionComposition:PENTOXIFYLLINE-400MG
prescription
Prescription Medicine
info
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Pentoxia 400 ER Tablet is used to treat pain in the legs due to insufficient blood flow (intermittent claudication). It also reduces cramping, numbness, or weakness in the legs on walking in such patients. It works by decreasing the viscosity (thickness) of blood, allowing it to pass more easily through the blood vessels, especially in the small blood vessels of the hands and feet. It can also increase the distance you can walk without pain since it improves your legs blood circulation. It is recommended in patients whose pain has not improved even after lifestyle changes like quitting smoking and doing regular exercise. In some cases, it may cause side effects such as nausea, vomiting, diarrhoea, headache, lightheadedness, sleep problems, intrahepatic cholestasis (removal of bile from the liver is blocked), abdomen pain, constipation, and urine discolouration.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PENTOXIFYLLINE-400MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Pentoxia 400 ER Tablet

Pentoxia 400 ER Tablet is a prescription medication used to improve blood circulation in patients with chronic blood vessel problems. It is primarily prescribed to treat intermittent claudication, which is muscle pain, cramping, or tiredness in the legs that happens during walking. By helping blood flow more easily through narrowed vessels, it helps reduce these uncomfortable symptoms and improves your mobility.

For this medication to work effectively, you need to take it consistently and exactly as your doctor prescribes, which is typically three times a day. It is highly recommended to take your tablets with meals to prevent stomach upset or nausea. Combining this treatment with daily lifestyle adjustments, such as a structured walking program and eating a heart-healthy diet, can greatly improve your results.

While taking Pentoxia 400 ER Tablet, you may experience some common, mild side effects like a mild upset stomach, gas, or occasional dizziness. However, if you experience rare but serious symptoms like chest pain, an irregular heartbeat, or unusual bleeding, you must contact your healthcare provider immediately.

Talk to your doctor before starting Pentoxia 400 ER Tablet if you have a history of kidney disease, liver damage, or heart problems. Do not take this medicine if you have recently had severe bleeding in your brain or retina, as it can increase the risk of severe blood loss.

This medication can interact with other substances; for example, smoking can decrease its effectiveness by further narrowing your blood vessels, while alcohol may increase your risk of dizziness. Additionally, if you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, you should discuss the risks and benefits with your doctor or pharmacist before starting treatment.

Uses of Pentoxia 400 ER Tablet

Pentoxia 400 ER Tablet may be prescribed for the following conditions: 

  • Intermittent claudication: Pentoxia 400 ER Tablet helps ease the painful cramping, numbness, and weakness in your leg muscles that occur when walking, allowing you to walk longer distances comfortably.
  • Peripheral artery disease: It is used to manage circulation problems in the limbs by improving the flow of oxygen-rich blood through narrowed arteries.
     

Key Benefits

Pentoxia 400 ER Tablet helps improve blood flow by making blood flow more easily through narrowed blood vessels. It is commonly used to reduce symptoms of poor circulation, helping improve mobility and comfort during daily activities.

  • Improves Blood Circulation: Enhances blood flow to the arms and legs by improving the flexibility of red blood cells.
  • Reduces Leg Pain While Walking: Helps relieve pain and cramping caused by poor circulation, allowing you to walk longer distances with greater comfort.
  • Supports Physical Activity: Improved circulation may make exercise and routine daily activities easier to perform.
  • Promotes Tissue Oxygen Supply: Helps improve the delivery of oxygen and nutrients to tissues affected by reduced blood flow.
  • Enhances Quality of Life: Better circulation and reduced discomfort help support greater independence and overall well-being.

Directions for Use

  • Pentoxia 400 ER Tablet can be taken with meals or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Pentoxia 400 ER Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Pentoxia 400 ER Tablet Works

Pentoxia 400 ER Tablet contains pentoxifylline, a haemorheologic agent that helps improve blood circulation. It works by making red blood cells more flexible, allowing them to pass more easily through narrow blood vessels. Pentoxifylline also reduces blood viscosity, helping blood flow more smoothly through the circulation. Through these actions, pentoxifylline improves the delivery of oxygen and nutrients to body tissues, particularly the muscles of the legs, helping to reduce pain and discomfort caused by poor blood circulation.
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Alcohol

Caution

Avoid consumption of alcohol with Pentoxia 400 ER Tablet as it may increase adverse effects such as dizziness, fainting, light-headedness or headache.

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Pregnancy

Caution

Pentoxia 400 ER Tablet is a Category C pregnancy drug and is given to pregnant women only if the doctor thinks the benefits outweigh the risks. Please consult a doctor if you are pregnant.

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Breast Feeding

Unsafe

Pentoxia 400 ER Tablet is not recommended for breastfeeding mothers as it may harm the baby.

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Driving

Caution

Drive with caution, Pentoxia 400 ER Tablet may cause blurry vision, and dizziness or weariness.

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Liver

Caution

Pentoxia 400 ER Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Pentoxia 400 ER Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Pentoxia 400 ER Tablet is not recommended for children. The safety and effectiveness of Pentoxia 400 ER Tablet have not been established in children.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Safe if prescribed

Pentoxia 400 ER Tablet can be given safely to the elderly if advised by the doctor.

What if I have taken an overdose of Pentoxia 400 ER Tablet

If you take too much of this medication, you may experience symptoms like severe dizziness, flushing, fever, or fainting. Seek emergency medical attention or call your local poison control centre immediately.

