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compositionComposition:PRULIFLOXACIN-600MG
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Prescription Medicine
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Percin Tablet is used to treat bacterial infections. It contains Prulifloxacin which works by killing infection-causing bacteria. In some cases, this medicine may cause side effects such as vomiting, headache, dizziness, stomach pain, nausea, and diarrhoea. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PRULIFLOXACIN-600MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Percin Tablet

Percin Tablet is an oral antibiotic medication prescribed to treat various bacterial infections, including urinary tract infections and flare-ups of chronic bronchitis. Its medical purpose is to target and eliminate the specific bacteria causing these painful or uncomfortable infections, helping your body heal. By stopping the bacteria from growing and spreading, it provides a reliable way to resolve the underlying infection. It is particularly effective against many gram-negative bacteria, including Escherichia coli (E. coli), Klebsiella species, and Proteus species, making it useful for treating urinary tract infections and certain respiratory bacterial infections when prescribed by your doctor.

To ensure the infection is completely cleared, it is important to take this medicine consistently and at the same time each day as prescribed. You can take this oral tablet with or without food, but taking it with a full glass of water is highly recommended. Incorporating positive habits, such as drinking plenty of fluids throughout the day and getting adequate rest, can significantly support your body’s recovery process.

While taking this medicine, some patients may experience mild side effects like a temporary upset stomach, nausea, or mild headaches. However, if you experience serious symptoms such as severe joint pain, a sudden skin rash, or persistent watery diarrhoea, you must contact your doctor immediately.

Do not take this if you are allergic to similar antibiotics, have a history of tendon problems, or are under 18 years of age. Before starting this medication, talk to your doctor if you have a history of kidney problems, heart conditions, or epilepsy.

This medicine can interact with other substances, including antacids, iron supplements, and caffeine, which can alter how well the treatment works. You should avoid drinking alcohol during your treatment to reduce the risk of dizziness, and always consult your doctor if you are pregnant, breastfeeding, or managing treatment for an elderly patient.

Uses of Percin Tablet

Percin Tablet is used in the treatment of bacterial infections. The detailed uses of Percin Tablet are as follows:

  • Urinary Tract Infections (UTIs): Percin Tablet treats bacterial bladder and kidney infections, relieving painful urination, abdominal discomfort, and the constant urge to urinate.
  • Bronchitis Flare-ups: It helps resolve sudden worsenings of chronic bronchitis by killing the bacteria causing airway congestion, heavy coughing, and breathing difficulties.

Key Benefits

Percin Tablet offers targeted relief to help you recover quickly from uncomfortable bacterial infections. By directly halting the life cycle of the bacteria, it limits the spread of infection and allows your body to start healing almost immediately.

Key benefits of this treatment include:

  • Helps quickly reduce the painful burning of urinary infections and eases chest congestion within the first few days of treatment.
  • After it is converted into its active form, the medicine stays in your body long enough for once-daily dosing in many approved uses, helping improve treatment adherence.
  • By thoroughly clearing the bacteria, it lowers the risk of the infection returning or spreading to other organs.
Side effects of Percin Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Practice breathing exercises to improve lung efficiency along with the medical treatment advised by your healthcare professional.
  • Avoid smoking or inhaling any products that cause damage to lungs.
  • Drink hot herbal tea and hot foods that make you feel comfortable. Avoid refrigerated foods to get relief from wheezing.
  • Use air purifiers or humidifiers to improve the air quality and stay away from allergy triggers that worsen your health condition.
  • Relieve inflammation with cool compresses, oatmeal baths, and fragrance-free moisturizers.
  • Wear loose, breathable clothing and keep nails trimmed to minimise irritation.
  • Use over-the-counter treatments like calamine lotion for relief.
  • Identify and avoid triggers like new soaps, detergents, or foods.
  • Seek medical help if the rash is severe, spreading, persistent, or accompanied by fever, swelling, or difficulty breathing.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Stay hydrated by drinking plenty of water.
  • Limit salty foods to reduce sodium intake and minimize water retention.
  • Eat anti-inflammatory foods like berries, leafy greens, tomatoes, nuts, and fish.
  • Incorporate potassium-rich foods like bananas, avocados, sweet potatoes, and spinach.
  • Limit alcohol to minimize dehydration and fluid retention.
  • Get 7-9 hours of restful sleep each night.
  • Elevate your head while sleeping to reduce fluid accumulation and alleviate swollen eyelids.
  • Apply cold compresses to reduce swelling and soothe irritated skin.
  • Manage allergies by minimizing exposure to allergens and using antihistamines or allergy eye drops.
  • Practice gentle eye massage to stimulate circulation and reduce fluid retention.
  • Avoid rubbing your eyes to prevent irritation and worsening inflammation.
  • Reduce stress through relaxation techniques like meditation, yoga, or deep breathing exercises.
  • Consult a doctor if swollen eyelids persist, worsen, or are accompanied by pain.

