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  3. Periset-4 Tablet 10's

Prescription drug
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Periset-4 Tablet 10's, Pack of 10 TabletS
Periset-4 Tablet 10's, Pack of 10 TabletS
Periset-4 Tablet 10's, Pack of 10 TabletS
Periset-4 Tablet 10's, Pack of 10 TabletS
Periset-4 Tablet 10's, Pack of 10 TabletS
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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Periset-4 Tablet is used in the prevention of vomiting and nausea that usually occur after cancer chemotherapy, radiation treatment, or surgery. It contains ondansetron, which works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting. It may cause common side effects such as constipation, headache, diarrhea, drowsiness, flushing (a feeling of warmth), weakness, and tiredness. Before taking this medication, inform your doctor if you are allergic to any of its components.

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Composition :

ONDANSETRON-4MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Periset-4 Tablet

Periset-4 Tablet is primarily used in the prevention of vomiting and nausea. Nausea is an uneasy feeling in which a person feels an urge to vomit, while vomiting is the natural response of the body to expel the stomach contents from the mouth forcefully.

Periset-4 Tablet contains Ondansetron, which works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting.

You may experience common side effects such as constipation, headache, diarrhea, drowsiness, flushing (a feeling of warmth), weakness, and tiredness. If the side effects persist or worsen, please consult your doctor.

Before using Periset-4 Tablet , inform your doctor if you are allergic to any of its ingredients. Periset-4 Tablet should be used during pregnancy and breastfeeding only if prescribed by a doctor.

Uses of Periset-4 Tablet

Periset-4 Tablet is used in the prevention of Nausea and Vomiting. The detailed uses of Periset-4 Tablet are as follows:

  • Chemotherapy-Induced Nausea and Vomiting: Periset-4 Tablet is frequently prescribed to alleviate nausea and vomiting caused by chemotherapy treatments.
  • Radiation Therapy Support: Periset-4 Tablet can help manage nausea and vomiting experienced by patients undergoing radiation therapy, improving treatment tolerance.
  • Postoperative Nausea and Vomiting Relief: Many patients experience nausea or vomiting after surgical procedures, and Periset-4 Tablet is effective in controlling and reducing these symptoms.

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Directions for Use

  • Periset-4 Tablet can be taken with or without food, as advised by the doctor.
  • Typically, it is taken twice daily. However, follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow the tablet as a whole with a glass of water.
  • Do not crush, chew, break, or open it.

Medicinal Benefits

  • Periset-4 Tablet is an antiemetic medication primarily used to prevent and treat nausea and vomiting associated with conditions such as cancer chemotherapy, radiation treatment, and surgery.
  • When serotonin levels increase in the blood, it stimulates the CTZ receptor (chemoreceptor trigger zone) located in the brain, which is responsible for controlling nausea and vomiting.
  • Periset-4 Tablet contains Ondansetron, which works by inhibiting the release of serotonin, thereby preventing nausea and vomiting.

How Periset-4 Tablet Works

Periset-4 Tablet contains Ondansetron, which works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting. As a result, Periset-4 Tablet prevents the sensation of nausea and vomiting caused by conditions like surgery, cancer chemotherapy, pregnancy, or motion sickness.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Periset-4 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Avoid rubbing or scratching the affected area, as this can cause further irritation and discomfort.
  • Consider using a humidifier to add moisture to the air and help reduce the sensation.
  • Seek medical attention if the sensation is severe, persistent, or worsens over time.
  • Avoid extreme temperatures, such as hot or cold showers, that can exacerbate the sensation.
  • Wear light, breathable clothing to help keep the body cool and reduce the sensation.
  • Avoid triggers that can cause the sensation, such as spicy foods or hot drinks.
  • Use cool compresses or fans to help lower body temperature and reduce the sensation.
Managing Medication-Triggered malaise (Feeling Unwell): A Step-by-Step Guide:
  • If you experience persistent or severe malaise (a general feeling of discomfort, illness, or unease) after taking medication, seek medical attention immediately.
  • Inform your doctor about the medication you're taking and the symptoms you're experiencing.
  • Your treatment plan may be modified, which may include adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
  • To manage malaise symptoms, follow your doctor's advice, such as getting plenty of rest, staying hydrated, and practicing stress-reducing techniques.
  • Track your symptoms regularly and report any changes or concerns to your healthcare provider to ensure the malaise is managed effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of Periset-4 Tablet

Do not take more than the prescribed dose of Periset-4 Tablet , as it may lead to an overdose. Symptoms of an overdose may include sudden loss of vision for a short time, irregular heartbeat, constipation, fainting, dizziness, or light-headedness. If you suspect that you have taken an overdose of this medication or notice any unusual symptoms, please consult a doctor immediately.