Diet & Lifestyle Advise

  • Engage in a structured walking program: Regular, supervised walking exercises help your body build better natural circulation pathways over time.
  • Stop smoking: Tobacco smoke significantly narrows your blood vessels and can undo the positive effects of Pentoxia 400 ER Tablet. Talk to your pharmacist about quit-smoking aids.
  • Eat a heart-healthy diet: Focus on meals low in saturated fats and cholesterol to help prevent further fat buildup in your arteries.
  • Practice daily foot care: Because poor circulation slows healing, inspect your feet daily for any cuts, blisters, or redness, and wear comfortable, supportive shoes.
     
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How Soon It Starts Working

The time required for Pentoxia 400 ER Tablet to start to work: The time required for Pentoxia 400 ER Tablet to show its action is not clinically established. The time for which the effects of Pentoxia 400 ER Tablet last: The effect of Pentoxia 400 ER Tablet lasts for 8 hours.

What if you forget to take Pentoxia 400 ER Tablet

If you miss a dose, take it as soon as you remember with food. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the one you missed.

Storage

•Store the tablets at controlled room temperature, between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original container to protect it from moisture and direct light.

Drug Warnings

  • Swallow Extended-Release Tablets Whole: Do not crush, chew, or split extended-release tablets, as this can affect how the medicine is released.
  • Watch for Signs of Bleeding: Inform your doctor if you notice unusual bruising, prolonged bleeding, or blood in your stools or urine, especially if you are taking blood-thinning medicines.
  • Inform Healthcare Providers: Tell your doctor, dentist, or surgeon that you are taking Pentoxia 400 ER Tablet before any medical, dental, or surgical procedure.
  • Stand Up Slowly: Rise gradually from a sitting or lying position to help reduce dizziness or lightheadedness.
  • Attend Regular Follow-Up Appointments: Keep all scheduled appointments so your doctor can monitor your circulation, kidney function, and overall response to treatment.

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact with Pentoxia 400 ER Tablet:

  • Blood Thinners: Medicines such as warfarin, aspirin, or other anticoagulants may increase the risk of bleeding.
  • Blood Pressure Medicines: Combining these medicines may increase the risk of low blood pressure and dizziness.
  • Diabetes Medicines: Pentoxia 400 ER Tablet may occasionally enhance the blood sugar-lowering effects of antidiabetic medicines, requiring closer monitoring.
     

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verifiedApollotooltip

Inform your doctor about your dietary habits and follow their recommendations during treatment.

  • High-Fat Meals: Taking Pentoxia 400 ER Tablet consistently with regard to meals is recommended, as high-fat meals may affect its absorption.
  • Caffeine: Limit excessive intake of coffee, tea, energy drinks, chocolate, and other caffeinated products, as they may increase side effects such as nervousness, tremors, or a rapid heartbeat.
     

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[VASODILATORS]

FAQs

Pentoxia 400 ER Tablet is used to treat pain in the legs due to insufficient blood flow (intermittent claudication). It also reduces cramping, numbness, or weakness in the legs when walking in such patients.
No, you should not stop taking Pentoxia 400 ER Tablet even if you feel better as the pain might come back and become even worse.
No, it is a prescribed drug given by a physician to prevent specific medical conditions. Taking it on your own can cause unwanted side effects.
No. Pentoxia 400 ER Tablet is not a blood thinner. It contains pentoxifylline, which improves blood flow by making red blood cells more flexible and reducing blood viscosity (thickness). This helps improve circulation and relieves symptoms such as leg pain caused by poor blood flow (intermittent claudication). Although it is not classified as a blood thinner, it may increase the risk of bleeding in some people, especially when taken with anticoagulants or antiplatelet medicines. Use it only as prescribed by your doctor.
If you forget to take Pentoxia 400 ER Tablet at any time, take it as soon as you remember, then continue to take it at the usual times. Do not take a double dose to make up for a forgotten dose.
You are not recommended to take Pentoxia 400 ER Tablet with warfarin as co-administration of these two medicines may increase the risk of bleeding. However, if you experience severe bleeding, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted to use safely.
It is best to limit or avoid alcohol while taking this medicine, as alcohol can increase side effects like dizziness, lightheadedness, and flushing. Talk to your doctor or pharmacist for personalised advice.
You should always take Pentoxia 400 ER Tablet with food or a meal. This helps protect your stomach lining and reduces common side effects like nausea and indigestion.
No, Pentoxia 400 ER Tablet does not cure peripheral artery disease or blood circulation issues; it helps manage your symptoms so you can walk farther with less pain. You should continue taking it as long as your doctor recommends.
If you feel dizzy, sit or lie down immediately. Stand up slowly when rising from a sitting or lying position, and avoid driving or operating machinery until the dizziness passes. If it persists, talk to your doctor.
No, you must swallow the tablet whole. Crushing, chewing, or splitting the tablet destroys its special slow-release mechanism, which can cause too much medicine to enter your body at once.
The safety of Pentoxia 400 ER Tablet during pregnancy has not been fully established. If you are pregnant or planning to become pregnant, talk to your doctor to weigh the benefits against potential risks.
Yes, Pentoxia 400 ER Tablet can slightly increase your risk of bleeding, especially if you take it with blood thinners or have an underlying bleeding disorder. Watch for signs like nosebleeds or easy bruising, and report them to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India
Other Info - PE61858
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