Directions for Use

  • Percin Tablet can be taken with or without food or as directed by your doctor.
  • Avoid intake of Percin Tablet with dairy products, such as milk, cheese, or curd, as they may decrease its absorption and efficacy.
  • It is usually taken once daily or as prescribed by your doctor.
  • Swallow Percin Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Percin Tablet Works

Percin Tablet is an antibacterial medicine belonging to the fluoroquinolone class. Once swallowed, the tablet is absorbed and converted by your body into its active form. This active compound targets and blocks two essential bacterial enzymes: DNA gyrase and topoisomerase IV. Percin Tablet prevents the bacteria from copying, repairing, or multiplying their genetic material. Without the ability to duplicate their DNA, the bacteria cannot survive or spread. Your body's natural immune system then steps in to clear away the remaining inactive bacteria, leading to a complete recovery from the infection.
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Alcohol

Caution

Alcohol is not known to cause any unpleasant side effects if taken along with Percin Tablet. But intake of alcohol with Percin Tablet may damage your liver. So intake of Percin Tablet should be avoided with Percin Tablet.

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Pregnancy

Caution

Percin Tablet is a pregnancy Category B medicine. It may not cause harm to an unborn foetus. However, Percin Tablet should be taken only when prescribed by a doctor only if he/she thinks benefits overweigh the risks.

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Breast Feeding

Caution

Before taking this drug doctor's consultation is mandatory. It is not known whether Percin Tablet can pass through the breast milk or not.

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Driving

Caution

After taking this drug, you can experience side effects like feeling dizzy, tired, or alterations in your vision. If this occurs, do not drive or perform any work that requires high level of concentration.

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Liver

Caution

Percin Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may have to adjust the dose if there are symptoms of nausea, vomiting, loss of appetite, dark-coloured urine or yellowing of skin/eye.

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Kidney

Caution

Percin Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Caution

The safety and efficacy of Percin Tablet are not studied in children below the age of 18 years. So, it should be only taken by the children if a doctor has prescribed it.

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Heart

Safe if prescribed

Percin Tablet can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Caution

Exercise caution before using Percin Tablet in older patients. Please consult your doctor if you have any concerns.

What if I have taken an overdose of Percin Tablet

If you accidentally take more than your prescribed dose, seek emergency medical assistance or contact a poison control centre immediately. Symptoms of an overdose may include severe dizziness, confusion, or severe stomach pain.

Diet & Lifestyle Advise

  • Drink plenty of water: Increase your daily water intake to help flush bacteria out of your urinary tract and keep your kidneys functioning optimally.
  • Avoid dairy at dosing time: Do not take your dose at the same time as milk, yoghurt, or calcium-fortified juices, as calcium binds to the medicine and prevents your body from absorbing it properly.
  • Protect yourself from the sun: This medicine increases your skin's sensitivity to sunlight. Wear protective clothing, apply a broad-spectrum sunscreen, and avoid tanning beds during your treatment.
  • Rest your joints: Avoid high-intensity sports, heavy weightlifting, or strenuous physical activities while taking this medicine to protect your tendons from strain or injury.
health query

Have a query?

How Soon It Starts Working

The time required for Percin Tablet to start to work: The time required for Percin Tablet to show its action is unknown. The time for which the effects of Percin Tablet last: The duration of action for Percin Tablet is clinically unknown.

What if you forget to take Percin Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Percin Tablet tablets at room temperature, strictly between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Monitor for tendon pain: Stop exercising and contact your doctor immediately if you feel any sudden pain or swelling in your ankles, knees, or wrists.
  • Keep a mineral gap: Always wait at least 2 hours before or 4 to 6 hours after taking multivitamin pills, iron, zinc, or antacids to take your medicine.
  • Watch for nerve sensations: Inform your doctor right away if you experience sudden tingling, numbness, or a burning sensation in your limbs.
  • Avoid anti-diarrhoea pills: If you develop severe watery diarrhoea, do not self-treat with over-the-counter anti-diarrhoea medications, as they can make the condition worse. Contact your doctor instead.
  • Finish the full pack: Even if you feel 100% recovered, finish all the pills in your prescription to prevent the bacteria from becoming resistant to antibiotics.