Drug Warnings

  • Do not use Periset-4 Tablet if you are allergic to any of its ingredients.
  • Avoid using Periset-4 Tablet if you are taking apomorphine (a medicine used to treat Parkinson's disease), as it may cause a sharp drop in blood pressure and even fainting.
  • Inform your doctor before using Periset-4 Tablet if you have any medical conditions, such as severe constipation, bowel obstruction, depression, electrolyte imbalance, heart or blood vessel problems (such as irregular heartbeats and high blood pressure), diabetes, liver problems, or a history of tonsils or adenoid removal surgery.
  • Tell your doctor if you are taking any medications for depression, as using them alongside Periset-4 Tablet may increase the risk of serotonin syndrome, a potentially life-threatening condition.
  • Periset-4 Tablet is not recommended for use during early pregnancy (first trimester), as it may increase the risk of birth defects in the mouth and face of the baby.
  • Avoid breastfeeding while taking Periset-4 Tablet , as small amounts of the medicine may pass into breast milk.
  • Avoid consuming alcohol while taking Periset-4 Tablet , as it may worsen the side effects like drowsiness.

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
OndansetronLinezolid
Severe

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
How does the drug interact with Periset-4 Tablet:
Taking Periset-4 Tablet with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Periset-4 Tablet with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
OndansetronLinezolid
Severe
How does the drug interact with Periset-4 Tablet:
When Periset-4 Tablet is taken with linezolid it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Periset-4 Tablet along with linezolid can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.
OndansetronMoxifloxacin
Severe
How does the drug interact with Periset-4 Tablet:
Taking Periset-4 Tablet with Moxifloxacin increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking Periset-4 Tablet along with Moxifloxacin can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience dizziness, shortness of breath, or rapid heartbeat. Do not discontinue any medications without a doctor's advice.
OndansetronNortriptyline
Severe
How does the drug interact with Periset-4 Tablet:
Using Nortriptyline together with Periset-4 Tablet can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Periset-4 Tablet along with nortriptyline can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, or diarrhea. while taking these medications. Do not discontinue any medications without a doctor's advice.
OndansetronMifepristone
Severe
How does the drug interact with Periset-4 Tablet:
Co-administration of Periset-4 Tablet with mifepristone can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Periset-4 Tablet with mifepristone together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
OndansetronDuloxetine
Severe
How does the drug interact with Periset-4 Tablet:
Taking Periset-4 Tablet with duloxetine can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in body).

How to manage the interaction:
Although taking Periset-4 Tablet with duloxetine can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting a doctor.
OndansetronAnagrelide
Severe
How does the drug interact with Periset-4 Tablet:
Taking Periset-4 Tablet with anagrelide increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Periset-4 Tablet alongside anagrelide can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without a doctor's advice.
OndansetronTapentadol
Severe
How does the drug interact with Periset-4 Tablet:
Using Tapentadol together with Periset-4 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although taking Periset-4 Tablet along with tapentadol can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, and diarrhea, see a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronNilotinib
Severe
How does the drug interact with Periset-4 Tablet:
Taking Periset-4 Tablet with nilotinib increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Periset-4 Tablet along with nilotinib can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without a doctor's advice.
OndansetronEscitalopram
Severe
How does the drug interact with Periset-4 Tablet:
Taking Periset-4 Tablet with escitalopram may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Co-administration of Periset-4 Tablet along with escitalopram can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat small meals throughout the day and eat slowly to help digestion.
  • If you are sensitive to food smells, try eating cold or room-temperature foods instead of hot ones.
  • Avoid acidic foods or drinks like orange or grapefruit juice.
  • After your meals, rest with your head elevated about 12 inches above your head.
  • Drink liquids or water between meals rather than during meals.
  • Eat when you are least nauseated to help prevent discomfort.
  • Avoid consuming greasy or oily foods, as these foods can trigger nausea and vomiting.
  • Include clear broths, non-fat yoghurt, fruit juice, sherbet, and sports drinks for fluid makeup that has been lost due to vomiting.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Periset-4 Tablet Substitute

Substitutes safety advice
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Alcohol

Caution

Alcohol has no known direct interaction with Periset-4 Tablet . However, it is advisable to avoid consuming alcohol while taking Periset-4 Tablet , as it may worsen the side effects like drowsiness.