Drug-Drug Interactions

verifiedApollotooltip
  • Antacids and Mineral Supplements (e.g., aluminium hydroxide, magnesium hydroxide, iron, zinc): Can heavily reduce the absorption of Percin Tablet, making your treatment less effective.
  • Nonsteroidal Anti-inflammatory Drugs (e.g., ibuprofen, diclofenac): Taking these pain relievers with this antibiotic may increase the risk of central nervous system stimulation and seizures.
  • Heart rhythm medicines (Class IA or Class III antiarrhythmics) (e.g., quinidine, amiodarone): Combining these can increase the risk of developing abnormal heart rhythms.
  • Probiotics (e.g., Lactobacillus): This antibiotic may reduce the effectiveness of active bacterial cultures in probiotics; space their administration by at least 2 hours.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Dairy Products and Calcium-Fortified Foods (e.g., milk, yoghurt, cheese, calcium-fortified juice): Can bind to the medication in your stomach, drastically reducing how much medication enters your bloodstream.
  • Caffeine (e.g., coffee, tea, energy drinks): This medicine can slow down how fast your body processes caffeine, leading to increased jitters, anxiety, or sleep issues.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Percin Tablet is used to treat bacterial infections of the urinary tract, tonsils, sinus, nose, throat, female genital organ, skin and soft tissues, and lungs (pneumonia).
Percin Tablet contains Prulifloxacin, primarily used to treat or prevent certain infections caused by bacteria. The bactericidal (killing) action of Percin Tablet results from interference with the enzyme DNA gyrase and DNA synthesis process needed to survive the bacteria.
Take the missed dose as soon as possible and try not to take a double dose to make up for the missed dose as it may cause harmful effects. It is advised to jump to the next dose if it's been too late to take the missed dose.
It is recommended not to take dairy products such as milk, yoghurt, and Percin Tablet as they might decrease the effectiveness of Percin Tablet. Please maintain a gap of at least 2 hours between both of them.
No. Percin Tablet is an antibacterial medicine that acts only against bacterial infections and not against viral infections, causing cough, cold and flu. You should not take Percin Tablet without prior consulting your doctor. Self-medication is dangerous and can lower the efficacy of Percin Tablet, leading to antibiotic resistance.
Yes. Like other fluoroquinolone antibiotics, Percin Tablet can increase the risk of tendonitis and tendon rupture. The risk is higher in people over 60 years of age, those taking corticosteroids, and people with certain medical conditions. Seek medical attention immediately if you develop tendon pain, swelling, or difficulty moving a joint.
Percin Tablet may cause diarrhea in some individuals, as it is a commonly reported side effect. However, this effect may subside over time as the medication adjusts to the body. If the diarrhea persists, it is recommended to consult your doctor without hesitation for proper management of the symptoms.
No, you should not stop taking Percin Tablet even if you feel better without consulting your doctor. It's best to complete the prescribed duration, even if your symptoms vanish. Stopping earlier may lead to the recurrence of the infection and negative effects. Instead, inform your doctor. They will assess your condition, guide you on how to safely stop the medication if necessary.
Yes. Percin Tablet may increase the risk of tendonitis, tendon rupture, and muscle damage. The risk is higher in older adults, people with myasthenia gravis, and those taking corticosteroids. Stop taking the medicine and contact your doctor immediately if you develop tendon pain, swelling, or muscle weakness.
In some individuals, Percin Tablet may cause some common side effects such as vomiting, headache, dizziness, stomach pain, nausea, diarrhea, and abnormal liver function tests, allergic reactions. However, this effect may subside over time as the medication adjusts to the body. If these side effects persist, it is recommended to consult your doctor.
Percin Tablet is generally not recommended during pregnancy or while breastfeeding unless your doctor decides the potential benefits outweigh the risks. Although there are limited data on Percin Tablet specifically in humans, fluoroquinolone antibiotics as a class have raised concerns about possible effects on developing bones and joints in babies. Talk to your doctor about safer alternatives if you are pregnant, planning a pregnancy, or breastfeeding.
Most patients start feeling relief within 48 to 72 hours of starting the medicine. However, you must finish your entire prescribed course even if you feel completely better. Talk to your doctor if your symptoms do not improve after a few days.
Complete the entire course exactly as prescribed, even if you start feeling better. If your symptoms do not improve, worsen, or return after finishing the treatment, contact your doctor promptly. Your doctor may need to reassess your condition, perform additional tests, or prescribe a different antibiotic if the bacteria are resistant or another condition is causing your symptoms. Do not start another course of antibiotics without medical advice.
This medicine makes your skin highly sensitive to UV rays, which can cause severe sunburns, rashes, or blistering. Wear protective clothing and apply sunscreen when outdoors. Talk to your doctor if you develop a sunburn-like rash.
Do not take multivitamins containing iron, calcium, or zinc at the same time as this medicine. They block the absorption of the antibiotic. Take your medicine 2 hours before or 4 to 6 hours after your vitamins. Talk to your doctor or pharmacist to help schedule your doses.
No, this medicine is not recommended for children and teenagers under 18 years of age. This is because it can potentially interfere with the healthy development of their bones and joints. Talk to your doctor for pediatric-safe options.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. National Center for Biotechnology Information (NCBI). Prulifloxacin Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  2. PubChem PubChem. [Accessed on 01 Apr. 2019]Check here
  3. Guillem Prats, Vilma Rossi, Enrica Salvatori, Beatriz Mirelis. Prulifloxacin: a new antibacterial fluoroquinolone. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. February 2006. [Accessed on 1st June 2022]Check here
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 01 Apr. 2019]Check here
  5. Chaves RG, Lamounier JA Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-98Check here
  6. Prulifloxacin [SmPC]. [Accessed on 06 Nov. 2025]Check here
  7. Drugbank.prulifloxacin.[[Accessed on 24 Sept].2019]Check here

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - PER0065
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