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Pregnancy

Unsafe

Periset-4 Tablet should be used during pregnancy only if prescribed by a doctor. It is generally not recommended for use during early pregnancy (first trimester), as it may increase the risk of birth defects in the mouth and face of the baby.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Periset-4 Tablet , as small amounts of the medicine may pass into breast milk.

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Driving

Caution

Periset-4 Tablet does not affect your ability to drive. However, if you experience drowsiness or blurred vision after taking Periset-4 Tablet , avoid driving or operating any heavy machinery.

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Liver

Caution

In individuals with liver problems, the use of Periset-4 Tablet is allowed if prescribed by a doctor. However, patients with severe liver impairment should take a low dose of Periset-4 Tablet as much as possible. Do not take more than 8 mg of Periset-4 Tablet per day in case of liver disease.

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Kidney

Safe if prescribed

The use of Periset-4 Tablet is considered safe in patients with kidney disorders. No dose adjustment is required.

bannner image

Children

Safe if prescribed

Periset-4 Tablet should not be given to children below 4 years of age, as its safety and effectiveness have not been established in this age group. The use of Periset-4 Tablet is safe in children above 4 years of age if prescribed by a doctor.

FAQs

Periset-4 Tablet is used in the prevention of vomiting and nausea that usually occur after cancer chemotherapy, radiation treatment, or surgery.

Periset-4 Tablet contains Ondansetron, which works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting.

Periset-4 Tablet may cause drowsiness and changes in vision, so avoid driving or operating any machines that require mental alertness.

People with an irregular heartbeat (arrhythmia) and phenylketonuria (too much of the protein phenylalanine in the blood) should not take Periset-4 Tablet as it may cause serious conditions. The patient with liver disease should not take more than 8 mg of Periset-4 Tablet daily. Taking Periset-4 Tablet with apomorphine can cause a sharp dip in blood pressure, even leading to death, so avoid its intake together.

Periset-4 Tablet contains Ondansetron, an antiemetic drug, used in the prevention of vomiting and nausea.

Periset-4 Tablet is ineffective in preventing nausea associated with motion sickness.

Before taking Periset-4 Tablet , inform your doctor about all your medical conditions, sensitivities, and medications you are using. Also, tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Periset-4 Tablet usually works quickly, usually within 30 minutes, but it can take up to two hours for the full effect.

Common side effects of Periset-4 Tablet may include constipation, headache, diarrhea, drowsiness, flushing (a feeling of warmth), weakness, and tiredness. However, not every person experiences these side effects, and some of the unpleasant effects of Periset-4 Tablet do not require medical attention. If the side effects persist or worsen, please consult your doctor.

Periset-4 Tablet was not found to be beneficial in the treatment of seasickness.

Periset-4 Tablet works by blocking the action of a chemical in the body (serotonin) that is responsible for causing nausea and vomiting. As a result, Periset-4 Tablet prevents the sensation of nausea and vomiting caused by conditions like surgery, cancer chemotherapy, pregnancy, or motion sickness.

Yes, you can take Periset-4 Tablet half an hour to 1 hour before meals.

If you forget to take a dose of Periset-4 Tablet , take it as soon as you remember. However, if it is time for your next dose, skip the missed dose and take your regular dose. Never take a double dose to make up for a forgotten dose.

If you take more than the recommended dose of Periset-4 Tablet , it may result in an overdose. Signs and symptoms of an overdose of Periset-4 Tablet may include constipation, dizziness or lightheadedness, fainting, irregular heartbeat, and sudden loss of vision for a short time. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

No, Periset-4 Tablet is not a steroid. Periset-4 Tablet belongs to a class of drugs known as antiemetics.

While specific dosing instructions will vary depending on your individual needs and medical history. Always follow your doctor's prescribed dosage and timing for taking these medications.

Take Periset-4 Tablet exactly as prescribed by the doctor. Take it at the same time daily, as it will help you remember to take the medication.

Yes, Periset-4 Tablet can be given during pregnancy if prescribed by a doctor. However, it is not recommended for use during early pregnancy (first trimester), as it may increase the risk of birth defects in the mouth and face of the baby.

Country of origin

India

Manufacturer/Marketer address

142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - PER0085

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Sep 18, 2025 | 1:05 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://pdf.hres.ca/dpd_pm/00068458.PDF
  2. https://assets.hpra.ie/products/Human/20212/1c456dc8-a1c3-4bbd-a64e-bf71394c3935.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020103s035_020605s019_020781s019lbl.pdf
  4. https://www.medicines.org.uk/emc/product/10160/smpc
  5. https://www.drugs.com/ondansetron.html
  6. https://medlineplus.gov/druginfo/meds/a601209.html

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